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Session 3:
Research and
Case Studies
Learning Objectives
Research at university
What case studies are and how they are used to understand what
studying is like at university
How to approach a case study
Walkthrough and assessment of a diagnostic case study
Q&A
Research at University
Lectures are seen as
an introduction to
content
2-3 hours of
individual study per
hour of lecture time
You will not know
everything from the
start!
Ask questions! Email
tutors/lecturers! Get
involved!
Utilise the
libraries!!!!
Cardiovascular
revision
 Normal blood pressure level is
<120/80mmHg
What causes this to be outside the
normal range?
 Normal resting heart rate range :
60-100bpm
 Normal levels of cardiac troponin
in the bloodstream is < 14 ng/L
What causes this to be outside the
normal range?
What are case studies and why do we use them?
Used to provide insight into general biomedical
principles
Presentation of a ‘patient’ with symptoms – provokes
research and analysis
Gain valuable problem solving and analytical skills as
well as enhancing your biomedical knowledge
How to approach a case study
Collect all information
together and sort into
categories – signs and
symptoms
Signs – recordings
taken such as blood
pressure, heart rate or
temperature
Symptoms – anecdotal
information given by
the patient like pains
or dizziness
Assess the relevance
of these
Whether a symptom is
severe or unusual or if
a sign is significantly
veering from the
normal values
Extra research – you
won’t know every
disease/illness
Crosscheck data from
trusted sources that
are in line with the
data given
Not all information
will be useful! Some
might even distract
from the real diagnosis
Case study 1
Case Study 1
 Mr. Johnson is A 57-year-old man who has the following symptoms:
 Chest pain
 Dyspnea (shortness of breath)
 Nausea
 Unexplained Weakness
 The man declares he is diabetic and a smoker and experienced 3 hours of chronic
chest pain prior to the visit to the hospital.
 Doctors run a series of simple, physical tests with the following results:
Signs and Symptoms
 Heart rate of 100bpm
 Blood pressure of 140/90mmHg
 Heart Murmur
 No Lung irregularities
 30ng/L of cardiac troponin T in the bloodstream
Are any of these significant?
Electrocardiograms
Patient:
Normal:
Can you spot the
abnormality?
Let’s zoom in!
Patient
Normal
Diagnosis
Non-ST elevation myocardial infarction
(NSTEMI)
Essentially a light form of heart attack
– less severe than other types
Caused by a lack of oxygenation of the
coronary tissue – from clogged arteries
or low haemoglobin production
Still life threatening, but less likely to
cause death than other, more
identifiable heart attacks
How could you tell?
 High blood pressure
 Heart murmur
 Cardiac troponin T concentration of 30ng/L heavily indicative of myocardial
infarction (MI)
 ST portion of the ECG shown to be more depressed than on a healthy heart
 Reported symptoms from the patient are indicative of MI
Look again at your booklets. Did you notice any of
these?
Pharmaceutical treatment
 Antiplatelet medications (aspirin): inactivate platelets,
leading to less blood clotting
 Angiotensin-converting enzyme (ACE) inhibitors: targets
angiotensin, interfering with its ability to increase blood
pressure, causing an overall decrease in blood pressure.
 Beta-blockers: cause your heart to beat at a slower rate
and with less force.
 Nitroglycerin: widens your blood vessels, reducing blood
pressure and improving blood flow and chest pain
 Statins: lower the cholesterol level in the blood
Lifestyle treatment
and prevention
 Maintain a healthy lifestyle,
providing the best chance for
your heart to be healthy
 Balanced diet
 High amounts of exercise
 No smoking
Myocardial infarction summary
 NSTEMI myocardial infarction is a form of heart attack
 Caused by atherosclerotic plaque erosion or rupture which results in vasoconstriction and occlusion
of blood vessels
 Lack of blood flow and oxygen to the cardiac myocytes which results in myocardial ischemia
 Signs and symptoms include high blood pressure, chest pain, high heart rate, cardiac
murmurs...
 Tests will reveal high cardiac troponin T levels in the blood stream
 12 lead ECG will reveal an ST wave depression due to the lack of blood flow to a portion of the
heart muscle which causes an imbalance of the electrical activity
 Risk factors: overweight/obese, age, type 2 diabetes, smoking, unhealthy diet, lack of exercise
 Treatments: Antiplatelet medications (aspirin), Angiotensin-converting enzyme (ACE)
inhibitors, Beta-blockers, Nitroglycerin, Statins.
 Lifestyle changes: healthy diet, no smoking, exercise.
In Summary
 Private study and research at university is very dependent on individual involvement
and extra study.
 Case studies are an important tool in furthering diagnostic ability and analytical
thinking.
 Not all information is important, a key skill is analysing information and assessing its
importance and relevance.
 Enhance problem solving, analytical and communication skills.
This is just the beginning!
Big Case Study next session!
Any Questions???

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Lesson 3 slides.pptx

  • 2. Learning Objectives Research at university What case studies are and how they are used to understand what studying is like at university How to approach a case study Walkthrough and assessment of a diagnostic case study Q&A
  • 3. Research at University Lectures are seen as an introduction to content 2-3 hours of individual study per hour of lecture time You will not know everything from the start! Ask questions! Email tutors/lecturers! Get involved! Utilise the libraries!!!!
  • 4. Cardiovascular revision  Normal blood pressure level is <120/80mmHg What causes this to be outside the normal range?  Normal resting heart rate range : 60-100bpm  Normal levels of cardiac troponin in the bloodstream is < 14 ng/L What causes this to be outside the normal range?
  • 5. What are case studies and why do we use them? Used to provide insight into general biomedical principles Presentation of a ‘patient’ with symptoms – provokes research and analysis Gain valuable problem solving and analytical skills as well as enhancing your biomedical knowledge
  • 6. How to approach a case study Collect all information together and sort into categories – signs and symptoms Signs – recordings taken such as blood pressure, heart rate or temperature Symptoms – anecdotal information given by the patient like pains or dizziness Assess the relevance of these Whether a symptom is severe or unusual or if a sign is significantly veering from the normal values Extra research – you won’t know every disease/illness Crosscheck data from trusted sources that are in line with the data given Not all information will be useful! Some might even distract from the real diagnosis
  • 8. Case Study 1  Mr. Johnson is A 57-year-old man who has the following symptoms:  Chest pain  Dyspnea (shortness of breath)  Nausea  Unexplained Weakness  The man declares he is diabetic and a smoker and experienced 3 hours of chronic chest pain prior to the visit to the hospital.  Doctors run a series of simple, physical tests with the following results:
  • 9. Signs and Symptoms  Heart rate of 100bpm  Blood pressure of 140/90mmHg  Heart Murmur  No Lung irregularities  30ng/L of cardiac troponin T in the bloodstream Are any of these significant?
  • 12. Diagnosis Non-ST elevation myocardial infarction (NSTEMI) Essentially a light form of heart attack – less severe than other types Caused by a lack of oxygenation of the coronary tissue – from clogged arteries or low haemoglobin production Still life threatening, but less likely to cause death than other, more identifiable heart attacks
  • 13. How could you tell?  High blood pressure  Heart murmur  Cardiac troponin T concentration of 30ng/L heavily indicative of myocardial infarction (MI)  ST portion of the ECG shown to be more depressed than on a healthy heart  Reported symptoms from the patient are indicative of MI Look again at your booklets. Did you notice any of these?
  • 14. Pharmaceutical treatment  Antiplatelet medications (aspirin): inactivate platelets, leading to less blood clotting  Angiotensin-converting enzyme (ACE) inhibitors: targets angiotensin, interfering with its ability to increase blood pressure, causing an overall decrease in blood pressure.  Beta-blockers: cause your heart to beat at a slower rate and with less force.  Nitroglycerin: widens your blood vessels, reducing blood pressure and improving blood flow and chest pain  Statins: lower the cholesterol level in the blood
  • 15. Lifestyle treatment and prevention  Maintain a healthy lifestyle, providing the best chance for your heart to be healthy  Balanced diet  High amounts of exercise  No smoking
  • 16. Myocardial infarction summary  NSTEMI myocardial infarction is a form of heart attack  Caused by atherosclerotic plaque erosion or rupture which results in vasoconstriction and occlusion of blood vessels  Lack of blood flow and oxygen to the cardiac myocytes which results in myocardial ischemia  Signs and symptoms include high blood pressure, chest pain, high heart rate, cardiac murmurs...  Tests will reveal high cardiac troponin T levels in the blood stream  12 lead ECG will reveal an ST wave depression due to the lack of blood flow to a portion of the heart muscle which causes an imbalance of the electrical activity  Risk factors: overweight/obese, age, type 2 diabetes, smoking, unhealthy diet, lack of exercise  Treatments: Antiplatelet medications (aspirin), Angiotensin-converting enzyme (ACE) inhibitors, Beta-blockers, Nitroglycerin, Statins.  Lifestyle changes: healthy diet, no smoking, exercise.
  • 17. In Summary  Private study and research at university is very dependent on individual involvement and extra study.  Case studies are an important tool in furthering diagnostic ability and analytical thinking.  Not all information is important, a key skill is analysing information and assessing its importance and relevance.  Enhance problem solving, analytical and communication skills.
  • 18. This is just the beginning! Big Case Study next session! Any Questions???