5. TECHNICALLY
• WHAT IS HEMOSTASIS: It is a complex
physiological respond of the body to insult
brought about by bleeding,based on the
interaction of :
• Plasma factors
• Thrombocytes or platelets
• Blood vessel.
10. HOW DOES IT HAPPEN
(SPASM OF VESSELS)
• 1. The endothelial cells send information
to the smooth muscle cell and this causes
their contraction.
• Information is related to the smooth to the
nerve innervation of the smooth muscle
13. STEPS IN PLUG FORMATION
• PLATELETS ACTIVATION
• ADHESION OF LATELETS
• AGGREGATION OF PLATELETS.
14. PLATELET ACTIVATION
• Factors that activate platelets are release
from their cytoplasm, and they include
• 1.ADP
• 2.Serotonin
• 3.PDGF, (platelet derived growth factor)
• Platelet factor 4
15. WHAT HAPPEN WHEN THEY
ARE ACTIVATED?
• When platelets are activated they change
their shape from a disc shape to a
spherical shape
• This change of shape helps them to obtain
the ability to adhere and aggregate.
18. We get the platelet plug or the
primary hemostatic plug.
19. COAGULATION CASCADE
• Main purpose is to stabilize and
strengthens the platelet plug
• To form the fibrin mesh that give that
stability required.
20. Definition
• Coagulation cascade is a complex
biological process that leads to the
conversion of soluble plasma fibrinogen to
fibrin.
• 3 main stages
• -formation of thromboplastine comlex
• -transformation of prothrombin to
Thrombin
.-transformation of fibrinogen to fibrin
23. LIMITATION OF
COAGULATION
• It is a good thing that this process is
restricted to the particular region involve in
the insult,this is achieved by inhibitors of
activated coagulation factors, and
fibrinolysis
24. FIBRINOLYTIC SYSTEM
• This process leads to the restoration of
vessel potency, that is the continuity of the
vessel.