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Hybridoma Technology ( Production , Purification , and Application )
Rheology physical pharmaceutics
1. Rheology: it means that study of flow of the
Liquids and the distribution of solid.
Rheology use to understanding of packaging,
Suspension formulation,solid into viscous solution.
Types of Flow and Distribution
Pseudo
plastic
Plastic
system
dilatant
2.
3.
4.
5. MOST OF PHARMACEUTICAL FORMULATION DO NOT FOLLOW NEWTONIAN
SYSTEM
BECAUSE OF VISCOSITY OF FLUID WITH A VARIOUS RATE OF SHEAR (G).
PLASTIC OR BINGHAM FLOW
RHEOGRAM DOES NOT PASS THROUGH THE ORIGIN A BINGHAM BODY DOSE
NOT FLOW UNTIL THE SHEARING STRESSCORRESPONDING
TO THE YEILLD VALUE IF THE STRESS IS LESS THAN THE YIELD VALUE THE
SYSTEM
BEHAVE LIKE A SOLID
BINGHAM EQUATION
U=F-f/G
WHERE ,f=yield
F=SHEAR STRESS
G=RATE OF SHEAR
MOBILITY=1/U
NON NEWTONIAN
SYSTEMS