The document describes a neuronal model that investigates local and global mechanisms of synaptic plasticity. The model includes input, excitatory, and inhibitory neurons fully connected in layers. Trial I presents stimuli randomly to form local representations, while Trial II pairs one stimulus with basal nucleus activity to modify representations globally. Experimental results show that without basal activity in Trial I, neurons largely form specific local representations of stimuli.
The document discusses neural correlates of higher level brain functions. It covers several topics:
1) Experience arises at the quantum level in ion channel proteins, with quantum properties like coherence and entanglement playing a role.
2) Construction of perception involves transitions from quantum to classical domains in the brain, mediated by ion channel proteins. Top-down processes and long-range connections in large brains are important for conscious perception.
3) Perception emerges from complex interactions between ascending and recurrent signaling in the brain, with feedback thought to be crucial for awareness. Receptive field properties evolve along synaptic distances in hierarchical cortical networks.
The document discusses visual thinking and information visualization design. It covers several topics:
1) How the brain forms patterns by combining ideas with evidence from the visual world. Patterns emerge through top-down and bottom-up processes in the visual cortex.
2) The binding problem, where disconnected visual features must be combined into coherent patterns and objects. Binding is needed for contour detection and associating information across the brain.
3) Later visual areas like V4 and LOC that can detect more complex patterns like textures and generalized contours beyond just simple features.
4) How visual pattern recognition is shaped by both innate neural architecture and individual learning and experience.
This document contains descriptions of 14 art submissions to the Art of Neuroscience 2017. The submissions include jewelry and artworks inspired by neuroscience concepts, research on gender stereotyping and brain responses, paintings exploring connections between neuroscience and art, images of brain structures and cells created using various microscopy techniques, and more. The submissions are from researchers in multiple countries and cover a wide range of neuroscience topics communicated through different artistic mediums and styles.
The document describes several submissions to the Art of Neuroscience 2017 competition. The submissions include:
1. An electron microscope image showing a microglial lysosome and autophagosome, capturing the process of autophagy.
2. A description and calcium imaging data from cortical neurons in a mouse brain, showing patterns of neuronal activity.
3. A sample of hippocampal neurons labeled for microtubules and actin, imaged with a fluorescent microscope.
4. An artwork inspired by Michelangelo's "The Creation of Adam", depicting interacting pyramidal cells in the mouse brain.
5. Diffusion MRI data quantifying whole-brain axonal connections in the rat brain, clearly
(1) Consensus learning aims to improve problem-solving by combining the knowledge and predictions of multiple machine learning models or agents.
(2) It is motivated by distributed artificial intelligence, where multi-agent systems need to learn and adapt to complex environments.
(3) The consensus approach aggregates the opinions of different models/agents to reach a general agreement, with the goal of producing better and more robust predictions than any single model.
The document discusses power relations and cooperation regarding water resources in the Nile River Basin. It notes that the basin is made up of 10 riparian countries with unequal contributions to and utilization of the Nile's waters, creating potential for conflict. However, organizations like the Nile Basin Initiative and Cooperative Framework Agreement seek more equitable utilization and cooperation between countries through benefit-sharing agreements and developing alternative water resources to prevent conflict over the Nile's waters.
The document provides a visual guide to using Web Registration at the University at Buffalo to add courses. It outlines the steps to log into MyUB, select a semester and year, update your intended major if needed, check for any registration holds, search for and add open courses, and view your updated class schedule. The guide highlights important registration dates and resources for course planning and scheduling.
This document provides tips for effective note taking in class. It recommends focusing on the key points rather than writing down every word, using visual cues from the teacher, and finding the main thesis through multiple readings. The Cornell note taking method is also described, which organizes notes into columns for main ideas, key terms, and summaries to create an easy-to-use study guide.
The document discusses neural correlates of higher level brain functions. It covers several topics:
1) Experience arises at the quantum level in ion channel proteins, with quantum properties like coherence and entanglement playing a role.
2) Construction of perception involves transitions from quantum to classical domains in the brain, mediated by ion channel proteins. Top-down processes and long-range connections in large brains are important for conscious perception.
3) Perception emerges from complex interactions between ascending and recurrent signaling in the brain, with feedback thought to be crucial for awareness. Receptive field properties evolve along synaptic distances in hierarchical cortical networks.
The document discusses visual thinking and information visualization design. It covers several topics:
1) How the brain forms patterns by combining ideas with evidence from the visual world. Patterns emerge through top-down and bottom-up processes in the visual cortex.
2) The binding problem, where disconnected visual features must be combined into coherent patterns and objects. Binding is needed for contour detection and associating information across the brain.
3) Later visual areas like V4 and LOC that can detect more complex patterns like textures and generalized contours beyond just simple features.
4) How visual pattern recognition is shaped by both innate neural architecture and individual learning and experience.
This document contains descriptions of 14 art submissions to the Art of Neuroscience 2017. The submissions include jewelry and artworks inspired by neuroscience concepts, research on gender stereotyping and brain responses, paintings exploring connections between neuroscience and art, images of brain structures and cells created using various microscopy techniques, and more. The submissions are from researchers in multiple countries and cover a wide range of neuroscience topics communicated through different artistic mediums and styles.
The document describes several submissions to the Art of Neuroscience 2017 competition. The submissions include:
1. An electron microscope image showing a microglial lysosome and autophagosome, capturing the process of autophagy.
2. A description and calcium imaging data from cortical neurons in a mouse brain, showing patterns of neuronal activity.
3. A sample of hippocampal neurons labeled for microtubules and actin, imaged with a fluorescent microscope.
4. An artwork inspired by Michelangelo's "The Creation of Adam", depicting interacting pyramidal cells in the mouse brain.
5. Diffusion MRI data quantifying whole-brain axonal connections in the rat brain, clearly
(1) Consensus learning aims to improve problem-solving by combining the knowledge and predictions of multiple machine learning models or agents.
(2) It is motivated by distributed artificial intelligence, where multi-agent systems need to learn and adapt to complex environments.
(3) The consensus approach aggregates the opinions of different models/agents to reach a general agreement, with the goal of producing better and more robust predictions than any single model.
The document discusses power relations and cooperation regarding water resources in the Nile River Basin. It notes that the basin is made up of 10 riparian countries with unequal contributions to and utilization of the Nile's waters, creating potential for conflict. However, organizations like the Nile Basin Initiative and Cooperative Framework Agreement seek more equitable utilization and cooperation between countries through benefit-sharing agreements and developing alternative water resources to prevent conflict over the Nile's waters.
The document provides a visual guide to using Web Registration at the University at Buffalo to add courses. It outlines the steps to log into MyUB, select a semester and year, update your intended major if needed, check for any registration holds, search for and add open courses, and view your updated class schedule. The guide highlights important registration dates and resources for course planning and scheduling.
This document provides tips for effective note taking in class. It recommends focusing on the key points rather than writing down every word, using visual cues from the teacher, and finding the main thesis through multiple readings. The Cornell note taking method is also described, which organizes notes into columns for main ideas, key terms, and summaries to create an easy-to-use study guide.
Versatility! Effective Marketing! TeachStreet’s New Listings Editor! allows teachers to create comprehensive listings for their classes and services. The editor provides templates to include key information like a catchy title, descriptive tags, session details, pricing, location, dates and times, and student reviews. Teachers can easily add and edit listings by following the step-by-step process of filling out sections for the title, description, subject tags, sessions, photos and other components. This gives teachers organizational control and flexibility while also providing students with thorough information to find the right class.
This document expresses gratitude for a precious friendship, one that provides mutual love and support during both difficult and happy times. The author thanks their friend for filling their life with happiness and promises to always be there to listen, comfort, and celebrate with their friend. They hope this message reminds the recipient of the sender's friendship and thoughts for them.
This document contains 13 phrases of advice on living and relationships from Gabriel García Márquez. The phrases counsel embracing who you are with loved ones, not crying over those who don't value you, accepting that not all love will be returned but still feeling loved, cherishing true friends, smiling even when sad to attract love, being someone's whole world, avoiding spending time with those who don't value your time, trusting after hurts but remaining cautious, knowing yourself before new relationships, and allowing the best things to happen unexpectedly. The document encourages sharing these phrases with friends regardless of contact frequency, as everything happens for a reason.
From Idea to Exit, the story of our startupNatalie Downe
Natalie launched the first version of Lanyrd.com with a co-founder and her husband Simon, while on honeymoon in Casablanca. As the site took off, they realized their side project was destined to become something much bigger.
This talk will tell the story of Lanyrd from a two-week proof of concept to a fully-fledged startup, the lessons learned along the way about building and launching a product, running a company, raising investment and the entrepreneurship journey. This is the talk she wished she heard before getting started!
Natalie Downe co-founded Lanyrd, a YCombinator backed startup (W11) that helps companies and individuals get more out of conferences and professional events. She is an experienced product designer, product manager and front-end web engineer. Lanyrd was acquired by Eventbrite in August 2013 and she is now the Director of Frontend Engineering at Eventbrite.
This is the blog of Andrew W. E. Bowey, who is a professor of physics at the California Institute of Technology. The blog discusses topics related to physics research and education, as well as other interests of Dr. Bowey like science policy and communication. It provides brief summaries of recent research papers and events in a casual style intended for a general audience.
This document discusses different methods of assessment, including traditional paper tests, computer-based tests, and online tools. It covers topics like item banking, computer-adaptive tests, web-based tests, and their advantages like being flexible, easy to program, and providing immediate feedback. However, it also notes potential disadvantages like limitations, validation issues, and the risk of cheating. Different online tools are also presented for assessing speaking, listening, reading, and writing skills.
BRANDZ is an in-depth study of over 50,000 global and local brands that evaluates brand strength. It is based on Millward Brown's BrandDynamics system and uses over 1,000,000 consumer interviews. BRANDZ covers major markets and provides analysis across 250+ categories. It measures brands on awareness, relevance, performance, advantage/bonding, and voltage to understand strengths/weaknesses versus competitors and predict likely changes in market share.
This Chinese proverb discusses how money cannot buy certain important things in life like a sense of home, time, rest, knowledge, good health, respect, life, or love. While money can be used to obtain material possessions, it cannot purchase things that provide true meaning or happiness. The proverb aims to encourage people to pursue non-materialistic values.
Cascao Cortona Gambella Sharing Water Land ResourcesAna Cascao
The document discusses the complex issues around political and geographic borders in the Gambella region located between Ethiopia and Sudan. It notes that while political borders aim to be static, natural resources like land and water are more fluid and subject to environmental changes. As a result, competition over these shared and shifting resources among different groups has led to various conflicts in Gambella without clear borders and risks potential disputes if borders are politically manipulated.
Your boss informs you that there will be no salary increases, bonuses, or paid overtime for the year, expenses will not be reimbursed, and the annual Christmas party has been cancelled. This disappointing news from management about compensation and benefits cuts would likely generate an unhappy reaction from employees who were expecting or relying on these rewards and traditions.
A 10-year-old boy named Pedro Santisteban introduces himself and his family which includes 4 brothers, 1 dog, 2 birds, and 15 fish. He states his goal is to finish high school and then go to college to become a teacher to help others learn.
El documento habla sobre un equipo de trauma en la sección 13. En pocas palabras, menciona el nombre de un equipo médico y la ubicación donde trabajan.
The article discusses the 7 best sleeping positions and then teases an additional best position. It likely focuses on different sleeping positions and their purported benefits, ranking them from best to even better. In 3 sentences or less, it aims to identify the top positions and hint at an 8th top choice without fully revealing it.
When BlackDog refers to brand, the brand, or branding, you can be sure that we’re not talking about your logo. When we talk brand we’re talking about a much bigger inspiration: The Big Idea.
The Big Idea that possesses the psyche and triggers the zeal of a working community. The Big Idea that inspires change, grabs hold of an opportunity, and purposes to do what no one else had the courage to do. The sort of Big Idea that wins over the last skeptic, pushes the limits, makes something bold happen, and escalates enthusiasm to a visceral level. The kind of Big Idea that has the power to turn heads, change minds, and re-order the hierarchy from who has the business to a more just system of who deserves the business. The kind of Big Idea that’s deserving of a little attention, please.
The Big Idea isn’t hype, spin, or hoopla.
The Big Idea very often begins with a question. “What do we want this company to look like when it grows up”, or “What organizational flaws are clues to my true strengths”, or “Given our expertise and proximity to other area businesses what need can we meet (locally, regionally, nationally, or internationally)” While explanations get bogged down with details, the Big Idea, vividly painted in clear strokes of purpose and outcomes, has the power to clarify. The Big Idea is easily understood, passed on and carried forth. The Big Idea is clear and compelling, serves as a unifying focal point of effort, and acts as a catalyst for team spirit.
This document provides information on water therapy and its benefits according to Dr. Mahmoud Hussain Ibn Sina Company. It claims that drinking 1.5 liters of water per day can cure diseases like constipation, acidity, diabetes, cancer, pulmonary tuberculosis, blood pressure, and more. The therapy procedure involves drinking 1.5 liters of water first thing in the morning on an empty stomach. It states that certain diseases like constipation and acidity can be cured within 1-2 days, while others like diabetes, cancer and pulmonary tuberculosis take weeks or months.
Organic Gardener's Guide to Lead NurturingPete Jakob
Presentation given at a seminar organised by B2B Marketing Magazine at the Century Club, London - Sept 23rd. The presentation provides 9 practical steps for improving the yield from your marketing campaigns.
The document outlines the schedule and services provided for the USNS Mercy Pacific Partnership 2008 deployment. It includes:
- A 146 day deployment from May to September visiting ports in Asia Pacific and providing surgery, dentistry, optometry, pharmacy, engineering and education services.
- Stops planned in locations like Vietnam, Timor Leste, Papua New Guinea, Philippines, and the Pacific islands offering medical and humanitarian aid.
- Onboard laboratory capabilities including collection and analysis of samples for microbiology, chemistry and hematology.
The document discusses the human body and its parts. It notes that the body is made up of many complex systems that work together, such as the skeletal, muscular, circulatory, respiratory, digestive, nervous, and reproductive systems. All of these systems allow the body to function and keep us alive through intricate and coordinated processes.
Computational neuroscience is the scientific study of the nervous system using computational approaches. It is an interdisciplinary field that uses techniques from biology, chemistry, computer science, engineering, linguistics, mathematics, medicine, physics, psychology and philosophy to study the molecular, cellular, developmental, structural, functional, evolutionary and medical aspects of the nervous system. Some examples of current areas of study include Parkinson's disease, epilepsy, hearing loss, and brain-machine interfaces. Computational neuroscience aims to understand what computations are performed in neural systems and how they are implemented at molecular, cellular and system levels.
This document provides an overview of artificial neural networks and supervised learning. It discusses how artificial neural networks are modeled after biological neural networks in the brain. The basic building block of both biological and artificial neural networks is the neuron. A single neuron is then described as a simple computing element that takes weighted inputs and compares them to a threshold. The perceptron, one of the earliest and simplest types of artificial neural networks, is then introduced and its learning process via weight adjustments is explained.
Versatility! Effective Marketing! TeachStreet’s New Listings Editor! allows teachers to create comprehensive listings for their classes and services. The editor provides templates to include key information like a catchy title, descriptive tags, session details, pricing, location, dates and times, and student reviews. Teachers can easily add and edit listings by following the step-by-step process of filling out sections for the title, description, subject tags, sessions, photos and other components. This gives teachers organizational control and flexibility while also providing students with thorough information to find the right class.
This document expresses gratitude for a precious friendship, one that provides mutual love and support during both difficult and happy times. The author thanks their friend for filling their life with happiness and promises to always be there to listen, comfort, and celebrate with their friend. They hope this message reminds the recipient of the sender's friendship and thoughts for them.
This document contains 13 phrases of advice on living and relationships from Gabriel García Márquez. The phrases counsel embracing who you are with loved ones, not crying over those who don't value you, accepting that not all love will be returned but still feeling loved, cherishing true friends, smiling even when sad to attract love, being someone's whole world, avoiding spending time with those who don't value your time, trusting after hurts but remaining cautious, knowing yourself before new relationships, and allowing the best things to happen unexpectedly. The document encourages sharing these phrases with friends regardless of contact frequency, as everything happens for a reason.
From Idea to Exit, the story of our startupNatalie Downe
Natalie launched the first version of Lanyrd.com with a co-founder and her husband Simon, while on honeymoon in Casablanca. As the site took off, they realized their side project was destined to become something much bigger.
This talk will tell the story of Lanyrd from a two-week proof of concept to a fully-fledged startup, the lessons learned along the way about building and launching a product, running a company, raising investment and the entrepreneurship journey. This is the talk she wished she heard before getting started!
Natalie Downe co-founded Lanyrd, a YCombinator backed startup (W11) that helps companies and individuals get more out of conferences and professional events. She is an experienced product designer, product manager and front-end web engineer. Lanyrd was acquired by Eventbrite in August 2013 and she is now the Director of Frontend Engineering at Eventbrite.
This is the blog of Andrew W. E. Bowey, who is a professor of physics at the California Institute of Technology. The blog discusses topics related to physics research and education, as well as other interests of Dr. Bowey like science policy and communication. It provides brief summaries of recent research papers and events in a casual style intended for a general audience.
This document discusses different methods of assessment, including traditional paper tests, computer-based tests, and online tools. It covers topics like item banking, computer-adaptive tests, web-based tests, and their advantages like being flexible, easy to program, and providing immediate feedback. However, it also notes potential disadvantages like limitations, validation issues, and the risk of cheating. Different online tools are also presented for assessing speaking, listening, reading, and writing skills.
BRANDZ is an in-depth study of over 50,000 global and local brands that evaluates brand strength. It is based on Millward Brown's BrandDynamics system and uses over 1,000,000 consumer interviews. BRANDZ covers major markets and provides analysis across 250+ categories. It measures brands on awareness, relevance, performance, advantage/bonding, and voltage to understand strengths/weaknesses versus competitors and predict likely changes in market share.
This Chinese proverb discusses how money cannot buy certain important things in life like a sense of home, time, rest, knowledge, good health, respect, life, or love. While money can be used to obtain material possessions, it cannot purchase things that provide true meaning or happiness. The proverb aims to encourage people to pursue non-materialistic values.
Cascao Cortona Gambella Sharing Water Land ResourcesAna Cascao
The document discusses the complex issues around political and geographic borders in the Gambella region located between Ethiopia and Sudan. It notes that while political borders aim to be static, natural resources like land and water are more fluid and subject to environmental changes. As a result, competition over these shared and shifting resources among different groups has led to various conflicts in Gambella without clear borders and risks potential disputes if borders are politically manipulated.
Your boss informs you that there will be no salary increases, bonuses, or paid overtime for the year, expenses will not be reimbursed, and the annual Christmas party has been cancelled. This disappointing news from management about compensation and benefits cuts would likely generate an unhappy reaction from employees who were expecting or relying on these rewards and traditions.
A 10-year-old boy named Pedro Santisteban introduces himself and his family which includes 4 brothers, 1 dog, 2 birds, and 15 fish. He states his goal is to finish high school and then go to college to become a teacher to help others learn.
El documento habla sobre un equipo de trauma en la sección 13. En pocas palabras, menciona el nombre de un equipo médico y la ubicación donde trabajan.
The article discusses the 7 best sleeping positions and then teases an additional best position. It likely focuses on different sleeping positions and their purported benefits, ranking them from best to even better. In 3 sentences or less, it aims to identify the top positions and hint at an 8th top choice without fully revealing it.
When BlackDog refers to brand, the brand, or branding, you can be sure that we’re not talking about your logo. When we talk brand we’re talking about a much bigger inspiration: The Big Idea.
The Big Idea that possesses the psyche and triggers the zeal of a working community. The Big Idea that inspires change, grabs hold of an opportunity, and purposes to do what no one else had the courage to do. The sort of Big Idea that wins over the last skeptic, pushes the limits, makes something bold happen, and escalates enthusiasm to a visceral level. The kind of Big Idea that has the power to turn heads, change minds, and re-order the hierarchy from who has the business to a more just system of who deserves the business. The kind of Big Idea that’s deserving of a little attention, please.
The Big Idea isn’t hype, spin, or hoopla.
The Big Idea very often begins with a question. “What do we want this company to look like when it grows up”, or “What organizational flaws are clues to my true strengths”, or “Given our expertise and proximity to other area businesses what need can we meet (locally, regionally, nationally, or internationally)” While explanations get bogged down with details, the Big Idea, vividly painted in clear strokes of purpose and outcomes, has the power to clarify. The Big Idea is easily understood, passed on and carried forth. The Big Idea is clear and compelling, serves as a unifying focal point of effort, and acts as a catalyst for team spirit.
This document provides information on water therapy and its benefits according to Dr. Mahmoud Hussain Ibn Sina Company. It claims that drinking 1.5 liters of water per day can cure diseases like constipation, acidity, diabetes, cancer, pulmonary tuberculosis, blood pressure, and more. The therapy procedure involves drinking 1.5 liters of water first thing in the morning on an empty stomach. It states that certain diseases like constipation and acidity can be cured within 1-2 days, while others like diabetes, cancer and pulmonary tuberculosis take weeks or months.
Organic Gardener's Guide to Lead NurturingPete Jakob
Presentation given at a seminar organised by B2B Marketing Magazine at the Century Club, London - Sept 23rd. The presentation provides 9 practical steps for improving the yield from your marketing campaigns.
The document outlines the schedule and services provided for the USNS Mercy Pacific Partnership 2008 deployment. It includes:
- A 146 day deployment from May to September visiting ports in Asia Pacific and providing surgery, dentistry, optometry, pharmacy, engineering and education services.
- Stops planned in locations like Vietnam, Timor Leste, Papua New Guinea, Philippines, and the Pacific islands offering medical and humanitarian aid.
- Onboard laboratory capabilities including collection and analysis of samples for microbiology, chemistry and hematology.
The document discusses the human body and its parts. It notes that the body is made up of many complex systems that work together, such as the skeletal, muscular, circulatory, respiratory, digestive, nervous, and reproductive systems. All of these systems allow the body to function and keep us alive through intricate and coordinated processes.
Computational neuroscience is the scientific study of the nervous system using computational approaches. It is an interdisciplinary field that uses techniques from biology, chemistry, computer science, engineering, linguistics, mathematics, medicine, physics, psychology and philosophy to study the molecular, cellular, developmental, structural, functional, evolutionary and medical aspects of the nervous system. Some examples of current areas of study include Parkinson's disease, epilepsy, hearing loss, and brain-machine interfaces. Computational neuroscience aims to understand what computations are performed in neural systems and how they are implemented at molecular, cellular and system levels.
This document provides an overview of artificial neural networks and supervised learning. It discusses how artificial neural networks are modeled after biological neural networks in the brain. The basic building block of both biological and artificial neural networks is the neuron. A single neuron is then described as a simple computing element that takes weighted inputs and compares them to a threshold. The perceptron, one of the earliest and simplest types of artificial neural networks, is then introduced and its learning process via weight adjustments is explained.
The document discusses image recognition using convolutional neural networks (CNNs). It explains that CNNs consist of multiple layers of small neuron collections that look at small portions of an input image called receptive fields. The results are tiled to overlap and represent the original image better. CNNs learn filters through training rather than relying on hand-engineered features. Convolution involves calculating the overlap between functions as one is translated, and is used in CNNs to identify patterns across translated versions of inputs like images. Pointwise nonlinearities are applied between CNN layers to introduce nonlinearity.
This PhD proposal aims to study synaptic integration of inputs in a realistic in vivo environment. Previous in vitro studies of input integration in neurons have limitations as they do not account for background activity and noise present in vivo. The project will use computational modeling and dynamic photo stimulation to evaluate non-linear integration effects, how the neuron's output depends on input correlation and location, and better understand rate coding versus temporal coding in a more realistic setting.
This document provides an introduction to artificial neural networks (ANNs) and compares them to natural neural networks. It discusses how ANNs work by using basic processing units called neurons that are connected and can learn by adapting their connectivity patterns. Like natural neural networks, ANNs transmit information as electrical signals between neurons. The document outlines common activation functions used in ANNs and provides examples of simple neuron models, comparing the McCulloch-Pitts neuron model to real biological neurons. It also discusses capabilities of basic threshold neurons and differences between natural and artificial neural networks.
CVPR 2020 Workshop: Sparsity in the neocortex, and its implications for conti...Christy Maver
Numenta VP Research Subutai Ahmad presents a talk on "Sparsity in the Neocortex and its Implications for Continual Learning" at the virtual CVPR 2020 workshop. In this talk, he discusses how continuous learning systems can benefit from sparsity, active dendrites and other neocortical mechanisms.
CVPR 2020 Workshop: Sparsity in the neocortex, and its implications for conti...Numenta
Numenta VP Research Subutai Ahmad presents a talk on "Sparsity in the Neocortex and its Implications for Continual Learning" at the virtual CVPR 2020 workshop. In this talk, he discusses how continuous learning systems can benefit from sparsity, active dendrites and other neocortical mechanisms.
Introduction to Spiking Neural Networks: From a Computational Neuroscience pe...Jason Tsai
The document provides an introduction to spiking neural networks (SNNs) and neuromorphic computing. It discusses the characteristics and advantages of SNNs, including their spatio-temporal nature, asynchronous processing, sparsity, and energy efficiency. It also covers basic neuroscience concepts like neurons, action potentials, synaptic plasticity, and learning rules like STDP. Common SNN models and neural encoding schemes are described. Examples of SNN applications in visual processing and pattern generation are presented. Finally, neuromorphic hardware platforms like Intel's Loihi chip are introduced.
This document provides an overview of self-organizing maps (SOM) as an unsupervised learning technique. It discusses the principles of self-organization including self-amplification, competition, and cooperation. The Willshaw-von der Malsburg model and Kohonen feature maps are presented as two approaches to building topographic maps through self-organization. The Kohonen SOM learning algorithm is described as involving competition between neurons to determine a winning neuron, cooperation between neighboring neurons, and adaptive changes to synaptic weights based on Hebbian learning principles.
This document describes a study that used laser stimulation of neurons expressing channelrhodopsin-2 (ChR2) to study synaptic transmission in cultured hippocampal neurons. Recombinant adeno-associated virus (rAAV) was used to deliver the ChR2 gene to the neurons. Laser stimulation was able to activate action potentials in ChR2-expressing neurons. By voltage-clamping a neuron and scanning a laser, synaptic responses were observed at some locations, indicating spatial localization of stimulation. Pharmacological tests identified responses that were synaptic. While monosynaptic responses could not be entirely distinguished from polysynaptic ones, smaller amplitudes, simpler shapes, and latencies around 8 ms suggested monosynaptic interactions.
Artificial neural networks are computational models inspired by biological neural networks. They are composed of artificial neurons that are connected and communicate with each other. Each neuron receives inputs, performs simple computations, and transmits outputs. The connections between neurons are associated with adaptive weights that are adjusted during learning. Neural networks can be trained to perform complex tasks like pattern recognition, prediction, and classification. They have many applications in business including data mining, resource allocation, and prediction.
Artificial neural networks (ANNs) are processing systems inspired by biological neural networks. They consist of interconnected processing elements that dynamically change their outputs based on external inputs. While much simpler than actual brains, some ANNs have accurately modeled systems like the retina. ANNs are initially trained on large datasets to learn input-output relationships, then make predictions on new inputs. They are nonlinear, adaptable systems suited for parallel processing tasks.
Computational neuropharmacology drug designingRevathi Boyina
This document discusses computational neuropharmacology, which uses computational modeling approaches from neuroscience and dynamical systems theory integrated with traditional neuropharmacological methods to study drug effects on the brain and behavior. It describes how computational models are used in neuroscience to simulate neurons, neural circuits, and brain regions. It suggests computational neuropharmacology could help integrate molecular and systems-level descriptions of the nervous system to analyze drug effects on neural activity patterns and behavioral states. This may provide strategies for molecular screening of drugs and searching for target-specific drugs to shift pathological brain dynamics to normal patterns.
(1) Synaptic transmission occurs via either electrical or chemical synapses. (2) At chemical synapses, neurotransmitters are released from presynaptic terminals and bind to receptors on the postsynaptic cell, eliciting electrical responses. (3) The summation of excitatory and inhibitory postsynaptic potentials determines whether an action potential is generated in the postsynaptic neuron.
This document summarizes information presented about neurons, glial cells, and neural plasticity mechanisms. It describes the different types of neurons and glial cells, how they connect and function. It discusses various techniques for visualizing neurons. It also summarizes concepts of short and long-term synaptic plasticity mechanisms like LTP and LTD, and how the strength of connections between neurons changes based on their firing patterns over time through processes like Hebbian and homeostatic plasticity. The document encourages thinking about applying this neurobiology knowledge to develop potential therapeutic approaches.
Design of Cortical Neuron Circuits With VLSI Design Approachijsc
A simple CMOS circuitry using very less number of MOSFETs reproduce most of the electrophysiological cortical neuron types and is capable of producing a variety of different behaviors with diversity similar to that of real biological neuron cell. The firing pattern of basic cell classes like regular spiking (RS), chattering (CH), intrinsic bursting (IB) and fast spiking(FS) are obtained with a simple adjustment of only one biasing voltage makes circuit suitable for applications in reconfigurable neuromorphic devices that implement biologically resemble circuit of cortex. This paper discusses spice simulation of the various spiking pattern ability with required and firing frequency of a given cell type. The circuit operation is verified for both conditions-constant input and pulsating input.
The document discusses the structure and function of the brain as a complex network. It notes that the brain exhibits both segregation and integration at multiple scales from neurons to regions. The structural connectivity of the brain forms a small-world network that allows for both specialized processing within clusters and integrated processing between regions via short path lengths. Computational models can capture large-scale brain activity and dynamics based on the underlying structural connectivity.
The role of machine learning in modelling the cellbutest
The document discusses the role of machine learning in modelling the cell. It provides an overview of cell biology and challenges in modelling the cell. It then discusses machine learning techniques like neural networks that can be used to model biological sequences and patterns. Specifically, it discusses how recurrent neural networks have been applied to predict subcellular localization of proteins to organelles like the endoplasmic reticulum and peroxisomes.
The document provides information about soft computing techniques and artificial neural networks. It contains the following key points:
1. It introduces soft computing techniques such as neural networks, fuzzy logic, and genetic algorithms. It recommends books on these topics.
2. It discusses the biological neural network in the human brain and its characteristics such as the ability to learn and generalize knowledge.
3. It describes the goal of artificial neural networks is to simulate the human brain for functions like planning, thought, and speech recognition.
4. It outlines the basic biological components of neurons like the cell body, dendrites, axon, and synapse. It also introduces the characteristics of artificial neural networks and different neural network models like
Similar to Local and Global Gating of Synaptic Plasticity (20)
Learning Kinematics from direct Self-Observation using Nearest-Neighbour Methodscijat
Commonly, the kinematic function of robotic manipulators is derived from the robot model analytically and can be represented in closed form. However, there are cases in which a model is not apriori available. We propose an approach that enables an autonomous robot to estimate the kinematic and inverse kinematic function on-the-fly directly from self-observations. As observations, we sample pairs of randomly chosen joint configurations and the resulting world positions. For approximating the kinematic and inverse kinematic function, we use instance-based learning techniques, such as Nearest Neighbour (NN) and Locally Weighted Regression (LWR). The sampled pairs not only contain information about the kinematics, but also implicitly encode the connectivity and reachability both in the configuration and world space. The robot can take advantage of this information to build roadmaps with a combined cost function. We present an analysis of our approach as well as the results obtained from experiments on a real robot and from simulation. We show in our talk, that with our approach, it becomes possible to accurately control robots with unknown kinematic models of various complexity and joint types from little data obtained through self-observation.
This document discusses sampling algorithms for quickly sampling in high-dimensional configuration spaces. It introduces configuration space and roadmaps, describes two main ideas for improving sampling, and presents a utility-guided multi-query sampling algorithm evaluated in experiments.
CRF-Filters: Discriminative Particle Filters for Sequential State Estimationcijat
The document presents a method for state estimation using conditional random fields (CRF). It first introduces CRF and shows how a directed model can be transformed into a CRF model for state estimation. It then describes the CRF filter algorithm and learning the model parameters. Experimental results demonstrating the approach on a robot localization problem are also presented.
The document describes a method for detecting balls in images and videos taken during a soccer game. It discusses challenges in ball detection due to the ball's small size and similarity to other objects. The method first finds ball candidates using color segmentation in YUV color space and grouping connected pixels. It then classifies candidates as balls or non-balls using a support vector machine trained on color and texture features. Experiments show the method can reliably identify balls in soccer footage.
This document analyzes the features of auxiliary verbs in Head-Driven Phrase Structure Grammar (HPSG). It discusses how auxiliaries are optional, determine the form of the following verb, and occur in a fixed order. Examples are provided to show how auxiliaries like "could have been" license certain word orders in sentences but not others. The analysis aims to account for these properties of auxiliaries in a way that is compatible with HPSG structures.
This document discusses J.J. Gibson's concept of affordances. Some key points:
1. Gibson defined affordances as all that environments offer animals for good or ill. This refers both to the environment and animal.
2. He founded the school of ecological psychology, arguing that perception is direct and animals stand in relation to their environment.
3. Affordances include things like nutrition, dying, drive-on surfaces, stove controls, and cognitive affordances provided by culture. Later authors expanded on affordances based on body size.
Letter and Document Automation for Bonterra Impact Management (fka Social Sol...Jeffrey Haguewood
Sidekick Solutions uses Bonterra Impact Management (fka Social Solutions Apricot) and automation solutions to integrate data for business workflows.
We believe integration and automation are essential to user experience and the promise of efficient work through technology. Automation is the critical ingredient to realizing that full vision. We develop integration products and services for Bonterra Case Management software to support the deployment of automations for a variety of use cases.
This video focuses on automated letter generation for Bonterra Impact Management using Google Workspace or Microsoft 365.
Interested in deploying letter generation automations for Bonterra Impact Management? Contact us at sales@sidekicksolutionsllc.com to discuss next steps.
Ivanti’s Patch Tuesday breakdown goes beyond patching your applications and brings you the intelligence and guidance needed to prioritize where to focus your attention first. Catch early analysis on our Ivanti blog, then join industry expert Chris Goettl for the Patch Tuesday Webinar Event. There we’ll do a deep dive into each of the bulletins and give guidance on the risks associated with the newly-identified vulnerabilities.
Let's Integrate MuleSoft RPA, COMPOSER, APM with AWS IDP along with Slackshyamraj55
Discover the seamless integration of RPA (Robotic Process Automation), COMPOSER, and APM with AWS IDP enhanced with Slack notifications. Explore how these technologies converge to streamline workflows, optimize performance, and ensure secure access, all while leveraging the power of AWS IDP and real-time communication via Slack notifications.
Generating privacy-protected synthetic data using Secludy and MilvusZilliz
During this demo, the founders of Secludy will demonstrate how their system utilizes Milvus to store and manipulate embeddings for generating privacy-protected synthetic data. Their approach not only maintains the confidentiality of the original data but also enhances the utility and scalability of LLMs under privacy constraints. Attendees, including machine learning engineers, data scientists, and data managers, will witness first-hand how Secludy's integration with Milvus empowers organizations to harness the power of LLMs securely and efficiently.
Building Production Ready Search Pipelines with Spark and MilvusZilliz
Spark is the widely used ETL tool for processing, indexing and ingesting data to serving stack for search. Milvus is the production-ready open-source vector database. In this talk we will show how to use Spark to process unstructured data to extract vector representations, and push the vectors to Milvus vector database for search serving.
HCL Notes und Domino Lizenzkostenreduzierung in der Welt von DLAUpanagenda
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-und-domino-lizenzkostenreduzierung-in-der-welt-von-dlau/
DLAU und die Lizenzen nach dem CCB- und CCX-Modell sind für viele in der HCL-Community seit letztem Jahr ein heißes Thema. Als Notes- oder Domino-Kunde haben Sie vielleicht mit unerwartet hohen Benutzerzahlen und Lizenzgebühren zu kämpfen. Sie fragen sich vielleicht, wie diese neue Art der Lizenzierung funktioniert und welchen Nutzen sie Ihnen bringt. Vor allem wollen Sie sicherlich Ihr Budget einhalten und Kosten sparen, wo immer möglich. Das verstehen wir und wir möchten Ihnen dabei helfen!
Wir erklären Ihnen, wie Sie häufige Konfigurationsprobleme lösen können, die dazu führen können, dass mehr Benutzer gezählt werden als nötig, und wie Sie überflüssige oder ungenutzte Konten identifizieren und entfernen können, um Geld zu sparen. Es gibt auch einige Ansätze, die zu unnötigen Ausgaben führen können, z. B. wenn ein Personendokument anstelle eines Mail-Ins für geteilte Mailboxen verwendet wird. Wir zeigen Ihnen solche Fälle und deren Lösungen. Und natürlich erklären wir Ihnen das neue Lizenzmodell.
Nehmen Sie an diesem Webinar teil, bei dem HCL-Ambassador Marc Thomas und Gastredner Franz Walder Ihnen diese neue Welt näherbringen. Es vermittelt Ihnen die Tools und das Know-how, um den Überblick zu bewahren. Sie werden in der Lage sein, Ihre Kosten durch eine optimierte Domino-Konfiguration zu reduzieren und auch in Zukunft gering zu halten.
Diese Themen werden behandelt
- Reduzierung der Lizenzkosten durch Auffinden und Beheben von Fehlkonfigurationen und überflüssigen Konten
- Wie funktionieren CCB- und CCX-Lizenzen wirklich?
- Verstehen des DLAU-Tools und wie man es am besten nutzt
- Tipps für häufige Problembereiche, wie z. B. Team-Postfächer, Funktions-/Testbenutzer usw.
- Praxisbeispiele und Best Practices zum sofortigen Umsetzen
Dive into the realm of operating systems (OS) with Pravash Chandra Das, a seasoned Digital Forensic Analyst, as your guide. 🚀 This comprehensive presentation illuminates the core concepts, types, and evolution of OS, essential for understanding modern computing landscapes.
Beginning with the foundational definition, Das clarifies the pivotal role of OS as system software orchestrating hardware resources, software applications, and user interactions. Through succinct descriptions, he delineates the diverse types of OS, from single-user, single-task environments like early MS-DOS iterations, to multi-user, multi-tasking systems exemplified by modern Linux distributions.
Crucial components like the kernel and shell are dissected, highlighting their indispensable functions in resource management and user interface interaction. Das elucidates how the kernel acts as the central nervous system, orchestrating process scheduling, memory allocation, and device management. Meanwhile, the shell serves as the gateway for user commands, bridging the gap between human input and machine execution. 💻
The narrative then shifts to a captivating exploration of prominent desktop OSs, Windows, macOS, and Linux. Windows, with its globally ubiquitous presence and user-friendly interface, emerges as a cornerstone in personal computing history. macOS, lauded for its sleek design and seamless integration with Apple's ecosystem, stands as a beacon of stability and creativity. Linux, an open-source marvel, offers unparalleled flexibility and security, revolutionizing the computing landscape. 🖥️
Moving to the realm of mobile devices, Das unravels the dominance of Android and iOS. Android's open-source ethos fosters a vibrant ecosystem of customization and innovation, while iOS boasts a seamless user experience and robust security infrastructure. Meanwhile, discontinued platforms like Symbian and Palm OS evoke nostalgia for their pioneering roles in the smartphone revolution.
The journey concludes with a reflection on the ever-evolving landscape of OS, underscored by the emergence of real-time operating systems (RTOS) and the persistent quest for innovation and efficiency. As technology continues to shape our world, understanding the foundations and evolution of operating systems remains paramount. Join Pravash Chandra Das on this illuminating journey through the heart of computing. 🌟
Digital Marketing Trends in 2024 | Guide for Staying AheadWask
https://www.wask.co/ebooks/digital-marketing-trends-in-2024
Feeling lost in the digital marketing whirlwind of 2024? Technology is changing, consumer habits are evolving, and staying ahead of the curve feels like a never-ending pursuit. This e-book is your compass. Dive into actionable insights to handle the complexities of modern marketing. From hyper-personalization to the power of user-generated content, learn how to build long-term relationships with your audience and unlock the secrets to success in the ever-shifting digital landscape.
Have you ever been confused by the myriad of choices offered by AWS for hosting a website or an API?
Lambda, Elastic Beanstalk, Lightsail, Amplify, S3 (and more!) can each host websites + APIs. But which one should we choose?
Which one is cheapest? Which one is fastest? Which one will scale to meet our needs?
Join me in this session as we dive into each AWS hosting service to determine which one is best for your scenario and explain why!
Taking AI to the Next Level in Manufacturing.pdfssuserfac0301
Read Taking AI to the Next Level in Manufacturing to gain insights on AI adoption in the manufacturing industry, such as:
1. How quickly AI is being implemented in manufacturing.
2. Which barriers stand in the way of AI adoption.
3. How data quality and governance form the backbone of AI.
4. Organizational processes and structures that may inhibit effective AI adoption.
6. Ideas and approaches to help build your organization's AI strategy.
Skybuffer AI: Advanced Conversational and Generative AI Solution on SAP Busin...Tatiana Kojar
Skybuffer AI, built on the robust SAP Business Technology Platform (SAP BTP), is the latest and most advanced version of our AI development, reaffirming our commitment to delivering top-tier AI solutions. Skybuffer AI harnesses all the innovative capabilities of the SAP BTP in the AI domain, from Conversational AI to cutting-edge Generative AI and Retrieval-Augmented Generation (RAG). It also helps SAP customers safeguard their investments into SAP Conversational AI and ensure a seamless, one-click transition to SAP Business AI.
With Skybuffer AI, various AI models can be integrated into a single communication channel such as Microsoft Teams. This integration empowers business users with insights drawn from SAP backend systems, enterprise documents, and the expansive knowledge of Generative AI. And the best part of it is that it is all managed through our intuitive no-code Action Server interface, requiring no extensive coding knowledge and making the advanced AI accessible to more users.
Unlock the Future of Search with MongoDB Atlas_ Vector Search Unleashed.pdfMalak Abu Hammad
Discover how MongoDB Atlas and vector search technology can revolutionize your application's search capabilities. This comprehensive presentation covers:
* What is Vector Search?
* Importance and benefits of vector search
* Practical use cases across various industries
* Step-by-step implementation guide
* Live demos with code snippets
* Enhancing LLM capabilities with vector search
* Best practices and optimization strategies
Perfect for developers, AI enthusiasts, and tech leaders. Learn how to leverage MongoDB Atlas to deliver highly relevant, context-aware search results, transforming your data retrieval process. Stay ahead in tech innovation and maximize the potential of your applications.
#MongoDB #VectorSearch #AI #SemanticSearch #TechInnovation #DataScience #LLM #MachineLearning #SearchTechnology
HCL Notes and Domino License Cost Reduction in the World of DLAUpanagenda
Webinar Recording: https://www.panagenda.com/webinars/hcl-notes-and-domino-license-cost-reduction-in-the-world-of-dlau/
The introduction of DLAU and the CCB & CCX licensing model caused quite a stir in the HCL community. As a Notes and Domino customer, you may have faced challenges with unexpected user counts and license costs. You probably have questions on how this new licensing approach works and how to benefit from it. Most importantly, you likely have budget constraints and want to save money where possible. Don’t worry, we can help with all of this!
We’ll show you how to fix common misconfigurations that cause higher-than-expected user counts, and how to identify accounts which you can deactivate to save money. There are also frequent patterns that can cause unnecessary cost, like using a person document instead of a mail-in for shared mailboxes. We’ll provide examples and solutions for those as well. And naturally we’ll explain the new licensing model.
Join HCL Ambassador Marc Thomas in this webinar with a special guest appearance from Franz Walder. It will give you the tools and know-how to stay on top of what is going on with Domino licensing. You will be able lower your cost through an optimized configuration and keep it low going forward.
These topics will be covered
- Reducing license cost by finding and fixing misconfigurations and superfluous accounts
- How do CCB and CCX licenses really work?
- Understanding the DLAU tool and how to best utilize it
- Tips for common problem areas, like team mailboxes, functional/test users, etc
- Practical examples and best practices to implement right away
Programming Foundation Models with DSPy - Meetup SlidesZilliz
Prompting language models is hard, while programming language models is easy. In this talk, I will discuss the state-of-the-art framework DSPy for programming foundation models with its powerful optimizers and runtime constraint system.
Programming Foundation Models with DSPy - Meetup Slides
Local and Global Gating of Synaptic Plasticity
1. Local and Global Gating of
Synaptic Plasticity
Manuel A. Sanchez-Montañes
Hannes Schulz
University of Osnabrück, Department of Cognitive Science
Action and Cognition II / May 2nd 2005
2. Learning on Global vs. Local Scale
Mechanisms for learning in neuronal nets:
Local Global
Hebb’s Rule & modifications Signals to the whole network
Forms representations on Modifies local learning
cortex
3. Learning Goals
Local Learning: Global Learning:
Representation of all Influence size of
stimuli representation
Possibility to add new (→ experimental
stimuli later on evidence on basal
forebrain)
Independence from
presentation frequency
◮ How to connect both?
4. The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
5. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
6. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
The Cell Model
integrate-and-fire
delayed transmission
refractory period
Hannes Schulz Local and Global Gating of Synaptic Plasticity
7. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
8. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
9. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Hannes Schulz Local and Global Gating of Synaptic Plasticity
10. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Hannes Schulz Local and Global Gating of Synaptic Plasticity
11. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Layers 1&2, 3&2 fully connected
Random weight initialization
Hannes Schulz Local and Global Gating of Synaptic Plasticity
12. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Network Topology
Input Cells Excitatory Cells Inhibitory Cells
Nucleus Basalis
Layers 1&2, 3&2 fully connected
Random weight initialization
Hannes Schulz Local and Global Gating of Synaptic Plasticity
13. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Retrograde Signal Inhibition
Retrograde Signal
Inhibitory Signal
Dendrit
◮ Retrograde signal
of firing cell
Firing blocked by
inhibitory inputs
Cell
Hannes Schulz Local and Global Gating of Synaptic Plasticity
14. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Heterosynaptic Long Term Depression
Presynaptic Cell Postsynaptic Cell
“Normal” Condition
Hannes Schulz Local and Global Gating of Synaptic Plasticity
15. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Heterosynaptic Long Term Depression
Presynaptic Cell Postsynaptic Cell
Heterosynaptic LTD:
postsynaptic cell
active
presynaptic cell
“Normal” Condition inactive in time
window
◮ Synaptic efficacy
decrease
LTD
Hannes Schulz Local and Global Gating of Synaptic Plasticity
16. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Relative Timing in Hebb Learning
Sample interpretations of “Synchronous activity”:
Symmetric coincidence
window.
Hannes Schulz Local and Global Gating of Synaptic Plasticity
17. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Relative Timing in Hebb Learning
Sample interpretations of “Synchronous activity”:
Symmetric coincidence
window.
Asymmetric
coincidence window.
Used in this study.
Hannes Schulz Local and Global Gating of Synaptic Plasticity
18. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I
Ten different stimuli
pseudorandom order
500 examples shown to
network
Hannes Schulz Local and Global Gating of Synaptic Plasticity
19. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I Trial II
Ten different stimuli 9+1 different stimuli
pseudorandom order pseudorandom order
500 examples shown to 500 examples shown to
network network
One stimulus paired with
stimulus in basal-neuron
Hannes Schulz Local and Global Gating of Synaptic Plasticity
20. The Neuronal Model Experimental Results Discussion The Cell The Network The Inputs
Input
Trial I Trial II
Ten different stimuli 9+1 different stimuli
pseudorandom order pseudorandom order
500 examples shown to 500 examples shown to
network network
One stimulus paired with
stimulus in basal-neuron
Both run 40 times with random start parameters
Hannes Schulz Local and Global Gating of Synaptic Plasticity
21. The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
22. The Neuronal Model Experimental Results Discussion
Formed Representations – Trial I
Neuron Specificity
Stimuli shown more often
44.8% unspecific
to network not better
50.5% specific to 1 stimulus
represented
4.7% intermediate
Hannes Schulz Local and Global Gating of Synaptic Plasticity
23. The Neuronal Model Experimental Results Discussion
Formed Representations – Trial II
Number of neurons
representing
paired stimulus
increases
Number of neurons
representing other
stimuli stay the
same
Hannes Schulz Local and Global Gating of Synaptic Plasticity
24. The Neuronal Model Experimental Results Discussion
Role of the Global Mechanism
1 Basal ganglion neuron fires
2 Inhibitory neurons have a
prolonged refractory period
3 Inhibitory neurons do not fire
4 Excitatory neurons can fire
and shorten refractory period
again
Network Topology
Hannes Schulz Local and Global Gating of Synaptic Plasticity
25. The Neuronal Model Experimental Results Discussion
Role of the Global Mechanism
◮ Unchanged mean activity of
inhibitory neurons
◮ Delay of inhibitory activity relative to
excitatory activity
◮ Retrograde APs invade dendritic
tree
Network Topology
Hannes Schulz Local and Global Gating of Synaptic Plasticity
26. The Neuronal Model Experimental Results Discussion
The Same, in Graphs
Delay of inhibitory Number of neurons
activity relative to representing paired
excitatory activity stimulus increases
Number of neurons
representing other stimuli
stay the same
Hannes Schulz Local and Global Gating of Synaptic Plasticity
27. The Neuronal Model Experimental Results Discussion
Outline
1 The Neuronal Model
The Cell
The Network
The Inputs
2 Experimental Results
3 Discussion
Hannes Schulz Local and Global Gating of Synaptic Plasticity
28. The Neuronal Model Experimental Results Discussion
Comparison of Results to Goals
New stimuli can be trained w/o loss
Optimally activated neurons inhibit others
Unspecific neurons are result
Frequency invariance, variable representation size
Invariance due to mechanism described above
Stimulus representation enhanced by global
mechanism
Hannes Schulz Local and Global Gating of Synaptic Plasticity
29. The Neuronal Model Experimental Results Discussion
Predictions for Experimentors
During basal forbrain stimulation:
Delayed inhibitory activity
Invasion of dendritic tree by more retrograde APs
Hannes Schulz Local and Global Gating of Synaptic Plasticity