Megaprosthetic replacement of knee in a young boy of 14 yearsApollo Hospitals
Now a days, Total Knee Replacement (TKR) is a common for elderly patients but is an uncommon procedure in young individuals. Recently, limb conservation surgery for malignant bone tumours like osteosarcoma around the knee has become a common indication for TKR in young. We report, here a histologically confirmed osteosarcoma in right
proximal tibia of a 14-year-old boy who was managed successfully by limb salvage surgery using Global Modular Replacement System (GMRS, Stryker).
A comparative study on the clinical and functional outcome of limb salvage su...NAAR Journal
The aim of this study was to analyze the survival, recurrence, complications as well as the quality of life (QOL) in tibial osteosarcoma (OSA) patients managed by limb salvage surgery (LSS), either by a prosthesis, resection or graft or by amputation. 106 tibial osteosarcoma patients were enrolled where 39 had custom-designed endoprosthetic arthroplasty (LSS1), 36 underwent resection and bone graft (LSS2) while only 31 underwent amputation. A Comparison was done based on post-operative survival rates, postoperative recurrence, and complications. The impact of the patient’s QOL was also evaluated.
Megaprosthetic replacement of knee in a young boy of 14 yearsApollo Hospitals
Now a days, Total Knee Replacement (TKR) is a common for elderly patients but is an uncommon procedure in young individuals. Recently, limb conservation surgery for malignant bone tumours like osteosarcoma around the knee has become a common indication for TKR in young. We report, here a histologically confirmed osteosarcoma in right
proximal tibia of a 14-year-old boy who was managed successfully by limb salvage surgery using Global Modular Replacement System (GMRS, Stryker).
A comparative study on the clinical and functional outcome of limb salvage su...NAAR Journal
The aim of this study was to analyze the survival, recurrence, complications as well as the quality of life (QOL) in tibial osteosarcoma (OSA) patients managed by limb salvage surgery (LSS), either by a prosthesis, resection or graft or by amputation. 106 tibial osteosarcoma patients were enrolled where 39 had custom-designed endoprosthetic arthroplasty (LSS1), 36 underwent resection and bone graft (LSS2) while only 31 underwent amputation. A Comparison was done based on post-operative survival rates, postoperative recurrence, and complications. The impact of the patient’s QOL was also evaluated.
Adult Stem cells in Orthopaedics present and future perspectives.
Παρουσίαση του Δρ. Σταύρου Αλευρογιάννη που έγινε στο ξενοδοχείο Χίλτον, στις 12/06/15 στα πλαίσια Ημερίδας της Ελληνικής Εταιρείας Αναγεννητικής Ιατρικής, Αντιγήρανσης και Βιοτεχνολογίας, στο 41ο Πανελλήνιο Ιατρικό Συνέδριο.
"H θέση της αναγεννητική Ιατρικής στις παθήσεις Οστών και Αρθρώσεων"
Adult Stem cells in Orthopaedics present and future perspectives.
Παρουσίαση του Δρ. Σταύρου Αλευρογιάννη που έγινε στο ξενοδοχείο Χίλτον, στις 12/06/15 στα πλαίσια Ημερίδας της Ελληνικής Εταιρείας Αναγεννητικής Ιατρικής, Αντιγήρανσης και Βιοτεχνολογίας, στο 41ο Πανελλήνιο Ιατρικό Συνέδριο.
"H θέση της αναγεννητική Ιατρικής στις παθήσεις Οστών και Αρθρώσεων"
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
2. LONG-TERM OUTCOMES OF LIMB RECONSTRUCTION USING TIBIAL
STRUT AUTOGRAFT
THE ARCHIVES OF BONE AND JOINT SURGERY. ABJS.MUMS.AC.IR
VOLUME 9. NUMBER 5. SEPTEMBER 2021
)568(
bone scintigraphy, contrast‑enhanced chest and
abdomen computerized axial tomography (CAT),
contrast‑enhanced magnetic resonance imaging (MRI)
of the whole tumor-involved bone, and magnetic
resonance angiography (MRA) to assess the vascular
supply of the affected region.
The diagnosis was confirmed by histopathological
examination for all patients preoperatively. Four cases
had Ewing sarcoma (ES) and two had osteosarcoma
(OS). All the tumors were evaluated according to the
Enneking malignant tumor staging system (14). Two
patients were stage III and four patients were stage IIB.
We assessed the clinical outcomes by MSTS functional
scoring system and the radiological outcomes by plain
orthogonal
radiographs (14).
All patients and their families had signed a written
consent to use of their data and images for publication
in this study.
Operative technique
We determined the level and the length of tumor
resection, and the length of the autograft from the
preoperative images. After surgical resection of the
tumor according to the plan, surgical instruments,
gowns, gloves, and draping were renewed to prevent
tumor contamination of the donor site.
The tibial strut autograft was harvested from the
ipsilateral tibia in femoral lesions and from the
contralateral tibia in tibial lesions. In contralateral
harvestings, a tourniquet was applied on the thigh (220
mmHg) for a maximum of 120 minutes.
A longitudinal incision was made over the anteromedial
aspect of the tibia down to the periosteum [Figure 1].
The periosteal sheath was incised longitudinally and
raised gently with a sharp periosteal elevator from
all around the tibia protected by small blunt bone
elevators inserted under the periosteal sheath around
the proximal and distal ends of the proposed osteotomy.
Multiple 2.5 mm diameter drill holes were made at the
proposed level of osteotomy of the tibia proximally and
distally. Bone ends were cut by a small sharp osteotome
and the tibial graft was removed in one piece involving
all the cortices without leaving a strut of normal bone.
The medullary canal to the remaining bones was
opened proximally and distally using a curette
(size 3mm) to allow the free communication of the
bone marrow with the bone defect. The remaining
periosteal sheath around the bone defect was tightly
closed using Vicryl 2/0 continuous suture to form a
periosteal tube. The skin was closed using Vicryl 2/0
subcuticular sutures.
After closure, 40-80 ml of aspirated iliac crest bone
marrow was injected into the periosteal tube using
plastic green cannula size G 16 to prevent the collapse of
the periosteal tube and to promote new bone formation.
This step was repeated after one week via percutaneous
approach under general anesthesia.
Stabilization of the leg of the donor site was achieved by
a monoplanar external fixator in four patients, a multi-
axial ring fixator in one patient, and an intramedullary
nail in one patient. The aim was to keep the leg stable in
result in a variety of postoperative complications after
reconstruction. This will prompt physicians to look for
an appropriate function-preserving alternative after
massive resection of such tumors and affected soft
tissues (5).
Thesurgicaloptionsforreconstructioninmetaphyseal/
metaphyseal-diaphyseal tumors in adolescent
patients usually include special endoprostheses that
providesatisfactory results shortly after surgery (6).
Extendable or expandable mega prostheses have gained
enormous popularity in growing patients (7,8).
Other various methods of limb reconstruction have
been proposed for diaphyseal tumors. These include
fibular autografts (vascularized/ non-vascularized),
intercalary allografts, allografts combined with
a vascularized fibular graft, irradiated autografts
combined with vascularized fibular grafts, composite
grafts of devitalized autografts and vascularized fibular
grafts, fibular transport, and distraction osteogenesis
(9-13). However, it is difficult to determine the best
reconstructive option for particular patients.
The most common autografts used for reconstruction
are the vascularized and non-vascularized fibular grafts.
To the best of our knowledge, no previous studies
reported the use of the tibia as an intercalary strut
autograft for reconstruction of large bone defects in
skeletally immature patients.
Inthisstudy,wereportourexperienceandthelong-term
clinical and radiological outcomes of using intercalary
tibial autograft for treatment of six skeletally immature
patients as a novel technique for reconstruction of large
bone defects after resection of primary malignant bone
tumors in the long bones of the lower extremity.
Materials and Methods
We retrospectively reviewed the medical records of six
skeletally immature patients diagnosed with primary
malignant bone sarcomas of the lower limbs and treated
by wide resection and reconstruction using tibial
intercalary autografts. All surgical procedures were
done by the same orthopaedic surgeon at our hospital
between the years 2000 and 2013.
After obtaining an approval from our institutional
review board, we collected the clinical and radiological
data of these patients. The following information
is reported: demographic and diagnostic data
(age, sex, tumor location, histologic diagnosis,
and musculoskeletal tumor society (MSTS) score),
therapeutic data (harvesting and reconstruction
details, adjuvant/ neoadjuvant chemotherapy, and
radiotherapy), length of the autograft, method of
autograft fixation, re-operations, the need for a plastic
surgeon’s assistance in soft tissue coverage, the status
of autograft, and the regeneration of the donor site.
We also report the postoperative complications (non-
union, fracture, implant failure, or infection) and the
time required for the bone union at the proximal and
distal ends of the autografts.
All patients underwent complete staging workup
in addition to the radiographic investigations which
include plain radiographs, whole‑body isotope
3. LONG-TERM OUTCOMES OF LIMB RECONSTRUCTION USING TIBIAL
STRUT AUTOGRAFT
THE ARCHIVES OF BONE AND JOINT SURGERY. ABJS.MUMS.AC.IR
VOLUME 9. NUMBER 5. SEPTEMBER 2021
)569(
a straight position and under tension to allow the new
regeneration of the tibia within the periosteal tube.
The non-vascularized tibia strut graft was implanted
in the bone defect resulting from tumor resection. This
was fixed proximally and distally by different methods
according to each case [Table 1].
Postoperative measures and outcomes
Prophylactic antibiotics were administered to all
patients on induction of anesthesia and continued
for seven days postoperatively. All patients were
transferred to the intensive care unit for 48 hours
postoperatively until hemodynamic stability was
ensured. Hemoglobin levels and systolic arterial blood
pressure were maintained above 9 mg/dl and 100
mmHg, respectively.
On postoperative day three, range of motion
exercises were started under the guidance of the
rehabilitation team. Patients started to walk with the
aid of a walker frame, allowing full weight-bearing on
the intact lower limb in patients with femoral tumors.
Patients with tibial lesions were allowed to mobilize
using wheelchair in the first 2 weeks then weight-
bearing as tolerated on the donor limb. No weight
bearing was allowed on the reconstructed limb until
early signs of radiological union were observed.
Patients then progressed to partial weight-bearing
and later to full weight-bearing according to the signs
of graft healing.
Four weeks post-operatively, after all surgical wounds
were healed, patients were referred to the oncology
service to continue the planned adjuvant chemotherapy
and radiotherapy.
External fixators on the donor site were removed after
Figure 1. Steps (from A to D) for harvesting the tibia as strut autograft.
Table 1. Demographic and clinical data for each patient
Age (years)/
Gender
Location
Diagnosis/
MSTS stage
Length of
resected
specimen
Length of
bone graft
Fixation
proximally
Fixation
distally
Plastic
surgery cover
1 6 / Male Distal femur OS/ IIB 19 cm 14cm DCP Ex. Fix. -
2 12/ Male Femur shaft ES/ IIB 29 cm 25cm DCS-IMR
95° angled
blade plate
-
3 9/ Male Distal tibia ES/ III 16 cm 16cm DCP
T-plate, screw,
bone graft
Bilateral fasciocutaneous
flaps + FTSG
4 15/ Male Tibial shaft ES/ III 20 cm 20cm IMN-DCP IMN + DCP
Fasciocutaneous Flap +
STSG
5 12/ Female Proximal tibia ES/ IIB 24 cm 24cm IMN IMN -
6 6/ Male Distal femur OS/ IIB 17 cm 17cm DCP + Ilizarov
T-plate +
Ilizarov
-
OS: Osteosarcoma, ES: Ewing’s sarcoma, MSTS: Musculoskeletal Tumor Society system, IMR: intramedullary rod, IMN: intramedullary nail, DCP:
Dynamic compression plate, DCS: dynamic compression screw, Ex. Fix.: External fixator, FTSG: Full-thickness skin graft, STSG; Split-thickness skin graft
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adequate consolidation had been observed on plain
radiographs.
Patients were evaluated in the clinic clinically and
radiographically every (4-8) weeks in the first year,
every three months during the second year, every six
months during the next three years, and then annually.
Conventional radiographs of the recipient site were
obtained to evaluate evidence of graft union, bony
consolidation, tumor recurrence, and complications.
Union was defined as the disappearance of the autograft-
host junction or bridging bone across three cortices on AP
and lateral views. Radiographs of the donor site were
performed at 2 weeks, 6 weeks, and then every 8 weeks
to evaluate bone regeneration in the tibial periosteal
tube.
Results
The mean age at diagnosis was ten years (range 6-15
years). Five patients were males and one patient was
female. In all patients, bone tumors were localized to the
lower extremity. The two cases of OS were in the distal
femur (one in the metaphyseo-diaphysis and the other in
the metaphysis). Of the four cases of ES, three were in the
tibia (one in the diaphysis and two in the metaphyseo-
diaphysis) and one in the femoral diaphysis.
The mean length of the resected tumor specimen
was 20.83 cm (range 16-29 cm). The length of the tibia
autograftsmatchedthelengthoftheresections;themean
length of the harvested autografts was 19.33 cm (range
14-25 cm). Table 1 summarizes the details of the clinical
and demographic data of each patient. The outcomes
and complications encountered postoperatively are
shown in Table 2.
Two patients developed a hematoma at the recipient
site despite the use of a wide-bore drain. Cultures from
the hematomas revealed negative bacterial growth in
both patients.
Four patients (two femoral OS and two tibial ES) were
alive with the preservation of the limb at the final follow-
up. Two patients died of tumor-related reasons without
failure of the autograft. The first patient had femoral ES
who died after 14 months due to local recurrence and
lung and bone metastases. The other patient had tibial
ES who died after five years due to multiple lung and
bone metastases.
On the last follow-up, the alive patients (4 cases) had
a mean of 24.25/30 (80.8%) score on the MSTS87
functional assessment. They reported as mean scores
the following: Pain (4.5/5), function (3.5/5), emotional
acceptance (3.75/5), need for support (4/5), walking
ability (4.75/5), and gait (3.75/5).
We observed no limb-length discrepancy (LLD) in
one patient with preservation of both physes during
oncologic resection of the tumor. In the remaining
three patients, LLD developed as a result of the loss of
one or both physes. One patient with femoral OS had
lengthening of the tibia one year after the initial surgery
(9 cm) and lengthening of the femur 5 years later (7 cm).
However, at maturity, he has had a 1.5 cm LLD [Figure 2].
One patient with distal tibial ES developed a 3 cm LLD
and he is currently using a
1.5 cm shoe lift. The other
patient with femoral OS is waiting for a lengthening
procedure of his femur.
Osseous consolidationwas considered complete when
the graft united to the recipient site with signs of new
bone formation. Eleven out of twelve (91.6 %) junctions
between tibial autografts and the recipient sites united.
One patient had a residual non-union of the proximal
junction; high-dose adjuvant radiotherapy might have
contributed to that [Figure 3].
All patients received neoadjuvant and adjuvant
chemotherapy. None of the patients received
Table 2. Follow-up duration, complications, and clinical outcomes
Follow up Complications
Proximal
union
Distal
union
Further surgical
procedures
Prognosis
MSTS
functional
score %
1 20 Years
Hematoma, pin tract infections,
varus distal femur, valgus tibia
donor site
3 months 12 months
3 procedures for limb length-
ening in both femur ant tibia
(total 25cm), femoral nailing
No recurrence 86.6
2 14 months
Valgus tibia donor site, proximal
local recurrence, lung and bone
metastases
6 months 10 months - Dead -
3 3 Years
Hematoma, foot drop, anterolateral
bowing leg (donor site), partial skin
necrosis, LLD 3 cm
Not united 10 months
Bone graft for nonunion,
tibial retrograde rod, strut
fibula autograft, ankle
arthrodesis
No recurrence 66.6
4 15 Years Varus leg (donor site). 4 months 5 months - No recurrence 100
5 5 Years Varus ankle, LLD 3 cm, metastasis. 4 months 4 months - Dead -
6 6 Years LLD 5 cm 3 months 12 months Planned for lengthening No recurrence 70
(LLD: limb-length discrepancy, MSTS: Musculoskeletal Tumor Society)
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neoadjuvant radiotherapy. Three patients with Ewing’s
sarcoma received adjuvant radiotherapy as they have
poor chemotherapeutic response.
The exact time to bony union was identified using
plain orthogonal
radiographs. All the proximal junctions
united at a mean duration of four months (range 3-6
months), except one proximal end. The mean duration of
the distal junction union was 8.8 months (4-12 months).
Bony union appeared to be earlier and stronger at the
proximal compared to the distal junction, probably
due to richer proximal blood supply and better muscle
coverage.
Three patients underwent joint arthrodesis due
to tumor encroachment on the growth plate and
impossibility to preserve the articular surface of the
bone; one distal femoral OS, one proximal tibial ES, and
one distal tibial ES. One patient needed an ankle fusion
due to difficulty in preserving the distal tibia epiphysis,
however, he developed a foot drop due to tumor invasion
of the peroneal nerve branches and the anterolateral
muscles of the leg.
All donor sites consolidated[Figure 2-5]. The earliest
sign of new bone formation was at (2-4) weeks and well-
formed bone regeneration was observed at four months
in all cases. The external fixation on the donor site
was removed after complete regeneration. The mean
duration of external fixation on the donor site was six
months (range 5-8 months).
One varus and two valgus tibias and one anterolateral
bowing of the tibia were documented as complications
at the donor site [Figure 2; 3; and 5].
Figure 3. Preoperative and postoperative images for patient number 3
A. AP view radiograph of both legs on the third postoperative day showing the right leg with
the tibial graft fixed proximally and distally by plates and screws. The left leg radiograph
shows the defect in the tibia after graft harvesting and the monoplanar external fixator to
stabilize the leg.
B. AP view radiograph 14 weeks postoperatively showing regeneration of the left tibia at the
site of graft harvesting.
C. Radiographs three years later. The AP view of the right leg shows nonunion of the proximal
graft junction and the fused ankle with an intramedullary rod. The left tibia appeared well-
regenerated with mild lateral bowing.
Figure 2. Immediate postoperative images and the outcome after
20 years for patient number 1
A. AP view radiograph of the distal femur and the donor site in
the second postoperative day showing the tibial autograft in the
distal half of the femur fixed proximally by a plate and screws and
distally by two Schanz screws attached to external fixator that is
also fixing the leg at the same time (donor site).
B. Long film standing radiographs after 20 years of follow-up
showing well-remodeled right femur and tibia, fused right knee,
15-degree varus angulation of the right distal femur, mild valgus
deformity of the right leg, and pelvic tilt to the right side due to 2
cm limb-length discrepancy.
C. A clinical photograph of the lower limbs from the front showing
the preserved right lower limb with evidence of scars of the
previous surgeries.
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Discussion
Among neoplasms affecting humans, primary
malignant bone tumors are rare. They represent an
incidence rate of roughly ten cases per one million
inhabitants per year. During childhood (<15 years), the
percentage of malignant bone tumors accounts for 6% of
all childhood malignancies (15).
Themainaimofprimarymalignantbonetumorsurgery
resection is to obtain local control while maximizing
the functional outcomes without compromising the
long‑term survival of the patient. This can be achieved by
limb salvage surgery or amputation with wide surgical
margins. Numerous studies have shown no difference
between long‑term survival in patients treated with
limb salvage surgery or amputation if negative surgical
margins were achieved (16).
The availability of advanced imaging techniques,
improvement of surgical margins with neoadjuvant
chemotherapy, and advances in the surgical techniques
have made limb salvage surgery an accepted method of
local control.
Many tumors of the metaphyseal-diaphyseal region
of long bones can be resected with joint preservation
resulting in intercalary bone defects. There are many
options for the reconstruction of these defects as
biological and non-biological techniques. Each of these
Figure 4. Radiograph and clinical photo of patient number 4 after
15 years of follow-up.
Standing AP view radiograph of both legs (A) showing the well
regenerated, remodeled right tibia with mild varus deformity.
The left tibia appeared fully remodeled and the graft is well-
incorporated. Photograph (B) in standing position showing
symmetrical leg alignments and scars of previous surgeries.
Figure 5. Radiograph and clinical photo of patient number 5.
Immediate postoperative radiograph of the right leg (A) showing the tibia fixation using intramedullary nail after
harvesting the graft. After 5 years of follow-up, standing AP view radiograph of both legs (B) showing the well
regenerated, remodeled right tibia with distal varus deformity. The left tibia graft is well-incorporated after nail
fixation. (C) Clinical photograph of both legs in a standing position (from the front) showing the varus deformity of
the right ankle with evidence of scars of previous surgeries.
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techniques has its advantages and disadvantages;
every patient must be carefully evaluated and the
reconstructive option should be selected individually
[Table 3] (17).
Endoprosthetic reconstruction gives a good functional
result with early stability, mobilization, emotional
acceptance, and rapid restoration of function due to
the advantage of early weight‑bearing (18). However,
treating skeletally immature pediatric patients with
such reconstructive methods is enormously challenging
especially in patients younger than ten years of age.
First, the size of the remaining bone can be too small for
endoprosthetic reconstruction (19). Second, even when
the remaining bone is large enough for endoprosthetic
reconstruction there is a greater possibility of future
implant failure in younger patients (19).
All of our cases were not amenable for endoprosthetic
reconstruction either due to the age of the patient (three
under the age of ten years), the location of the tumor
(two diaphyseal, and one large tibial metaphyseo-
diaphyseal tumor), or inadequate soft tissue coverage
(in two cases). Problems such as infection, mechanical
insufficiency, and aseptic loosening limit the long‑term
survival of the endoprosthesis, especially in young
patients with continuing skeletal development (20,21).
Extendable or expandable mega prostheses have
gained enormous popularity as they have the ability
of longitudinal extension with a tube within a tube
design which lengthens like a telescope offering a
great alternative to amputation in growing pediatrics.
However, the affordability and non-availability in the
developing countries are real concerns.
The optimal reconstructive method after resection
of diaphyseal primary malignant bone tumor remains
controversial (18). Despite unpredictable healing,
allograft has traditionally been one of the treatment
choices for limb salvage, particularly for diaphyseal
lesions. When successful, allograft reconstruction can
ultimately provide good outcomes (22,23).
Performing intercalary segment reconstruction after
primary malignant bone tumor resections results in
both mechanical and biological challenges. Fixation
must be solid enough to avoid early mechanical failure
(24). The solid fixation using the new modality of limited
Table 3. Advantages and limitations of different reconstruction methods for diaphyseal defects
Method of reconstruction Advantages Limitations
Endoprosthetic replacement
Early full weight bearing
Well controlled size and length by custom
made prosthesis
No external fixation
Good for long femur defects
Higher failure rate if bone other than femur
Higher failure rate if short residual normal bone remains for
fixation
May need flap coverage in tibial lesions
High reoperation rate
Loosening, wear and breakage are concerns in young patients
High cost
Allograft
Different allograft sizes and lengths are
available
The patient must remain non- or partially weight bearing for
few months
Higher risk of infection, non-union or delayed union, and fracture
Less impressive and higher risk of complications for femur
defects
The incidence of allograft–host junction nonunion is considered
to be higher in patients who receive adjuvant therapy
Vascularized fibula autograft
Patient`s own tissue
Better incorporation rates than allograft
Donor site morbidity
Relatively short segment
Hypertrophy of the graft sufficient to allow full weight bearing
can take years in adults
Requires microvascular surgery setup
Prolonged surgery time
Non-vascularized fibula auto-
graft
Patient`s own tissue
No need for microvascular surgery setup
Better incorporation rates than allograft
Limited size and length
Donor site morbidity
Extracorporeal
irradiated autologous bone graft
Provides size-matched bone
Non-availability of
radiation centers
Risks of infection due to long surgical hours
Tibia strut
autograft
Patient`s own tissue
No need for bone bank or radiation facility
Well-matched size and length
Complete remodeling of donor site
Delayed weight bearing
Prolonged surgery
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contact locking plates, if were available at the time of our
treatment of those patients, could have helped the early
recovery of at least three patients. We noticed a more
rapid recovery after using intramedullary nailing in two
patients.
The results of intercalary segmental defects
reconstruction after bone tumor resection were good
from an oncologic and radiological point-of-views. One
or more operative procedures are sometimes needed to
obtain bone union (24).
Good results have been reported after use of
osteoarticular allografts for limb reconstruction after
massive resection of malignant bone tumors (25).
However, several disadvantages are associated with
their use. These include nonunion, late fracture, the
potential transmission of disease, allograft rejection,
and higher risk of
infection in patients receiving
adjuvant chemotherapy and radiotherapy (5,9,21,25).
Furthermore, they require a bone-banking system that
is not available in all countries (26). Allografts and bone
banks were not available in our country at the time of
these surgeries.
To reduce the number of failures, the use of allografts
should be considered for reconstructions of bone defects
less than 15 cm in length, especially in older patients,
and applying bridging osteosynthesis with the use of
plate fixation (25). The bone defects in our patients were
more than 16 cm in length.
The segmental prostheses provide immediate stability
and early weight-bearing capability. However, the risk of
complications such as loosening, rotational instability,
breakage and disassembly of the prostheses, infection,
implant failure, and fracture of the adjacent bone may be
higher than those for biological reconstructions with a
10-year implant survival of 63% (18,27,28).
Indeed, the intercalary prosthesis is not recommended
to reconstruct defects exceeding 10 cm in length (28).
The unavailability of the segmental prosthesis, the sizes
of defects of more than 16 cm, and the younger age of the
patients (<12 years) made this option not viable for the
patients included in our series.
Vascularized fibular autografts have been previously
described as a primary biological reconstruction
method for treatment of metaphyseo-diaphyseal defects
after resection of primary malignant bone tumors
of the long bones of the lower extremity. It is a highly
demanding surgical procedure that needs an expert
vascular surgeon with complex microsurgical skills.
Furthermore, patients need a long period of non-weight
bearing due to poor mechanical stability if used for
intercalary reconstruction of lower limb tumor defects
in larger bones (15, 29-31).
Table 4. A comparison between the outcomes of this study and other studies reporting different reconstruction techniques for diaphyseal defects
Study
Number of
patients
Mean age
(year)
Mean
defect
length cm
Method of
Reconstruction
Mean
follow up
Mean
MSTS
score
Survival
rate
Others
The current
study
6 10 (6-15) 20.83 Tibia strut autograft 8.4 years 80.8%. 66.6 %
Mean time for proximal
and distal junction’s
union was 4 and 8.8
months respectively
Salunke A. et
al 2019 (33)
16 20 (9-45) 14
Non-vascularized
fibula
36 months 28 75%
Mean Union time 8.5 mon
2 Nonunion
2 surgical site infections
1 local recurrence
Salunke A. et
al 2019 (33)
12 20 (9-45) 16
Extracorporeal
irradiated autologous
bone graft
24 months 28 83%
Mean Union time 8.75
months
1 Nonunion
1 Implant failure
Hanna S. et al
2010 (27)
23
41.3 (10-
68)
NA
Endoprosthetic
replacement
97 months 87% 77%
Rate of re-operation was
26%
Aldlyami E. et
al 2005 (4)
35 29 (8-75) 19
Endoprosthetic
replacement
107
months
NA 65% 5 local recurrences
Muscolo D. et
al 2004 (34)
59 28 (4-66) NA Allograft 5 years NA 79%
Infection and fracture
rates were 5% and 7%
respectively
(MSTS: Musculoskeletal Tumor Society, NA: not available)
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Combining an allograft with vascularized fibula graft
achieves better results, although anastomoses are
demanding and the procedure is time-consuming and
not devoid of complications at the donor site (32).
On the donor sites, we did not notice any major
complications. Some sort of angular deformities was
evident in most patients in addition to the simple pin
tract infections that were treated by regular pin tract
care. We believe that use of rigid external fixator is
important for early rehabilitation and also may enhance
bone regeneration.
The ideal reconstruction option should be similar
to human biology, resistant to infection, have good
strength, and be mechanically stable. We introduce
this method as a valuable procedure in skeletally
immature children. The technique we used avoided
the use of allografts, endoprostheses, and extendable
endoprosthesis that were not available in our country
at the time of surgeries. Therefore, we suggest that this
surgical technique is a valid option in countries with
limited resources.
The outcomes of the described surgical technique
are comparable in terms of reconstruction success,
patient satisfaction, and complication rates with the
outcomes of other different reconstruction methods
that have been described for diaphyseal defects. [Table 4]
(4,27,33,34).
The only other available option for our cases was
amputation, which is technically less challenging than
limb salvage procedures. Several complications are
associated with amputation in young patients such as
phantom pain, bleeding, infection, bone overgrowth, soft
tissue-stump migration, and muscle imbalance (35). The
concept of amputation is also not easily acceptable by
the patients and their parents in our community. Hence,
we opted for another method of limb reconstruction to
overcome these difficult challenges.
No previous study has highlighted the effectiveness
of subperiosteal tibial autograft reconstruction after
resection of primary malignant bone tumors of the
long bones of the lower extremity. A similar technique
using the fibula has been described by Yeung et al (13)
.
Additionally, subperiosteal resection of benign cystic
bone tumors has been reported with successful complete
regeneration of the bone defect without bone grafting
(36). Preservation of the integrity of the periosteum
after subperiosteal bone resection constitutes a valuable
matrix for bone regeneration in children and young
adolescents. It plays a major role in the complete filling
of the bone defects and avoids the morbidity associated
with other techniques (36).
The beneficial effect of the periosteum in the
regeneration of the tibia after subperiosteal resection as
a large long bone for intercalary strut bone graft has not
been discussed before. On the assumption that the inner
layer of the periosteum has an osteoblastic capability
that allows invasion of the hematoma in the tightly
sutured periosteal tube by osteoprogenitor cells, we
chose our technique of tight closure of the periosteum.
We achieved excellent results after two occasions of
filling the newly developed periosteal tube with blood
and osteogenic bone marrow cells.
Healing of the remaining defect occurred in a
progressive manner that suggests osteogenesis occurred
initially at the margins of the cavity and moved toward
its center over the following weeks (36). We noticed
the progressive calcification and ossification until the
defect was transformed into a solid new reformed bony
mass.
We used intramedullary nail to bridge the defect
in the donor site after harvesting the tibia graft in
one case. The aim was to avoid external fixation. The
healing time did not differ from other cases in which
external fixation was used in the donor site. Though,
this finding cannot be generalized based on the result
of one case.
This study has certain limitations. First, the sample
size was small to determine the true incidence of the
complications associated with our technique. Second,
this article is a retrospective descriptive study; it does
not compare different reconstructive techniques at the
same institution. We believe that large comparative
studies are needed to evaluate our technique. Though,
the small number of malignant bone tumor cases may
limit the applicability of these studies.
The use of non-vascularized tibial autografts serves as
a considerable alternative for reconstruction of various
types and sizes of bone defects following resection of
primary malignant bone tumors in the lower extremities
of the immature skeleton.
This new technique has several advantages. However,
it is cost-effective in countries with limited resources.
Additionally, it does not require the availability of a bone
bank and can replace the use of an expensive prostheses.
Italsoprovidesexcellentpsychologicalcopingpossibility
for the patients and their families who do not accept
amputation.
Bassem I. Haddad MD1
Mohammed S. Alisi MD1,2
Mohamad S. Yasin MD1
Mohammad Q. Hamdan MD1
Freih O. Abu Hassan FRCS MD1
1DepartmentofSpecialSurgery,Divisionof Orthopaedics,
School of Medicine, The University of Jordan, Amman,
Jordan
2 Faculty of Medicine, Islamic University of Gaza, Gaza,
Palestine
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