Biomaterials for medical implantation research strategies - PubricaPubrica
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Effect of the Gayatri Mantra Playing on Microbial Load in Room AirBhoj Raj Singh
In the study, the effect of the Gayatri Mantra playing for 24 hr on microbial quality of air was examined in 12 rooms of scientists of the ICAR-Indian Veterinary Research Institute, Izatnagar, India willing to participate in the study and in 7 empty classroom/ examination hall lying vacant since March 2020 due to COVID-19. Of the empty rooms, 6 were used as the control for the first two days, then after a week, all rooms were also used to detect the effect of playing the Gayatri Mantra. A total of 31 bacterial species of medical importance were isolated and identified in the air of the rooms. After playing the Gayatri Mantra in Raag Bhairvi for 24 h bacterial count significantly decreased in rooms inhabited by vegetarian (OR 24, CI 95: 0.00-0.88; p, 0.036) than in rooms occupied by non-vegetarians. Rooms occupied by vegetarians. The effect of Gayatri Mantra in the empty room had no significant difference but bacterial count reduced. Bacterial counts of rooms occupied by non-vegetarian increased significantly post Mantra playing. Bacterial counts of rooms occupied by non-vegetarians and empty rooms varied significantly (OR 18, p, 0.02, CI 95: 0.00 – 0.79). Empty rooms with and without mantra not varied significantly for the reduction of the bacterial count. Paenibacillus spp. was not detected in any of the 12 rooms occupied by the scientists/ staff but in 3 of the 7 empty rooms (p, 0.01) it was detected even without playing any mantra. It indicated that daily disturbance in the environment may be detrimental to the survival of Paenibacillus spp. After playing Mantra P. alvei, P. cookie, P. lautus were detected in 5 of the seven rooms occupied by Non-vegetarians, while P. pantothenicus continued to be present in three of the vacant rooms even after playing the Mantra. Paenibacillus spp. bacteria are known for their probiotic potential and its significance in the study is not clear. It seems that the Gayatri mantra has some enrichment effect on Paenibacillus spp. but a detrimental effect on other microbes.
Biomaterials for medical implantation research strategies - PubricaPubrica
Biomaterials and medical instruments are widely researched and incorporated, which greatly increase the quality of human life, thanks to the rapid advancement of biomedical science and practice
Continue Reading: https://bit.ly/2UOpyqw
For our services: https://pubrica.com/sevices/research-services/
Why Pubrica:
When you order our services, We promise you the following – Plagiarism free | always on Time | 24*7 customer support | Written to international Standard | Unlimited Revisions support | Medical writing Expert | Publication Support | Biostatistical experts | High-quality Subject Matter Experts.
Contact us:
Web: https://pubrica.com/
Blog: https://pubrica.com/academy/
Email: sales@pubrica.com
WhatsApp : +91 9884350006
United Kingdom: +44-1618186353
Effect of the Gayatri Mantra Playing on Microbial Load in Room AirBhoj Raj Singh
In the study, the effect of the Gayatri Mantra playing for 24 hr on microbial quality of air was examined in 12 rooms of scientists of the ICAR-Indian Veterinary Research Institute, Izatnagar, India willing to participate in the study and in 7 empty classroom/ examination hall lying vacant since March 2020 due to COVID-19. Of the empty rooms, 6 were used as the control for the first two days, then after a week, all rooms were also used to detect the effect of playing the Gayatri Mantra. A total of 31 bacterial species of medical importance were isolated and identified in the air of the rooms. After playing the Gayatri Mantra in Raag Bhairvi for 24 h bacterial count significantly decreased in rooms inhabited by vegetarian (OR 24, CI 95: 0.00-0.88; p, 0.036) than in rooms occupied by non-vegetarians. Rooms occupied by vegetarians. The effect of Gayatri Mantra in the empty room had no significant difference but bacterial count reduced. Bacterial counts of rooms occupied by non-vegetarian increased significantly post Mantra playing. Bacterial counts of rooms occupied by non-vegetarians and empty rooms varied significantly (OR 18, p, 0.02, CI 95: 0.00 – 0.79). Empty rooms with and without mantra not varied significantly for the reduction of the bacterial count. Paenibacillus spp. was not detected in any of the 12 rooms occupied by the scientists/ staff but in 3 of the 7 empty rooms (p, 0.01) it was detected even without playing any mantra. It indicated that daily disturbance in the environment may be detrimental to the survival of Paenibacillus spp. After playing Mantra P. alvei, P. cookie, P. lautus were detected in 5 of the seven rooms occupied by Non-vegetarians, while P. pantothenicus continued to be present in three of the vacant rooms even after playing the Mantra. Paenibacillus spp. bacteria are known for their probiotic potential and its significance in the study is not clear. It seems that the Gayatri mantra has some enrichment effect on Paenibacillus spp. but a detrimental effect on other microbes.
"The Future of Sleep with Neurotechnology" - Anant Sachetee (Rythm)Hyper Wellbeing
"The Future of Sleep with Neurotechnology" - Anant Sachetee (Rythm)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
Seu 2017 pode ser melhor do que você imagina! Disponibilizo para você os 5 propósitos que utilizo no meu dia a dia e fazem total diferença nos meus resultados.
Succession planning often falls from the agenda in a difficult economic climate when companies are downsizing or experiencing a recruitment freeze. The truth, however, is that in times like these, succession planning really is a critical activity that should not be overlooked.
"The Future of Sleep with Neurotechnology" - Anant Sachetee (Rythm)Hyper Wellbeing
"The Future of Sleep with Neurotechnology" - Anant Sachetee (Rythm)
Delivered at the inaugural Hyper Wellbeing Summit, 14th November 2016, Mountain View, California.
For more information including details of subsequent events, please visit http://hyperwellbeing.com
The summit was created to foster a community around an emerging industry - Wellness as a Service (WaaS). Consumer technologies, in particular wearables and mobile, are powering a consumer revolution. A revolution to turn health and wellness into platform delivered services. A revolution enabling consumer data-driven disease risk reduction. A revolution extending health care past sick care towards consumer-led lifelong health, wellness and lifestyle optimization.
WaaS newsletter sign-up http://eepurl.com/b71fdr
@hyperwellbeing
Seu 2017 pode ser melhor do que você imagina! Disponibilizo para você os 5 propósitos que utilizo no meu dia a dia e fazem total diferença nos meus resultados.
Succession planning often falls from the agenda in a difficult economic climate when companies are downsizing or experiencing a recruitment freeze. The truth, however, is that in times like these, succession planning really is a critical activity that should not be overlooked.
View the clinical evidence from the Angel Catheter Pivotal Study. This investigation was concluded in December 2015. The primary objective of this clinical trial was to evaluate the safety and effectiveness of the Angel® Catheter in subjects at high risk of PE and with recognized contraindications to standard pharmacological therapy.
The Angel Catheter received 510(k) Clearance in July 2016.
Email sbrewer@bio2medical.com to request a meeting to review the study results and device.
DOI:10.21276/ijlssr.2016.2.4.1
ABSTRACT- Introduction: Surgical Site Infections (SSI) still remains a significant problem following an operation
and the third most frequently reported nosocomial infections. SSI contributes significantly to increased health care costs in
terms of prolonged hospital stay and lost work days.
Objective: The current study was undertaken to identify incidence of SSI and the risk factors associated with it, and the
common organism isolated and its antibiotic sensitivity and resistance.
Material and Methods: A total number of 3211 patients admitted in general surgical wards for elective surgery in the
study period, out of which 1225 were clean and clean contaminated cases, fulfilling our study criteria. Totally 56 cases
had surgical site infections which had been taken up for this study. Wound discharges were sent for culture and sensitivity.
Results and Conclusions: The overall infection rate was 4.57%. The SSI rate was almost equal in clean surgeries and
clean contaminated ones. Superficial surgical site infections in the most commonest type and accounted for about 66.07%
of all the SSI’s and deep surgical site infection accounted for about 25% with 8.92% was organ space. The most
commonly isolated organism from surgical site infections was staphylococcus aureus followed by pseudomonas and then
E. coli. Drains, prosthesis usage and other risk factors of SSI have been identified. Most of the organisms which were
isolated were multidrug resistant. The high rate of resistance to many antibiotics underscored the need for a policy that
could promote a more rational use of antibiotics. Key-words- Surgical site infections, National Nosocomial Infections Surveillance (NNIS) risk index, Antibiotic
Webinar: Defeating Superbugs: Hospitals on the Front Lines Modern Healthcare
About the Webinar: Defeating Superbugs: Hospitals on the Front Lines
http://www.modernhealthcare.com/article/20140917/INFO/309179926
Hospitals across the country are facing a grim reality in which some of the most deadly healthcare-associated infections they encounter are untreatable with first- or even second-line antibiotics. These “superbugs” affect at least 2 million Americans each year and lead to 23,000 deaths. And their threat is growing, public health officials warn. This editorial webinar and “Defeating Superbugs” white paper will explore the steps providers must take to ramp up surveillance efforts, promote appropriate antibiotic use and control outbreaks. Our panel of experts will share their organizations' experiences as well as proven strategies for success.
Registration for this webinar includes Modern Healthcare's “Defeating Superbugs” white paper, with proven tips and strategies for promoting appropriate antibiotic use, improving infection surveillance, identifying drug-resistant infections and dealing with outbreaks.
KEY TAKEAWAYS
- Best practices for effective antimicrobial stewardship
- Real-world examples of effective interventions, including universal rapid testing for drug-resistant MRSA
- Tips for engaging senior leadership
- Aggressive strategies for controlling outbreaks
PANELISTS
Lance Peterson
Director of the Clinical Microbiology and Infectious Disease Research Division
NorthShore University HealthSystem, Evanston, Ill.
Anurag Malani
Medical Director for the Infection Prevention and Antimicrobial Stewardship Programs
St. Joseph Mercy Hospital, Ann Arbor, Mich.
Robert Weinstein
Chief Medical Officer for Population Health
Chairman of the Department of Medicine, Cook County Health and Hospitals System; Professor, Rush University Medical Center, Chicago
MODERATOR
Maureen McKinney
Editorial Programs Manager
Modern Healthcare
Alan Lesniewicz Memorial Lecture at UIC - July 2015Cassandra Quave
This is the keynote lecture given at the University of Illinois at Chicago Garden Walk event in the department of Pharmacognosy. The objectives of the talk were:
·Discuss the role of medical ethnobotany in drug discovery efforts
·Explore state-of-the-art research techniques that examine the activity of botanical natural products with next generation antibiotic discovery efforts focused on “alternative targets”, such as bacterial communication systems
·Provide examples of current research underway by her group both in the field (especially through fieldwork in the Mediterranean) and the lab (natural product research on multidrug resistant bacteria).
24x7 Automated Behavior Tracking For Rodent Safety Pharmacology & PhenotypingInsideScientific
Actual Analytics Ltd and its development partners present an exclusive webinar describing the applications of a novel Home Cage Analysis system for tracking behavior in group housed rodents, with retained identity, in regular IVC racked home cages.
In this webinar, Dr. Will Redfern of AstraZeneca and Dr. Sara Wells of MRC Harwell discuss 24/7 monitoring of group-housed rodents in their true IVC racked home cage environment for safety pharmacology and phenotyping applications.
Discussions describe the types of new insights that can be obtained from 24/7 monitoring of research animals including activity differences in single and group animals and body temperature profiles in response to drug treatment. Presenters show how they are using this system in various applications from safety pharmacology in rats through to phenotyping studies in mice.
Objectives:
•Learn about the current of SSI prevention in Canada
•Review the updated SSI-GSK
•Compare CPSI SSI-GSK to national and international literature
Similar to LoftinAH _Smart_ Coatings for Spine Implant-Related Infection (20)
Fresh from the press: Updated best practices in Surgical Site Infection Preve...
LoftinAH _Smart_ Coatings for Spine Implant-Related Infection
1. A novel implant coating
to deliver antibiotic
through an active trigger
mechanism in a spine
infection mouse model
UCLA Department of
Orthopaedic Surgery
“Smart”
Coatings: Amanda
H. Loftin
AALAS Annual Meeting
Wednesday Nov. 4th, 2015
2. Despite advances in
aseptic surgical
technique &
perioperative
antibiotic
use...
Chahound
et.
al.
Front
Med.
2014
.5 -18.8% of patients
post-
operative
infection is
reported to still
occur in approximately
Undergoing spine surgeries.
3. Surgical site
infection
following
spine surgery
is a dreaded
complication
with
significant:
Negative outcomes
for the patient
Detrimental effects on
the healthcare system
Economic burden
1
2
3
Stavrakis et. al. Front Med. 2015
6. This amounts to huge costs,
with the treatment of a single
implant-associated spinal wound
infection potentially costing
more than $900,000
Stavrakis
et
al.
Front
Med.
2015
8. 1 year post-op
Bardis, Alexander. (2014). Late Post-operative Spinal Infections [PowerPoint Slide]. Retrieved from http://
www.slideshare.net/AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=3
9. 1 year post-op
Bardis, Alexander. (2014). Late Post-operative Spinal Infections [PowerPoint Slide]. Retrieved from
http://www.slideshare.net/AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=3
10. Staphylococcus aureus
remains that leading agent of spine implant
infections, responsible for around 50% of cases1
1. Chahoud et al. Front Med. 2014
2. Stavrakis et. al. Front Med. 2015
Staphylococcus epidermidis
& Propionibacterium acnes
are also common pathogens 1-2
11. BIOFILM FORMATION
1. Attachment of
S. aureus to
implanted surface
2. Growth
Formation of an
extracellular matrix
that is not
susceptible to
antimicrobial killing.
3. Dispersal of
further
establishes the
biofilm making
treatment
extremely
difficult
Biofilms block penetration of immune cells and
antimicrobials, promoting bacterial survival
12. Orthopedic spinal implant infections are unique in that
the implant is typically retained to prevent destabilizing
the spine making treatment more challenging
Bardis, Alexander. (2014). Late Post-operative Spinal Infections
[PowerPoint Slide]. Retrieved from http://www.slideshare.net/
AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=3
13. 13
Implants provide
an avascular
surface for bacteria
to form biofilm1-3
1. Cappen DA et al Orthop. Clin North Am 1996
2. Massie JB et al C. O. R.R., 1992
3. Knapp DR et al C. O. R.R. 1988
Bardis, Alexander. (2014). Late Post-operative Spinal Infections [PowerPoint Slide]. Retrieved from
http://www.slideshare.net/AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=3
14. The use of
instrumentation
increases the risk
of infection1-3
1. Cappen DA et al Orthop. Clin North Am 1996
2. Massie JB et al C. O. R.R., 1992
3. Knapp DR et al C. O. R.R. 1988
Bardis, Alexander. (2014). Late Post-operative Spinal Infections [PowerPoint Slide]. Retrieved
fromhttp://www.slideshare.net/AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=3
15. The incidence of
spine implant related
infection is:
1. Stavrakis et. al. Front Med. 2015
2. Chahoud et a. Front Med. 2014
3. Smith et. al. Spine. 2011.
1% without instrumentation1
3.4-10% with instrumentation1
One study reports a 28% higher
infection rate with instrumentation
16.
Once biofilm is formed,
bacteria are 100-1,000 times
less susceptible to
antibiotics1
Olsen
et.
al.
J
Neurosurg.
2003
18. Modification of the host
is difficult and often
beyond the surgeons control
18
Reduction of preoperative risk factors is:
timely, requires extreme patient compliance,
and often impossible
20. Some surgical risk factors can
be modified by the surgeon
to decrease risk of infection,
but this may compromise the
intended benefit of the procedure
20
22. Current methods of
local antibiotic delivery
Short-lived
Vancomycin powder
Via passive release from suboptimal loading vehicles
Antibiotic loaded beads
23. 23
Bardis, Alexander. (2014). Late Post-operative Spinal Infections [PowerPoint Slide]. Retrieved from
ttp://www.slideshare.net/AlexanderBardis/postoperative-spinal-infection-65o-eexot?related=2
24. 24
No antibiotic barrier is
present on the implant
itself to protect it from
bacterial colonization and
subsequent biofilm formation
25. 25
Develop a novel, non-toxic,
biodegradable poly (ethylene
glycol )-propylene sulfide (PEG-PPS)
polymer coating that can be used
As a vehicle to deliver antibiotics locally through
both a passive and active mechanism.
To actively release antibiotic in response to the
reactive oxygen cascade initiated by the presence of
bacteria, allowing the “smart” polymer to release
antibiotic where it is needed most.
27. Combines the use of bioluminescent bacteria and
genetically modified mice with advanced imaging to
noninvasively monitor infection and inflammation in real time,
without requiring euthanasia.
Provides a rapid, accurate, and inexpensive in vivo
preclinical screening tool to evaluate the efficacy
of potential strategies to prevent or treat implant
related spine infections.
Strengths of our model
28. 28
Postoperative evaluation of infection and inflammation
Bioluminescence
and fluorescence
imaging
PODs* 0, 1, 3,
5, 7, 10, 14, 18,
21, 28, 35
POD 35
24 lysEGFP mice
(12 wks., male)
POD 35
Evaluation of
bacterial burden
immune response
Visualization
of biofilm
on implant
Colony forming
units (CFUs)
harvested from
implant and
joint tissues
Variable Pressure
Scanning Electron
Microscopy
(VP-SEM)
ex vivo confirmation
of bacterial
burden
POD 0: Intraoperative
inoculation of
S. aureus Xen36
29. Provides a rapid, accurate, and
inexpensive in vivo preclinical screening
tool to evaluate the efficacy of
potential strategies to prevent or
treat implant related spine
infections.
32. PEG-PPS Coating
32
O
O
OH
m
O
O S
S
S
S N
m n
NaH
O
O
O
m
Br
AIBN
SH
O
O
O
O S
OS
O
O S
S
S
m n
N S
S N
1.
2.
NaOMe
star PEG-PPS
star PEG OH
OH
OH
OH
SH
Si
O
O
O
OH
SH
Si
OCH3
OCH3
H3CO
+
Implant
A B
33. Polyethylene glycol polymer
33
• Coating of optimal “timed” release
• Coating of targeted abx
!
S O
OOS
S
PPS PEG
Antibiotic
0.5% Star PEG-PPS
solution at 4°C
Dry coat at 37°C
Implant
Implant
!
!
Figure!7.!Antibiotic!loaded!implant!coating!process!using!star!
PEG6PPS!polymer.!A!solution!of!star!0.5%!PEG6PPS!with!
antibiotic!will!be!used!to!rapidly!coat!the!implant.!Metal!
34. Titanium
Pins
Uncoated
3%
PEG-‐PPS
6%
PEG-‐PPS
Polymer
is
low
profile:
nano-‐micro
scale
Covalent
linkage:
resistant
to
wear
39. Ex Vivo Bacterial Counts
39
0
1000
2000
3000
4000
5000
6000
ColonyFormingUnits
PEG Vanc Tig
Tissue Colony Forming Units Post-
Operative Day 21
40. 40
PEG-PPS is an optimal vehicle to deliver
antibiotics in the setting of spinal implants as
it passively delivers antibiotics above the
MIC and actively increases drug delivery in
the presence of bacteria.
The Vanc impregnated PEG-PPS coating
prevented implant colonization by bacteria and
prevented implant infection completely
This novel coating shows promise in the
prevention and/or treatment of orthopaedic
spine implant infections and further large animal
studies and biosafety studies are warranted.
41. Now that we have a vehicle to
deliver antibiotics,
can we redesign
antibiotics?
41
43. Special Thanks
43
Bernthal Lab
Alexandra Stavrakis
Yan He
Erik Dworsky
Jannifer Manegold
Los Angeles
Orthopaedic Hospital
Fabrizio Billi, PhD
CRUMP
INSTITUTE OF
MOLECULAR
IMAGING
David Stout, PhD
Center for Experimental
Medicine, University of
Tokyo, Japan
Yoichiro Iwakura, D. Sc,
Cedars-Sinai
George Liu, M.D., PhD
Moshe Arditi, M.D.
Caliper Life Sciences
Kevin Francis, Ph.D.Department of Biomedical
Engineering. UC. Davis
Scott Simon, Ph.D.
UCLA Orthopaedic
Hospital Research
Center
John Adams, MD
Jeff Miller, MD
UCLA Department of
Orthopaedic Surgery
Jeffrey Eckardt, MD
Gerald Finerman, MD
Department of
Microbiology and
Immunology.
Dartmouth Medical
School
Ambrose Cheung, MD