Research libraries face many challenges but also many opportunities in the Open Science Environmenet. The new LIBER Strategy 2018-2022 will support member libraries in this process.
Library futures: converging and diverging directions for public and academic ...lisld
The major influence on library futures is the changing character of their user communities. As patterns of research, learning and personal development change in a network environment so library services need to change. At the same time, libraries are focused on engaging with their communities more strongly - getting into their work and learning flows. This means that libraries are becoming more unlike each other, they are diverging as they meet the specific needs of their communities. Research libraries diverge from academic libraries, and each is different from urban public libraries, and so on.
At the same time, at a broader level libraries are experiencing similar pressures. The need to engage more strongly with their communities. The need to assess what they do. The need to configure space around experiences rather than around collections. Libraries are converging around some of these issues.
This presentation will consider the future of libraries from the point of view of convergence and divergence between types of libraries.
The identity of the library is closely bound with its collections. In a print world, this made sense, as the central role of the library was to place materials close to the user and arrange them for effective use.
However, in a network environment this is no longer the case. Lorcan Dempsey, Vice President, Membership and Research, and Chief Strategist at the Online Computer Library Center, will discuss the following three trends that are changing the character of library collections:
The facilitated collection, where the library connects users to resources of interest to their research and learning needs, whether or not they are assembled locally.
The collective collection, where libraries begin to think about moving to shared environments to manage their collections and assuming collective responsibility for stewardship of the scholarly record.
The inside-out collection, where libraries work with other campus partners to support the creation, management and disclosure of institutional materials—research data, special collections, and so on. Here the library supports the creative enterprise of scholarship directly. Together, these trends are changing how we think about collections, libraries, and services to their users.
Together, these trends are changing how we think about collections, libraries, and services to their users.
The Thomas Lecture Series honors the outstanding work that Shirley K. Baker, former Vice Chancellor for Scholarly Resources & Dean of University Libraries, led in the areas of networked information and resource sharing.
Keynote presentation at Montana Library Association meeting, Helena, 7 February. It looks at public and academic library directions in a network environment.
The network reshapes the research library collectionlisld
The library collection has been central to library identity and service, however we are now seeing major changes in how libraries help discover, curate and create collections. This is a response to evolving research and learning behaviors in a network environment. This presentation considers trends which are influencing how we think about library curatorial activities and are reshaping their collections. The first direction is the ‘inside-out library’ which is a response to the reorganization of research work by the digital environment. The second is the facilitated collections, which is a response to the reorganization of the information space by the network. The presentation discusses three ways in which we are thinking differently about collections: the inside out collection, the facilitated collection, and the collective collection.
The Library in the Life of the User: Two Collection Directionslisld
Our understanding of library collections is changing in a digital, network environment. This presentation focuses on two trends in this context. First, the inside-out library is a trend which sees libraries support the creation, management and discoverability of institutional materials: research data, expertise, preprints, and so on. Second, the facilitated collection is a trend which sees libraries increasingly organize resources around user interests, whether these resources are external, collaborative or locally acquired.
This presentation was given at 'The transformation of academic library collecting: a symposium inspired by Dan C. Hazen'. Harvard Library, 20/21 Oct. 2016
Library collections and the emerging scholarly recordlisld
A high level review of collection trends followed by a summary of recent work on the evolving scholarly record.
Presented at the OCLC Research Library Partnership meeting at the University of Melbourne, 2 December 2015.
Library futures: converging and diverging directions for public and academic ...lisld
The major influence on library futures is the changing character of their user communities. As patterns of research, learning and personal development change in a network environment so library services need to change. At the same time, libraries are focused on engaging with their communities more strongly - getting into their work and learning flows. This means that libraries are becoming more unlike each other, they are diverging as they meet the specific needs of their communities. Research libraries diverge from academic libraries, and each is different from urban public libraries, and so on.
At the same time, at a broader level libraries are experiencing similar pressures. The need to engage more strongly with their communities. The need to assess what they do. The need to configure space around experiences rather than around collections. Libraries are converging around some of these issues.
This presentation will consider the future of libraries from the point of view of convergence and divergence between types of libraries.
The identity of the library is closely bound with its collections. In a print world, this made sense, as the central role of the library was to place materials close to the user and arrange them for effective use.
However, in a network environment this is no longer the case. Lorcan Dempsey, Vice President, Membership and Research, and Chief Strategist at the Online Computer Library Center, will discuss the following three trends that are changing the character of library collections:
The facilitated collection, where the library connects users to resources of interest to their research and learning needs, whether or not they are assembled locally.
The collective collection, where libraries begin to think about moving to shared environments to manage their collections and assuming collective responsibility for stewardship of the scholarly record.
The inside-out collection, where libraries work with other campus partners to support the creation, management and disclosure of institutional materials—research data, special collections, and so on. Here the library supports the creative enterprise of scholarship directly. Together, these trends are changing how we think about collections, libraries, and services to their users.
Together, these trends are changing how we think about collections, libraries, and services to their users.
The Thomas Lecture Series honors the outstanding work that Shirley K. Baker, former Vice Chancellor for Scholarly Resources & Dean of University Libraries, led in the areas of networked information and resource sharing.
Keynote presentation at Montana Library Association meeting, Helena, 7 February. It looks at public and academic library directions in a network environment.
The network reshapes the research library collectionlisld
The library collection has been central to library identity and service, however we are now seeing major changes in how libraries help discover, curate and create collections. This is a response to evolving research and learning behaviors in a network environment. This presentation considers trends which are influencing how we think about library curatorial activities and are reshaping their collections. The first direction is the ‘inside-out library’ which is a response to the reorganization of research work by the digital environment. The second is the facilitated collections, which is a response to the reorganization of the information space by the network. The presentation discusses three ways in which we are thinking differently about collections: the inside out collection, the facilitated collection, and the collective collection.
The Library in the Life of the User: Two Collection Directionslisld
Our understanding of library collections is changing in a digital, network environment. This presentation focuses on two trends in this context. First, the inside-out library is a trend which sees libraries support the creation, management and discoverability of institutional materials: research data, expertise, preprints, and so on. Second, the facilitated collection is a trend which sees libraries increasingly organize resources around user interests, whether these resources are external, collaborative or locally acquired.
This presentation was given at 'The transformation of academic library collecting: a symposium inspired by Dan C. Hazen'. Harvard Library, 20/21 Oct. 2016
Library collections and the emerging scholarly recordlisld
A high level review of collection trends followed by a summary of recent work on the evolving scholarly record.
Presented at the OCLC Research Library Partnership meeting at the University of Melbourne, 2 December 2015.
Rightscaling, engagement, learning: reconfiguring the library for a network e...lisld
The edge of the world. Theta 2013: the Higher Education Technology Agenda. Hobart, Tasmania, 7-10 April, 2013.
The network continues to reconfigure personal and organizational relationships. Libraries face three important challenges in this environment.
1. Rightscaling infrastructure.
Libraries were predominantly ‘institution-scale’ – they provided services at the level of the institution for their local users. However, their users now look to the network for information services (e.g. Google Scholar, Wikipedia, …). And libraries now look to the network to collaborate or to externalize services (e.g. HathiTrust, cloud-based discovery or systems, shared systems infrastructure, …). In this environment the need for local infrastructure declines (e.g. extensive print collections, redundantly deployed local systems which provide necessary but not distinctive services). The scale advantage manifests itself in both impact and efficiency.
2. The shift to engagement.
Users used to build their workflows around libraries. Now the library needs to build services around user workflows, as those workflows form around network services. Libraries used to acquire and organize ‘published’ materials. Now they are engaged with the full range of creation, management and disclosure of learning and scholarly resources. Library spaces were configured around print collections; now they are configured around experiences, expertise, and specialist facilities. These are all examples of how libraries are reallocating resource and effort to engage more strongly with the learning and research lives of their users, improving the learning experience and making research more productive and research outputs more visible.
3. Institutional innovation
Innovation is important, especially to support greater engagement. But in many ways the most important form of innovation is institutional. Libraries have to develop new and routine ways of collaborating to achieve their goals. At the same time they have to negotiate internal boundaries and forge new structures within institutions. In each case, they are developing new ‘relationship architectures’. Think for example of the institutional innovation required to move to shared systems and collections in the Orbis Cascade Alliance or 2CUL for example. Or think of the innovative approach which makes new relationships within institutions (with Learning and Teaching Support, with the Office of Research, the University Press, emerging e-research infrastructure, IT, etc, for example, or with various educational or social services in a public setting). Evolving such relationships requires an enterprising approach and ensures continual learning.
From local infrastructure to engagement - thinking about the library in the l...lisld
Libraries are rebalancing services and directions so that they are more active in the lives of their users. This presentation frames this discussion. It looks at shifts in user behaviours, collections, and spaces, and describes how OCLC Reseach is helping libraries make these transitions.
This presentation was given at the Minitex ILL Meeting in St Paul on 12 May 2015.
Libraries, collections, technology: presented at Pennylvania State University...lisld
Library collections are changing in a network environment. This presentation considers how collections are being reconfigured, it looks at research support services, and it explores the shift from the purchased/licensed collection to the facilitated collection.
Collections unbound: collection directions and the RLUK collective collectionlisld
A presentation given to RLUK Members' meeting at the University of Warwick.
The library identity has been closely bound with its collection. However this is changing as research and learning behaviours evolve in a network environment. There are three interesting trends. First, atttention is shifting from a library-centric view of a locally owned collection to a user-centred view of a facilitated collection in places where the library can add value. Second, there is growing emphasis on support for creation, for the process of research, as well as for the products, the article or book. And third, we are seeing a changing perspective on the historic core, the print book collection. Increasingly, this is being seen in collective ways as institutions manage down print, or think about its management in cooperative settings, or retire collections as space is reconfigured around research and learning experiences. This presentation also provides preliminary findings for the analysis being carried out by OCLC Research of the RLUK collective collection.
OCLC Research Update at ALA Chicago. June 26, 2017.OCLC
Rachel Frick, OCLC Executive Director of the OCLC Research Library Partnership, reviews some of the broad agenda items and recent publications related to the work of OCLC Research. Rachel is then joined for two presentations on specific research topics. First, Sharon Streams (OCLC Director of WebJunction) and Monika Sengul-Jones (OCLC Wikipedian-in-Residence) present on “Public Libraries and Wikipedia.” Next, Kenning Arlitsch (Dean, Montana State University Library) and Jeff Mixter (OCLC Senior Software Engineer) share their findings on “Accurate Institutional Repository Download Measurement using RAMP, the Repository Analytics and Metrics Portal.”
We are what we own: Deselection strategies for our profession's viabilityjeperez8
We are what we own: Deselection strategies for our profession's viability
Florida Library Association Conference 2011
Jorge Perez
St. Petersburg College
Museum as Platform; Curator as ChampionNancy Proctor
"Museum as Platform; Curator as Champion: Learning to sing in the age of social media," a presentation by Nancy Proctor at the conference, "Event Culture: The Museum and Its Staging of Contemporary Art" organized by the Copenhagen Doctoral School of Cultural Studies, Department of Arts and Cultural Studies, Louisiana Museum of Modern Art, 7 November 2009.
Creative Commons License Attribution-Noncommercial 3.0 United States
The facilitated collection: collections and collecting in a network environmentlisld
We often think of collections as local – whether owned or licensed. Increasingly this picture is changing in several ways. Libraries are sharing responsibility for collections. Libraries are providing access to materials they do not own, but which are available to their users (freely available digital book collections for example). Demand driven acquisitions changes the view of local collections. Institutions are also thinking about how to manage locally produced materials (research data for example) and support access across institutions. This trend is supported by changes as discovery is peeled away from local collections. This presentation discusses these trends, and collections and discovery change in a network environment.
This was a presentation at the Libraries Australia Forum, Melbourne, 2015
Library discovery: past, present and some futureslisld
A presentation at the NISO virtual conference on Webscale Discovery Services, 20 November 2013.
Considers some of the issues that have led to the adoption of these services, and some future directions.
Distinguishes between discovery (providing a library destination) and discoverability (making stuff discoverable elsewhere).
Challenges and opportunities for academic librarieslisld
Research and learning behaviors are changing in a network environment. What challenges do Academic libraries face? What opportunities do they have? A presentation given at a symposium on the future of academic libraries at the Open University.
Keynote presentation at the Lita Forum, Albuquerque. Research and learning practices are enacted in technology rich environments. New tools support digital workflows and the volume and variety of research and learning outputs are growing. Libraries are working to support these new environments and to connect their services to them.
Collection directions - towards collective collectionslisld
How the emergence of new research and learning workflows in digital environments is affecting library collecting and collections. Several trends are reviewed. In the light of diversifying competing requirements, the need to manage down print and develop shared print responses is discussed.
Presentation to OCLC Asia Pacific Regional Council meeting. 13 Oct. 2014.
This presentation was given at Bobcatsss2013 in Ankara.
Once the library assembled a collection and people came to the library to use it. Now, people build communication, workflows and behaviors around a variety of network resources. The library needs to think about how it is visible and relevant in those workflows and behaviors.
BIS Congres 2010 Lausanne presentation: Anna Torriani, Lorenzo Pagnamenta - "Mariners Harbor Branch Library, The award winning building for the New York Public Library"
Rightscaling, engagement, learning: reconfiguring the library for a network e...lisld
The edge of the world. Theta 2013: the Higher Education Technology Agenda. Hobart, Tasmania, 7-10 April, 2013.
The network continues to reconfigure personal and organizational relationships. Libraries face three important challenges in this environment.
1. Rightscaling infrastructure.
Libraries were predominantly ‘institution-scale’ – they provided services at the level of the institution for their local users. However, their users now look to the network for information services (e.g. Google Scholar, Wikipedia, …). And libraries now look to the network to collaborate or to externalize services (e.g. HathiTrust, cloud-based discovery or systems, shared systems infrastructure, …). In this environment the need for local infrastructure declines (e.g. extensive print collections, redundantly deployed local systems which provide necessary but not distinctive services). The scale advantage manifests itself in both impact and efficiency.
2. The shift to engagement.
Users used to build their workflows around libraries. Now the library needs to build services around user workflows, as those workflows form around network services. Libraries used to acquire and organize ‘published’ materials. Now they are engaged with the full range of creation, management and disclosure of learning and scholarly resources. Library spaces were configured around print collections; now they are configured around experiences, expertise, and specialist facilities. These are all examples of how libraries are reallocating resource and effort to engage more strongly with the learning and research lives of their users, improving the learning experience and making research more productive and research outputs more visible.
3. Institutional innovation
Innovation is important, especially to support greater engagement. But in many ways the most important form of innovation is institutional. Libraries have to develop new and routine ways of collaborating to achieve their goals. At the same time they have to negotiate internal boundaries and forge new structures within institutions. In each case, they are developing new ‘relationship architectures’. Think for example of the institutional innovation required to move to shared systems and collections in the Orbis Cascade Alliance or 2CUL for example. Or think of the innovative approach which makes new relationships within institutions (with Learning and Teaching Support, with the Office of Research, the University Press, emerging e-research infrastructure, IT, etc, for example, or with various educational or social services in a public setting). Evolving such relationships requires an enterprising approach and ensures continual learning.
From local infrastructure to engagement - thinking about the library in the l...lisld
Libraries are rebalancing services and directions so that they are more active in the lives of their users. This presentation frames this discussion. It looks at shifts in user behaviours, collections, and spaces, and describes how OCLC Reseach is helping libraries make these transitions.
This presentation was given at the Minitex ILL Meeting in St Paul on 12 May 2015.
Libraries, collections, technology: presented at Pennylvania State University...lisld
Library collections are changing in a network environment. This presentation considers how collections are being reconfigured, it looks at research support services, and it explores the shift from the purchased/licensed collection to the facilitated collection.
Collections unbound: collection directions and the RLUK collective collectionlisld
A presentation given to RLUK Members' meeting at the University of Warwick.
The library identity has been closely bound with its collection. However this is changing as research and learning behaviours evolve in a network environment. There are three interesting trends. First, atttention is shifting from a library-centric view of a locally owned collection to a user-centred view of a facilitated collection in places where the library can add value. Second, there is growing emphasis on support for creation, for the process of research, as well as for the products, the article or book. And third, we are seeing a changing perspective on the historic core, the print book collection. Increasingly, this is being seen in collective ways as institutions manage down print, or think about its management in cooperative settings, or retire collections as space is reconfigured around research and learning experiences. This presentation also provides preliminary findings for the analysis being carried out by OCLC Research of the RLUK collective collection.
OCLC Research Update at ALA Chicago. June 26, 2017.OCLC
Rachel Frick, OCLC Executive Director of the OCLC Research Library Partnership, reviews some of the broad agenda items and recent publications related to the work of OCLC Research. Rachel is then joined for two presentations on specific research topics. First, Sharon Streams (OCLC Director of WebJunction) and Monika Sengul-Jones (OCLC Wikipedian-in-Residence) present on “Public Libraries and Wikipedia.” Next, Kenning Arlitsch (Dean, Montana State University Library) and Jeff Mixter (OCLC Senior Software Engineer) share their findings on “Accurate Institutional Repository Download Measurement using RAMP, the Repository Analytics and Metrics Portal.”
We are what we own: Deselection strategies for our profession's viabilityjeperez8
We are what we own: Deselection strategies for our profession's viability
Florida Library Association Conference 2011
Jorge Perez
St. Petersburg College
Museum as Platform; Curator as ChampionNancy Proctor
"Museum as Platform; Curator as Champion: Learning to sing in the age of social media," a presentation by Nancy Proctor at the conference, "Event Culture: The Museum and Its Staging of Contemporary Art" organized by the Copenhagen Doctoral School of Cultural Studies, Department of Arts and Cultural Studies, Louisiana Museum of Modern Art, 7 November 2009.
Creative Commons License Attribution-Noncommercial 3.0 United States
The facilitated collection: collections and collecting in a network environmentlisld
We often think of collections as local – whether owned or licensed. Increasingly this picture is changing in several ways. Libraries are sharing responsibility for collections. Libraries are providing access to materials they do not own, but which are available to their users (freely available digital book collections for example). Demand driven acquisitions changes the view of local collections. Institutions are also thinking about how to manage locally produced materials (research data for example) and support access across institutions. This trend is supported by changes as discovery is peeled away from local collections. This presentation discusses these trends, and collections and discovery change in a network environment.
This was a presentation at the Libraries Australia Forum, Melbourne, 2015
Library discovery: past, present and some futureslisld
A presentation at the NISO virtual conference on Webscale Discovery Services, 20 November 2013.
Considers some of the issues that have led to the adoption of these services, and some future directions.
Distinguishes between discovery (providing a library destination) and discoverability (making stuff discoverable elsewhere).
Challenges and opportunities for academic librarieslisld
Research and learning behaviors are changing in a network environment. What challenges do Academic libraries face? What opportunities do they have? A presentation given at a symposium on the future of academic libraries at the Open University.
Keynote presentation at the Lita Forum, Albuquerque. Research and learning practices are enacted in technology rich environments. New tools support digital workflows and the volume and variety of research and learning outputs are growing. Libraries are working to support these new environments and to connect their services to them.
Collection directions - towards collective collectionslisld
How the emergence of new research and learning workflows in digital environments is affecting library collecting and collections. Several trends are reviewed. In the light of diversifying competing requirements, the need to manage down print and develop shared print responses is discussed.
Presentation to OCLC Asia Pacific Regional Council meeting. 13 Oct. 2014.
This presentation was given at Bobcatsss2013 in Ankara.
Once the library assembled a collection and people came to the library to use it. Now, people build communication, workflows and behaviors around a variety of network resources. The library needs to think about how it is visible and relevant in those workflows and behaviors.
BIS Congres 2010 Lausanne presentation: Anna Torriani, Lorenzo Pagnamenta - "Mariners Harbor Branch Library, The award winning building for the New York Public Library"
LIBER Strategy for libraries and research dataJeannette Frey
A presentation about the new LIBER (Ligue Européenne des bibliothèques de recherche) Strategy 2018-2022, with a special focus on the question of research data.
LIBER, Ligue Européenne des Bibliothèques de Recherche, launched its new strategy 2018-2022 in November 2017. This presentation gives an overview about LIBER's vision, strategic directions, steering committee and working groups - existing and to be created in the years to come.
LIBER DH Working Group Workshop: Launch of the Working Group by Andreas Degwi...LIBER Europe
This presentation was given as part of the Digital Humanities workshop at LIBER 2017, Patras. For more about LIBER and the Digital Humanities Working Group, please see: www.libereurope.eu
Melanie Imming LIBER Working together towards World Class ResearchLIBER Europe
As part of our work to connect and represent research libraries in Europe, LIBER initiates and participates in strategic and innovative European projects. At the moment, LIBER is involved in nine EU projects, all to do with our three strategic directions: to enable open science, to lead in changings scholarship, and to shape innovative research.
Natalie Harrower - DRI, RDA and Irelanddri_ireland
From "A National Approach to Open Research Data in Ireland", a workshop held on 8 September 2017 in National Library of Ireland, organised by The National Library of Ireland, the Digital Repository of Ireland, the Research Data Alliance and Open Research Ireland.
An introduction to LIBER as an organisation, and the key ways in which we help our network of 400+ libraries across Europe. Presented in Slovenia in September 2016.
A Manifesto for the Digital Shift in Research LibrariesTorsten Reimer
A report from the Digital Shift working group for RLUK (Research Libraries UK) on the challenges libraries face with regards to the digital shift and how to overcome them. Presented at a virtual RLUK seminar on 18th May 2020.
From paper to digits. Challenges and opportunities of Digital reserachLIBIS
Technology is everywhere. In most, if not all research projects, hard- and software are used aplenty. Moreover, when you look at the research data lifecycle, it is hard to think of data collection, analysis, preservation, and reuse in terms of paper. Policy makers and funders alike are encouraging projects with an IT component. As a result, new tools, databases and data models sprout from every research project; the original goal of sharing and collaboration surpassed by the conviction that there is a need for this particular software or that custom developed database. This is not entirely a bad thing, since it also drives innovation and brings new perspectives to the use of digital components in research. The problem lies more in the sustainability of the developed tools and databases after the
project s' lifetime. This presentation focuses on the challenges of research infrastructure sustainability and the important role that national and pan-European research infrastructures such as DARIAH can play in providing researchers with best practices and support in building and maintaining access to innovative tools, databases and datasets.
This presentation was provided by Marshall Breeding, Independent Consultant and Founder of Library Technology Guides; Co-Chair, ODI Working Group, at the
2012 NISO Standards Update at ALA.
CILIP Conference 2019 - The Mitchell Library In-Reach project with Citizen's ...CILIP
The presentation describes The Mitchell Library’s homeless in-reach initiative; how the idea came together with the collaboration of the Citizens Advice Bureau, and how it was put to our frontline staff. Dan Monks and Iain Riley discussed the reservations and obstacles we encountered along the way, and concluded with the impact this initiative has had on both staff and library users.
#cilipconf19
The Canadian Linked Data Initiative: Charting a Path to a Linked Data FutureNASIG
As libraries prepare to shift away from MARC to a linked data framework, new convergences in the metadata production activities of our libraries' technical services units, special collections, and digital libraries are becoming possible. In September 2015, the Canadian Linked Data Initiative (CLDI) was formed to leverage the existing collaboration between the Technical Services departments of Canada’s top 5 research libraries and the Library and Archives of Canada. Working cooperatively, our objective is to provide a path to linked data readiness for our institutions and leadership for the adoption of linked data by libraries across Canada. To achieve this goal, partner libraries are working across departments and institutions to create new workflows and tools and adapt to a new conceptual understanding of descriptive metadata. This presentation is a preliminary report on the progress made in five key areas of interest: digital collections, education and training, MARC record enhancement, evaluation of linked data tools and vendor supplied metadata. Building on existing initiatives, the CLDI is investigating the potential of integrating linked data elements into digitized collections, as well as MARC-based bibliographic and authority records, with the aim of fostering new and interesting pathways for resource discovery. To strengthen and expand the professional knowledge of staff, partner institutions are collaborating in the production of educational and training materials related to linked data principles and practices. The evaluation and potential development of linked data tools is another area of concentration. Finally, with the goal of changing workflows upstream, the CLDI is working to engage publishers and vendors in the linked data conversation. In addition to reporting on the work undertaken in the first year of the project, this presentation will also cover lessons learned and outline some of the new opportunities gained from working on a collaborative project that spans across multiple boundaries.
Marlene van Ballegooie, Metadata Librarian,
University of Toronto
Juliya Borie, University of Toronto Libraries
Andrew Senior, Coordinator,
E-Resources and Serials, McGill University
Data-Informed Decision Making for Libraries - Athenaeum21Megan Hurst
Athenaeum21 presents three case studies of assessment and evaluation programs in libraries--one past, one current, and one future. The cases use three different modes of data gathering and analysis to show the power of understanding user needs and how well your organization is meeting them.
Similar to LIBER's Strategy Supporting The Role of Libraries in the Open Science Environment (20)
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
In silico drugs analogue design: novobiocin analogues.pptx
LIBER's Strategy Supporting The Role of Libraries in the Open Science Environment
1. LIBER's strategy supporting the roles of
libraries in the open science
environment
Budapest, September 12, 2016
Jeannette Frey, Vice-president, LIBER
2. Outline
• What is LIBER?
• The LIBER strategy 2013-2017
• The LIBER strategy 2018-2022
• The LIBER strategy process
• The results so far
• The changing role of research libraries
4. What is LIBER ?
• Founded in 1971 (Foundation under Dutch law
from 2009)
• More than 400 national, university and other
libraries
• Over 40 countries
• Represent the interest of European research
libraries in several key areas
• Lobby policymakers
• Collaboration with member libraries on
European-funded projects
• Create opportunities for library professionals
7. LIBER strategy
2013-2017
Steering Committee Scholarly
Communication & Research
Infrastructures è Enabling Open
Science.
• Provide a forum for best practice
• Support development of skills in RDM
• Collaborate with stakeholders
• Share information and developments
in some areas like digital humanities
• Develop best practice in use of metrics
8. LIBER strategy
2013-2017
Steering Committee “Reshaping
The Research Library” è Lead
in Changing Scholarship
• LIBER Leadership seminar
• LIBER Journées programme
• Digital Collections WG
• Toolkits
9. LIBER strategy
2013-2017
Steering Committee “Advocacy &
Communications” è Shape
Innovative Research
• Develop and promote positions
on topics relevant to research
libraries
• Increase uptake of TDM
• Advocate policies and practices
• Implementing Open Access
• Shaping EU copyright
11. Strategy 2013-‐2017
Brainstorming LIBER
Working
Group
Interview
with
researchers
and
stakeholders
Strategy
working group:
Strategic
directions
LIBER
annual
conference
2016:
Strategy café
7-‐8.
2016:
Feedback
from
LIBER
members
9-‐2016-‐2.2017:
Strategy
working
group
developes the
Strategy
plan
2.2017-‐7.2017:
Strategy
working
group
developes the
implementation
plan
Presentation
of
new
strategy
at
LIBER
conference
2017
in
Patras
10.2017:
Launch
of
new
LIBER
strategy
2018-‐
2022
13. Results so far:
PEST Analysis
Politics:
• Libraries = Collaboration;; Universities =
Competition
• Open Science embraced by research funders,
universities and EU
• Recognition of role of Libraries
Economics:
• Pressure on library budgets
• Funding at European level (Horizon 2020)
• Financial situation of LIBER is good and stable
14. Results so far:
PEST Analysis
Society:
• Library is node in network of resources
• Changing user needs è changes in library’s
services
• Research data storage & sharing increases as a
result of data-driven science
Technology:
• Migration to the cloud
• Aggregation of content (example Europeana)
• Increased need for identifiers (ORCID, ISNI…)
15. Results so far:
Interviews of
researchers
• Be more involved in research creation process
(supporting data management plan)
• Be more visible and more proud
• Open Access is the best structure for scholarly
communication
• If possible, take up a role in the development of
Open Science infrastructures
• Training and retraining in order to be able to
adapt to the new system
16. Results so far:
Interviews of
stakeholders
“Support the researcher by clarifying what Open
Access publications and Research Data
Management means”
• Digital literacy is key
• Revise the existing business models
• Pay attention in the debate on knowledge
commons
• Research metrics are an issue
18. LIBER strategy
2018-2022
Vision statement
• In 2022:
• Open Access is predominant form of publishing
• Research data is findable, accessible,
interoperable and reusable (FAIR)
• Digital skills underpin an open and transparent
research life cycle
• Research infrastructure is participatory, tailored
and scaled to the needs of the diverse disciplines
• Cultural heritage of tomorrow is distilled from
today’s digital information
19. LIBER strategy
2018-2022
Strategic
directions 2018-
2022
• Libraries as platform for innovative publishing
• Libraries as a hub for digital skills and
services
• Libraries partnering in research infrastructure
21. LIBER strategy
2018-2022
Changing roles of
research libraries
Libraries as platform
for innovative publishing:
• Develop innovative services on top of repository
networks
• Take a role in Open Access business models for
journals
• Be an Open Access publisher!
• Manage research data
• Use innovative metrics
• Go into innovative peer review
22. LIBER strategy
2018-2022
Changing roles of
research libraries
Libraries as a hub for
digital skills and services
• Diversify digital skills of library staff
• Change management
• Influence copyright and legal matters
• Be a hub for digital humanities and digital
cultural heritage
• Engage in information ethics
23. LIBER strategy
2018-2022
Changing roles of
research libraries
Libraries partnering in
research infrastructure
• Cooperate in development of interoperable and
scalable infrastructures and services
• Shared services & cloud services
• Engage in semantic interoperability (LOD)
• Data stewardship
• Disciplinary partnership