Uploaded byNobuyuki Takahashi
Jsolシンポジウム（高橋＠京大農学）改定
The document discusses how compounds derived from tomatoes, specifically 9-oxo-octadecadienoic acid (9-oxo-ODA) and 13-oxo-octadecadienoic acid (13-oxo-ODA), were found to activate peroxisome proliferator-activated receptor alpha (PPARα) and improve abnormalities in hepatic lipid metabolism. Mice fed a high-fat diet supplemented with 13-oxo-ODA showed decreased hepatic triglyceride accumulation, lower plasma triglyceride levels, and increased rectal temperature compared to controls. The tomato-derived compounds were therefore found to prevent fatty liver development.
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Jsolシンポジウム（高橋＠京大農学）改定
- 1. Tomato-derived Compounds Improve Abnormalitiesin Hepatic Lipid Metabolism.
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- 4. There Are ManyPeople Having Fatty Liver.
- 5. One of ThreeJapanese Has Fatty Liver.
- 6. Fatty Liver Patients HaveIncreased.
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- 11. Healthy Liver Fatty Liver (NAFLD) NASH Fibrosis Cancers Fatty LiverFinally Progresses to Hepatic Cancers.
- 12. Healthy Liver Fatty Liver (NAFLD) NASH Fibrosis Fatty LiverFinally Progresses to Hepatic Cancers. Cancers
- 13. Fatty Liver ShouldBe Improved.
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- 15. Nuclear Receptors AreActivated by Small Hydrophobic Compounds. Nuclear Receptor Ligand Retinoic Acid Receptor (RAR) Vitamin D Receptor (VDR) Estrogen Receptor (ER) etc.
- 16. Nuclear Receptor Nuclear Receptors AreActivated by Small Hydrophobic Compounds. Ligand Target Gene
- 17. Nuclear Receptors AreActivated by Small Hydrophobic Compounds. Target Gene Nuclear Receptor Ligand
- 18. Nuclear Receptors AreActivated by Small Hydrophobic Compounds. Target Gene Target Gene Products Nuclear Receptor Ligand
- 19. Nuclear Receptors AreActivated by Small Hydrophobic Compounds. Target Gene Food-derived Compound Nuclear Receptor Target Gene Products
- 20. Peroxisome Proliferator-activated Receptors (PPARs)Are Involved in Lipid Metabolism.
- 21. Insulin Sensitivity Insulin Sensitivity EnergyConsumption Energy Consumption ? Energy Consumption ? Energy Consumption Lipogenesis ? PPARg PPARdPPARa Peroxisome Proliferator-activated Receptors (PPARs) Are Involved in Lipid Metabolism.
- 22. Peroxisome Proliferator-activated Receptors (PPARs)Are Involved in Lipid Metabolism. Energy Consumption PPARa
- 23. Peroxisome Proliferator-activated Receptors (PPARs)Are Involved in Lipid Metabolism. 0 250 500 750 1000 cont beza AOX mRNA relativeofcontrol(%) Energy Consumption PPARa 0 1000 2000 3000 4000 cont beza CPT-1 mRNA relativeofcontrol(%)
- 24. PPARa Activation Enhances Fatty Acid Oxidationin the Liver.
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- 26. 0 500 1000 1500 control RF54 RF55RF56 RF57 RF58 RF59 GW RelativeLuciferaseActivity (%ofcontrol) RF57 * * We Identified an Active Fraction Activating PPARa Using Tomato EtOH Extract.
- 27. 0 500 1000 1500 control RF54 RF55RF56 RF57 RF58 RF59 GW RelativeLuciferaseActivity (%ofcontrol) RF57 * * C18H30O3 (MW: 294) We Identified an Active Fraction Activating PPARa Using Tomato EtOH Extract.
- 28. Oxo-octadecadienoic Acids were ResponsibleCompounds of RF57. O COOH 9-oxo-ODA
- 29. Oxo-octadecadienoic Acids were ResponsibleCompounds of RF57. O COOH O COOH 9-oxo-ODA 13-oxo-ODA
- 30. 9-oxo-ODA Decreased Lipid Accumulation inMouse Primary Hepatocytes. 0 * * * 20 30 TGAccumulation (mg/gprotein) 10 GW7647 (nM) 9-oxo-ODA (mM) - 100 10 20- - - -
- 31. KK-Ay Obese Diabetic Model mice High-Fat-Diet Containing13-oxo- ODA (0.02 & 0.05%) 4 Weeks
- 32. 50 μm control The 13-oxo-ODAFeeding Decreased Hepatic TG Accumulation.
- 33. 50 μm control 50 μm 0.02% 50μm 0.05% The 13-oxo-ODA Feeding Decreased Hepatic TG Accumulation.
- 34. 0 25 50 75 100 control 0.02% 0.05% (mg/gLiver) * The13-oxo-ODA Feeding Decreased Hepatic TG Accumulation. *
- 35. 0 50 100 150 200 control 0.02% 0.05% (mg/dL) * The13-oxo-ODA-fed Mice Showed Lowering Plasma TG Levels. *
- 36. control 0.02% 0.05% RectalTemperature Was Increased by the 13-oxo-ODA Feeding. 37.0 37.5 38.0 38.5 RectalTemperature (oC) * *
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- 39. Tomato-derived Compounds Prevent FattyLiver Development. Healthy Liver Fatty Liver (NAFLD) High-Fat- Diet 9/13-oxo- ODAs
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- 43. More Tomatoes ... Thanks!!! E-mail: nobu@kais.kyoto- u.ac.jp