Hemostasis

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Hemostasis

  1. 1. Hemostasis
  2. 2. Blood Components: Platelets• Coagulate, form plug, prevent blood loss• Formed by fragmentation from megakaryoctyes Figure 16-10c: Megakaryocytes and platelets
  3. 3. Overview of Hemostasis:Clot Formation & Vessel Repair Figure 16-11: Overview of hemostasis and tissue repair
  4. 4. Hemostasis: Vasoconstriction & Plug Formation• Vasoconstriction• Platelet activation – Multiple factors – Positive feedback• Aggregation• Loose plug
  5. 5. Hemostasis: Vasoconstriction & Plug Formation Figure 16-12: Platelet plug formation
  6. 6. Hemostasis: Coagulation & Clot Stabilization• Prothrombin• Ca++• Fibrinogen• Fibrin• Polymerization Figure 16-13: The coagulation cascade
  7. 7. Dissolving the Clot and Anticoagulants• Bleeding stopped• Vessel repair• Plasmin• Fibrinolysis• Clot dissolved
  8. 8. Dissolving the Clot and Anticoagulants Figure 16-14: Coagulation and fibrinolysis
  9. 9. Coagulation and Disease• Hemophilia• Cardiovascular Diseases – Key problem – clots block undamaged blood vessels – Anticoagulants prevent coagulation • Keep platelets from adhering • Prevent fibrin coagulation – "Clot Busters": Prevent further clotting • Speed fibrinolysis • Limit tissue damage (heart, brain…)
  10. 10. Summary• Blood is about 50% plasma, water solvent & solutes: ions, elements, gasses, proteins, wastes & nutrients• White blood cells function in internal defense• Iron in hemoglobin is key to RBC transport of O2• Platelet activation initiates clot formation• Clotting prevents blood loss but is a problem in cardiovascular disease

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