This study investigated the efficacy of Interactive Spaced Education (ISE) for teaching physical examination skills to medical students. 170 second-year students were randomly assigned to receive ISE via daily emails over 3 cycles or act as a control. ISE combined spaced repetition with self-testing. Students receiving ISE showed an average retention improvement of 7.9% after the first cycle and 74.4% after the third cycle compared to controls. Students found ISE to be an effective and acceptable learning method and recommended continuing the program. However, the study was limited by being conducted at a single institution and only assessing physical exam knowledge rather than skills.