Lect 1 introduction_to_dosage_form_design_
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This document provides an introduction to dosage form design. It discusses the aims of the course, which are to explain pharmaceutical processing, drug formulation, and biopharmaceutics. It also discusses why a dosage form is needed for a drug and lists some key terms related to dosage form design. The document notes that three main factors contribute to designing an effective dosage form: dosage form related factors, drug related factors, and physiological factors. It provides examples of common dosage forms that will be considered, including solid, liquid, gas delivery, semisolid, transdermal, sustained release, and sterile products.
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Introduction to dosage form design
The document provides an introduction to dosage form design. It discusses key principles such as how drugs are formulated using excipients to create various dosage forms like solutions, suspensions, and tablets. It also covers important considerations for dosage form design like routes of administration, drug properties, factors that influence absorption, and therapeutic factors. The goals of dosage design are to deliver drugs in a suitable form for the administration route and provide desired release properties and stability.
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This document discusses several key topics related to dosage form design and biopharmaceutics:
1. It defines important terms like bioavailability, bioequivalence, pharmaceutical equivalents, and therapeutic equivalents.
2. It describes how drugs are absorbed, distributed, metabolized and eliminated in the body. Common routes of drug administration and factors that can influence bioavailability are also outlined.
3. Requirements for generic drug approval are summarized, including demonstrating bioequivalence to the pioneer drug.
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Pharmaceutics is the science of dosage form design and drug delivery. It draws from many disciplines to understand how drugs interact inside and outside the body. The goal is to design safe and effective dosage forms for drugs' intended uses. Dosage form design considers the drug's physicochemical properties, biopharmaceutical factors like absorption site, and logistical factors like storage stability. It is important to deliver drugs via dosage forms that provide accurate dosing, protect unstable drugs, and facilitate optimal drug action based on route of administration. Proper dosage form design allows drugs to be delivered safely and effectively.
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FORMULATION FACTORS EFFECTING BIOAVAILABILITY OF DRUGS
Bioavailability means the rate and extent to which the active ingredient is absorbed from a drug product and becomes available at the site of action.
When the drug is given orally, only part of the administered dose appears in the plasma.
By plotting plasma concentrations of the drug versus time, one can measure the area under the curve (AUC).
This curve reflects the extent of absorption of the drug.
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This document discusses biopharmaceutical considerations and problems of variable control in dissolution testing. It addresses the importance of establishing in vitro-in vivo correlations to understand how a drug's dissolution rate relates to its absorption and bioavailability. Several factors can influence dissolution and absorption rates, including the drug's properties, dosage form characteristics, and patient factors. Understanding these relationships is important for ensuring drugs are delivered effectively to achieve their intended therapeutic effects.
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Introduction to dosage form design
The document provides an introduction to dosage form design. It discusses key principles such as how drugs are formulated using excipients to create various dosage forms like solutions, suspensions, and tablets. It also covers important considerations for dosage form design like routes of administration, drug properties, factors that influence absorption, and therapeutic factors. The goals of dosage design are to deliver drugs in a suitable form for the administration route and provide desired release properties and stability.
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1. It defines important terms like bioavailability, bioequivalence, pharmaceutical equivalents, and therapeutic equivalents.
2. It describes how drugs are absorbed, distributed, metabolized and eliminated in the body. Common routes of drug administration and factors that can influence bioavailability are also outlined.
3. Requirements for generic drug approval are summarized, including demonstrating bioequivalence to the pioneer drug.
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This document provides an overview of the pharmaceutical industry from drug discovery through delivery to patients. It discusses how active pharmaceutical ingredients are formulated into dosage forms along with excipients for safe and effective delivery. Various dosage forms are classified by route of administration and physical form. The document also outlines considerations for drug development including effectiveness, safety, stability, and consumer acceptance. It briefly discusses pharmacokinetics, therapeutic use, adverse effects, regulations, and standards for quality evaluation of drugs.
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Pharmaceutics is the science of dosage form design and drug delivery. It draws from many disciplines to understand how drugs interact inside and outside the body. The goal is to design safe and effective dosage forms for drugs' intended uses. Dosage form design considers the drug's physicochemical properties, biopharmaceutical factors like absorption site, and logistical factors like storage stability. It is important to deliver drugs via dosage forms that provide accurate dosing, protect unstable drugs, and facilitate optimal drug action based on route of administration. Proper dosage form design allows drugs to be delivered safely and effectively.
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FORMULATION FACTORS EFFECTING BIOAVAILABILITY OF DRUGS
Bioavailability means the rate and extent to which the active ingredient is absorbed from a drug product and becomes available at the site of action.
When the drug is given orally, only part of the administered dose appears in the plasma.
By plotting plasma concentrations of the drug versus time, one can measure the area under the curve (AUC).
This curve reflects the extent of absorption of the drug.
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introduction.pptx
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This document provides an introduction to pharmaceutics, which is concerned with the preparation and use of medicinal drugs. It discusses key topics including:
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- Quality assurance processes to ensure safe and effective drug production in a consistent manner
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The seminar featured presentations from various perspectives, including industry, regulatory bodies, and academia. Topics included the history and principles of Problem Formulation, industry perspectives on Problem Formulation and how it is applied internally for microbial pesticides, regulatory approaches, and specific case studies. The seminar provided an overview of the challenges, considerations, and potential solutions in harmonising Problem Formulation for biopesticide risk assessment. It emphasised the need for collaboration and discussion to develop Problem Formulation guidance for biopesticides.
Medication Administration for Nursing Students
This document discusses medication administration, including:
- The nurse's role in safely administering medications according to the six rights.
- Factors to consider like dosage, routes of administration, forms, and calculating amounts.
- Common techniques like oral administration, injections, and Z-track injections to prevent leakage.
- Key interventions to safely administer medications and assess patient responses.
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Lect 1 introduction_to_dosage_form_design_
- 1. Introduction to Dosage Form Design Abubakr O. Nur (M.Pharm; PhD) Assoc. Prof. in Pharmaceutics (U of K) August 2010
- 2. Introduction • What the course aim at? • What are pharmaceutical processing, drug formulation and biopharmaceutics? • Why DS or a dosage form for a drug? 2Dr. Abubakr O. Nur
- 3. • You are already familiar with the following terms: –Route of administration, bioavailability, bioequivalence, biopharmaceutics, rate and extent of drug absorption, onset of drug action, first pass effect, dissolution and disintegration. Are you????? 3Dr. Abubakr O. Nur
- 4. • In fact, to design a dosage form three factors contribute similarly. 1. Dosage form related factors 2. Drug related factors 3. Physiological factors 4Dr. Abubakr O. Nur
- 5. Dosage forms to be considered are: – Solid dosage forms (tablets and capsules) – Liquid dosage forms (solution, suspensions and emulsions) – Gas delivery (aerosols and inhalations) – Semisolid delivery systems (dermatological products) – Products for Transdermal applications (skin patches) – Sustained and novel DDS. – Sterile products 5Dr. Abubakr O. Nur