These slides were used in the lecture, "Basic Biology," in Kinki University in 2013.
These are a Japanese version of the slides, "JSOL Symposium in Tsukuba 2013."
These slides were used in the lecture, "Basic Biology," in Kinki University in 2013.
These are a Japanese version of the slides, "JSOL Symposium in Tsukuba 2013."
This document discusses research on food factors that can improve obesity and metabolic disorders. It describes how tomato-derived oxo-octadecadienoic acids (ODAs) and fenugreek-derived diosgenin activate or inhibit nuclear receptors like PPARα and LXR to reduce lipid accumulation and improve fatty liver. Mice fed high-fat diets supplemented with 9-oxo-ODA or fenugreek showed decreased hepatic triglyceride levels and increased fatty acid oxidation gene expression compared to controls. In cell studies, 9-oxo-ODA and diosgenin also reduced lipid accumulation and modulated nuclear receptor pathways involved in lipid metabolism. The findings suggest certain food compounds can help prevent and
The document discusses how compounds derived from tomatoes, specifically 9-oxo-octadecadienoic acid (9-oxo-ODA) and 13-oxo-octadecadienoic acid (13-oxo-ODA), were found to activate peroxisome proliferator-activated receptor alpha (PPARα) and improve abnormalities in hepatic lipid metabolism. Mice fed a high-fat diet supplemented with 13-oxo-ODA showed decreased hepatic triglyceride accumulation, lower plasma triglyceride levels, and increased rectal temperature compared to controls. The tomato-derived compounds were therefore found to prevent fatty liver development.
This document discusses research on food factors that can improve obesity and metabolic disorders. It describes how tomato-derived oxo-octadecadienoic acids (ODAs) and fenugreek-derived diosgenin activate or inhibit nuclear receptors like PPARα and LXR to reduce lipid accumulation and improve fatty liver. Mice fed high-fat diets supplemented with 9-oxo-ODA or fenugreek showed decreased hepatic triglyceride levels and increased fatty acid oxidation gene expression compared to controls. In cell studies, 9-oxo-ODA and diosgenin also reduced lipid accumulation and modulated nuclear receptor pathways involved in lipid metabolism. The findings suggest certain food compounds can help prevent and
The document discusses how compounds derived from tomatoes, specifically 9-oxo-octadecadienoic acid (9-oxo-ODA) and 13-oxo-octadecadienoic acid (13-oxo-ODA), were found to activate peroxisome proliferator-activated receptor alpha (PPARα) and improve abnormalities in hepatic lipid metabolism. Mice fed a high-fat diet supplemented with 13-oxo-ODA showed decreased hepatic triglyceride accumulation, lower plasma triglyceride levels, and increased rectal temperature compared to controls. The tomato-derived compounds were therefore found to prevent fatty liver development.