mannose a sugar monomer of aldohexose series of carbohydrate

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this is a small ppt on mannose a part of biochemistry

MANNOSE
-Gulshan Banu

BASIC INTRODUCTION:
D-mannose is a hexose
monosaccharide,that belongs to
group of aldose.(aldohexos).
Mannose commonly exsits as two
different rings,the pyranose(six –
memberd)form and furanose (five –

Mannoseistransportedtomammaliancellsviafacilitated
diffusionbyhexosetransporterpresentonplasma
membrane.
Withinthecell,mannoseisphosphorylatedbyHexokinase
(HK)toproduceMannose-6-phosphate(Man-6-p).
Itiseithercatabolizedbyphosphomannoseisomerace
(MIP)ordirectedtoN-glycosylationvia
phosphomannomutase(PMM2).

ThefateofMan-6-P largelydependsontheratioofMPItoPMM2within
acell–higherratioleadstogreatercatabolism,whilelowerratio favors
theglycosylation pathway.
PMM2-derivedmannose-1-phosphate(Man-1-P)isthenincorporatedinto
severalglycosylation intermediatesincludingGDP-mannose(GDP-Man),
GDP-fucose,anddolichol phosphatemannose(Dol-P-Man).
TheseintermediatesthencontributetoN-glycosylation, O-glycosylation,
C-mannosylation, andGPIanchorsynthesis.

N-linkedglycosylationplaysanessentialroleinthefolding
andthe qualitycontrolofproteinsintheER.
O-Mannosylation isknownasayeast-type modification,and
O-mannosylated glycoproteinsareabundant intheyeast cell
wall.
C-Mannosylation isapost-translationalmodificationof
proteinsintheendoplasmicreticulum.

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Beginners Guide to TikTok for Search - Rachel Pearson - We are Tilt __ Bright...

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12 Ways to Increase Your Influence at Work

12 Ways to Increase Your Influence at Work

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ChatGPT webinar slides

ChatGPT webinar slides

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Ride the Storm: Navigating Through Unstable Periods / Katerina Rudko (Belka G...

Ride the Storm: Navigating Through Unstable Periods / Katerina Rudko (Belka G...

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Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well

Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well

Good Stuff Happens in 1:1 Meetings: Why you need them and how to do them well

mannose a sugar monomer of aldohexose series of carbohydrate

1. MANNOSE -Gulshan Banu

2. BASIC INTRODUCTION: D-mannose is a hexose monosaccharide,that belongs to group of aldose.(aldohexos). Mannose commonly exsits as two different rings,the pyranose(six – memberd)form and furanose (five –

3.

4. Mannoseistransportedtomammaliancellsviafacilitated diffusionbyhexosetransporterpresentonplasma membrane. Withinthecell,mannoseisphosphorylatedbyHexokinase (HK)toproduceMannose-6-phosphate(Man-6-p). Itiseithercatabolizedbyphosphomannoseisomerace (MIP)ordirectedtoN-glycosylationvia phosphomannomutase(PMM2).

5.

6. ThefateofMan-6-P largelydependsontheratioofMPItoPMM2within acell–higherratioleadstogreatercatabolism,whilelowerratio favors theglycosylation pathway. PMM2-derivedmannose-1-phosphate(Man-1-P)isthenincorporatedinto severalglycosylation intermediatesincludingGDP-mannose(GDP-Man), GDP-fucose,anddolichol phosphatemannose(Dol-P-Man). TheseintermediatesthencontributetoN-glycosylation, O-glycosylation, C-mannosylation, andGPIanchorsynthesis.

7. N-linkedglycosylationplaysanessentialroleinthefolding andthe qualitycontrolofproteinsintheER. O-Mannosylation isknownasayeast-type modification,and O-mannosylated glycoproteinsareabundant intheyeast cell wall. C-Mannosylation isapost-translationalmodificationof proteinsintheendoplasmicreticulum.