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LARGE
INTESTINE
Mr. Mickey Banda
Texila American University
Large intestine
• extends from the distal end
of the ileum to the anus,
• Measures approximately
1.5 m.
• It absorbs fluids and salts
from the gut contents, thus
forming faeces.
• consists of the caecum,
appendix, colon, rectum,
and anal canal
Large intestine ctd
Begins in the right
groin (inguinal) as the
caecum, with its
associated appendix.
It continues upward as
the ascending colon
through the right flank
and into the right
hypochondrium
Large intestine ctd
 It bends to the left
Just below the liver, to
form the right colic
flexure (hepatic
flexure).
crosses the abdomen
as the transverse colon
to the left
hypochondrium
Large intestine ctd
• Just below the spleen, it bends downward,
forming the left colic flexure (splenic
flexure),
• and continues as the descending colon
through the left flank and into the left groin.
• It enters the upper part of the pelvic cavity as
the sigmoid colon.
• continues on the posterior wall of the pelvic
cavity as the rectum, and finally
• terminates as the anal canal.
General characteristics
large internal diameter
compared to that of the
small intestine.
peritoneal-covered
accumulations of fat (the
omental appendices) are
associated with the colon;
General
characteristics
 The segregation of
longitudinal muscle in
its walls into three
narrow bands (the
taeniae coli), which are
primarily observed in
the cecum and colon
and less visible in the
rectum.
the sacculations of the
colon (the haustra of
colon)
Caecum and appendix
The caecum is the first
part of the large
intestine.
It is inferior to the
ileocaecal opening and in
the right iliac fossa.
It is an intraperitoneal
structure because of its
mobility not because of
its suspension by a
mesentery
Caecum and appendix ctd
• Caecum is continuous with the
ascending colon at the entrance of
the ileum and is usually in contact
with the anterior abdominal wall.
• It may cross the pelvic brim to lie in
the true pelvis.
• The appendix is attached to the
posteromedial wall of the caecum,
just inferior to the end of the
ileum.
Caecum and appendix ctd
• The appendix is a narrow,
hollow tube connected to the
cecum.
• It has large aggregations of
lymphoid tissue in its walls
• suspended by the
mesoappendix, which contains
the appendicular vessels
Location of the appendix
• Retrocecal - posterior
to the cecum
• Retrocolic - posterior
to the lower ascending
colon
• Subcecal location -
below the cecum
• Preileal position -
anterior to the terminal
ileum
• Postileal position -
posterior to the terminal
ileum
• The surface projection of the base of the
appendix is at the junction of the lateral
and middle one-thirds of a line from the
anterior superior iliac spine to the
umbilicus (McBurney's point).
• appendicular problems may present pain
near this location
The colon
 consists of the
ascending, transverse,
descending, and sigmoid
parts.
Its ascending and
descending segments are
retroperitoneal.
transverse and sigmoid
segments are
intraperitoneal.
Colon ctd
Note:
 the right colic flexure
(hepatic flexure) just
inferior to right liver lobe.
The left colic flexure
(splenic flexure)
Splenic flexure is
higher and more
posterior and is attached
to the diaphragm by the
phrenicocolic ligament.
Colon ctd
Immediately lateral to
the ascending and
descending colons are
the right and left
paracolic gutters
(depressions)
Colon ctd
• These depressions are formed between the
lateral margins of the ascending and
descending colon and the posterolateral
abdominal wall.
• Gutters are spaces through which material can
pass from one region of the peritoneal cavity to
another.
The sigmoid colon
marks the final
segment of the colon.
begins above the
pelvic inlet and
extends to the level of
vertebra SIII,
it is continuous with
the rectum.
sigmoid Colon ctd
• This S-shaped structure is quite mobile
except at its beginning where it continues
from the descending colon, and at its end,
where it continues as the rectum.
• Between these points, it is suspended by the
sigmoid mesocolon.
Rectum
• Last part of the large intestine
• Rectum is continuous with the
sigmoid colon at the level of S2 -
S3 or at the end of the sigmoid
mesocolon because the
rectum is a retroperitoneal
structure
• Terminates at the upper end of
the anal canal
• The anorectal junction is 2–3 cm
in front of and slightly below the
tip of the coccyx
Rectum: Curvatures
• The rectum also deviates in
three lateral curves: upper,
convex to the right; middle,
convex to the left; lower,
convex to the right
• Anteroposterior curvatures:
sacral and anorectal
curvature
• Variable length (12 to 16 cm
long)
• Initial diameter is similar to
that of the sigmoid colon
Rectum
Inferiorly it becomes
dilated as the rectal
ampulla
Rectum is the most
posterior element of the
pelvic viscera, is
immediately anterior to,
concave contour of the
sacrum.
Rectum
• Rectum differs from the sigmoid
colon in having no sacculations
or appendices epiploicae
• Rectum lacks distinct taeniae
coli muscles
• Rectum is encircled by layer of
longitudinal muscle, which
invests the entire length
Function
• Water absorption (stool is
thickened)
• Absorption of eletrolytes from
the stool
Rectum
• Rectum also plays an
important part in defecation
• When stool enters the rectal
ampulla which is usually
empty, it stimulates stretch
receptors
• The information is conveyed
to the CNS, giving the person
the urge to defecate
• The person can now decide
either to initiate or delay
defecation by relaxing or
tensing the levator ani
muscles and the EAS
Rectum
• Rectum has three
permanent semi-lunar
transverse folds or valves
of Houston
• Superior fold is at the
beginning of the rectum
may be either on the left
or right
• The middle fold is largest
projecting from the
anterior and right wall
• inferior fold is found on the
left
Rectum
• Rectum is subdivided into
3 parts;
• Upper third lies
intraperitoneally
• Middle third lies
retroperitoneally
• Lower third lies
extraperitoneally
Rectum
• The upper third of the
rectum is covered by
peritoneum on its anterior
and lateral aspects
• The peritoneum is reflected
superiorly onto the urinary
bladder in males to form the
rectovesical pouch
• In females, onto the
posterior vaginal wall to
form the recto-uterine
pouch (pouch of Douglas)
Mesorectum
• mesorectum is enclosed by
mesorectal fascia
• It contains the superior
rectal artery and its
branches, the superior
rectal vein and its
tributaries, the lymphatic
vessels and nodes that lie
along the superior rectal
artery
Blood supply
Blood supply
• Superior rectal artery
• Middle rectal artery
• Inferior rectal artery
• Median sacral artery
Venous drainage and innervation
Venous drainage
• Superior rectal vein
• Middle rectal vein
• Inferior rectal vein
• Median sacral vein
Nerve supply
• Autonomic:
• Sympathetics – lumbar
solanchnic nerves
• Parasympathetics – pelvic
splanchnic nerves
Lymphatics
Applied Anatomy
Digital Rectal Examination
-Prostate gland can be
palpated
-- Rectal tumor below
the middle rectal
transverse fold can be
palpated
Anal Canal
• The anal canal begins at the terminal end
of the rectal ampulla where it narrows at
the pelvic floor.
• It terminates as the anus after passing
through the perineum.
• As it passes through the pelvic floor, the
anal canal is surrounded along its entire
length by the internal and external anal
sphincters, which normally keep it closed.
Anal Canal
• Rectal mucosa lines
the upper part of the
anal canal.
• Anal region
distinguished by a
number of
longitudinally oriented
folds known as anal
columns, which are
united inferiorly by
crescentic folds
termed anal valves.
• Superior to each valve is a depression termed
an anal sinus.
• The anal valves together form a circle around
the anal canal at a location known as the
pectinate line,
• Inferior to the pectinate line is a transition zone
known as the anal pecten, which is lined by
nonkeratinized stratified squamous epithelium.
• The anal pecten ends inferiorly at the
anocutaneous line ('white line'), or where the
lining of the anal canal becomes true skin.
Anal Canal
Anal cushions
 Infolding of anal mucosa
 Three anal cushions located at
the 3 o'clock, 7 o'clock and 11
o'clock in lithotomy position
 Two are located on the right
and one on the left side
 These cushions play an
important role for air and
water tight closure of the anal
canal and promote continence
Function of Anal cushions
• Internal anal sphincter
alone cannot completely
close the anal canal
• The anal cushions
physiologically contributes
as well to the complete
closure of the anal canal
• When they become
pathological, they are
referred as haemorrhoids
Internal anal sphincter
• is a well-defined ring of
obliquely orientated
smooth muscle fibres
continuous with the
circular muscle of the
rectum.
• terminates at the
junction of the
superficial and
subcutaneous
components of the
external sphincter.
• It is usually thinner in
females and becomes
thicker with age.
External anal sphincter
• is an oval tube-shaped of
slow twitch skeletal
muscle fibres surrounding
the anal canal
• Consists of 3 parts: deep,
superficial and
subcutaneous
• They are well suited to
prolonged contraction
• Innervated by the inferior
rectal nerve a branch of
pudendal nerve
(voluntary control)
• Function: controls
defecation
Blood Supply
Upper part:
• Superior rectal artery
• Middle rectal artery
Lower part:
• Inferior rectal artery
Blood Supply
Venous drainage
Upper part:
• Superior rectal vein
• Middle rectal vein
Lower part:
• Inferior rectal vein
Systemic and Portal Anastomosis
of the Anal Canal
Lymphatic drainage
Nerve Supply
Clinical correlates
Clinical correlates
• Appendicitis
• Chronic diarrhea
• Colon cancer
• Crohn's disease (Inflammatory
bowel disease)
• Diverticulitis
• Fecal incontinence
Appendicitis
Clinical correlates
Crohn's disease Diverticulitis
Reference Books
1. Standring, Susan and Standring (2015).Gray's anatomy.
41st International edition, Elsevier Health Sciences.
ISBN 9780702052309.
2. Keith L. Moore, Arthur F. Dalley, Anne M. R. Agur
(2017). Moore's Clinically Oriented Anatomy, 8th
edition, Walter Kluwer. ISBN 9781496347213.
3. Alan J. Detton (2020). Grant’s Dissector. 17th edition,
Lippincott Williams & Wilkins. ISBN 9781975134600.
4. Adrian Kendal Dixon, David J. Bowden, Bari M. Logan
and Harold Ellis (2017). Human Sectional Anatomy -
Pocket atlas of body sections, CT and MRI images, 4th
edition, CRC Press. ISBN 9781498708548.
The End
Thank you

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LARGE INTESTINE in the human body of a person

  • 2. Large intestine • extends from the distal end of the ileum to the anus, • Measures approximately 1.5 m. • It absorbs fluids and salts from the gut contents, thus forming faeces. • consists of the caecum, appendix, colon, rectum, and anal canal
  • 3. Large intestine ctd Begins in the right groin (inguinal) as the caecum, with its associated appendix. It continues upward as the ascending colon through the right flank and into the right hypochondrium
  • 4. Large intestine ctd  It bends to the left Just below the liver, to form the right colic flexure (hepatic flexure). crosses the abdomen as the transverse colon to the left hypochondrium
  • 5. Large intestine ctd • Just below the spleen, it bends downward, forming the left colic flexure (splenic flexure), • and continues as the descending colon through the left flank and into the left groin. • It enters the upper part of the pelvic cavity as the sigmoid colon. • continues on the posterior wall of the pelvic cavity as the rectum, and finally • terminates as the anal canal.
  • 6. General characteristics large internal diameter compared to that of the small intestine. peritoneal-covered accumulations of fat (the omental appendices) are associated with the colon;
  • 7. General characteristics  The segregation of longitudinal muscle in its walls into three narrow bands (the taeniae coli), which are primarily observed in the cecum and colon and less visible in the rectum. the sacculations of the colon (the haustra of colon)
  • 8. Caecum and appendix The caecum is the first part of the large intestine. It is inferior to the ileocaecal opening and in the right iliac fossa. It is an intraperitoneal structure because of its mobility not because of its suspension by a mesentery
  • 9. Caecum and appendix ctd • Caecum is continuous with the ascending colon at the entrance of the ileum and is usually in contact with the anterior abdominal wall. • It may cross the pelvic brim to lie in the true pelvis. • The appendix is attached to the posteromedial wall of the caecum, just inferior to the end of the ileum.
  • 10. Caecum and appendix ctd • The appendix is a narrow, hollow tube connected to the cecum. • It has large aggregations of lymphoid tissue in its walls • suspended by the mesoappendix, which contains the appendicular vessels
  • 11. Location of the appendix • Retrocecal - posterior to the cecum • Retrocolic - posterior to the lower ascending colon • Subcecal location - below the cecum • Preileal position - anterior to the terminal ileum • Postileal position - posterior to the terminal ileum
  • 12. • The surface projection of the base of the appendix is at the junction of the lateral and middle one-thirds of a line from the anterior superior iliac spine to the umbilicus (McBurney's point). • appendicular problems may present pain near this location
  • 13. The colon  consists of the ascending, transverse, descending, and sigmoid parts. Its ascending and descending segments are retroperitoneal. transverse and sigmoid segments are intraperitoneal.
  • 14. Colon ctd Note:  the right colic flexure (hepatic flexure) just inferior to right liver lobe. The left colic flexure (splenic flexure) Splenic flexure is higher and more posterior and is attached to the diaphragm by the phrenicocolic ligament.
  • 15. Colon ctd Immediately lateral to the ascending and descending colons are the right and left paracolic gutters (depressions)
  • 16. Colon ctd • These depressions are formed between the lateral margins of the ascending and descending colon and the posterolateral abdominal wall. • Gutters are spaces through which material can pass from one region of the peritoneal cavity to another.
  • 17. The sigmoid colon marks the final segment of the colon. begins above the pelvic inlet and extends to the level of vertebra SIII, it is continuous with the rectum.
  • 18. sigmoid Colon ctd • This S-shaped structure is quite mobile except at its beginning where it continues from the descending colon, and at its end, where it continues as the rectum. • Between these points, it is suspended by the sigmoid mesocolon.
  • 19. Rectum • Last part of the large intestine • Rectum is continuous with the sigmoid colon at the level of S2 - S3 or at the end of the sigmoid mesocolon because the rectum is a retroperitoneal structure • Terminates at the upper end of the anal canal • The anorectal junction is 2–3 cm in front of and slightly below the tip of the coccyx
  • 20. Rectum: Curvatures • The rectum also deviates in three lateral curves: upper, convex to the right; middle, convex to the left; lower, convex to the right • Anteroposterior curvatures: sacral and anorectal curvature • Variable length (12 to 16 cm long) • Initial diameter is similar to that of the sigmoid colon
  • 21. Rectum Inferiorly it becomes dilated as the rectal ampulla Rectum is the most posterior element of the pelvic viscera, is immediately anterior to, concave contour of the sacrum.
  • 22. Rectum • Rectum differs from the sigmoid colon in having no sacculations or appendices epiploicae • Rectum lacks distinct taeniae coli muscles • Rectum is encircled by layer of longitudinal muscle, which invests the entire length Function • Water absorption (stool is thickened) • Absorption of eletrolytes from the stool
  • 23. Rectum • Rectum also plays an important part in defecation • When stool enters the rectal ampulla which is usually empty, it stimulates stretch receptors • The information is conveyed to the CNS, giving the person the urge to defecate • The person can now decide either to initiate or delay defecation by relaxing or tensing the levator ani muscles and the EAS
  • 24. Rectum • Rectum has three permanent semi-lunar transverse folds or valves of Houston • Superior fold is at the beginning of the rectum may be either on the left or right • The middle fold is largest projecting from the anterior and right wall • inferior fold is found on the left
  • 25. Rectum • Rectum is subdivided into 3 parts; • Upper third lies intraperitoneally • Middle third lies retroperitoneally • Lower third lies extraperitoneally
  • 26. Rectum • The upper third of the rectum is covered by peritoneum on its anterior and lateral aspects • The peritoneum is reflected superiorly onto the urinary bladder in males to form the rectovesical pouch • In females, onto the posterior vaginal wall to form the recto-uterine pouch (pouch of Douglas)
  • 27. Mesorectum • mesorectum is enclosed by mesorectal fascia • It contains the superior rectal artery and its branches, the superior rectal vein and its tributaries, the lymphatic vessels and nodes that lie along the superior rectal artery
  • 28. Blood supply Blood supply • Superior rectal artery • Middle rectal artery • Inferior rectal artery • Median sacral artery
  • 29. Venous drainage and innervation Venous drainage • Superior rectal vein • Middle rectal vein • Inferior rectal vein • Median sacral vein
  • 30. Nerve supply • Autonomic: • Sympathetics – lumbar solanchnic nerves • Parasympathetics – pelvic splanchnic nerves
  • 32. Applied Anatomy Digital Rectal Examination -Prostate gland can be palpated -- Rectal tumor below the middle rectal transverse fold can be palpated
  • 33. Anal Canal • The anal canal begins at the terminal end of the rectal ampulla where it narrows at the pelvic floor. • It terminates as the anus after passing through the perineum. • As it passes through the pelvic floor, the anal canal is surrounded along its entire length by the internal and external anal sphincters, which normally keep it closed.
  • 34.
  • 35. Anal Canal • Rectal mucosa lines the upper part of the anal canal. • Anal region distinguished by a number of longitudinally oriented folds known as anal columns, which are united inferiorly by crescentic folds termed anal valves.
  • 36. • Superior to each valve is a depression termed an anal sinus. • The anal valves together form a circle around the anal canal at a location known as the pectinate line, • Inferior to the pectinate line is a transition zone known as the anal pecten, which is lined by nonkeratinized stratified squamous epithelium. • The anal pecten ends inferiorly at the anocutaneous line ('white line'), or where the lining of the anal canal becomes true skin.
  • 38. Anal cushions  Infolding of anal mucosa  Three anal cushions located at the 3 o'clock, 7 o'clock and 11 o'clock in lithotomy position  Two are located on the right and one on the left side  These cushions play an important role for air and water tight closure of the anal canal and promote continence
  • 39. Function of Anal cushions • Internal anal sphincter alone cannot completely close the anal canal • The anal cushions physiologically contributes as well to the complete closure of the anal canal • When they become pathological, they are referred as haemorrhoids
  • 40. Internal anal sphincter • is a well-defined ring of obliquely orientated smooth muscle fibres continuous with the circular muscle of the rectum. • terminates at the junction of the superficial and subcutaneous components of the external sphincter. • It is usually thinner in females and becomes thicker with age.
  • 41. External anal sphincter • is an oval tube-shaped of slow twitch skeletal muscle fibres surrounding the anal canal • Consists of 3 parts: deep, superficial and subcutaneous • They are well suited to prolonged contraction • Innervated by the inferior rectal nerve a branch of pudendal nerve (voluntary control) • Function: controls defecation
  • 42. Blood Supply Upper part: • Superior rectal artery • Middle rectal artery Lower part: • Inferior rectal artery
  • 44. Venous drainage Upper part: • Superior rectal vein • Middle rectal vein Lower part: • Inferior rectal vein
  • 45. Systemic and Portal Anastomosis of the Anal Canal
  • 49. Clinical correlates • Appendicitis • Chronic diarrhea • Colon cancer • Crohn's disease (Inflammatory bowel disease) • Diverticulitis • Fecal incontinence Appendicitis
  • 51. Reference Books 1. Standring, Susan and Standring (2015).Gray's anatomy. 41st International edition, Elsevier Health Sciences. ISBN 9780702052309. 2. Keith L. Moore, Arthur F. Dalley, Anne M. R. Agur (2017). Moore's Clinically Oriented Anatomy, 8th edition, Walter Kluwer. ISBN 9781496347213. 3. Alan J. Detton (2020). Grant’s Dissector. 17th edition, Lippincott Williams & Wilkins. ISBN 9781975134600. 4. Adrian Kendal Dixon, David J. Bowden, Bari M. Logan and Harold Ellis (2017). Human Sectional Anatomy - Pocket atlas of body sections, CT and MRI images, 4th edition, CRC Press. ISBN 9781498708548.