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Kim Solez 204 years of banff spirit November 10 2017

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Kim Solez 204 years of banff spirit and local heroes, presentation for wall mounted screen in cyberNephrology office, November 10, 2017. Copyright (c) 2017, JustMachines Inc.

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Kim Solez 204 years of banff spirit November 10 2017

  1. 1. Kim Solez World Exponential Timeline From Homer Smith 1895 to Aug. 7, 2099 1934 Leonard Cohen 1941 Paul Simon 1945 Rod Stewart 1991 Ed Sheeran 1994 Mallory Chipman 1901 Louis Armstrong 1920 Robert Heptinstall 1943 Janis Joplin 1961 Peter Diamandis
  2. 2. Think Different It is different to mix science, music, and poetry together as we have done in this presentation!
  3. 3. Think Different – Kim Solez sharing cyberNephrology 5B3.09 WCM HSC with Students & Fellows Annette Shaff / Shutterstock.com
  4. 4. 204 Years of the Spirit of Banff 1895-2099 122 Back 82 Forward
  5. 5. Homer Smith, born 1895, turned Kim on to the kidney in med school 3rd yr.
  6. 6. Homer Smith born 1895 Turned me on to kidney in med school 3rd year .
  7. 7. Louis Armstrong, born 1901, Turned Kim on to the trumpet and jazz.
  8. 8. Robert Heptinstall, born 1920, was Kim Solez’s mentor in renal pathology
  9. 9. Solez, Morel-Maroger, and Sraer Medicine 58:362-376, 1979. Morphology of "acute tubular necrosis" in man: Analysis of 57 renal biopsies and comparison with the glycerol model. My most cited paper before coming to Edmonton as Chair of Pathology.
  10. 10. Solez, Morel-Maroger, and Sraer Medicine 58:362-376, 1979 1. Of the 12 lesions assessed in the 57 “ATN” biopsies 10 persisted after functional recovery. Only 2 lesions correlated with function, were present when renal failure was present and absent after recovery: 1)thinning of PAS positive brush border, & 2) shedding of individual tubular epithelial cells leaving bare basement membrane.
  11. 11. Solez, Morel-Maroger, and Sraer Medicine 58:362-376, 1979 2. Lesions which persisted after recovery of function included tubular dilation, regeneration, mitoses, casts, interstitial edema, inflammation, nucleated cells in vasa recta, dilation of Bowman’s capsule, tubularization of Bowman’s capsule epithelium, & juxtaglomerular apparatus hyperplasia. The latter two were more prominent in recovery biopsies.
  12. 12. Solez, Morel-Maroger, and Sraer Medicine 58:362-376, 1979 3. Lumping all acute tubular injury lesions together guarantees that histology assessment will appear to be inferior to molecular assessment, since the majority of ATI lesions persist after functional recovery. Only studies which separately assess the two lesions which correlate functionally are valid. i.e. 1)thinning or absence of PAS positive brush border, & 2) shedding of individual tubular epithelial cells .
  13. 13. Paper still referred to in recent reviews, findings uncontested. Basile et al., 2012
  14. 14. Cannot say molecules change faster than morphology until you look at these two lesions, BB loss and cell exfoliation! Basile et al., 2012
  15. 15. Heptinstall called the 1979 paper ”the best that can be done with a difficult subject!”
  16. 16. Later work on Transplant Acute Tubular Injury Was an Important Antecedent to Banff Studies 1993 KI paper on Transplant ATI.
  17. 17. New insights into transplant ATN, Solez et al. 1993 Brush border loss not a feature of transplant ATN.
  18. 18. Leonard Cohen, born 1934, turned Kim on to poetry and his style of music
  19. 19. Nine months after meeting Kim Solez over 3 day weekend in 2005 Leonard wrote song inspired by their discussion of Banff borderline changes.
  20. 20. Ten years later Leonard removed all but one of the borderlines and the song became the popular “Treaty” on the 2016 You Want It Darker album. “I wish there was a treaty we could sign I do not care who takes this bloody hill … I wish there was a treaty we could sign It’s over now the water and the wine We were broken then but now we’re borderline I wish there was a treaty I wish there was a treaty Between your love and mine” The notebook pages showing this ten year song transition were the only such pages reproduced in the program for the “Tower of Song” Tribute Concert in Montreal at the Bell Centre November 6th, 2017.
  21. 21. Paul Simon, born 1941, has inspired Kim with his lyrics for a long time
  22. 22. Janis Joplin, born 1943, inspired Kim and was a friend of Leonard Cohen
  23. 23. Rod Stewart, born 1945, inspired Kim Solez and Lorraine Racusen
  24. 24. Kim Solez, born 1946, already plotting things at age 3 seen here with father.
  25. 25. His first memory of event impacting outside world, age 7: Hearing Queen Elizabeth Coronation on Radio in 1953
  26. 26. The Origin of Kim’s Diversity Beliefs at Age 7, Yasmini.
  27. 27. Which Led to This 2008 Essay
  28. 28. Ray Kurzweil, born 1948, co-founder of Singularity University, is Kim Solez’s most important technology influence.
  29. 29. Peter Diamandis, co-founder of Singularity University born in 1961, is an important technology influence.
  30. 30. Ed Sheeran, born in 1991, is an important musical influence on Kim.
  31. 31. Banff Transplant Pathology Classification Began at The TransCanada Pipeline Pavilion at the Banff Centre for Conferences in 1991
  32. 32. Banff meeting slide box mentioned in first Banff abstract in 1991 is in itself also an important player in story .
  33. 33. Ironically the last Banff classification workshop in which these slides were used was in 2004 in Aleppo, Syria.
  34. 34. Mallory Chipman, born 1994, is an important musical collaborator in technology&Leonard Cohen events!
  35. 35. Kim&Mallory initiated Technology&All That Jazz Project to broaden the reach of important ideas in science.
  36. 36. We had our own “Stanley meets Livingstone” moment when Tori Sheldon and Mallory met in June 2017. They will be working together at the TERMIS International Congress in Kyoto in September 2018.
  37. 37. So where will it end? The farthest future date in song Kim Solez can conceptualize is Aug. 7, 2099
  38. 38. So where will it end? The farthest future date in song Kim Solez can conceptualize is Aug. 7, 2099
  39. 39. So where will it end? The farthest future date in song Kim Solez can conceptualize is Aug. 7, 2099
  40. 40. We have ended the timeline with Aug. 7, 2099, and will create an event page but then again there is also this song!
  41. 41. So maybe we have to push our imaginations to 5555. Kim Solez can imagine that Banff will still be remembered in 2525, but not in 5555!
  42. 42. Kim Solez, MD
  43. 43. Pennan, Scotland near Banff is where classic 1983 movie “Local Hero” was shot
  44. 44. Kim Solez with meeting coordinator Michele Hales in 2002 in Pennan.
  45. 45. 2003 image from Aberdeen Banff meeting. Lorraine Racusen is in the center and Michele Hales is beside her. Phil Halloran is behind Michele. Jake Demetris is at far left.
  46. 46. Tori Sheldon and Akshatha Raghuveer. In 2007 we lost our funding from the NKF and student staffing began.
  47. 47. Many students have contributed extensively to Banff meetings.
  48. 48. Video has become an important part of meetings, Patricia Bacus, Banff 2017
  49. 49. Nikki Olson was important part of early video efforts and creation of Tech&Future of Medicine course
  50. 50. Laurie Bennett also provided early videography assistance to Kim Solez
  51. 51. In recent years Tatiana Zagorac has become main videography advisor to Kim Solez
  52. 52. Another important local hero is the local Banff meeting director, like Daniel Seron in Banff 2017. The subject of another ppt!
  53. 53. Kim Solez, MD
  54. 54. In 1991 Kim Solez and Lorraine Racusen Directed the First Banff Meeting Which Created the Banff Classification of Transplant Pathology and Banff Consensus Process Classification established, lesion scoring, diagnostic categories, physician-led consensus
  55. 55. BANFF CLASSIFICATION STANDARD FOR TRANSPLANT BIOPSY INTERPRETATION Began in kidney (Solez et al. 1993), and was then extended to liver, pancreas, composite tissue grafts etc. Meetings also consider heart, lung, small bowel. Uses semiquantitative lesion scoring 0-3+ and diagnostic categories. A pathologic classification of all pathologic changes, not just rejection.
  56. 56. 1993 Meeting was joint with Canadian Association of Pathologists – Future Consortium was Important Antecedent 1993 Meeting - Liver classification, chronic rejection, first presentation on molecular pathology approaches, CAP Future of Pathology Consortium consensus discussions 1988-94 were an important antecedent to Banff consensus discussions .
  57. 57. 1995 Banff meeting at Banff Centre for Conferences Group Picture of Liver Attendees
  58. 58. 1995 Shot - Bruce McManus in Center, Pekka Hayry Behind, Fred Sanfillipo in Doorway - Who Else Can You Identify?
  59. 59. More 1995 Shots Kim Solez and Lorraine Racusen 1995 Meeting - Pancreas classification, glomerulitis, first international medical meeting on CD-ROM, first Banff conference with microscope sessions. Lesion scoring normalized with CADI.
  60. 60. 1997 Meeting – Banff Springs Hotel 1997 Meeting - Merging of Banff and CCTT classifications, establishing basis for current Banff classification, post-transplant lymphoproliferative disorder, first Banff conference with posters.
  61. 61. 1999 Meeting - Larry Hunsicker, Agnes Fogo, and Elaine Solez 1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant.
  62. 62. 1999 Meeting – Michael Kashgarian and Agnes Fogo 1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant.
  63. 63. 1999 Meeting – Glomerulitis Study Group with Kiril Trpkov 1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant. Glomerulitis study group.
  64. 64. 1999 Meeting – Agnes Fogo 1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant. Glomerulitis study group.
  65. 65. 1999 Meeting – Larry Hunsicker, Elaine Solez, and Agnes Fogo 1999 Meeting - Protocol biopsies, chronic rejection, and viral diseases, clinical practice guidelines. First conference supported by an NIH grant. Glomerulitis study group.
  66. 66. 2001 Meeting – Larry Hunsicker, Agnes Fogo, Kim Solez and Bob Colvin 2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
  67. 67. 2001 Meeting – Parmjeet Randhawa and Volker Nickeleit 2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
  68. 68. 2001 Meeting – Peter Furness 2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
  69. 69. 2001 Meeting – Lorraine Racusen 2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
  70. 70. 2001 Meeting – David Rush and Denis Glotz 2001 Meeting - AMR, donor biopsies, genomics, CAN, heart transplantation
  71. 71. 2003 Meeting – J. Stewart Cameron and Andrew Rees 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  72. 72. 2003 Meeting – Andrew Rees 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  73. 73. 2003 Meeting – Doug Wilson 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  74. 74. 2003 Meeting – Sony Aibo Robotic Dog 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  75. 75. 2003 Meeting – Michele Hales and Janice McDonald 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  76. 76. 2003 Meeting – Lorraine Racusen and Family 2003 Meeting - C4d, macrophages, tolerance, accommodation, immunodepletion
  77. 77. 2005 Meeting – Phil Halloran, Ginny Halloran, Vido Ramassar 2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with elimination of CAN, establishment of criteria for chronic rejection.
  78. 78. 2005 – Janice McDonald, Charlene Hunter, Banu Sis, Michele Hales 2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with elimination of CAN, establishment of criteria for chronic rejection.
  79. 79. 2005 – Kim Solez and Banu Sis 2005 Meeting - Genomics and molecular markers, B cells, chronic allograft injury with elimination of CAN, establishment of criteria for chronic rejection.
  80. 80. 2007 Meeting – Michele Hales and Eduardo Martul 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas
  81. 81. 2007 Meeting – Kunio Morozumi and Michael Mihatsch 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  82. 82. 2007 Meeting – Banu Sis 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  83. 83. 2007 Meeting – Ian Gibson 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  84. 84. 2007 Meeting – Roz Mannon 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  85. 85. 2007 Meeting – Michael Mengel 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  86. 86. 2007 Meeting – Eduardo and Lorraine 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  87. 87. 2007 Meeting – Nikki Olson and Kim Solez 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  88. 88. 2007 Meeting – Tori Sheldon, Nikki Olson and Paula Blanco 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  89. 89. 2007 Meeting – Michael Mengel 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  90. 90. 2007 Meeting – Tori Sheldon and Nikki Olson 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  91. 91. 2007 Meeting –Nikki Olson 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  92. 92. 2007 Meeting –Eduardo and Lorraine and Richard Racusen 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  93. 93. 2007 Meeting – Dinner in Castle, Nikki Olson, Tori Sheldon, and Bob Colvin 2007 Meeting - Protocol biopsies, transcriptome, mechanisms of rejection, ptc grading, new total inflammation score; working groups for v-lesion, genomic integration, pancreas and composite tissue rejection schemas.
  94. 94. 2009 Meeting – Jubilant Tori and Akshatha Return to Edmonton! 2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft accommodation, endothelial cells, surrogate markers. Working groups.
  95. 95. 2009 Meeting – Lorraine Racusen and Michael Mengel 2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft accommodation, endothelial cells, surrogate markers. Working groups.
  96. 96. 2009 Meeting – Mark Haas 2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft accommodation, endothelial cells, surrogate markers. Working groups.
  97. 97. 2009 Meeting – Jubilant Dar, Akshatha and Tori Head Back to Edmonton! 2009 Meeting - Viruses, quality assurance, AMR in kidney, heart, and pancreas, liver allograft accommodation, endothelial cells, surrogate markers. Working groups.
  98. 98. 2011 Meeting – Banu Sis Isolated V 2011 Sensitized patient, C4d, isolated v-lesion, the future, genomics, glomerulitis, epithelial injury /epithelial mesenchymal transformation, operational tolerance monitoring in liver grafts.
  99. 99. 2013, 2015, and 2017 – Recent so you have your own favorite images! Kim Solez’s favorite image from Banff 2017 capturing the spirit of Banff!
  100. 100. Banff 2019 and 2021 will be in Pittsburgh, USA and Banff, Canada. Banff 2019 will have a regenerative medicine/tissue engineering themed pre-meeting. New Kinnear Conference Center holding 470 people at the Banff Centre for Conferences!
  101. 101. From Kinnear Centre Where We Will Be in 2021 Can See TransCanada Pipeline Pavilion out the Window! Can see our original site for Banff 1991, 1993, and 1995 out the window!!

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