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Insulin & Its Metabolic Effect
Dr. Sara Sadiq
MBBS, M.Phil
Insulin release
• ↑ Blood glucose (hyperglycemia)
• ↑ Plasma amino acids (lysine, arginine)
• Diet
• Vagus stimulation: acetylcholine
• GIP and GLP-1 (glucagon-like peptide I)
Insulin Inhibition
• Somatostatin
• Catecholamines
• Fasting
• Exercise
Mechanism of Insulin Action
Actions of Insulin
• Metabolic effect
• Ion transport
• Role in cell growth and development
Metabolic Effect
1. Carbohydrate Metabolism
Metabolic Effect
2. Lipid Metabolism
Increase Lipogenesis
Decrease Lipolysis
Reduce ketogenesis
Metabolic Effect
3. Protein Metabolism
Stimulate protein synthesis by increasing transport into cell
Inhibit Proteolysis
Role in Cell Growth & Development
• Anabolic action
• Direct stimulatory effect on macromolecules
 cartilage & bone
• Stimulation of other growth factors
 Somatomedins (IGF 1&2),
 Epidermal growth
Ion Transport
• Increase K+ uptake
• Causes hypokalemia
↑Insulin
•  Glucose
•  Amino acids
•  FFA
•  Ketoacids
↑ Glucose transport, FFA transport, Amino acids transport
↑ Cell growth (RNA, DNA and protein synthesis),
Differentiation
Insulin & its metabolic effect

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Insulin & its metabolic effect