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Kim Solez 204 years of banff spirit7 new august 13 2018
1. Kim Solez World Exponential Timeline
From Homer Smith 1895 to Aug. 7, 2099
1934 Leonard
Cohen
1941 Paul Simon 1945 Rod Stewart 1991 Ed Sheeran
1994 Mallory Chipman
1901 Louis
Armstrong
1920 Robert
Heptinstall
1943
Janis
Joplin
1961 Peter
Diamandis
2. Think Different
It is different to mix
science, music, and
poetry together as
we have done in this
presentation!
3. Think Different – Kim Solez sharing
cyberNephrology 5B3.09 WCM HSC with
Students & Fellows
Annette Shaff / Shutterstock.com
4. 204 Years of the Spirit of Banff 1895-2099 122
Back 82 Forward
5. Homer Smith, born 1895, turned Kim on to the
kidney in med school 3rd yr.
6. Homer Smith born 1895 Turned me on to
kidney in med school 3rd year .
9. Solez, Morel-Maroger, and Sraer
Medicine 58:362-376, 1979. Morphology
of "acute tubular necrosis" in man:
Analysis of 57 renal biopsies and
comparison with the glycerol model. My
most cited paper before coming to
Edmonton as Chair of Pathology.
10. Solez, Morel-Maroger, and Sraer
Medicine 58:362-376, 1979
1. Of the 12 lesions assessed in the 57 “ATN”
biopsies 10 persisted after functional
recovery. Only 2 lesions correlated with
function, were present when renal failure
was present and absent after recovery:
1)thinning of PAS positive brush border, & 2)
shedding of individual tubular epithelial cells
leaving bare basement membrane.
11. Solez, Morel-Maroger, and Sraer
Medicine 58:362-376, 1979
2. Lesions which persisted after recovery of
function included tubular dilation, regeneration,
mitoses, casts, interstitial edema, inflammation,
nucleated cells in vasa recta, dilation of
Bowman’s capsule, tubularization of Bowman’s
capsule epithelium, & juxtaglomerular
apparatus hyperplasia. The latter two were
more prominent in recovery biopsies.
12. Solez, Morel-Maroger, and Sraer
Medicine 58:362-376, 1979
3. Lumping all acute tubular injury lesions
together guarantees that histology assessment
will appear to be inferior to molecular
assessment, since the majority of ATI lesions
persist after functional recovery. Only studies
which separately assess the two lesions which
correlate functionally are valid. i.e. 1)thinning or
absence of PAS positive brush border, & 2)
shedding of individual tubular epithelial cells .
13. Paper still referred to in recent reviews,
findings uncontested.
Basile et al., 2012
14. Cannot say molecules change faster than
morphology until you look at these two
lesions, BB loss and cell exfoliation!
Basile et al., 2012
16. Later work on Transplant Acute Tubular Injury
Was an Important Antecedent to Banff Studies
1993 KI paper on Transplant ATI.
17. New insights into transplant ATN, Solez et al. 1993
Brush border loss not a feature of transplant ATN.
18. Forty years later a more nuanced
understanding of the post ischemic kidney
is that tubular injury and microvascular
injury are separable components which
can be influenced in opposite ways by
pharmacologic interventions. Both types
of injury contribute to renal functional
impairment. These issues are the subject
of major precision medicine initiatives
which should bear fruit in 2019-2020.
20. Nine months after meeting Kim Solez over 3 day
weekend in 2005 Leonard wrote song inspired by
their discussion of Banff borderline changes.
21. Ten years later Leonard removed all but one of the
borderlines and the song became the popular
“Treaty” on the 2016 You Want It Darker album.
“I wish there was a treaty we could sign
I do not care who takes this bloody hill …
I wish there was a treaty we could sign
It’s over now the water and the wine
We were broken then but now we’re borderline
I wish there was a treaty
I wish there was a treaty
Between your love and mine”
The notebook pages showing this ten year song transition were the
only such pages reproduced in the program for the “Tower of Song”
Tribute Concert in Montreal at the Bell Centre November 6th, 2017.
22. Paul Simon, born 1941, has inspired Kim with
his lyrics for a long time
45. Kim Solez with meeting coordinator Michele
Hales in 2002 in Pennan.
46. 2003 image from Aberdeen Banff meeting.
Lorraine Racusen is in the center and
Michele Hales is beside her. Phil Halloran is
behind Michele. Jake Demetris is at far left.
47. Tori Sheldon and Akshatha Raghuveer. In 2007 we
lost our funding from the NKF and student staffing
began.
55. In 1991 Kim Solez and Lorraine Racusen Directed the First Banff Meeting
Which Created the Banff Classification of Transplant Pathology and Banff
Consensus Process
Classification established, lesion scoring,
diagnostic categories, physician-led consensus
56. BANFF CLASSIFICATION STANDARD FOR
TRANSPLANT BIOPSY INTERPRETATION
Began in kidney (Solez et al. 1993), and was then extended
to liver, pancreas, composite tissue grafts etc. Meetings
also consider heart, lung, small bowel.
Uses semiquantitative lesion scoring 0-3+ and diagnostic
categories. A pathologic classification of all pathologic
changes, not just rejection.
57. 1993 Meeting was joint with Canadian
Association of Pathologists – Future
Consortium was Important Antecedent
1993 Meeting - Liver classification, chronic rejection, first presentation on
molecular pathology approaches, CAP Future of Pathology Consortium consensus discussions
1988-94 were an important antecedent to Banff consensus discussions .
58. 1995 Banff meeting at Banff Centre for
Conferences Group Picture of Liver Attendees
59. 1995 Shot - Bruce McManus in Center, Pekka Hayry
Behind, Fred Sanfillipo in Doorway - Who Else Can
You Identify?
60. More 1995 Shots
Kim Solez and Lorraine Racusen
1995 Meeting - Pancreas classification, glomerulitis, first international medical meeting on
CD-ROM, first Banff conference with microscope sessions. Lesion scoring normalized with CADI.
61. 1997 Meeting – Banff Springs Hotel
1997 Meeting - Merging of Banff and CCTT classifications, establishing basis for current Banff
classification, post-transplant lymphoproliferative disorder, first Banff conference with posters.
62. 1999 Meeting - Larry Hunsicker,
Agnes Fogo, and Elaine Solez
1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines.
First conference supported by an NIH grant.
63. 1999 Meeting – Michael Kashgarian and Agnes
Fogo
1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines.
First conference supported by an NIH grant.
64. 1999 Meeting – Glomerulitis Study Group with
Kiril Trpkov
1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines.
First conference supported by an NIH grant. Glomerulitis study group.
65. 1999 Meeting – Agnes Fogo
1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines.
First conference supported by an NIH grant. Glomerulitis study group.
66. 1999 Meeting – Larry Hunsicker,
Elaine Solez, and Agnes Fogo
1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines.
First conference supported by an NIH grant. Glomerulitis study group.
67. 2001 Meeting – Larry Hunsicker,
Agnes Fogo, Kim Solez and Bob Colvin
2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
77. 2003 Meeting –
Lorraine Racusen and Family
2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
78. 2005 Meeting – Phil Halloran, Ginny Halloran,
Vido Ramassar
2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with
elimination of CAN, establishment of criteria for chronic rejection.
79. 2005 – Janice McDonald, Charlene Hunter,
Banu Sis, Michele Hales
2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with
elimination of CAN, establishment of criteria for chronic rejection.
80. 2005 – Kim Solez and Banu Sis
2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with
elimination of CAN, establishment of criteria for chronic rejection.
81. 2007 Meeting – Michele Hales and Eduardo
Martul
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas
82. 2007 Meeting – Kunio Morozumi and Michael
Mihatsch
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
83. 2007 Meeting – Banu Sis
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
84. 2007 Meeting – Ian Gibson
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
85. 2007 Meeting – Roz Mannon
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
86. 2007 Meeting – Michael Mengel
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
87. 2007 Meeting – Eduardo and Lorraine
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
88. 2007 Meeting – Nikki Olson and
Kim Solez
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
89. 2007 Meeting – Tori Sheldon, Nikki Olson and
Paula Blanco
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
90. 2007 Meeting – Michael Mengel
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
91. 2007 Meeting – Tori Sheldon and
Nikki Olson
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
92. 2007 Meeting –Nikki Olson
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
93. 2007 Meeting –Eduardo and
Lorraine and Richard Racusen
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
94. 2007 Meeting – Dinner in Castle, Nikki Olson,
Tori Sheldon, and Bob Colvin
2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new
total inflammation score; working groups for v-lesion, genomic integration, pancreas and
composite tissue rejection schemas.
95. 2009 Meeting – Jubilant Tori and Akshatha
Return to Edmonton!
2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft
accommodation, endothelial cells, surrogate markers. Working groups.
96. 2009 Meeting – Lorraine Racusen and Michael
Mengel
2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft
accommodation, endothelial cells, surrogate markers. Working groups.
97. 2009 Meeting – Mark Haas
2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft
accommodation, endothelial cells, surrogate markers. Working groups.
98. 2009 Meeting – Jubilant Dar, Akshatha and Tori
Head Back to Edmonton!
2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft
accommodation, endothelial cells, surrogate markers. Working groups.
99. 2011 Meeting – Larry Hunsicker, Agnes Fogo,
and Kim Solez
2011 Sensitized patient, C4d, isolated v-lesion, the future, genomics, glomerulitis, epithelial injury
/epithelial mesenchymal transformation, operational tolerance monitoring in liver grafts.
100. 2011 Meeting – Banu Sis Isolated V
2011 Sensitized patient, C4d, isolated v-lesion, the future, genomics, glomerulitis, epithelial injury
/epithelial mesenchymal transformation, operational tolerance monitoring in liver grafts.
101. 2013, 2015, and 2017 – Recent so you have
your own favorite images!
Kim Solez’s favorite image from Banff 2017 capturing the spirit of Banff!
102. Banff 2019 and 2021 will be in Pittsburgh, USA and
Banff, Canada. Banff 2019 will have a regenerative
medicine/tissue engineering themed pre-meeting.
New Kinnear Conference Center holding 470 people at the Banff Centre for Conferences!
103. From Kinnear Centre Where We Will Be in 2021 Can
See TransCanada Pipeline Pavilion out the Window!
Can see our original site for Banff 1991, 1993, and 1995 out the window!!
105. It Was Always the Intention that Banff Would
be Digital, Portable, Morphometric, AI Based.
Can see our original site for Banff 1991, 1993, and 1995 out the window!!
106. YouTube channel www.youtube.com/user/kimsolez
explores pathologist/AI interaction and tissue
engineering pathology influence in the future. Rate
of subscription has increased five fold in 2018!
New Kinnear Conference Center holding 470 people at the Banff Centre for Conferences!