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CHILD HEALTH NURSING
BILLROTH COLLEGE OF NURSING
 Leukemia, cancer of the blood-forming tissues, is the
most common form of chilhood cancer.
 INCIDENCE
3 to 4 cases per 100,000 children younger than 15year
of age.
 It is more common in male.
 Peak onset between 2 and 5 year of age.
 It is one of the forms of cancer that has demonstrated
dramatic improvement in survival rates.
 Fatigue
 Bone or joint pain
 Fever
 Weight loss
 Abnormal masses
 Purpura
 Hemorrhage
 Infection
 Breathlessness
 Excessive and unexplained bruising.
 Enlarged lymph node,liver and spleen.
 Investigation (serum uric acid)
 Coagulation profile
 LFT,RFT
 Chest x-ray
 CT scan of chest & brain
 Blood culture
 Echo , ECG.
 Investigation ( confirmative)
 CBC
 Bone marrow aspiration/biopsy
 Cyto genetics.
 Supportive care
 A total of 10mg/kg/day of allopurinl in
divided doses is given in all cases before the
commencement antileukemic drug.
 When the blast cell count is more than
50,000/mm3 0r there are large tumor
masses, allopurinol is obligatory, together
with a fluid intake of 2-3 L/m2/day.
 Use of packed red cells
 Platelet transfusions should be administered
to patients with over bleeding or when the
platelets count is below 10,000/mm3.
 Usually done in second remission.
 Can be done in first remission in high risk
patients
WBC>25000.
PHILADEPHIA CHROMOSOME
POSITIVE.
POOR INITIAL RESPONSE TO REMISSION
INDUCTION.
 MONOCLONAL ANTIBODIES
 Rituximad (CD2O)
 Epratuzumad(CD22)
 ANTIMETABOLITES
 Clofarabine
 Nelarabine
 TYROSINE KINASE INHIBITOR
 Imatinib
 Nilotinib
 Monitor vital sings every 4 hours
 Proper hand washing
 Inspect skin daily
 Plan neutopenic diet
 Isolate the child from children who are sick
 Administer acetominophen for fever and anti
emetic before therapy.
 Daily weight checkup.
Leukemia ppt.pptx

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Leukemia ppt.pptx

  • 1. CHILD HEALTH NURSING BILLROTH COLLEGE OF NURSING
  • 2.  Leukemia, cancer of the blood-forming tissues, is the most common form of chilhood cancer.  INCIDENCE 3 to 4 cases per 100,000 children younger than 15year of age.  It is more common in male.  Peak onset between 2 and 5 year of age.  It is one of the forms of cancer that has demonstrated dramatic improvement in survival rates.
  • 3.
  • 4.
  • 5.  Fatigue  Bone or joint pain  Fever  Weight loss  Abnormal masses  Purpura  Hemorrhage  Infection  Breathlessness  Excessive and unexplained bruising.  Enlarged lymph node,liver and spleen.
  • 6.  Investigation (serum uric acid)  Coagulation profile  LFT,RFT  Chest x-ray  CT scan of chest & brain  Blood culture  Echo , ECG.  Investigation ( confirmative)  CBC  Bone marrow aspiration/biopsy  Cyto genetics.
  • 7.  Supportive care  A total of 10mg/kg/day of allopurinl in divided doses is given in all cases before the commencement antileukemic drug.  When the blast cell count is more than 50,000/mm3 0r there are large tumor masses, allopurinol is obligatory, together with a fluid intake of 2-3 L/m2/day.  Use of packed red cells  Platelet transfusions should be administered to patients with over bleeding or when the platelets count is below 10,000/mm3.
  • 8.  Usually done in second remission.  Can be done in first remission in high risk patients WBC>25000. PHILADEPHIA CHROMOSOME POSITIVE. POOR INITIAL RESPONSE TO REMISSION INDUCTION.
  • 9.  MONOCLONAL ANTIBODIES  Rituximad (CD2O)  Epratuzumad(CD22)  ANTIMETABOLITES  Clofarabine  Nelarabine  TYROSINE KINASE INHIBITOR  Imatinib  Nilotinib
  • 10.  Monitor vital sings every 4 hours  Proper hand washing  Inspect skin daily  Plan neutopenic diet  Isolate the child from children who are sick  Administer acetominophen for fever and anti emetic before therapy.  Daily weight checkup.