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Glycogen and Athletic Performance 
Richard A. Wang, MPH 
NuLiv Science USA Inc 
It is well known that prolonged and sustained high intensity exercise causes glycogen depletion in 
individuals. As a result, the macro nutrient intake for active persons and athletes must be dramatically 
different from those who are sedentary. This article will provide a brief overview of glycogen and the 
functions it serves, as well as how it affects endurance and exercise performance. Using recent literature 
and research as a reference, glycogen intake recommendations for athletes will also be discussed. 
Put simply, glycogen is a polysaccharide of glucose. Glucose is obtained through the breakdown of 
simple and complex carbohydrates such as corn, sugar, wheat and vegetables. Because of its availability, 
glucose is one of the main sources of energy for the body. Glycogen is a much more space-efficient form 
of glucose, therefore it is stored primarily in the liver and muscle cells. When performing high-intensity 
exercise, your body uses these glycogen stores for energy first then starts burning triglycerides 
(fats/lipids). It is estimated that glycogen concentration is around 1-2% in most individuals, although this 
concentration can be increased through physical training. Increasing glycogen concentration allows 
athletes to increase muscular endurance and performance. 
By adjusting the frequency, amount and timing of carbohydrate intake, athletes can prevent glycogen 
depletion and increase their endurance. For athletes performing long duration events such as marathon 
runners and cyclists, the technique of supercompensation has been proved beneficial. 
Supercompensation involves “swelling” muscle glycogen by changing diet and exercise patterns several 
days before a major competitive event. Currently, there are two methods that can be use to accomplish 
this: depletion/repletion, and the modified moderate approach. 
The depletion/repletion approach involves depleting glycogen reserves as much as possible using a low 
carbohydrate diet in combination with long bouts of exercise about 7-10 days prior to competition. On 
the third day, carbohydrate intake is increased and studies have shown that glycogen stores can be 
increased by as much as 50%. The modified moderate approach is a little less extreme – carbohydrates 
are increased while training is tapered. This can lead to increases in glycogen storage of around 20%. 
Glycogen depletion training works well for athletes who compete in one-time long distance events, but 
is not recommended for those who perform consecutive competitions. For these athletes, proper 
manipulation of carbohydrate availability before, during, and after training is very important. Most 
strength and performance coaches advise that athletes should consume a high carbohydrate meal 3-5 
hours before physical activity. This will increase liver and muscle glycogen stores that are decreased 
after an overnight fast. It is estimated that 50% of liver glycogen is decreased after an hour of exercise at 
75% V02 max.
Carbohydrate consumption during exercise that lasts longer than 45 minutes can also improve 
performance. This helps athletes maintain blood glucose levels, spare liver glycogen, and increase their 
motor skills. Most athletes prefer to ingest simple carbohydrates by drinking sports drinks, eating 
granola bars or bananas. 
Replenishing glycogen stores after exercise is extremely important. The rate of glycogen synthesis 
depends on glucose transport to the muscle and the enzymes involved in glycogen synthesis. To 
optimize glycogen synthesis, carbohydrates should be ingested within two hours of high intensity 
exercise. Ideally, you should consume 0.7-1.0 grams of carbohydrates per kg every two hours. These 
carbohydrates should be complex – rice, vegetables, oatmeal, quinoa, etc. 
Supplementing with intra & post recovery products may also aid in glycogen storage and enhanced 
sports performance. ActiGin has proven in a human clinical (pending publication in peer reviewed 
journal) to activate more glycogen synthesis in muscle tissue, enabling prolonged peak endurance. 
In conclusion, an athlete’s carbohydrate and glycogen storage can have a huge effect on their endurance 
and performance. By modifying and adjusting carbohydrate levels, the optimal diet for athletes can be 
achieved and their training will surely benefit. 
References: 
Berardi, J.M., et al (2006) Postexercise Muscle Glycogen Recovery Enhanced with a Carbohydrate - 
Protein Supplement. Medicine and Science in Sports and Exercise. 38(6): 1106-13 
Hawley, J.A. (2014) Manipulating Carbohydrate Availability to Promote Training Adaptation. Sport 
Science Exchange. 27(134): 1-7 
Rapoport B.L. (2010) Metabolic Factors Limiting Performance in Marathon Runners. PLoS Comput Biol 
6(10): e1000960. doi:10.1371/journal.pcbi.1000960 
Rodriguez, N.R., et al. (2010). Nutrition and Athletic Performance. Web arti cle [accessed on October 15 
2014]

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Glycogen and athletic performance

  • 1. Glycogen and Athletic Performance Richard A. Wang, MPH NuLiv Science USA Inc It is well known that prolonged and sustained high intensity exercise causes glycogen depletion in individuals. As a result, the macro nutrient intake for active persons and athletes must be dramatically different from those who are sedentary. This article will provide a brief overview of glycogen and the functions it serves, as well as how it affects endurance and exercise performance. Using recent literature and research as a reference, glycogen intake recommendations for athletes will also be discussed. Put simply, glycogen is a polysaccharide of glucose. Glucose is obtained through the breakdown of simple and complex carbohydrates such as corn, sugar, wheat and vegetables. Because of its availability, glucose is one of the main sources of energy for the body. Glycogen is a much more space-efficient form of glucose, therefore it is stored primarily in the liver and muscle cells. When performing high-intensity exercise, your body uses these glycogen stores for energy first then starts burning triglycerides (fats/lipids). It is estimated that glycogen concentration is around 1-2% in most individuals, although this concentration can be increased through physical training. Increasing glycogen concentration allows athletes to increase muscular endurance and performance. By adjusting the frequency, amount and timing of carbohydrate intake, athletes can prevent glycogen depletion and increase their endurance. For athletes performing long duration events such as marathon runners and cyclists, the technique of supercompensation has been proved beneficial. Supercompensation involves “swelling” muscle glycogen by changing diet and exercise patterns several days before a major competitive event. Currently, there are two methods that can be use to accomplish this: depletion/repletion, and the modified moderate approach. The depletion/repletion approach involves depleting glycogen reserves as much as possible using a low carbohydrate diet in combination with long bouts of exercise about 7-10 days prior to competition. On the third day, carbohydrate intake is increased and studies have shown that glycogen stores can be increased by as much as 50%. The modified moderate approach is a little less extreme – carbohydrates are increased while training is tapered. This can lead to increases in glycogen storage of around 20%. Glycogen depletion training works well for athletes who compete in one-time long distance events, but is not recommended for those who perform consecutive competitions. For these athletes, proper manipulation of carbohydrate availability before, during, and after training is very important. Most strength and performance coaches advise that athletes should consume a high carbohydrate meal 3-5 hours before physical activity. This will increase liver and muscle glycogen stores that are decreased after an overnight fast. It is estimated that 50% of liver glycogen is decreased after an hour of exercise at 75% V02 max.
  • 2. Carbohydrate consumption during exercise that lasts longer than 45 minutes can also improve performance. This helps athletes maintain blood glucose levels, spare liver glycogen, and increase their motor skills. Most athletes prefer to ingest simple carbohydrates by drinking sports drinks, eating granola bars or bananas. Replenishing glycogen stores after exercise is extremely important. The rate of glycogen synthesis depends on glucose transport to the muscle and the enzymes involved in glycogen synthesis. To optimize glycogen synthesis, carbohydrates should be ingested within two hours of high intensity exercise. Ideally, you should consume 0.7-1.0 grams of carbohydrates per kg every two hours. These carbohydrates should be complex – rice, vegetables, oatmeal, quinoa, etc. Supplementing with intra & post recovery products may also aid in glycogen storage and enhanced sports performance. ActiGin has proven in a human clinical (pending publication in peer reviewed journal) to activate more glycogen synthesis in muscle tissue, enabling prolonged peak endurance. In conclusion, an athlete’s carbohydrate and glycogen storage can have a huge effect on their endurance and performance. By modifying and adjusting carbohydrate levels, the optimal diet for athletes can be achieved and their training will surely benefit. References: Berardi, J.M., et al (2006) Postexercise Muscle Glycogen Recovery Enhanced with a Carbohydrate - Protein Supplement. Medicine and Science in Sports and Exercise. 38(6): 1106-13 Hawley, J.A. (2014) Manipulating Carbohydrate Availability to Promote Training Adaptation. Sport Science Exchange. 27(134): 1-7 Rapoport B.L. (2010) Metabolic Factors Limiting Performance in Marathon Runners. PLoS Comput Biol 6(10): e1000960. doi:10.1371/journal.pcbi.1000960 Rodriguez, N.R., et al. (2010). Nutrition and Athletic Performance. Web arti cle [accessed on October 15 2014]