Interlukins and post coronary artery bypass delirium in icu

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The document presents research on the correlation between serum interleukins 6 and 10 and delirium in intensive care patients following coronary artery bypass surgery. The study included 20 patients who developed delirium after CABG surgery. Blood samples were taken before, during, and after delirium episodes to analyze interleukin levels. The results showed interleukin 6 levels were higher during delirium compared to after, and higher still for those with hyperactive delirium. Interleukin 10 levels did not differ between delirious and post-delirious periods. The conclusion is that interleukin 6 may contribute to post-CABG delirium pathogenesis, especially for hyperactive behavior, but interleukin 10 does not correlate with delirium.

Presented by : Mansoor Masjedi MD
Ass. Prof. of anesthesia , Critical care consultant
Shiraz university of medical sciences ,Iran
Milan , Italy - October , 2016

Interleukins and post coronary artery bypass delirium in intensive care unit
S.H. Akhlagh , M. Masjedi , K. Hozhabri , E. Kamali
INTRODUCTION
 Delirium is a common Complication in elderly pts after Cardiac surgery.
 The pathophysiology of delirium remains poorly understood.
 Several conditions associated with delirium are characterized by
activation of inflammatory Cascade.

OBJECTIVE
The purpose of this study was to find out
the correlation between serum interleukins 6 and 10 with
delirium in intensive care unit
following coronary artery bypass surgery
Interleukins and post coronary artery bypass delirium in intensive care unit
S.H. Akhlagh , M. Masjedi , K. Hozhabri , E. Kamali

METHODS
• In an exploratory observational study we included 20 pts with delirium
that has undergone coronary artery bypass surgery (CABG) .
• Serum samples were taken, postoperatively, before, during and after
development of delirium in cardiac intensive care unit .
• Delirium was diagnosed by Confusion Assessment Method- ICU
(CAM- ICU).
• IL6 and IL10 were determined by Enzyme Linked Immunosorbent Assay.
Interleukins and post coronary artery bypass delirium in intensive care unit
S.H. Akhlagh , M. Masjedi , K. Hozhabri , E. Kamali

RESULTS
 Delirium was detected in 20 of 380 pts (5.2%) admitted in
cardiac ICU during a 17 month period.
 In delirious pts, Plasma IL6 Level were higher in delirious stage
than post delirium period ( p = 0.002 ) .
 Pts with the hyperactive Subtype of delirium had higher IL6 Levels in
delirious stage than post delirium period (p=0.009).
 There was no difference in Serum IL10 levels in delirious and post
delirious period.
Interleukins and post coronary artery bypass delirium in intensive care unit
S.H. Akhlagh , M. Masjedi , K. Hozhabri , E. Kamali

CONCLUSIONS
 Interleukin 6 may contribute to the pathogenesis of post coronary
artery bypass delirium.
 Its role is more prominent in the hyperactive behavior of delirium.
 No correlation was found between serum interleukin10 & delirium.
 Further studies are needed to elucidate the relationship of other
cytokines with the pathogenesis of delirium.
Interleukins and post coronary artery bypass delirium in intensive care unit
S.H. Akhlagh , M. Masjedi , K. Hozhabri , E. Kamali

Thanks for your attention & hope to see you in Shiraz - Iran

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