This document provides an overview of Polycystic Ovary Syndrome (PCOS) and its association with thyroid disorders, emphasizing their distinct etiopathogenesis but common features. It highlights the symptoms, pathophysiology, and the increased prevalence of thyroid disorders in PCOS patients, as well as the potential implications for fertility. The conclusion points out the lack of extensive research on the interplay between these conditions despite their shared characteristics.

1. An overview of Polycystic Ovary Syndrome (PCOS) and thyroid
Submitted by : Khushi
Roll No: 75191807
B. Pharmacy, 4th
Year (8th
Semester)
Supervisor:
Miss Sapna Rani
Department of Pharmaceutical Science’s
M.M. College of Pharmacy,
Department of Pharmaceutical Sciences
M.M. College of Pharmacy

2. Table of Content
• Introduction
• Polycystic Ovary Syndrome (PCOS)
• Thyroid
• PCOS associated with thyroid related disorder
• Symptoms of PCOS associated with thyroid
• Pathophysiology of PCOS
• Pathophysiology of thyroid disorder

3. Introduction:
• Thyroid disorder and Polycystic Ovary Syndrome (PCOS) are very common endocrine
disorder among general population.
• But both thyroid dysfunction and PCOS have completely different etiopathogenesis & also
have some various common features.
• An increased ovarian volume and cystic changes in ovaries have been reported in both
primary hypothyroidism and PCOS.
• Both PCOS and thyroid have possible etiological and clinical connections between them.

4. Polycystic Ovary Syndrome (PCOS):
• Common endocrine disorder and cause of infertility among females.
• It is a complex endocrine disorder associated with long term annovulation and an excess of
androgen circulation in blood.Imbalance of sex hormones cause the abnormal growth of
ovarain cyst.
Polycystic
ovary
Amenor
rhea
obesity
Hirsutism

5. It is estimated that 6-10% of women are affected by PCOS in their
reproductive age.
14-
17yrs
18-
25yrs
26-
30yrs
31-
35yrs
36-
40yrs
0
5
10
15
20
25
Group 1
Group 2

6. Thyroid:
• The thyroid is a butterfly –shaped gland in the neck.
• It produces hormones responsible for controlling body’s metabolism and growth.
• The thyroid gland works with pituitary gland located in the centre of skull.
• The hormones secreted by thyroid gland includes:
T3-Triidothronine
T4-Thyroxine
TSH-Thyroid Stimulating Hormone

7. PCOS associated with thyroid related disorder:
• An increased estrogenic and estrogenic/progesterone ratio seem to be directly involved in
high thyroid antibody levels in PCOS patients.
• In PCOS estrogen ratio increases and progesterone ratio decreases.
• Whereas in thyroid disorder like Hashimoto’s TSH ratio increases and the ratio of other
hormones such as T4 and T3 decreases.

8. Symptoms of PCOS associated with thyroid:
Symptoms
of PCOS
associated
with thyroid
Irregular
periods
Increased
insulin
resistance
Fertility
Struggles

9. Pathophysiology of PCOS:

10. Pathophysiology of thyroid disorder :

11. Conclusion:
• Thyroid disorders, especially HT, in the course of PCOS, are observed significantly more
frequently than in the general population. However, their concomitance in the context of
fertility disorders has not been investigated extensively.
• The data concerning joint etiology, pathogenesis and clinical consequences are scarce. This is
probably caused by complex etiology of both diseases and changes of PCOS diagnostic
criteria over time.
• Three genetic polymorphisms: FBN3, GnRHR and CYP1B1, have been described to play a
role in PCOS as well as in HT. Polymorphism of the FBN3 gene seems to be most suitable,
due to the relationship with TGFß activity, and Treg level in consequence. The role of TGFß in
the pathogenesis of both disorders has been understood.
• Among patients with PCOS only A8 D19S884 carriers had a normal TGFß1 level; others have
been found to have increased values compared with the general population. High estrogen
levels during prenatal life may disrupt development of the thymus and its role in creating
immune tolerance.

12. Reference:
• Sinha U, Sinharay K, Saha S, Longkumer TA, Baul SN, Pal SK. Thyroid disorders in
polycystic ovarian syndrome subjects: A tertiary hospital based cross-sectional study from
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Google Scholar]
• . Benetti-Pinto CL, Berini Piccolo VR, Garmes HM, Teatin Juliato CR. Subclinical
hypothyroidism in young women with polycystic ovary syndrome: An analysis of clinical,
hormonal, and metabolic parameters. Fertil Steril. 2013;99:588–92. [PubMed] [
Google Scholar]
• . Ramanand SJ, Ghongane BB, Ramanand JB, Patwardhan MH, Ghanghas RR, Jain SS.
Clinical characteristics of polycystic ovary syndrome in Indian women. Indian J Endocrinol
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• Janssen OE, Mehlmauer N, Hahn S, Offner AH, Gärtner R. High prevalence of autoimmune
thyroiditis in patients with polycystic ovary syndrome. Eur J Endocrinol. 2004;150:363–9. [
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13. THANK YOU