This document summarizes the findings of two working groups on using science to manage large marine ecosystems and open oceans. It identifies critical emerging science issues that require further study, such as climate change impacts, multiple stressors on ecosystems, and the effects of land-use and pollution. The document also discusses challenges in applying science to transboundary management through activities like TDAs, SAPs, and monitoring. It recommends establishing advisory groups, information systems, scientific conferences, and scientist-policymaker dialogues to better link science and adaptive management in support of the vision for large marine ecosystems and open oceans.