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Clusters & (VC) Capital:
                     Scaling Up for Innovation
Russia/BII US State Dept: Biotech for Regional Development
Kirov Russia, 26/28 June 2007

                 Innovative Ventures Inc.
                     Haslett, MI. USA
                     Moscow, Russia
                                              Thomas Nastas
                                                  President
                                             Tom@IVIpe.com
                                             www.IVIpe.com
   26/28 June 2007          www.IVIpe.com
                            Info@IVIpe.com
Clusters & (VC) Capital:
                  Scaling Up for Innovation




26/28 June 2007          www.IVIpe.com
                         Info@IVIpe.com
Today’s Message
1. What’s Happening in the Market?
       The Good & the Bad
       Issues: $ & Deal Flow, Other?
2. GoForward Plan to Spur More $$
      Strategies & Structures
      Boosting Quality/Quantity of Deals
      How Do Supply Chain Needs as Clusters Fit
      into the Picture?

  26/28 June 2007      www.IVIpe.com
                       Info@IVIpe.com
IVI History-Direct Invest &
                        Advisory
  Canada (1992)
                                                  Europe (1992/94)
C$100MM-Canadian
                                                  TP Fund, $10MM-
  Bus. Dev. Bank
                                                  EU, $-Financière
                                                  St Dominique,
                                                  Paris


     USA (1986)
                                                   Russia (1997)
The Michigan Product
                                                HP LP, $30MM-EBRD &
Dev. Fund ($5MM)
                                                USAID
                         Africa (1993/96)
                       E. Africa $5MM, Sub-
                       Saharan, $200MM, South
                       Africa,$30MM, IFC/WB
   26/28 June 2007     www.IVIpe.com
                       Info@IVIpe.com
IVI in Russia & Russian Tech
1997: Transact Russian VC Deals-Infrastructure
2001: IVI’s Russian Technology Investment Forum
(2 day biz plan comp, 35 top IT SMEs) & VC Workshop (2
days; education/trainings-presentations & elevator pitch)
2002: Russian Tech for Oil/Gas (e.g., SLB), IT,
Biotech, Medical, Homeland Security (Global)
2004: Partnership with Shell (STV/GameChanger)
         • ‘Snapshot’ the mkt, invest in Gamechanging tech for
           global mkts & start a relationship to build a portfolio
         • Member, Russian Tech Tour Committee (biz plan)
 26/28 June 2007           www.IVIpe.com
                           Info@IVIpe.com
Successes in the Market
                    Since 2001

                                              PBC Lasers
                                              & Wostec




        Multinationals w/R&D Labs in Russia


26/28 June 2007       www.IVIpe.com
                      Info@IVIpe.com
Some Clouds Too: Learning
               Curve Lessons
                       Optiva ($49M) liquidates:
                       Nanotech's 1st big flame-out

                          Startup doctors ease portfolio
                          pain-Trustworks ($23M)
                                                    Cybiko Ceases
                                                    Operations

Not Seeing Entrepreneurial SME Creation
          from MNC R&D Labs
        Multinationals w/R&D Labs in Russia


26/28 June 2007       www.IVIpe.com
                      Info@IVIpe.com
Realities of VC
Equity is a Great Product, but:
      1. It’s Expensive (% ownership)
      2. Very Selective-1/100 SMEs (in the USA)
         seeking VC receive $$$-High Risk/High Return
             Sales $ Need Big Markets ($50-$100MM)
             People (Technical, Mkting, Mgt, Support,
             etc.)
      3. Requires Access to Liquidity (Capital Mkts
         &/or Strategic Buyers, Domestic or Foreign)
  26/28 June 2007      www.IVIpe.com
                       Info@IVIpe.com
Realities of VC (Emerging
                          Mkts)
1/200 SMEs seeking VC in emerging markets
receive $$$ Reasons, high rejection rates:
          Undeveloped Opportunity
          Lack of Uniqueness/No Competitive Advantage
          Too much $$$, too much time & too little reward
          People (mgt/employees)
          Lack of Transparency, No Clear Title/Ownership of IP
What to do with the SMEs that are rejected?
   Ignore? Sympathize? Seek New Solutions?
   26/28 June 2007         www.IVIpe.com
                           Info@IVIpe.com
What’s Working Against Early
         Stage Tech & VC in Russia
Plenty of $: It’s Competition:
   Domestic Growth, FMCC, F&B, Retailing,
   Financial Services, Media, etc.
   Keeps Entrepreneurs in Non-Tech
   From Other Asset Classes w/Quicker & >
   Profits, e.g., Stocks & Real Estate
   From Israel, Ireland, USA, etc., with Good
   Deals, Technologies, Entrepreneurs &
   Successes
  26/28 June 2007   www.IVIpe.com
                    Info@IVIpe.com
Russian Tech for Global Mkts:
          Alternative Strategy?



                  ?


26/28 June 2007       www.IVIpe.com
                      Info@IVIpe.com
GoForward Plan: Action Item
                       #1
1. Invest in Tech for Domestic Mkt
         Link w/Corporates: User Pull, Testing,
         Deployment & Commercialization

         Solve Tech & Supply Chain Needs

         Don’t Worry about Small Volumes

         Build Locally, Upgrade Later for National &
         Int’l Expansion
  26/28 June 2007      www.IVIpe.com
                       Info@IVIpe.com
Possibilities for Investment:
                          Build the Supply Chain
                                                                              Research, Testing, &
     Agricultural                           Medical Devices
                         Drugs &                                Hospitals
                                                                              Medical Laboratories
Feedstock & Chemicals Pharmaceuticals        & Equipment

   Agricultural            Medicinal &     Laboratory         Specialty         Biological
   processing              botanicals      apparatus &        hospitals         research
                                           furniture
   Basic organic           Pharma-                            University        Commercial
   chemicals               ceutical         Surgical,         medical           medical
                           preparations   medical, dental,    research          research
   Ethyl alcohol
                                          ophthalmic          hospitals
   mfg.                    Diagnostic                                            Testing
                                          & analytical
                           substances                          Clinical         laboratories
   Organic fiber                          instruments &
                                                              research
   mfg.                                   equipment
                           Biological                                           Medical
                                                              institutions
                           products                                             laboratories &
   Fertilizers                             Irradiation
                                                                                diagnostic
                                           apparatus &
   Pesticides and                                                               imaging
                                           electromedical
   other agricultural
                                                                                centers
   chemicals                               equipment



                         Product-Oriented www.IVIpe.com                Service-Oriented
       26/28 June 2007
                                           Info@IVIpe.com
Where’s the Customer Pain
                (Need) in the Industry?
1. MORE Perf, Execution & Cost Reduction
        Not GameChangers; blocking/tackling tech so
        customers meet business plan
2. MORE Local Content
        More Value-added Tech
        Tech Sold to Multiple Customers
        Generate Supplier Sustainability thru Multiple
        Products/Services
3. What Else?
    26/28 June 2007      www.IVIpe.com
                         Info@IVIpe.com
GoForward Plan: Action Item
                      #2

1. Invest in Tech: the Domestic Market
2. Capitalize a ‘Mini-Grant’ Program
         Define biz opts for a technology
         Cost is US$3,000-US$10,000/technology
         Not a biz plan, but 3-4 document on
         tech’s potential



  26/28 June 2007     www.IVIpe.com
                      Info@IVIpe.com
GoForward Plan: Action Item
                      #3

1. Invest in Tech: the Domestic Market
2. Capitalize a ‘Mini-Grant’ Program
3. Create ‘ Tech Proof of Concept’ Fund
         Transform ideas = deals
         Generate data to confirm performance,
         show weaknesses vs. competition &
         alternatives.
         Benchmarket to int’l standards
  26/28 June 2007     www.IVIpe.com
                      Info@IVIpe.com
GoForward Plan: Action Item
                         #4

1.   Invest in Tech: the Domestic Market
2.   Capitalize a ‘Mini-Grant’ Program
3.   Create ‘ Tech Proof of Concept’ Fund
4.   Inventory Your Tech & Publish as a
     Database on the Internet


     26/28 June 2007   www.IVIpe.com
                       Info@IVIpe.com
GoForward Plan: Action Item
                      #4

4. Inventory Your Tech & Publish as a
  Database on the Internet
      Org by tech, product & mkt
      Benefits by cost & performance
      Stage of dev., R&D, PD, Testing,
      Plan w/Timetable, milestones,
      budgets
      IP issued/filed & competing IP
  26/28 June 2007   www.IVIpe.com
                    Info@IVIpe.com
GoForward Plan: Action Item
                     #5
5. Establish a Biz Dev Office
    Scouts for Opts in SMEs & Institutes
    Develops projects for ‘Mini-Grant’ & ‘Proof of
    Concept’ Funds
    Sells to Customers
    Keeps the Team Focused. Align Interests
                Sell Data or Provide Answers?
                Incentives: Cash/Salary or Equity?
                Transparent or Opaque? Responsive or Egocentric?
   26/28 June 2007            www.IVIpe.com
                              Info@IVIpe.com
GoForward Plan: Action Item
                      #6
6.Create an IP Fund
         Fund costs of Filing IP, especially Int’l
         Pay-back as a Royalty on Sales
         Funded by Russian Gov’t Initiative/PPP




  26/28 June 2007        www.IVIpe.com
                         Info@IVIpe.com
GoForward Plan: Action
                     Item #7
6. Organize R&D & Supply Chain
   Competitions for Users of Tech
         Go After Corporates & Corporate Investors
         vs. Financial Investors
         Interaction between R&D developers &
         Corporations & Corporate VC
         Corporations fund R&D, guide development
         & access opts in the supply chain
         Lower dev risk & get to market quickly
         Establish Industry Consortiums
  26/28 June 2007      www.IVIpe.com
                       Info@IVIpe.com
Concluding Thoughts

New Zealand is a Fitting Example of Success
Not Emerging Market, but Small & Remote




  26/28 June 2007        www.IVIpe.com
                         Info@IVIpe.com
Technology In Many Places!
                Just Look & Define


    Slaughter                        Raising          Genetic Engineering
                                                         & Breeding




                                                            Butcher
                            Distribution, Storage &       Retail Locations
Processing- Ham, Kielbasa
                                    Delivery
    26/28 June 2007             www.IVIpe.com
                                Info@IVIpe.com
Thomas D. Nastas
                       Tom@IVIpe.com
                       www.IVIpe.com
                    Tel. 7.985.103.47.27
Innovative Ventures Inc. Moscow, Russia
                                            Haslett, MI USA
  26/28 June 2007          www.IVIpe.com
                           Info@IVIpe.com
Back-up Slides Follow




26/28 June 2007         www.IVIpe.com
                        Info@IVIpe.com
Best Practices

   Factors of                   Best Practice
     Success
Engaged             Institutes engaged in econ dev
Institutes with    & committed to tech transfer
Active
                     Have mechanism for tech
Leadership
                   commercialization




26/28 June 2007       www.IVIpe.com
                      Info@IVIpe.com
Best Practices
      Factors of                 Best Practice
       Success

Capital is            Programs for
Available           commercialization, pre-seed, &
                    seed financing gaps (help
                    establish & build SMEs)

                     Active informal angel networks

                     Investors include private & and
                    public entities

26/28 June 2007       www.IVIpe.com
                      Info@IVIpe.com
Best Practices
   Factors of                   Best Practice
    Success
Discretionary        Receive significant federal
R&D Funding        funding

                     Centers serve as anchors for a
                   region’s bioscience base




26/28 June 2007      www.IVIpe.com
                     Info@IVIpe.com
Best Practices
   Factors of                  Best Practice
    Success
Talent Pool          Talent is the #1 the variable
                   to build comparative advantage

                     Educational institutions
                   responsive to training students
                   to meet the needs for workers
                   at all skill levels, e.g.,
                   scientists, technicians, &
                   production workers


 26/28 June 2007        www.IVIpe.com
                        Info@IVIpe.com
Best Practices
    Factors of                   Best Practice
      Success
 Specialized         Leading bioscience regions
 Facilities and    have private markets that
 Equipment         provide facilities for bioscience
                   SMEs

                     Specialized bioscience
                   incubators and research parks
                   are a growing trend

                    Access to specialized facilities
                   and equipment
26/28 June 2007      www.IVIpe.com
                     Info@IVIpe.com
Best Practices
  Factors of         Best Practice States/Regions
    Success
Patience and        Building a critical mass takes
Long-term         years or even decades
Perspective
                   Early technology pioneers took
                  25 years, now 12 to 14 years to
                  mature




26/28 June 2007        www.IVIpe.com
                       Info@IVIpe.com

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Scaling Up Innovation with Clusters & VC Capital

  • 1. Clusters & (VC) Capital: Scaling Up for Innovation Russia/BII US State Dept: Biotech for Regional Development Kirov Russia, 26/28 June 2007 Innovative Ventures Inc. Haslett, MI. USA Moscow, Russia Thomas Nastas President Tom@IVIpe.com www.IVIpe.com 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 2. Clusters & (VC) Capital: Scaling Up for Innovation 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 3. Today’s Message 1. What’s Happening in the Market? The Good & the Bad Issues: $ & Deal Flow, Other? 2. GoForward Plan to Spur More $$ Strategies & Structures Boosting Quality/Quantity of Deals How Do Supply Chain Needs as Clusters Fit into the Picture? 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 4. IVI History-Direct Invest & Advisory Canada (1992) Europe (1992/94) C$100MM-Canadian TP Fund, $10MM- Bus. Dev. Bank EU, $-Financière St Dominique, Paris USA (1986) Russia (1997) The Michigan Product HP LP, $30MM-EBRD & Dev. Fund ($5MM) USAID Africa (1993/96) E. Africa $5MM, Sub- Saharan, $200MM, South Africa,$30MM, IFC/WB 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 5. IVI in Russia & Russian Tech 1997: Transact Russian VC Deals-Infrastructure 2001: IVI’s Russian Technology Investment Forum (2 day biz plan comp, 35 top IT SMEs) & VC Workshop (2 days; education/trainings-presentations & elevator pitch) 2002: Russian Tech for Oil/Gas (e.g., SLB), IT, Biotech, Medical, Homeland Security (Global) 2004: Partnership with Shell (STV/GameChanger) • ‘Snapshot’ the mkt, invest in Gamechanging tech for global mkts & start a relationship to build a portfolio • Member, Russian Tech Tour Committee (biz plan) 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 6. Successes in the Market Since 2001 PBC Lasers & Wostec Multinationals w/R&D Labs in Russia 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 7. Some Clouds Too: Learning Curve Lessons Optiva ($49M) liquidates: Nanotech's 1st big flame-out Startup doctors ease portfolio pain-Trustworks ($23M) Cybiko Ceases Operations Not Seeing Entrepreneurial SME Creation from MNC R&D Labs Multinationals w/R&D Labs in Russia 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 8. Realities of VC Equity is a Great Product, but: 1. It’s Expensive (% ownership) 2. Very Selective-1/100 SMEs (in the USA) seeking VC receive $$$-High Risk/High Return Sales $ Need Big Markets ($50-$100MM) People (Technical, Mkting, Mgt, Support, etc.) 3. Requires Access to Liquidity (Capital Mkts &/or Strategic Buyers, Domestic or Foreign) 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 9. Realities of VC (Emerging Mkts) 1/200 SMEs seeking VC in emerging markets receive $$$ Reasons, high rejection rates: Undeveloped Opportunity Lack of Uniqueness/No Competitive Advantage Too much $$$, too much time & too little reward People (mgt/employees) Lack of Transparency, No Clear Title/Ownership of IP What to do with the SMEs that are rejected? Ignore? Sympathize? Seek New Solutions? 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 10. What’s Working Against Early Stage Tech & VC in Russia Plenty of $: It’s Competition: Domestic Growth, FMCC, F&B, Retailing, Financial Services, Media, etc. Keeps Entrepreneurs in Non-Tech From Other Asset Classes w/Quicker & > Profits, e.g., Stocks & Real Estate From Israel, Ireland, USA, etc., with Good Deals, Technologies, Entrepreneurs & Successes 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 11. Russian Tech for Global Mkts: Alternative Strategy? ? 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 12. GoForward Plan: Action Item #1 1. Invest in Tech for Domestic Mkt Link w/Corporates: User Pull, Testing, Deployment & Commercialization Solve Tech & Supply Chain Needs Don’t Worry about Small Volumes Build Locally, Upgrade Later for National & Int’l Expansion 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 13. Possibilities for Investment: Build the Supply Chain Research, Testing, & Agricultural Medical Devices Drugs & Hospitals Medical Laboratories Feedstock & Chemicals Pharmaceuticals & Equipment Agricultural Medicinal & Laboratory Specialty Biological processing botanicals apparatus & hospitals research furniture Basic organic Pharma- University Commercial chemicals ceutical Surgical, medical medical preparations medical, dental, research research Ethyl alcohol ophthalmic hospitals mfg. Diagnostic Testing & analytical substances Clinical laboratories Organic fiber instruments & research mfg. equipment Biological Medical institutions products laboratories & Fertilizers Irradiation diagnostic apparatus & Pesticides and imaging electromedical other agricultural centers chemicals equipment Product-Oriented www.IVIpe.com Service-Oriented 26/28 June 2007 Info@IVIpe.com
  • 14. Where’s the Customer Pain (Need) in the Industry? 1. MORE Perf, Execution & Cost Reduction Not GameChangers; blocking/tackling tech so customers meet business plan 2. MORE Local Content More Value-added Tech Tech Sold to Multiple Customers Generate Supplier Sustainability thru Multiple Products/Services 3. What Else? 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 15. GoForward Plan: Action Item #2 1. Invest in Tech: the Domestic Market 2. Capitalize a ‘Mini-Grant’ Program Define biz opts for a technology Cost is US$3,000-US$10,000/technology Not a biz plan, but 3-4 document on tech’s potential 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 16. GoForward Plan: Action Item #3 1. Invest in Tech: the Domestic Market 2. Capitalize a ‘Mini-Grant’ Program 3. Create ‘ Tech Proof of Concept’ Fund Transform ideas = deals Generate data to confirm performance, show weaknesses vs. competition & alternatives. Benchmarket to int’l standards 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 17. GoForward Plan: Action Item #4 1. Invest in Tech: the Domestic Market 2. Capitalize a ‘Mini-Grant’ Program 3. Create ‘ Tech Proof of Concept’ Fund 4. Inventory Your Tech & Publish as a Database on the Internet 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 18. GoForward Plan: Action Item #4 4. Inventory Your Tech & Publish as a Database on the Internet Org by tech, product & mkt Benefits by cost & performance Stage of dev., R&D, PD, Testing, Plan w/Timetable, milestones, budgets IP issued/filed & competing IP 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 19. GoForward Plan: Action Item #5 5. Establish a Biz Dev Office Scouts for Opts in SMEs & Institutes Develops projects for ‘Mini-Grant’ & ‘Proof of Concept’ Funds Sells to Customers Keeps the Team Focused. Align Interests Sell Data or Provide Answers? Incentives: Cash/Salary or Equity? Transparent or Opaque? Responsive or Egocentric? 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 20. GoForward Plan: Action Item #6 6.Create an IP Fund Fund costs of Filing IP, especially Int’l Pay-back as a Royalty on Sales Funded by Russian Gov’t Initiative/PPP 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 21. GoForward Plan: Action Item #7 6. Organize R&D & Supply Chain Competitions for Users of Tech Go After Corporates & Corporate Investors vs. Financial Investors Interaction between R&D developers & Corporations & Corporate VC Corporations fund R&D, guide development & access opts in the supply chain Lower dev risk & get to market quickly Establish Industry Consortiums 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 22. Concluding Thoughts New Zealand is a Fitting Example of Success Not Emerging Market, but Small & Remote 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 23. Technology In Many Places! Just Look & Define Slaughter Raising Genetic Engineering & Breeding Butcher Distribution, Storage & Retail Locations Processing- Ham, Kielbasa Delivery 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 24. Thomas D. Nastas Tom@IVIpe.com www.IVIpe.com Tel. 7.985.103.47.27 Innovative Ventures Inc. Moscow, Russia Haslett, MI USA 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 25. Back-up Slides Follow 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 26. Best Practices Factors of Best Practice Success Engaged Institutes engaged in econ dev Institutes with & committed to tech transfer Active Have mechanism for tech Leadership commercialization 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 27. Best Practices Factors of Best Practice Success Capital is Programs for Available commercialization, pre-seed, & seed financing gaps (help establish & build SMEs) Active informal angel networks Investors include private & and public entities 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 28. Best Practices Factors of Best Practice Success Discretionary Receive significant federal R&D Funding funding Centers serve as anchors for a region’s bioscience base 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 29. Best Practices Factors of Best Practice Success Talent Pool Talent is the #1 the variable to build comparative advantage Educational institutions responsive to training students to meet the needs for workers at all skill levels, e.g., scientists, technicians, & production workers 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 30. Best Practices Factors of Best Practice Success Specialized Leading bioscience regions Facilities and have private markets that Equipment provide facilities for bioscience SMEs Specialized bioscience incubators and research parks are a growing trend Access to specialized facilities and equipment 26/28 June 2007 www.IVIpe.com Info@IVIpe.com
  • 31. Best Practices Factors of Best Practice States/Regions Success Patience and Building a critical mass takes Long-term years or even decades Perspective Early technology pioneers took 25 years, now 12 to 14 years to mature 26/28 June 2007 www.IVIpe.com Info@IVIpe.com