The document summarizes key aspects of cell membrane structure and function. It describes the fluid mosaic model of the membrane structure consisting of a phospholipid bilayer with embedded proteins. It discusses the components of the membrane including phospholipids, cholesterol, and carbohydrates. It explains the major functions of membrane proteins including transport, enzymatic activity, signal transduction, cell-cell recognition, intercellular joining, and attachment to the cytoskeleton. It also summarizes the different types of transport processes like diffusion, facilitated diffusion, active transport and examples of transport proteins and mechanisms.
The plasma membrane surrounds cells and organelles, protecting the interior while regulating what passes in and out. It is a selectively permeable lipid bilayer containing proteins. The fluid mosaic model describes its structure as lipids and proteins moving freely within. Membranes are composed mainly of phospholipids, cholesterol, and glycolipids, with integral and peripheral proteins embedded. Transport across membranes includes passive diffusion, facilitated diffusion using carrier proteins, and active transport using ATP. Receptors on the surface receive signals from outside the cell.
The document summarizes key aspects of cell membrane structure and function. It describes the fluid mosaic model of cell membranes, which views membranes as a fluid bilayer of phospholipids with embedded proteins. Membranes contain phospholipids, cholesterol, glycolipids, and integral and peripheral proteins. Transport across membranes is facilitated by both transporter proteins and channel proteins. Transport can occur through simple diffusion, facilitated diffusion, primary active transport using ATP hydrolysis, and secondary active transport coupling to the sodium-potassium pump. Membranes are selectively permeable and establish concentration gradients crucial for cell functions.
The plasma membrane envelops the cell and maintains its structure and integrity. It is composed of a lipid bilayer with embedded and associated proteins. The lipid bilayer is 7.5 nm thick and consists of phospholipids, glycolipids, and cholesterol arranged in a fluid mosaic. Integral proteins span the membrane or are anchored to one leaflet. Peripheral proteins are attached to the cytoplasmic side. The membrane regulates the movement of molecules via transport proteins and allows the cell to interact with its environment.
The document summarizes key aspects of cell membranes. It describes that cell membranes form a selectively permeable barrier and compartmentalize the cell. The basic structure is a phospholipid bilayer with embedded or attached proteins that transport molecules, act as receptors, and provide other functions. Cell membranes allow for communication within and between cells through transport proteins and junctions.
The document summarizes key aspects of cell membranes. It describes that cell membranes form a selectively permeable barrier and compartmentalize the cell. The basic structure is a phospholipid bilayer with embedded or attached proteins that transport molecules, act as receptors, or provide cell recognition. Membranes allow for compartmentalization of organelles and communication between cells through junctions.
Cells require transport mechanisms to move substances into and out of them. There are different mechanisms including diffusion, osmosis, and active transport. The cell membrane is a selectively permeable barrier composed of a phospholipid bilayer and embedded proteins. Transport proteins such as carrier and channel proteins facilitate the passage of molecules across the membrane through diffusion or active transport powered by ATP.
Membranes cover the surface of cells and surround organelles within cells. They serve several functions including maintaining cellular integrity by keeping components inside, selectively controlling movement of molecules in and out, and allowing cellular processes to occur separately within organelles. The plasma membrane forms the boundary of the cell and is made of a phospholipid bilayer with various embedded and attached proteins and carbohydrates. It regulates what enters and exits the cell.
Membranes cover the surface of cells and surround organelles within cells. They have several functions, including keeping cellular components inside the cell, allowing selective movement of molecules in and out, isolating organelles, and allowing cells to change shape. The plasma membrane forms the outer boundary of cells and is composed of a phospholipid bilayer with various embedded and attached proteins and carbohydrates. It regulates what moves in and out of cells.
The plasma membrane surrounds cells and organelles, protecting the interior while regulating what passes in and out. It is a selectively permeable lipid bilayer containing proteins. The fluid mosaic model describes its structure as lipids and proteins moving freely within. Membranes are composed mainly of phospholipids, cholesterol, and glycolipids, with integral and peripheral proteins embedded. Transport across membranes includes passive diffusion, facilitated diffusion using carrier proteins, and active transport using ATP. Receptors on the surface receive signals from outside the cell.
The document summarizes key aspects of cell membrane structure and function. It describes the fluid mosaic model of cell membranes, which views membranes as a fluid bilayer of phospholipids with embedded proteins. Membranes contain phospholipids, cholesterol, glycolipids, and integral and peripheral proteins. Transport across membranes is facilitated by both transporter proteins and channel proteins. Transport can occur through simple diffusion, facilitated diffusion, primary active transport using ATP hydrolysis, and secondary active transport coupling to the sodium-potassium pump. Membranes are selectively permeable and establish concentration gradients crucial for cell functions.
The plasma membrane envelops the cell and maintains its structure and integrity. It is composed of a lipid bilayer with embedded and associated proteins. The lipid bilayer is 7.5 nm thick and consists of phospholipids, glycolipids, and cholesterol arranged in a fluid mosaic. Integral proteins span the membrane or are anchored to one leaflet. Peripheral proteins are attached to the cytoplasmic side. The membrane regulates the movement of molecules via transport proteins and allows the cell to interact with its environment.
The document summarizes key aspects of cell membranes. It describes that cell membranes form a selectively permeable barrier and compartmentalize the cell. The basic structure is a phospholipid bilayer with embedded or attached proteins that transport molecules, act as receptors, and provide other functions. Cell membranes allow for communication within and between cells through transport proteins and junctions.
The document summarizes key aspects of cell membranes. It describes that cell membranes form a selectively permeable barrier and compartmentalize the cell. The basic structure is a phospholipid bilayer with embedded or attached proteins that transport molecules, act as receptors, or provide cell recognition. Membranes allow for compartmentalization of organelles and communication between cells through junctions.
Cells require transport mechanisms to move substances into and out of them. There are different mechanisms including diffusion, osmosis, and active transport. The cell membrane is a selectively permeable barrier composed of a phospholipid bilayer and embedded proteins. Transport proteins such as carrier and channel proteins facilitate the passage of molecules across the membrane through diffusion or active transport powered by ATP.
Membranes cover the surface of cells and surround organelles within cells. They serve several functions including maintaining cellular integrity by keeping components inside, selectively controlling movement of molecules in and out, and allowing cellular processes to occur separately within organelles. The plasma membrane forms the boundary of the cell and is made of a phospholipid bilayer with various embedded and attached proteins and carbohydrates. It regulates what enters and exits the cell.
Membranes cover the surface of cells and surround organelles within cells. They have several functions, including keeping cellular components inside the cell, allowing selective movement of molecules in and out, isolating organelles, and allowing cells to change shape. The plasma membrane forms the outer boundary of cells and is composed of a phospholipid bilayer with various embedded and attached proteins and carbohydrates. It regulates what moves in and out of cells.
The document discusses the structure and functions of cell membranes. It notes that membranes are composed of phospholipids, glycolipids, cholesterol and proteins. Membranes form a selectively permeable barrier and establish concentration gradients. They localize enzymes and processes like transport, signaling, endocytosis and exocytosis. The fluid mosaic model describes membranes as a fluid structure with proteins embedded and diffusing. Membrane composition and fluidity impact functions like signaling, vesicle movement and cell division.
This presentation include different kind of transport mechanism of different material inside the cell and outside the cell including Passive transport and Active transport mechenism.
The plasma membrane is a lipid bilayer with proteins embedded within it. It forms the boundary between a cell and its external environment. The fluid mosaic model describes the plasma membrane as having phospholipids that form a bilayer, within which proteins and other molecules like cholesterol are embedded. This allows the membrane to be fluid and flexible. Membrane proteins can be intrinsic, spanning the membrane, or extrinsic, attached to one surface. Together, the lipids and proteins allow the selective control of what enters and exits the cell.
The document discusses cell structure and function. It covers the cell theory, basic structures of the cell including the plasma membrane and organelles, and functions of the cell like communication and metabolism. It describes limits to cell size and provides details on the fluid mosaic model of the plasma membrane. It also summarizes the structure and roles of various organelles and discusses cell division and the life cycle.
1. The document discusses the cellular level of organization, describing the main parts of the cell including the plasma membrane, cytoplasm, and nucleus.
2. It explains the structure and functions of the plasma membrane, including its role in transport processes like diffusion, facilitated diffusion, and active transport.
3. The cytoplasm and its organelles are described, such as the cytoskeleton, endoplasmic reticulum, mitochondria, and lysosomes, as well as their roles in cellular processes.
1. The document discusses the structure and function of eukaryotic cells and their organelles. It describes the plasma membrane, mitochondria, nucleus, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, and cytoskeleton.
2. Key organelles include the mitochondria, which produces ATP through oxidative phosphorylation, and the nucleus, which contains DNA and directs protein synthesis.
3. The cytoskeleton is composed of microfilaments, microtubules, and intermediate filaments which help maintain cell shape and enable cell movement.
The cell membrane is composed of a bilayer of lipids and embedded proteins. The lipid bilayer provides structural organization with phospholipids as the major component. Proteins constitute 25-75% of the membrane mass and carry out specific functions. The membrane is selectively permeable due to transport proteins that regulate the passage of molecules. Transport proteins include channel proteins that form pores and carrier proteins that selectively bind molecules. In addition to transport, membrane proteins are involved in cell recognition, cell adhesion, and cell signaling.
The eukaryotic cell is divided into compartments by internal membranes. The plasma membrane encloses the cell and is made up of proteins and lipids organized into a fluid mosaic structure. Membranes are selectively permeable due to transport proteins that regulate the passage of molecules into and out of the cell by diffusion, facilitated diffusion, and active transport. Endocytosis and exocytosis allow for bulk transport across the plasma membrane through vesicle formation. Membranes have important functions including maintaining cell structure, regulating transport, and mediating cell-cell interactions.
The cell membrane, also known as the plasma membrane, defines the boundary of the cell and regulates what passes in and out. It is composed primarily of lipids and proteins arranged in a fluid mosaic structure. This structure allows the membrane to perform critical functions for the cell like controlling transport, sending and receiving signals, and interacting with other cells. The fluid mosaic model best explains the dynamic and semipermeable nature of the cell membrane.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model from 1972 describes the plasma membrane as a fluid bilayer with integral proteins embedded within it, peripheral proteins attached to its surface, and lipid-anchored proteins. The plasma membrane regulates what enters and exits the cell through diffusion, osmosis, facilitated diffusion using channel proteins, and active transport using carrier proteins that require ATP. Endocytosis and exocytosis allow bulk transport across the membrane through vesicles.
Unit 2-plasma membrane and membrane transportKomal Kp
The document discusses the plasma membrane and membrane transport. It defines the plasma membrane as the outer membrane of the cell composed of a phospholipid bilayer with embedded proteins. The plasma membrane regulates what enters and exits the cell and maintains the integrity of the cell's interior. Membrane transport involves the passage of solutes through the membrane via passive diffusion or with the aid of transport proteins and can occur down a concentration gradient or against it with active transport.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model describes the plasma membrane structure, with integral and peripheral proteins embedded within or attached to the fluid phospholipid bilayer. The plasma membrane regulates what enters and exits the cell through passive diffusion, facilitated diffusion, active transport, osmosis, and bulk transport mechanisms like endocytosis and exocytosis.
Cell Communication, Cell Junction and Cell Signaling.pptxSheetal Patil
-Cellular Communication
-There are three stages of cell: communication
a.Reception
b.Transduction
c. Response
-Receptors And Ligands
There are two basic types of receptors:
a.Internal receptors
b.Cell surface receptors
-Internal receptors-often steroid hormones
-There are several different types of ligands
a.Hydrophobic ligands
b. Water soluble hydrophilic ligands
-Three stages of cell communication
-How insulin works
Cell Junction
-There are three types of cell junctions:
1.Adhesive (Anchoring) junctions
2.Tight Junctions
3.Gap Junactions
-The two main kinds of adhesive cell-cell junctions are:
a.Adherens junctions
b.Desmosomes
a. Adherens junctions:
Adherens junction is the cell to cell junction, which connects the actin filaments. In adherens junction, the membranes of the adjacent cells are held together by some transmembrane proteins called cadherins.
b. Desmosome
Desmosome is a cell to cell junction, where the intermediate filaments connect two adjacent cells. Desmosome is also called macula adherens. Desmosomes function like tight junctions. The trans-membrane proteins involved in desmosome are mainly cadherins.
2. Tight Junctions
The cell membranes are connected by strands of trans-membrane proteins such as claudins and occludins.
Tight junctions bind cells together, prevent molecules from passing in between the cells, and also help to maintain the polarity of cells.
-Functions of Tight Junctions:
Another function of tight junctions is simply to hold cells together.
3. Gap Junction
Gap junctions are a type of cell junction in which adjacent cells are connected through protein channels. Gap junctions are made up of connexin proteins. Groups of six connexins form a connexon, and two connexons are put together to form a channel that molecules can pass through. Other channels in gap junctions are made up of pannexin proteins.
-Functions of Gap Junction
The main function of gap junctions is to connect cells together so that molecules may pass from one cell to other.
This allows for cell-to-cell communication.
-Cell Signaling
Cell signaling is the process of cellular communication within the body. The binding of extracellular signaling molecules to their receptors
-Modes of cell-cell signaling
1.Direct cell-cell signaling
2. Signaling by secreted molecule
a.Endocrine signaling:
-E. g. hormones produced by endocrine glands including pituitary, pancreas, adrenal, parathyroid glands etc.
b.Paracrine signaling:
-E.g. action of neurotransmitters in carrying signals between nerve cells at a synapse.
c.Autocrine signaling:
-When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.
d.Synaptic signaling:
-Types of signaling molecules
a.Nitric oxide
b.Carbon monoxide
c.Neurotransmitter
d.Peptide hormone
-Intracellular signaling pathway activated by an extracellular signal molecule
The plasma membrane encloses the cell and maintains differences between the cytosol and external environment. It has a bilayer structure of lipid and protein molecules. Early models like the Danielli and Davson model proposed a trilamellar structure of lipid bilayers separated by protein layers. The fluid mosaic model further described the membrane as a fluid bilayer with integral and peripheral proteins dispersed within. Transport across the membrane occurs through passive diffusion, facilitated transport, and active transport using carrier proteins and ion pumps. The membrane undergoes modifications like formation of microvilli, cilia, desmosomes and plasmodesmata to support cell functions.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model describes the plasma membrane structure, with integral and peripheral proteins embedded within or attached to the phospholipid bilayer. The plasma membrane regulates what enters and exits the cell through diffusion, osmosis, facilitated diffusion, active transport, endocytosis, and exocytosis. It also contains proteins that act as carriers, channels, pumps, receptors, enzymes, and adhesion molecules that perform important cell functions.
The human body contains over 200 cell types that all originate from a single fertilized egg cell. Cells differentiate and specialize to perform specific functions. The basic components of cells are the nucleus, which houses the DNA, and the cytoplasm, which contains organelles. The plasma membrane encloses the cell and regulates what enters and exits. Cells communicate through signaling molecules that bind receptors and trigger intracellular signal transduction pathways. Endocytosis and exocytosis allow materials to be transported into and out of cells while maintaining membrane integrity. The nucleus contains DNA and directs cellular activities through gene expression.
The document summarizes key components and functions of the cell membrane and cytoplasm. It describes the cell membrane as a selectively permeable phospholipid bilayer that envelops the cell. It also discusses the fluid mosaic model of the cell membrane and its integral and peripheral proteins. The cytoplasm is described as containing a cytosol and various organelles, including the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, and cytoskeleton. Various types of transport across the cell membrane, such as diffusion, osmosis, facilitated diffusion, and active transport, are also summarized.
power point presentation on the topic cellular level of organization from unit first of subject human anatomy and physiology I for first year B.PHARM it is useful for the student to study easily and find out the material easily for their study it is also useful for techers
Harnessing WebAssembly for Real-time Stateless Streaming PipelinesChristina Lin
Traditionally, dealing with real-time data pipelines has involved significant overhead, even for straightforward tasks like data transformation or masking. However, in this talk, we’ll venture into the dynamic realm of WebAssembly (WASM) and discover how it can revolutionize the creation of stateless streaming pipelines within a Kafka (Redpanda) broker. These pipelines are adept at managing low-latency, high-data-volume scenarios.
The document discusses the structure and functions of cell membranes. It notes that membranes are composed of phospholipids, glycolipids, cholesterol and proteins. Membranes form a selectively permeable barrier and establish concentration gradients. They localize enzymes and processes like transport, signaling, endocytosis and exocytosis. The fluid mosaic model describes membranes as a fluid structure with proteins embedded and diffusing. Membrane composition and fluidity impact functions like signaling, vesicle movement and cell division.
This presentation include different kind of transport mechanism of different material inside the cell and outside the cell including Passive transport and Active transport mechenism.
The plasma membrane is a lipid bilayer with proteins embedded within it. It forms the boundary between a cell and its external environment. The fluid mosaic model describes the plasma membrane as having phospholipids that form a bilayer, within which proteins and other molecules like cholesterol are embedded. This allows the membrane to be fluid and flexible. Membrane proteins can be intrinsic, spanning the membrane, or extrinsic, attached to one surface. Together, the lipids and proteins allow the selective control of what enters and exits the cell.
The document discusses cell structure and function. It covers the cell theory, basic structures of the cell including the plasma membrane and organelles, and functions of the cell like communication and metabolism. It describes limits to cell size and provides details on the fluid mosaic model of the plasma membrane. It also summarizes the structure and roles of various organelles and discusses cell division and the life cycle.
1. The document discusses the cellular level of organization, describing the main parts of the cell including the plasma membrane, cytoplasm, and nucleus.
2. It explains the structure and functions of the plasma membrane, including its role in transport processes like diffusion, facilitated diffusion, and active transport.
3. The cytoplasm and its organelles are described, such as the cytoskeleton, endoplasmic reticulum, mitochondria, and lysosomes, as well as their roles in cellular processes.
1. The document discusses the structure and function of eukaryotic cells and their organelles. It describes the plasma membrane, mitochondria, nucleus, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, and cytoskeleton.
2. Key organelles include the mitochondria, which produces ATP through oxidative phosphorylation, and the nucleus, which contains DNA and directs protein synthesis.
3. The cytoskeleton is composed of microfilaments, microtubules, and intermediate filaments which help maintain cell shape and enable cell movement.
The cell membrane is composed of a bilayer of lipids and embedded proteins. The lipid bilayer provides structural organization with phospholipids as the major component. Proteins constitute 25-75% of the membrane mass and carry out specific functions. The membrane is selectively permeable due to transport proteins that regulate the passage of molecules. Transport proteins include channel proteins that form pores and carrier proteins that selectively bind molecules. In addition to transport, membrane proteins are involved in cell recognition, cell adhesion, and cell signaling.
The eukaryotic cell is divided into compartments by internal membranes. The plasma membrane encloses the cell and is made up of proteins and lipids organized into a fluid mosaic structure. Membranes are selectively permeable due to transport proteins that regulate the passage of molecules into and out of the cell by diffusion, facilitated diffusion, and active transport. Endocytosis and exocytosis allow for bulk transport across the plasma membrane through vesicle formation. Membranes have important functions including maintaining cell structure, regulating transport, and mediating cell-cell interactions.
The cell membrane, also known as the plasma membrane, defines the boundary of the cell and regulates what passes in and out. It is composed primarily of lipids and proteins arranged in a fluid mosaic structure. This structure allows the membrane to perform critical functions for the cell like controlling transport, sending and receiving signals, and interacting with other cells. The fluid mosaic model best explains the dynamic and semipermeable nature of the cell membrane.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model from 1972 describes the plasma membrane as a fluid bilayer with integral proteins embedded within it, peripheral proteins attached to its surface, and lipid-anchored proteins. The plasma membrane regulates what enters and exits the cell through diffusion, osmosis, facilitated diffusion using channel proteins, and active transport using carrier proteins that require ATP. Endocytosis and exocytosis allow bulk transport across the membrane through vesicles.
Unit 2-plasma membrane and membrane transportKomal Kp
The document discusses the plasma membrane and membrane transport. It defines the plasma membrane as the outer membrane of the cell composed of a phospholipid bilayer with embedded proteins. The plasma membrane regulates what enters and exits the cell and maintains the integrity of the cell's interior. Membrane transport involves the passage of solutes through the membrane via passive diffusion or with the aid of transport proteins and can occur down a concentration gradient or against it with active transport.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model describes the plasma membrane structure, with integral and peripheral proteins embedded within or attached to the fluid phospholipid bilayer. The plasma membrane regulates what enters and exits the cell through passive diffusion, facilitated diffusion, active transport, osmosis, and bulk transport mechanisms like endocytosis and exocytosis.
Cell Communication, Cell Junction and Cell Signaling.pptxSheetal Patil
-Cellular Communication
-There are three stages of cell: communication
a.Reception
b.Transduction
c. Response
-Receptors And Ligands
There are two basic types of receptors:
a.Internal receptors
b.Cell surface receptors
-Internal receptors-often steroid hormones
-There are several different types of ligands
a.Hydrophobic ligands
b. Water soluble hydrophilic ligands
-Three stages of cell communication
-How insulin works
Cell Junction
-There are three types of cell junctions:
1.Adhesive (Anchoring) junctions
2.Tight Junctions
3.Gap Junactions
-The two main kinds of adhesive cell-cell junctions are:
a.Adherens junctions
b.Desmosomes
a. Adherens junctions:
Adherens junction is the cell to cell junction, which connects the actin filaments. In adherens junction, the membranes of the adjacent cells are held together by some transmembrane proteins called cadherins.
b. Desmosome
Desmosome is a cell to cell junction, where the intermediate filaments connect two adjacent cells. Desmosome is also called macula adherens. Desmosomes function like tight junctions. The trans-membrane proteins involved in desmosome are mainly cadherins.
2. Tight Junctions
The cell membranes are connected by strands of trans-membrane proteins such as claudins and occludins.
Tight junctions bind cells together, prevent molecules from passing in between the cells, and also help to maintain the polarity of cells.
-Functions of Tight Junctions:
Another function of tight junctions is simply to hold cells together.
3. Gap Junction
Gap junctions are a type of cell junction in which adjacent cells are connected through protein channels. Gap junctions are made up of connexin proteins. Groups of six connexins form a connexon, and two connexons are put together to form a channel that molecules can pass through. Other channels in gap junctions are made up of pannexin proteins.
-Functions of Gap Junction
The main function of gap junctions is to connect cells together so that molecules may pass from one cell to other.
This allows for cell-to-cell communication.
-Cell Signaling
Cell signaling is the process of cellular communication within the body. The binding of extracellular signaling molecules to their receptors
-Modes of cell-cell signaling
1.Direct cell-cell signaling
2. Signaling by secreted molecule
a.Endocrine signaling:
-E. g. hormones produced by endocrine glands including pituitary, pancreas, adrenal, parathyroid glands etc.
b.Paracrine signaling:
-E.g. action of neurotransmitters in carrying signals between nerve cells at a synapse.
c.Autocrine signaling:
-When interleukin-1 is produced in response to external stimuli, it can bind to cell-surface receptors on the same cell that produced it.
d.Synaptic signaling:
-Types of signaling molecules
a.Nitric oxide
b.Carbon monoxide
c.Neurotransmitter
d.Peptide hormone
-Intracellular signaling pathway activated by an extracellular signal molecule
The plasma membrane encloses the cell and maintains differences between the cytosol and external environment. It has a bilayer structure of lipid and protein molecules. Early models like the Danielli and Davson model proposed a trilamellar structure of lipid bilayers separated by protein layers. The fluid mosaic model further described the membrane as a fluid bilayer with integral and peripheral proteins dispersed within. Transport across the membrane occurs through passive diffusion, facilitated transport, and active transport using carrier proteins and ion pumps. The membrane undergoes modifications like formation of microvilli, cilia, desmosomes and plasmodesmata to support cell functions.
The plasma membrane is a selectively permeable membrane that surrounds the cell. It is composed of a phospholipid bilayer with embedded proteins. The fluid mosaic model describes the plasma membrane structure, with integral and peripheral proteins embedded within or attached to the phospholipid bilayer. The plasma membrane regulates what enters and exits the cell through diffusion, osmosis, facilitated diffusion, active transport, endocytosis, and exocytosis. It also contains proteins that act as carriers, channels, pumps, receptors, enzymes, and adhesion molecules that perform important cell functions.
The human body contains over 200 cell types that all originate from a single fertilized egg cell. Cells differentiate and specialize to perform specific functions. The basic components of cells are the nucleus, which houses the DNA, and the cytoplasm, which contains organelles. The plasma membrane encloses the cell and regulates what enters and exits. Cells communicate through signaling molecules that bind receptors and trigger intracellular signal transduction pathways. Endocytosis and exocytosis allow materials to be transported into and out of cells while maintaining membrane integrity. The nucleus contains DNA and directs cellular activities through gene expression.
The document summarizes key components and functions of the cell membrane and cytoplasm. It describes the cell membrane as a selectively permeable phospholipid bilayer that envelops the cell. It also discusses the fluid mosaic model of the cell membrane and its integral and peripheral proteins. The cytoplasm is described as containing a cytosol and various organelles, including the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, lysosomes, peroxisomes, and cytoskeleton. Various types of transport across the cell membrane, such as diffusion, osmosis, facilitated diffusion, and active transport, are also summarized.
power point presentation on the topic cellular level of organization from unit first of subject human anatomy and physiology I for first year B.PHARM it is useful for the student to study easily and find out the material easily for their study it is also useful for techers
Harnessing WebAssembly for Real-time Stateless Streaming PipelinesChristina Lin
Traditionally, dealing with real-time data pipelines has involved significant overhead, even for straightforward tasks like data transformation or masking. However, in this talk, we’ll venture into the dynamic realm of WebAssembly (WASM) and discover how it can revolutionize the creation of stateless streaming pipelines within a Kafka (Redpanda) broker. These pipelines are adept at managing low-latency, high-data-volume scenarios.
CHINA’S GEO-ECONOMIC OUTREACH IN CENTRAL ASIAN COUNTRIES AND FUTURE PROSPECTjpsjournal1
The rivalry between prominent international actors for dominance over Central Asia's hydrocarbon
reserves and the ancient silk trade route, along with China's diplomatic endeavours in the area, has been
referred to as the "New Great Game." This research centres on the power struggle, considering
geopolitical, geostrategic, and geoeconomic variables. Topics including trade, political hegemony, oil
politics, and conventional and nontraditional security are all explored and explained by the researcher.
Using Mackinder's Heartland, Spykman Rimland, and Hegemonic Stability theories, examines China's role
in Central Asia. This study adheres to the empirical epistemological method and has taken care of
objectivity. This study analyze primary and secondary research documents critically to elaborate role of
china’s geo economic outreach in central Asian countries and its future prospect. China is thriving in trade,
pipeline politics, and winning states, according to this study, thanks to important instruments like the
Shanghai Cooperation Organisation and the Belt and Road Economic Initiative. According to this study,
China is seeing significant success in commerce, pipeline politics, and gaining influence on other
governments. This success may be attributed to the effective utilisation of key tools such as the Shanghai
Cooperation Organisation and the Belt and Road Economic Initiative.
Presentation of IEEE Slovenia CIS (Computational Intelligence Society) Chapte...University of Maribor
Slides from talk presenting:
Aleš Zamuda: Presentation of IEEE Slovenia CIS (Computational Intelligence Society) Chapter and Networking.
Presentation at IcETRAN 2024 session:
"Inter-Society Networking Panel GRSS/MTT-S/CIS
Panel Session: Promoting Connection and Cooperation"
IEEE Slovenia GRSS
IEEE Serbia and Montenegro MTT-S
IEEE Slovenia CIS
11TH INTERNATIONAL CONFERENCE ON ELECTRICAL, ELECTRONIC AND COMPUTING ENGINEERING
3-6 June 2024, Niš, Serbia
TIME DIVISION MULTIPLEXING TECHNIQUE FOR COMMUNICATION SYSTEMHODECEDSIET
Time Division Multiplexing (TDM) is a method of transmitting multiple signals over a single communication channel by dividing the signal into many segments, each having a very short duration of time. These time slots are then allocated to different data streams, allowing multiple signals to share the same transmission medium efficiently. TDM is widely used in telecommunications and data communication systems.
### How TDM Works
1. **Time Slots Allocation**: The core principle of TDM is to assign distinct time slots to each signal. During each time slot, the respective signal is transmitted, and then the process repeats cyclically. For example, if there are four signals to be transmitted, the TDM cycle will divide time into four slots, each assigned to one signal.
2. **Synchronization**: Synchronization is crucial in TDM systems to ensure that the signals are correctly aligned with their respective time slots. Both the transmitter and receiver must be synchronized to avoid any overlap or loss of data. This synchronization is typically maintained by a clock signal that ensures time slots are accurately aligned.
3. **Frame Structure**: TDM data is organized into frames, where each frame consists of a set of time slots. Each frame is repeated at regular intervals, ensuring continuous transmission of data streams. The frame structure helps in managing the data streams and maintaining the synchronization between the transmitter and receiver.
4. **Multiplexer and Demultiplexer**: At the transmitting end, a multiplexer combines multiple input signals into a single composite signal by assigning each signal to a specific time slot. At the receiving end, a demultiplexer separates the composite signal back into individual signals based on their respective time slots.
### Types of TDM
1. **Synchronous TDM**: In synchronous TDM, time slots are pre-assigned to each signal, regardless of whether the signal has data to transmit or not. This can lead to inefficiencies if some time slots remain empty due to the absence of data.
2. **Asynchronous TDM (or Statistical TDM)**: Asynchronous TDM addresses the inefficiencies of synchronous TDM by allocating time slots dynamically based on the presence of data. Time slots are assigned only when there is data to transmit, which optimizes the use of the communication channel.
### Applications of TDM
- **Telecommunications**: TDM is extensively used in telecommunication systems, such as in T1 and E1 lines, where multiple telephone calls are transmitted over a single line by assigning each call to a specific time slot.
- **Digital Audio and Video Broadcasting**: TDM is used in broadcasting systems to transmit multiple audio or video streams over a single channel, ensuring efficient use of bandwidth.
- **Computer Networks**: TDM is used in network protocols and systems to manage the transmission of data from multiple sources over a single network medium.
### Advantages of TDM
- **Efficient Use of Bandwidth**: TDM all
KuberTENes Birthday Bash Guadalajara - K8sGPT first impressionsVictor Morales
K8sGPT is a tool that analyzes and diagnoses Kubernetes clusters. This presentation was used to share the requirements and dependencies to deploy K8sGPT in a local environment.
Redefining brain tumor segmentation: a cutting-edge convolutional neural netw...IJECEIAES
Medical image analysis has witnessed significant advancements with deep learning techniques. In the domain of brain tumor segmentation, the ability to
precisely delineate tumor boundaries from magnetic resonance imaging (MRI)
scans holds profound implications for diagnosis. This study presents an ensemble convolutional neural network (CNN) with transfer learning, integrating
the state-of-the-art Deeplabv3+ architecture with the ResNet18 backbone. The
model is rigorously trained and evaluated, exhibiting remarkable performance
metrics, including an impressive global accuracy of 99.286%, a high-class accuracy of 82.191%, a mean intersection over union (IoU) of 79.900%, a weighted
IoU of 98.620%, and a Boundary F1 (BF) score of 83.303%. Notably, a detailed comparative analysis with existing methods showcases the superiority of
our proposed model. These findings underscore the model’s competence in precise brain tumor localization, underscoring its potential to revolutionize medical
image analysis and enhance healthcare outcomes. This research paves the way
for future exploration and optimization of advanced CNN models in medical
imaging, emphasizing addressing false positives and resource efficiency.
International Conference on NLP, Artificial Intelligence, Machine Learning an...gerogepatton
International Conference on NLP, Artificial Intelligence, Machine Learning and Applications (NLAIM 2024) offers a premier global platform for exchanging insights and findings in the theory, methodology, and applications of NLP, Artificial Intelligence, Machine Learning, and their applications. The conference seeks substantial contributions across all key domains of NLP, Artificial Intelligence, Machine Learning, and their practical applications, aiming to foster both theoretical advancements and real-world implementations. With a focus on facilitating collaboration between researchers and practitioners from academia and industry, the conference serves as a nexus for sharing the latest developments in the field.
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3. 3
Membranes and Cell Transport
• All cells are surrounded by
a plasma membrane.
• Cell membranes are
composed of a lipid bilayer
with globular proteins
embedded in the bilayer.
• On the external surface,
carbohydrate groups join
with lipids to form
glycolipids, and with
proteins to form
glycoproteins. These
function as cell identity
markers.
4. 4
Fluid Mosaic Model
• In 1972, S. Singer and G. Nicolson proposed the Fluid
Mosaic Model of membrane structure
Extracellular fluid
Carbohydrate
Glycolipid
Transmembrane
proteins
Glycoprotein
Peripheral
protein
Cholesterol
Filaments of
cytoskeleton
Cytoplasm
5. 5
Phospholipids
• In phospholipids, two of the –OH groups on glycerol are joined to
fatty acids. The third –OH joins to a phosphate group which joins,
in turn, to another polar group of atoms.
• The phosphate and polar groups are hydrophilic (polar head) while
the hydrocarbon chains of the 2 fatty acids are hydrophobic
(nonpolar tails).
Structural formula Space-filling model Phospholipid symbol
Hydrophilic
head
Hydrophobic
tails
Fatty acids
Choline
Phosphate
Glycerol
7. 7
Phospholipid Bilayer
• Mainly 2 layers of phospholipids; the non-polar tails
point inward and the polar heads are on the surface.
• Contains cholesterol in animal cells.
• Is fluid, allowing proteins to move around within the
bilayer.
Polar
hydro-philic
heads
Nonpolar
hydro-phobic
tails
Polar
hydro-philic
heads
8. 8
The Fluidity of Membranes
• Membrane molecules are held in place by relatively weak hydrophobic
interactions.
• Most of the lipids and some proteins drift laterally in the plane of the
membrane, but rarely flip-flop from one phospholipid layer to the other.
• Membrane fluidity is influenced by temperature. As temperatures cool,
membranes switch from a fluid state to a solid state as the phospholipids
pack more closely.
• Membrane fluidity is also influenced by its components. Membranes rich in
unsaturated fatty acids are more fluid that those dominated by saturated
fatty acids because the kinks in the unsaturated fatty acid tails at the
locations of the double bonds prevent tight packing.
Lateral movement
(~107 times per second)
Flip-flop
(~ once per month)
9. 9
Membrane Components
• Steroid Cholesterol
o Wedged between phospholipid molecules in the plasma
membrane of animal cells.
o At warm temperatures (such as 37°C), cholesterol restrains the
movement of phospholipids and reduces fluidity.
o At cool temperatures, it maintains fluidity by preventing tight
packing.
o Thus, cholesterol acts as a “temperature buffer” for the
membrane, resisting changes in membrane fluidity as
temperature changes.
Cholesterol
10. 10
Membrane Components
• Membrane carbohydrates
o Interact with the surface molecules of other cells, facilitating cell-cell recognition
o Cell-cell recognition is a cell’s ability to distinguish one type of neighboring cell from
another
• Membrane Proteins
o A membrane is a collage of different proteins embedded in the fluid matrix of the
lipid bilayer
o Peripheral proteins are appendages loosely bound to the surface of the membrane
o Integral proteins penetrate the hydrophobic core of the lipid bilayer
o Many are transmembrane proteins, completely spanning the membrane
Glycoprotein
Carbohydrate
Microfilaments
of cytoskeleton Cholesterol Peripheral
protein
Integral
protein
Glycolipid
Fibers of extracellular
matrix (ECM)
N-terminus
C-terminus
a Helix
CYTOPLASMIC
SIDE
EXTRACELLULAR
SIDE
11. 11
Functions of Cell Membranes
• Regulate the passage of substance into
and out of cells and between cell
organelles and cytosol
• Detect chemical messengers arriving at
the surface
• Link adjacent cells together by membrane
junctions
• Anchor cells to the extracellular matrix
12. 12
6 Major Functions Of Membrane Proteins
1. Transport. (left) A protein that spans the membrane
may provide a hydrophilic channel across the
membrane that is selective for a particular solute.
(right) Other transport proteins shuttle a substance
from one side to the other by changing shape. Some of
these proteins hydrolyze ATP as an energy ssource to
actively pump substances across the membrane
2. Enzymatic activity. A protein built into the membrane
may be an enzyme with its active site exposed to
substances in the adjacent solution. In some cases,
several enzymes in a membrane are organized as a
team that carries out sequential steps of a metabolic
pathway.
3. Signal transduction. A membrane protein may have a
binding site with a specific shape that fits the shape of a
chemical messenger, such as a hormone. The external
messenger (signal) may cause a conformational change
in the protein (receptor) that relays the message to the
inside of the cell.
ATP
Enzymes
Signal
Receptor
13. 13
Cell-cell recognition. Some glyco-proteins serve as
identification tags that are specifically recognized
by other cells.
Intercellular joining. Membrane proteins of adjacent cells
may hook together in various kinds of junctions, such as
gap junctions or tight junctions
Attachment to the cytoskeleton and extracellular matrix
(ECM). Microfilaments or other elements of the
cytoskeleton may be bonded to membrane proteins,
a function that helps maintain cell shape and stabilizes
the location of certain membrane proteins. Proteins that
adhere to the ECM can coordinate extracellular and
intracellular changes
4.
5.
6.
Glyco-
protein
6 Major Functions Of Membrane Proteins
15. 15
Membrane Transport
• The plasma membrane is the boundary that
separates the living cell from its nonliving
surroundings
• In order to survive, A cell must exchange materials
with its surroundings, a process controlled by the
plasma membrane
• Materials must enter and leave the cell through the
plasma membrane.
• Membrane structure results in selective permeability,
it allows some substances to cross it more easily
than others
16. 16
Membrane Transport
• The plasma membrane exhibits selective permeability
- It allows some substances to cross it more easily
than others
17. Cell Membrane consists almost entirely of a lipid bilayer with protein
molecules,
Protein molecules are for transporting substances.
Most of these penetrating proteins, therefore, can function as transport
proteins. According to their function, they are of 2 types :
Channel proteins: they have watery spaces all the way through the molecule and
allow free movement of water, as well as selected ions or molecules.
Carrier proteins: they bind with molecules or ions that are to be transported; that
cause conformational changes in the protein molecules then move the substances
through the interstices of the protein to the other side of the membrane.
Both the channel proteins and the carrier proteins are usually highly
selective for the types of molecules or ions that are allowed to cross the
membrane.
18. Transport through the cell membrane occurs by two basic processes:
Diffusion : random molecular movement of substances molecule by molecule,
from one side of membrane to another.
2 subtypes :-
Simple diffusion: kinetic movement of molecules or ions occurs through a
membrane opening or through intermolecular spaces without any interaction
with carrier proteins in the membrane.
2 pathways:
(1) through the interstices of the lipid bilayer if the
diffusing substance is lipid soluble and,
(2) through watery channels that penetrate all the
way through some of the large transport
proteins
The protein channels has two main characteristics:
selectively permeable to certain substances,
channels can be opened or closed by gates that
are regulated by electrical signals (voltage-gated
channels) or chemicals that bind to the channel
proteins (ligand-gated channels).
Facilitated diffusion: Facilitated diffusion requires interaction of a carrier protein.
The carrier protein aids passage of the molecules or ions through the membrane by
binding chemically with them and shuttling them through the membrane.
19. Gated channel:
Gating of protein channels actually controlling the ion permeability of the
channels. Opening or closing of the channel can be done by conformational
change in the shape of the protein molecule itself.
2 principal ways:
Voltage gating: The molecular conformation of the gate responds to the
electrical potential across the cell membrane.
For e.g. strong negative charge on the inside of the cell membrane - gates remain tightly closed; when
the inside of the membrane loses its negative charge - gates open - allow sodium to pass inward.
when the inside of the cell membrane becomes positively charged - potassium gates open.
This is the basic mechanism for eliciting action potentials in nerves that are responsible for nerve
signals.
20. Chemical (ligand) gating: Binding of a chemical substance (a ligand)
with the protein; this causes a conformational or chemical bonding change in
the protein molecule that opens or closes the gate.
e.g. Acetylcholine opens the gate of the protein channel that allows uncharged
molecules or positive ions smaller than this diameter to pass through. This gate is
exceedingly important for the transmission of nerve signals from one nerve cell to
another and from nerve cells to muscle cells to cause muscle contraction.
Membrane Potential of Nerve
21. Osmosis Across Selectively Permeable Membranes—Water transport
Most abundant substance that diffuses through the cell membrane is water.
Water ordinarily diffuses in the two directions is balanced so precisely that
zero net movement of water occurs. Therefore, the volume of the cell remains
constant.
However, under certain conditions, water movement occur across the cell
membrane, causing the cell either to swell or shrink, depending on the
direction of the water movement. This process of net movement of water
caused by a concentration difference of water is called osmosis.
Osmotic Pressure: The exact amount
of pressure required to stop osmosis
is called the osmotic pressure.
The osmotic pressure exerted by
particles (molecules or ions) in a
solution, is determined by the number
of particles per unit volume of fluid, not
by the mass of the particles.
22. Active transport: movement of ions or other substances across the membrane in
combination with a carrier protein in such a way that the carrier protein causes the
substance to move against an energy gradient, such as from a low-concentration
state to a high-concentration state.
Active Transport of Substances Through Membranes
According to the source of the energy used to cause the transport:
primary active transport: the energy is derived directly from breakdown of adenosine
triphosphate (ATP) or of some other high-energy phosphate compound.
secondary active transport: the energy is derived secondarily from energy that has
been stored in the form of ionic concentration differences of secondary molecular or ionic
substances between the two sides of a cell membrane, created originally by primary active
transport.
23. Primary Active Transport
Sodium-Potassium (Na+ -K+ ) pump
a transport process that pumps sodium ions outward through the cell membrane
of all cells and at the same time pumps potassium ions from the outside to the
inside.
This pump is responsible for maintaining the sodium and potassium concentration
differences across the cell membrane, as well as for establishing a negative
electrical voltage inside the cells.
Na+ -K+ ATPase pump can run in reverse.
Na+ -K+ Pump is important for controlling Cell Volume.
Electrogenic Nature of the Na+-K+ Pump: The fact that the Na+-K+ pump moves
three Na+ ions to the exterior for every two K+ ions to the interior means that a net
of one positive charge is moved from the interior of the cell to the exterior for each
cycle of the pump. This creates positivity outside the cell while negativity on the
inside. Thus, it creates an electrical potential across the cell membrane.
24. The carrier protein has two separate globular proteins: a larger one called the
α subunit, and a smaller one called the β subunit.
Larger protein has 3 specific features that are important for the functioning of
the pump:
It has three receptor sites for binding
sodium ions on the inside portion of
the cell.
It has two receptor sites for potassium
ions on the outside.
The inside portion of this protein near
the sodium binding sites has ATPase
activity.
When 2K+ bind on the outside of the
carrier protein and 3 Na+ bind on the
inside, the ATPase function of the
protein becomes activated that cleaves
one ATP to adenosine diphosphate
(ADP) and liberating a high energy
phosphate bond of energy.
25.
26. Secondary Active Transport—
Co-Transport and Counter-Transport
excess sodium outside the cell membrane is always attempting to diffuse to the
interior. Under appropriate conditions, this diffusion energy of sodium can pull
other substances along with the sodium through the cell membrane. This
phenomenon is called co-transport.
Sodium-glucose co-transport mechanism:
A special property of the
transport protein is that a
conformational change to allow
sodium movement to the interior
will occur until a glucose
molecule also attaches, and
the sodium and glucose both are
transported to the inside of the
cell at the same time.
27. Counter-transport
this time, the substance to be transported is on the inside of the cell and must be
transported to the outside. Once both proteins bound, a conformational change
occurs, and energy released by the sodium ion moving to the interior causes the
other substance to move to the exterior.
Two important counter-transport mechanisms (transport in a direction opposite
to the primary ion) are:
Sodium-calcium counter-transport occurs
through all or almost all cell membranes, with
sodium ions moving to the interior and calcium
ions to the exterior.
Sodium-hydrogen counter-transport occurs
in several tissues. When sodium ions moving to
the interior and it can transport large numbers
of hydrogen ions, thus making it a key to
hydrogen ion control in the body fluids.
Editor's Notes
The rate of diffusion is determined by the amount of substance available, the velocity of kinetic motion, and the number and sizes of openings in the membrane through which the molecules or ions can move.
For instance, the lipid solubilities of oxygen, nitrogen, carbon dioxide, and alcohols are high, so all these can dissolve directly in the lipid bilayer and diffuse through the cell membrane
water ordinarily diffuses in the two directions is balanced so precisely that zero net movement of water occurs. Therefore, the volume of the cell remains constant.
However, under certain conditions, a concentration difference for water can develop across a membrane, just as concentration differences for other substances can occur. When this happens, net movement of water does occur across the cell membrane, causing the cell either to swell or shrink, depending on the direction of the water movement. This process of net movement of water caused by a concentration difference of water is called osmosis.
This liberated energy
is then believed to cause a chemical and conformational
change in the protein carrier molecule, extruding the
three sodium ions to the outside and the two potassium
ions to the inside.
sodium ions again attempt to diffuse to the interior of the cell because of their large concentration gradient. However, this time, the substance
to be transported is on the inside of the cell and must be transported to the outside. Therefore, the sodium ion binds to the carrier protein where it projects to the exterior surface of the membrane, while the substance to be counter-transported binds to the interior projection of the carrier protein. Once both have bound, a conformational change occurs, and energy released by the sodium ion moving to the interior causes the other substance to move to the exterior.