4. The reason behind this
hyperbilirubinaemia
Increases the production of bilirubin
Decreases the uptake of bilirubin
Decreases the conjugation of bilirubin
Decreases excretion of bilirubin into bile
5. Two types of hyperbilirubinaemia
• Hyperbilirubinaemia
• (cholestasis)
Predominantly
conjugated
• Hyperbilirubinaemia
Predominantly
unconjugated
7. Extrahepatic
It is mechanically obstruction
It seen in outside the liver bileduct
Common causes are gallstone , carcinoma head of
pancreas,tumor of bileduct
It can be complete and sudden and partialy AND
incomplete
8. Intrahepatic
Hereditary disorder
Obstruction on biliary duct excretion are
characterized by ‘pure cholestasis’.
It can be hepatocellular cholestasis causes by virus
hepatits and drugs are like chlorpromazine
,contraceptives