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An Introduction to  The World  Of ONCOLOGY By Emad Shash Medical Oncology Department National Cancer Institute  Cairo University
Origin of the Word Cancer ,[object Object],[object Object],[object Object],[object Object],[object Object],The History of Cancer, Lisa Fayed, About.com July,2008
The First Documented Case of Cancer ,[object Object],[object Object],[object Object],[object Object],The History of Cancer, Lisa Fayed, About.com July,2008
Ebers Papyrus  treatment for cancer: recounting a " tumor  against the god Xenus", it recommends "do nothing there against" Ancient Egyptian medical instruments depicted in a  Ptolemaic period  inscription on the  Temple of Kom Ombo . http://en.wikipedia.org/wiki/Ancient_Egyptian_medicine
What Early Physicians Thought Caused Cancer ,[object Object],[object Object],[object Object],The History of Cancer, Lisa Fayed, About.com July,2008
The Birth of the Pathological Autopsy ,[object Object],[object Object],[object Object],[object Object],The History of Cancer, Lisa Fayed, About.com July,2008
Cancer Staging
What is staging?  ,[object Object],[object Object],[object Object],[object Object],[object Object]
What is the basis for staging?  ,[object Object],[object Object],[object Object],[object Object],[object Object]
Cancer develops in stages
Colon Cancer Progression
What are the common elements of staging systems?  ,[object Object],[object Object],[object Object],[object Object],[object Object],*Information about tumor  grade  is available in the NCI fact sheet  Tumor Grade: Questions and Answers , which can be found at  http://www.cancer.gov/cancertopics/factsheet/Detection/tumor-grade  on the Internet.
What is the TNM system?  ,[object Object],[object Object],[object Object],[object Object]
TNM system ,[object Object],[object Object],[object Object],[object Object],[object Object]
TNM system ,[object Object],[object Object],[object Object],[object Object]
TNM system ,[object Object],[object Object],[object Object],[object Object]
TNM combinations correspond to one of five stages Stage Definition Stage 0 Carcinoma in situ (early cancer that is present only in the layer of cells in which it began). Stage I, Stage II, and Stage III Higher numbers indicate more extensive disease: greater tumor size, and/or spread of the cancer to nearby lymph nodes and/or organs adjacent to the primary tumor. Stage IV The cancer has spread to another organ.
Impact of staging on survival Data from Centre François Baclesse (Breast cancer patients survival) www.oncoprof.net
Impact of staging on survival Data from Centre François Baclesse (Breast cancer patients survival) www.oncoprof.net
Are all cancers staged with TNM classifications?  ,[object Object],[object Object],[object Object],[object Object]
NCI’s Surveillance, Epidemiology, and End Results Program (SEER) ,[object Object],[object Object],[object Object],[object Object],[object Object]
What types of tests are used to determine stage?  ,[object Object],[object Object],[object Object],[object Object],[object Object]
What types of tests are used to determine stage? ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cancer treatment
Modalities of treatment ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
SURGERY
Surgery ,[object Object],[object Object],[object Object]
Selected Historical Milestones in Surgical Oncology Year Surgeon Event 1809 Ephraim McDowell Elective abdominal surgery (excised ovarian tumor) 1846 John Collins Warren Use of ether anesthesia (excised submaxillary gland) 1867 Joseph Lister Introduction of antisepsis 1860-1890 Albert Theodore Billroth First gastrectomy, laryngectomy, and esophagectomy 1878 Richard von Volkmann Excision of cancerous rectum Year Surgeon Event 1880s Theodore Kocher Development of thyroid surgery 1890 William Stewart Halsted Radical mastectomy 1906 Ernest Wertheim Radical hysterectomy 1910-1930 Harvey Cushing Development of surgery for brain tumors 1935 A. O. Whipple Pancreaticoduodenectomy
Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object]
Surgery for prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Determinants of Operative Risk ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation therapy
Radiation therapy ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Radiation therapy ,[object Object],[object Object]
Radiation therapy ,[object Object],[object Object],[object Object]
Complication of radiation ,[object Object],[object Object],[object Object],[object Object]
NUCLEAR MEDICINE
Radionuclides ,[object Object],[object Object],[object Object],[object Object]
CHEMOTHERAPY
Chemotherapy ,[object Object],[object Object],[object Object]
Classification of cytotoxic drug ,[object Object]
Cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]
Chemotherapeutic agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complication of Chemotherapy ,[object Object],[object Object],[object Object],[object Object],[object Object]
Criteria used to describe response are ,[object Object],[object Object],[object Object],[object Object]
Please check the following web sites ,[object Object],[object Object],[object Object],[object Object],[object Object]
THANK YOU

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Introduction to the world of oncology

  • 1. An Introduction to The World Of ONCOLOGY By Emad Shash Medical Oncology Department National Cancer Institute Cairo University
  • 2.
  • 3.
  • 4. Ebers Papyrus treatment for cancer: recounting a " tumor against the god Xenus", it recommends "do nothing there against" Ancient Egyptian medical instruments depicted in a Ptolemaic period inscription on the Temple of Kom Ombo . http://en.wikipedia.org/wiki/Ancient_Egyptian_medicine
  • 5.
  • 6.
  • 8.
  • 9.
  • 12.
  • 13.
  • 14.
  • 15.
  • 16.
  • 17. TNM combinations correspond to one of five stages Stage Definition Stage 0 Carcinoma in situ (early cancer that is present only in the layer of cells in which it began). Stage I, Stage II, and Stage III Higher numbers indicate more extensive disease: greater tumor size, and/or spread of the cancer to nearby lymph nodes and/or organs adjacent to the primary tumor. Stage IV The cancer has spread to another organ.
  • 18. Impact of staging on survival Data from Centre François Baclesse (Breast cancer patients survival) www.oncoprof.net
  • 19. Impact of staging on survival Data from Centre François Baclesse (Breast cancer patients survival) www.oncoprof.net
  • 20.
  • 21.
  • 22.
  • 23.
  • 25.
  • 27.
  • 28. Selected Historical Milestones in Surgical Oncology Year Surgeon Event 1809 Ephraim McDowell Elective abdominal surgery (excised ovarian tumor) 1846 John Collins Warren Use of ether anesthesia (excised submaxillary gland) 1867 Joseph Lister Introduction of antisepsis 1860-1890 Albert Theodore Billroth First gastrectomy, laryngectomy, and esophagectomy 1878 Richard von Volkmann Excision of cancerous rectum Year Surgeon Event 1880s Theodore Kocher Development of thyroid surgery 1890 William Stewart Halsted Radical mastectomy 1906 Ernest Wertheim Radical hysterectomy 1910-1930 Harvey Cushing Development of surgery for brain tumors 1935 A. O. Whipple Pancreaticoduodenectomy
  • 29.
  • 30.
  • 31.
  • 33.
  • 34.
  • 35.
  • 36.
  • 38.
  • 40.
  • 41.
  • 42.
  • 43.
  • 44.
  • 45.
  • 46.