Indoor environments contribute significantly to total human exposure to air pollutants, as people spend most of their time indoors. Indoor air quality is influenced by: penetrating outdoor air; specific indoor pollution sources; interactions between building system/construction techniques; and occupants.
The presentation is based on interior landscaping and it's importance in the 21st century. The presentation is based on the interior construction of Stepping Park House, Ho Chi Minh City, Vietnam.
The presentation is based on interior landscaping and it's importance in the 21st century. The presentation is based on the interior construction of Stepping Park House, Ho Chi Minh City, Vietnam.
The systematic investigation of a facility to determine the success or failure of one
or more design elements within the project to be performed by a third-party
evaluate after the user has occupied the facility.
Ravikant kapil is working for Manomav engineers,In this presentation he outlined the Mechanical services,Electrical services,Plumbing services and MEP coordination..
Natural ventilation is the process of supplying and removing air through an indoor space by natural means, meaning without the use of a fan or other mechanical system. It uses outdoor air flow caused by pressure differences between the building and its surrounding to provide ventilation and space cooling.
Green building rating system equire an integrated design process to create projects that are environmentally responsible and resource-efficient throughout a building's life-cycle: from siting to design, construction, operation, maintenance, renovation, and demolition
The presentation shows the various measures to calculate the thermal comfort in buildings from ASHRAE to IMAC and also provides low energy methods to improve thermal comfort.
Improved lighting can help the UK’s ageing population enjoy their lives, improve their health and avoid some of distressing conditions of old age. Lighting solutions and technologies are often more cost-effective than drug-based treatments. You will see through this presentation how well-designed lighting can lead to improved health and alertness – and how we might push the issue up the health agenda.
Talk by Carl Gardner, CSG Lighting Consultancy Ltd
The systematic investigation of a facility to determine the success or failure of one
or more design elements within the project to be performed by a third-party
evaluate after the user has occupied the facility.
Ravikant kapil is working for Manomav engineers,In this presentation he outlined the Mechanical services,Electrical services,Plumbing services and MEP coordination..
Natural ventilation is the process of supplying and removing air through an indoor space by natural means, meaning without the use of a fan or other mechanical system. It uses outdoor air flow caused by pressure differences between the building and its surrounding to provide ventilation and space cooling.
Green building rating system equire an integrated design process to create projects that are environmentally responsible and resource-efficient throughout a building's life-cycle: from siting to design, construction, operation, maintenance, renovation, and demolition
The presentation shows the various measures to calculate the thermal comfort in buildings from ASHRAE to IMAC and also provides low energy methods to improve thermal comfort.
Improved lighting can help the UK’s ageing population enjoy their lives, improve their health and avoid some of distressing conditions of old age. Lighting solutions and technologies are often more cost-effective than drug-based treatments. You will see through this presentation how well-designed lighting can lead to improved health and alertness – and how we might push the issue up the health agenda.
Talk by Carl Gardner, CSG Lighting Consultancy Ltd
Blue Pure Air Purifier has a 360-degree air intake, Cleans your air fully 5 times an hour, 1 button activation, Largest filter area of any mobile purifier!
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Education Series: Reference Guide for Home Health CareCaringHomeCare
Caring Home Care and SurfMed present an education series aimed at understanding the disease process and home health tips. This presentation includes topics related to diabetes, cardiac diseases, COPD, basic home safety, medication management, personal emergency response and more!
Vishal kumar ,B.Sc-ID+ 2 Year Residential & Commercial Design Diplomadezyneecole
This Project has been Developed by the Student of Dezyne E'cole College Doing His Interior Design Studies Bachelor Degree Programme + 2Yr Residential & Commercial Design Diploma Programme www.dezyneecole.com
LIGHTING for use in the course INTERIOR DESIGN
This presentation helps to create a beautiful lighting design in Interior Residential project. Hope it helps you to understand about the different types of lighting and its proper placements.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
2. What is good indoor environmental quality?
• Indoor Environmental Quality (IEQ) is most simply described as the
conditions inside the building. It includes air quality, but also access
to daylight and views, pleasant acoustic conditions, and occupant
control over lighting and thermal comfort.
INDOOR ENVIRONMENT
• The main indoor physical environmental parameters relate to temperature,
relative humidity, lighting and noise.
3. LIGHTING
• Lighting can make the difference between seeing and not
seeing for older adults with deteriorating vision.
• Home designers, architects, and builders can improve the
quality of life of older adults by understanding how
lighting compensates for the changes that commonly occur
in aging eyes.
4. Designing lighting for the
elderly
It requires special consideration and care from architects and
lighting designers. As people age, they experience neural
degeneration in the retina.
Less light reaches the back of the eyes because the pupils decrease
in size as you age, the lens inside eye becomes thicker, and the lens
scatters lighter, causing objects and colors to appear less vivid.
5. What can we do to make lighting more effective for older adults?
• Increase ambient light levels – Less light reaches
the retina of the older eye. The light levels in living
environments used by older adults should be
increased by at least 50% over those comfortable for
younger people. In general, ambient light levels
should be at least 300 lux (lx) [30 footcandles (fc)].
• Increase task area light levels - At least three times
more light will be required in task areas to see fine
details (e.g., reading prescriptions) or low contrast
objects (e.g., black thread on blue cloth). Light
levels on the task should be at least 1000 lx (100 fc).
• Minimize glare – Although more light is required
for the older eye to see well, care should be taken to
avoid glare. Glare is experienced when light sources
or bright reflections in the field of view impair
vision, or are simply uncomfortable.
• Increase contrast – Because contrast sensitivity is
reduced with age, the visibility of important objects,
such as stair edges, curbs, ramps, or doorways, can
be greatly improved by increasing their contrast with
paint or similar techniques.
• Balance illuminance levels – Because the older
visual system cannot completely adapt to dim
conditions, illuminance levels in transitional spaces,
such as hallways and entrance foyers, should be
balanced with those of the adjacent spaces.
• Improve color perception – Color discrimination is
poorer for older adults. High illuminance levels and
high-quality fluorescent lamps, rather than
conventional incandescent lamps, will help older
adults to see colors well.
6. Lighting rooms
Lighting Tips
• Increase light level
by placing luminaires
close to the task, or
by selecting lamps
with more lumens
(look for the lamp
lumen rating on the
package).
• Use light color
finishes on walls and
ceilings to soften the
effects of bright light
sources, and to
reduce shadows.
There are many ways to light rooms in the homes of older adults. Following are a
few examples of good lighting. Each section describes the lighting goals and
principles for a room, illustrates a lighting solution, and summarizes how solutions
can be applied to meet a client’s needs.
Living Room
Dining Room
Kitchen
Lighting Tips
• Place luminaires over
the sink, stove,
countertops, and other
fixed work areas.
Locate these luminaires
slightly to the side and
in front of the position
where a person would
stand to see the task.
• Avoid having only one
ceiling luminaire in the
center of the room that
casts a person’s shadow
onto the counter or sink
where he/she is
working.
Lighting Tips
•Avoid using clear
glass luminaires.
• When using extra
light on objects of
special interest, such
as pictures, vases,
etc., aim the lighting
at the object, away
from faces.
7. Bathroom
Lighting Tips
• In the bathroom, use a
wet-location-rated
shower light for good
visibility.
• Luminaires that are not
wet-location-rated should
be mounted at least 3 ft
away from the bathtub or
shower.
• Choose a matte
countertop vanity surface
with light colors to
reflect light to the
underside of your chin.
Lighting Tips
•Install light switches
with toggle that glow in
the dark. Place switches
near the bed. Wall
outlets should be
installed 18 to 24 in.
above the floor for easy
access.
• Use lamps with good
color properties in
closets to help color
matching of clothes.
Bedroom
8. • Planning lighting for the people with special needs requires due considerations like;
• Install evenly distributed non-glare lighting with appropriate foot-candle levels
specific to tasks by area.
• Electric switches should be simple switches, easy to operate, and it should be possible
to switch lights on and off from 2 or even 3 points to avoid walking in the dark.
• Three-way switches on lamps will allow for extra lighting when it is needed.
• Use night lights
• Use lighted cover plates
• Cover windows with a transparent or translucent material like sheers to filter natural
light and eliminate glare. Adjustable blinds, shades or transparent reflecting film also
can control glare.
• All storage areas should have lights controlled by wall
Specific Guidelines for people with special needs
9. • In kitchens, provide lighting over counters and the sink. Track lighting or fluorescent light
sticks that plug into electrical outlets can be added.
• Switches on table lamps should be easy to use. Twisting switches may be more difficult so
they should be avoided.
• Ensure the bedroom has various types of light. The elderly person must be able to see, but he
might also like to a have a bedside lamp if he likes to read. He should be able to turn the light
off without getting out of bed.
• Bathroom should have even lighting without glare and the light switch should be near the
entrance.
• Stairways and stair halls should be well lighted. Two-way switches located at top and bottom
of stairs and at both sides of the halls are essential.
• Lamps should be easy to switch on and off and should not have extension cords running
across walking paths.
• Provide circuit breakers or fuses to prevent electrical overload and the accidents and the fires
due to it.
• Electric cords should be placed along the walls and away from the traffic areas.
10. Older people more over-sensitive to sounds
• The study revealed that when young adults are in a loud environment – such as a rock concert
– their brains become less sensitive to relatively quiet sounds. This allows the listener to hear
the relevant sounds (like a guitar riff) better without being distracted by irrelevant sounds.
• However, as a person ages, researchers found that older listeners become over-sensitive to
sounds, hearing both quiet and loud sounds without the ability to ignore or tune out irrelevant
auditory information. Without the ability to reduce sensitivity to irrelevant sounds, the
individual experiences hearing challenges.
• “When the sound environment is loud, the brain activity in younger adults loses sensitivity to
really quiet sounds because they’re not that important,” Herrmann said. “Whereas older
individuals still stay sensitive to these relatively quiet sounds, even though they’re not
important at the time.”
Noise
11. The Environmental Noise Directive focuses on three action areas:
• the determination of exposure to environmental noise
• ensuring that information on environmental noise and its effects is made available to the
public
• preventing and reducing environmental noise where necessary and preserving environmental
noise quality where it is good
Noise
12. Room temperature and relative humidity in the home are greatly influenced by the weather outside.
They vary naturally with the changing seasons and depending on whether we leave doors and windows open; significant, constant
disruptions are not advisable, however.
Temperature and Humidity
The relative humidity, meanwhile, plays a
determining role in the quality of your
indoor air. Health Canada recommends
keeping the humidity above 30% in winter
and making sure it doesn’t exceed 55% in
summer (ideally, it should be somewhere
between those percent values at all times).
Excessively high humidity in the home
creates a favourable environment for mould
and dust mites —powerful allergens and
irritants that can lead to respiratory
problems like asthma.
Conversely, if the relative humidity is below
30%, the air is too dry:
1. This can cause irritation of the mucous
membranes of the nose and throat, and
breathing difficulties in at-risk individuals
(e.g., people with asthma).
2. Dry air is also harmful to people with skin
or eye conditions.
13. Heat exhaustion
• is a warning that your body can no longer keep itself
cool.
• You might feel thirsty, dizzy, weak, uncoordinated
• Rest in a cool place and get plenty of fluids.
• If you don’t feel better soon, get medical care.
• Be careful—heat exhaustion can progress to heat
stroke.
Heat cramps
• are the painful tightening of muscles in
your stomach, arms, or legs. Cramps
can result from hard work or exercise.
• Find a way to cool your body down.
Rest in the shade or in a cool building.
Drink plenty of fluids, but not those
with alcohol or caffeine.
Heat edema
• is a swelling in your ankles and feet when you get
hot. Put your legs up to help reduce swelling.
Heat syncope
• is a sudden dizziness that can happen when you
are active in hot weather.
• If you take a heart medication called a beta
blocker or are not used to hot weather, you are
even more likely to feel faint.
• Rest in a cool place, put your legs up, and drink
water to make the dizzy feeling go away.
Too much heat is not safe for anyone. It is even riskier if you are older or have
health problems. It is important to get relief from the heat quickly
14. What temperature is dangerous for elderly?
• A body temperature below 98.2 degrees Fahrenheit is considered abnormal,
and anything below 95 degrees Fahrenheit is a major cause for concern, as it
indicates a risk of hypothermia.
• Keep your home at a safe temperature to help maintain a healthy
body temperature.
What temperature is too hot for seniors?
• Older people can have a tough time dealing with heat and humidity. The
temperature inside or outside does not have to reach 100°F (38°C) to put
them at risk for a heat-related illness. Headache, confusion, dizziness, or
nausea could be a sign of a heat-related illness.
15. What Is The Ideal Room Temperature For An Elderly Person?
According to the NHS website, the temperature inside your home should not reach below
18°C if you are over 65 years old or have a health condition, such as heart or lung disease.
• It’s understandable why people would struggle to keep their homes warm during these
months though. AGE UK found that 80% aren’t aware what the ideal room temperatures are,
and according to a 2018 survey, more than a million elderly people fear they won’t be able to
pay their energy bills this winter.
• For family members or carers looking after an elderly person, it can be a great cause of
anxiety as well. Many carers struggle to know the best way forward when it comes to keeping
the person they are caring for both safe and warm.
16. Why Is Room Temperature Important?
An appropriate room temperature will allow individuals to maintain a healthy body
temperature.
While 98.6 degrees Fahrenheit is commonly referred to as a “normal” internal temp,
some variation is expected. Really, anything between 98.2 and 99.9 degrees can be
considered normal.
A body temperature below 98.2 degrees Fahrenheit is considered abnormal, and
anything below 95 degrees Fahrenheit is a major cause for concern, as it indicates a
risk of hypothermia.
Keep your home at a safe temperature to help maintain a healthy body temperature.
17. What Is Hypothermia?
Hypothermia can be defined as the state of having an abnormally low body temperature—
typically below 95 degrees Fahrenheit.
Generally associated with exposure to freezing water, hypothermia can set in quickly, without
warning. But it may not have anything to do with exposure to wind and rain. Among the
young and old, hypothermia can set in anytime, even in their relatively warm homes.
Dangerously low body temperatures can lead to serious health problems like heart attack,
organ damage, and even death. Keeping the thermostat set to a safe temperature, between 68
and 74 degrees Fahrenheit, is the easiest way to safeguard against hypothermia.
18. What Other Steps Should Elderly Adults Take to Stay Warm and Healthy?
Outside of adjusting room temperature, there are many ways elderly individuals and their
caregivers can safeguard against temperature-related health problems.
These include:
• If consuming alcohol, do so moderately. Alcoholic beverages can contribute to the loss of
body heat.
• Inspect the home’s insulation. Protect against drafts by adding door snakes or thermal
curtains throughout the house.
• Dress for the weather. Wear layers so you can adjust your outfit for any fluctuation in
temperature.
• Keep extra blankets on your bed, and wear warm pajamas to bed.
• Eat small meals frequently throughout the day to keep your energy up and help maintain a
healthy body temperature.
• Believe in the buddy system. Check in with elderly friends and family regularly, in person or
over the phone, to make sure their warm and safe throughout the winter.