Management of anxiety:
Overview of
Pharmacotherapy
Dr. Sujit Kumar Kar
Additional Professor of Psychiatry
King George’s Medical University,
Lucknow, U.P
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Anxie
ty
Anxiety
disorders
Stress-
related
disorders
Depressio
n
Substance
use
disorder
Sleep
disorder
Psychotic
illnesses
Performa
nce
anxiety
Health
anxiety
Organic
anxiety
disorder
Medical
Condition
s
Management outlines of anxiety
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4
Anxiety Vs Anxiety
Disorders
Pharmacotherapy
Psychological treatments
Relaxation therapies
Somatic treatments
Alternative therapies (Yoga,
Meditation, Reki…)
The goal of
Pharmacotherapy in the
management of anxiety
• Short-term goals –
[Immediate release of anxiety]
• Long-term goals –
[Long-term control of anxiety
and prevention of relapses]
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Medications
with anxiolytic
properties
• Benzodiazepines
• Selective serotonin reuptake inhibitors (SSRIs)
• Serotonin norepinephrine reuptake inhibitors (SNRIs)
• Tricyclic antidepressants (TCAs)
• Monoamine oxidase inhibitors (MAOs)
• Buspirone
• Other antidepressants – Agomelatine, Tianeptine,
Mirtazapine
• Tofisopam
• Beta blockers
• Anticonvulsants
• Atypical antipsychotics
• Antihistaminic agents
• Etifoxine
Pharmacological management of
anxiety
Acute Control
Versus
Long-term Control
Acute Control
Versus
Long-term Control
Benzodiazepines (Less than 1 hour)
Selective serotonin reuptake inhibitors
(SSRIs)
Serotonin-norepinephrine reuptake
inhibitors (SNRIs)
Tricyclic antidepressants (TCAs)
Monoamine oxidase inhibitors (MAOIs)
Buspirone
Other antidepressants – Agomelatine,
Tianeptine, Mirtazapine
Tofisopam (2 hours to 3 days)
Beta-blockers (within 1 to 4 hours)
Anticonvulsants
Atypical antipsychotics
Antihistaminic agents (Less than 1 hour)
Etifoxine (2 to 3 hours) 8
Understanding Anxiolytics
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Anxiolytics
• With
antidepressant
property
• Without
antidepressant
property
Anxiolytics
• With sedative
property
• Without sedative
property
Anxiolytics
• Less risk in
pregnancy
& lactation
Anxiolytics
• With abuse
potential
• Without
abuse
potential
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Slee et al., 2019
Click icon to add picture
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Efficacy Acceptability
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Understanding Anxiolytics
Benzodiazepine anxiolytics Non-benzodiazepine anxiolytics
Future Need:
Sophisticated Anxiolytics
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Non-sedating
No hangover
No dependence
Good safety profile
Low cost
No cognitive slowing
Who can deliver these sophisticated
needs?
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Propranolol ????
Etifoxine ?????? Any other
drug??
Buspirone ????
Tofisopam ???
Thank you

Management of anxiety @ Overview of Pharmacotherapy.pptx