The document discusses the meaning of equality and Namasmaran, a practice of remembering God's name. It states that merely preaching equality can lead to misapplication of the concept unless it is studied with respect to justice. True equality embodies a holistic vision where policies aim to develop an environment for everyone to blossom. Namasmaran is described as a means of blossoming from within by reorienting one's being to the true self through remembering God's name. It is said to be a culmination of consciousness associated with all activities and a form of meditation that is a natural climax to other practices.
Our Sadguru Shri Brahmachaitanya Maharaj Gondavalekar said, тАЬTrust that the practice of NAMASMARAN as prescribed by Guru would emancipate the universe! Lord Rama would bless!тАЭ
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
BowmanтАЩs Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
2. The slogans per se are attractive and serve the
purpose to attract people towards their
essence. Thus preaching equality as such; is
not useless or counterproductive. But the lack
of its study with respect to justice; makes the
misuse of the slogan easy and rampant!
The enlightenment of an individual lets
him/her see the world holistically and hence
differently than the unenlightened individuals.
Hence it is essential to study the concept of
equality not merely by reading but by also by
blossoming from within through the practice
of the means of enlightenment! This way you
can understand and imbibe its purport of
equality.
Blind preaching of equality (either foolishly or
with ulterior motive); leads to misapplication
of the concept of equality in framing of
international laws, constitutions and local laws
3. and conventions. Thus equality does not mean
arbitrary equal distribution of the wealth, or
arbitrary imposition of the same education or
arbitrary rules and regulations of the conduct.
Thus neither barbaric тАЬfreedomтАЭ to amass
wealth at the cost of others nor fanatic
imposition of regimentalization of one kind or
another constitute equality!
Equality embodies the holistic vision and
perspective wherefrom manifest the policies,
plans and their execution for developing the
suitable environment for promotion of the
blossoming of everyone in the world. But what
is this blossoming? This blossoming is an
objective and all encompassing state that is
core of global civilization!
NAMASMARAN is one of the means of
blossoming from within and develop holistic
perspective!
4. BUT WHAT IS NAMASMARAN?
Namasmaran means; remembering the name
of God, Guru, great souls; such as prophets
and holy objects such as planets and stars. It
may be remembered silently, loudly, along
with music, dance, along with breathing, in
group or alone, either with counting by rosary
(called SMARANI or JAPAMALA) or without
counting. The traditions vary from region to
region and from religion to religion.
However the universal principle underlying
NAMASMARAN is to reorient your
physiological being with your true self. In fact
while reorienting with true self you aim to
establish and strengthen the bond or
connection; between; your physiological being;
with your true self. You aim at reunification
with yourself!
5. Since remembering your true self is the
pinnacle of or culmination of individual
consciousness, and individual consciousness is
the culmination of every activity in life,
remembering any name of God or Guru (any
symbol of your true self) is equivalent to
opening the final common pathway for the
individual consciousness associated with every
possible activity to get funneled into or unified
with objective or cosmic consciousness.
Thus NAMASMARAN is in fact the YOGA of
YOGA in the sense that it is the culmination of
consciousness associated with every possible
procedure and technique in the yoga that you
are familiar with. It is the YOGA of YOGA
because it is the culmination of consciousness
associated with all the activities in the universe,
which it encompasses as well! It is YOGA of
YOGA because everybody in the world
6. irrespective of his/her tradition and the beliefs;
would eventually, ultimately and naturally
reach it it in the process of liberation. Even so
called non believers also would not тАЬmissтАЭ the
тАЬbenefit of remembering the true self through
one symbol or anotherтАЭ!
Just as NAMASMARAN is YOGA of YOGA it
is meditation of meditation also! It is the
natural and ultimate climax of every form of
meditation.
These facts however have to be realized with
persistent practice of NAMSMARAN and
not blindly believed or blindly disbelieved with
casual approach!
In short NAMSMARAN is super-bounty of
cosmic consciousness for every individual to
realize it (cosmic consciousness)! This is truly a
super-bounty because a person who
7. experiences it, rises above mercenary,
commercial and even professional and charity
planes and manifest super-transactions in his
or her life!
These are just few observations to give rough
idea about what is NAMASMARAN.
NAMASMARAN is an ocean of bliss. Its true
meaning is beyond description in words.
DR. SHRINIWAS KASHALIKAR