Patients with traumatic brain injury (TBI) or spinal cord injury (SCI) have an increased risk of venous thromboembolism (VTE). The reported incidence of VTE in studies of TBI and SCI patients varies widely from 1-54% depending on factors like injury severity and use of prophylaxis. The true incidence is difficult to determine due to limitations of studies and many cases being asymptomatic. VTE risk is highest in the acute phase after injury.
Computerized scan findings and their correlation with outcome in patients wit...Amit Agrawal
CT scan has become the investigation of choice in traumatic brain injury patients . Because of its wide spread availability and ability to precisely detect and locate intracranial lesions
Intracranial aneurysms are rare in childhood. Approximately
0.5%–4.6% of intracranial aneurysms occur in patients 18
years of age or younger
Here is a case report.
Computerized scan findings and their correlation with outcome in patients wit...Amit Agrawal
CT scan has become the investigation of choice in traumatic brain injury patients . Because of its wide spread availability and ability to precisely detect and locate intracranial lesions
Intracranial aneurysms are rare in childhood. Approximately
0.5%–4.6% of intracranial aneurysms occur in patients 18
years of age or younger
Here is a case report.
Microsurgery for cerebral AVM, Theofanis et al, Neurosurg Focus, 2014Ersifa Fatimah
Microsurgery for cerebral AVM: postoperative outcomes & predictors of complications in 264 cases, by Theofanis et al, from Neurosurg Focus, 2014
--Topik journal reading-ku pas stase Neurosurgery..
Carotid Endarterectomy in Stroke Prevention UpdateDenise Crute
Neurocritical Care lecture on the role of carotid artery surgery in stroke prevention, reviewing the latest studies and evidence-based updates, along with neurosurgical techniques.
Keunikan anatomi small vessel of the brain dan neurovascular unit, kontroversi peran stganasi vena dalam patofisiologi, klasifikasi small vessel disease, variasi kriteria diagnostik, pitfall dalam neuroimaging, pilihan antiplatelet untuk prevensi sekundar, dampaknya bagi outcome pasien, hubungannya dengan gangguan fungsi kognitif.
Hmm, apa lagi nih yang baru?
Microsurgery for cerebral AVM, Theofanis et al, Neurosurg Focus, 2014Ersifa Fatimah
Microsurgery for cerebral AVM: postoperative outcomes & predictors of complications in 264 cases, by Theofanis et al, from Neurosurg Focus, 2014
--Topik journal reading-ku pas stase Neurosurgery..
Carotid Endarterectomy in Stroke Prevention UpdateDenise Crute
Neurocritical Care lecture on the role of carotid artery surgery in stroke prevention, reviewing the latest studies and evidence-based updates, along with neurosurgical techniques.
Keunikan anatomi small vessel of the brain dan neurovascular unit, kontroversi peran stganasi vena dalam patofisiologi, klasifikasi small vessel disease, variasi kriteria diagnostik, pitfall dalam neuroimaging, pilihan antiplatelet untuk prevensi sekundar, dampaknya bagi outcome pasien, hubungannya dengan gangguan fungsi kognitif.
Hmm, apa lagi nih yang baru?
Spinal Tumors: approach and managementAmit Agrawal
The spinal cord consists of
Central canal surrounded by an H-shaped gray matter region containing neurons
Outer myelinated nerve tracts, termed white matter, surround the central gray matter
Central canal is lined with ependymal cells
Astrocytes support gray matter neurons and white matter axons
To describe which are the common pathophysiological
features ofhead injury
To define the mechanisms of head injuries
Characteristic clinical and imaging findings
To define the management and outcome
Brain tumor surgery: challenges faced in rural set upAmit Agrawal
Management of brain tumours in developing countries displays a different perspective compared to developed nations
The disease is grossly advanced before the patient seeks treatment
Diagnosis as well as management requires minimum number of diagnostic tools
70% of RTA patients have head injury(HI).
One of the most important public health problems of today.
70% of deaths in RTA are due to HI.
At Risk population
Males 15-24
Infants
Young Children
Elderly
The interest in medical publication continues to grow each year
Provide the most reliable information for the management of our patients
The quality and number of publications is at the core of one’s reputation and promotion
Developing Acumen for Identification and Generation of Research Material and ...Amit Agrawal
The interest in medical publication continues to grow each year
Provide the most reliable information for the management of our patients
The quality and number of publications is at the core of one’s reputation and promotion
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...
Incidence and risk factors between TBI/SCI and venous thromboembolism
1. Incidence and risk factors between
TBI/SCI and venous
thromboembolism
Dr Amit Agrawal, MCh
Department of Neurosurgery
Narayana Medical College and Hospital
Chintareddypalem, Nellore (AP), India
3. Risk Factors High Risk Factors Very High Risk Factors
• Age > 40 years
• ISS > 9
• Blood transfusions
• Surgical procedure
within 72 hrs
• Immobilization
• Malignancy
• Extensive soft tissue
trauma
• Hormone therapy
• Obesity
• AIS ≥ 3 (any region)
Age > 60 years
ISS > 15
GCS < 9 for > 4 hours
Major venous
injury/repair
PMH of venous
thromboembolism
(VTE)
Lower extremity
fracture
Multiple spinal
fractures
Pregnancy
Spinal cord injury with
paraplegia or
quadriplegia
Complex or multiple
(≥ 2) lower extremity
fractures
Major pelvic fracture
Multiple (≥ 3) long
bone fractures (≥ 1 in
the lower extremity)
Age ≥ 75 years with
any high risk factor
Risk factors
Yablon SA, et al. Deep vein thrombosis: prevalence and risk factors in rehabilitation
admissions with brain injury. Neurology. 2004 10;63(3):485-91.
Ekeh AP, et al. Incidence and risk factors for deep venous thrombosis after moderate
and severe brain injury. J Trauma. 2010 ;68(4):912-5.
4. Patients with TBI/SCI are at increased risk of venous
thromboembolic events (VTE)
Risk factors
6. Deep venous thrombosis (DVT) has an incidence that varied
between 40 and 54% without prophylaxis in the context of
severe traumatic brain injury
In different population studies in different parts of the world
have reported an incidence ranging from 5 to 10%
Pulmonary embolism varied between 1 and 6%
TBI: Incidence
Phelan HA. Venous thromboembolism after traumatic brain injury. Semin Thromb Hemost 2013;39:541-8.
Phelan HA. Pharmacologic venous thromboembolism prophylaxis after traumatic brain injury: a critical literature review. J Neurotrauma 2012;29:1821-8
Denson et al. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J Surg 2007;193:380-4.
Bahloul M et al. Pulmonary embolism following severe traumatic brain injury: incidence, risk factors and impact outcome. Intensive Care Med
2017;43:1433-5.
Praeger AJ, et al. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study. Crit Care
Resusc 2012;14:10-3.
Khaldi A, Helo N, Schneck MJ, Origitano TC. Venous thromboembolism: deep venous thrombosis and pulmonary embolism in a neurosurgical
population. J Neurosurg 2011;114:40-6.
Skrifvars MB, Bailey M, Presneill J, French C, Nichol A, Little L, et al. investigators and the ANZICS Clinical Trials Group. Venous thromboembolic events in
critically ill traumatic brain injury patients. Intensive Care Med
7. VTE PE DVT
Abdel-Aziz H et al. 2.8% in over 4000 cases
Denson et al.
Bahloul M et al.
Praeger et al.
0.3 to 17%
Bradley et al. 2.58%
Geerts WH et al. 25%
Dengler BA et al. 12%
Eppsteiner et al. 20%
Denson K et al. 25%
TBI: Incidence
Abdel-Aziz H et al. Timing for deep vein thrombosis chemoprophylaxis in traumatic brain injury: an evidence-based review. Crit Care 19:96
Denson et al. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J Surg 2007;193:380-4.
Bahloul M et al. Pulmonary embolism following severe traumatic brain injury: incidence, risk factors and impact outcome. Intensive Care Med 2017;43:1433-5.
Praeger et al. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study. Crit Care Resusc 2012;14:10-3
Ali Seifi Bradley Dengler, Paola Martinez, Daniel Agustin Godoy. Pulmonary embolism in severe traumatic brain injury
Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. N Eng J Med 1994;331:1601-6.
Dengler BA, Mendez-Gomez P, Chavez A, Avila L, MichalekJ, Hernandez B, et al. Safety of chemical DVT prophylaxis in severe traumatic brain injury with invasive monitoring devices. Neurocrit Care
2016;25:215-23.
Eppsteiner et al. Mechanical compression versus subcutaneous heparin therapy in postoperative and posttrauma patients: a systematic review and meta-analysis. World J Surg;34(1):10-9
Denson K, Morgan D, Cunningham R, et al. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J Surg. 2007;193:380-383; discussion 383-384.
8. Acute spinal cord injury (SCI) have the highest incidence of
venous thromboembolism (VTE) among hospitalized patients*
Pulmonary embolism (PE) is the third most common cause of
mortality in patients with SCI (incidence as high as 5%)**
DVT does occur past the 3rd month, usually up to the 6th
month***
SCI: Incidence
*Paciaroni M, Ageno W, Agnelli G. Prevention of venous thromboembolism after acute spinal cord injury with low-dose heparin or low-molecular-weight heparin. Thromb
Haemost. 2008; 99(5): 978-80.
*Worley S, Short C, Pike J, et al. Dalteparin vs low-dose unfractionated heparin for prophylaxis against clinically evident venous thromboembolism in acute traumatic spinal cord
injury: a retrospective cohort study. J Spinal Cord Med. 2008; 31(4): 379-87.
**Teasell RW, Hsieh JT, Aubut JA, et al. Venous thromboembolism after spinal cord injury. Arch Phys Med Rehabil. 2009; 90(2): 232-45.
***Caprini JA. Risk assessment as a guide to thrombosis prophylaxis. Curr Opin Pulm Med 2010;16(5):448-52.
****Powell M et al. Duplex Ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission. Arch Phys Med Rehabil 1999;80(9): 1044-6.
****Chen et al. Medical complications during acute rehabilitation following spinal cord injury—current experience of the model systems. Arch Phys Med Rehabil 1999;
80(11):1397-401.
*****Green et al. Prevention of thromboembolism in spinal cord injury; role of low molecular weight heparin. Arch Phys Med Rehabil 1994;75(3): 290-2.
******Yelnik A et al. Systematic lower limb phlebography in acute spinal cord injury in 147 patients. Paraplegia 1991;29(4): 253-60.
9. Paraplegic patients more frequently than in tetraplegic
ones****
Tetraplegic patients more frequently than in paraplegic
ones*****
No difference between patients with paraplegia and
tetraplegia******
SCI: Incidence
*Paciaroni M, Ageno W, Agnelli G. Prevention of venous thromboembolism after acute spinal cord injury with low-dose heparin or low-molecular-weight heparin. Thromb
Haemost. 2008; 99(5): 978-80.
*Worley S, Short C, Pike J, et al. Dalteparin vs low-dose unfractionated heparin for prophylaxis against clinically evident venous thromboembolism in acute traumatic spinal cord
injury: a retrospective cohort study. J Spinal Cord Med. 2008; 31(4): 379-87.
**Teasell RW, Hsieh JT, Aubut JA, et al. Venous thromboembolism after spinal cord injury. Arch Phys Med Rehabil. 2009; 90(2): 232-45.
***Caprini JA. Risk assessment as a guide to thrombosis prophylaxis. Curr Opin Pulm Med 2010;16(5):448-52.
****Powell M et al. Duplex Ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission. Arch Phys Med Rehabil 1999;80(9): 1044-6.
****Chen et al. Medical complications during acute rehabilitation following spinal cord injury—current experience of the model systems. Arch Phys Med Rehabil 1999;
80(11):1397-401.
*****Green et al. Prevention of thromboembolism in spinal cord injury; role of low molecular weight heparin. Arch Phys Med Rehabil 1994;75(3): 290-2.
******Yelnik A et al. Systematic lower limb phlebography in acute spinal cord injury in 147 patients. Paraplegia 1991;29(4): 253-60.
10. Acute phase*
5.3-64% when prophylaxis is implemented
47 to 100% when no prophylactic measures
SCI: Incidence Acute Phase
*Jones T, Ugalde V, Franks P, Zhou H, White RH. Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in
16,240 adults and children. Arch Phys Med Rehabil 2005;86(12):2240-7.
*Furlan JC, Fehlings MG. Role of screening tests for deep venous thrombosis in asymptomatic adults with acute spinal cord injury: an evidence-based
analysis. Spine 2007;32(17):1908-16.
*Teasell RW, Hsieh JT, Aubut JA, Eng JJ, Krassioukov A, Tu L. Venous thromboembolism after spinal cord injury. Arch Phys Med Rehabil 2009;90(2):232-
45.
*Geerts WH, Code KI, Jay RM, Chen E, Szalai JP. A prospective study of venous thromboembolism after major trauma. New Engl J Med
1994;331(24):1601-6.
*Boudaoud L, Roussi J, Lortat-Jacob S, Bussel B, Dizien O, Drouet L. Endothelial fibrinolytic reactivity and the risk of deep venous thrombosis after spinal
cord injury. Spinal Cord 1997; 35(3):151-7.
*Powell M, Kirshblum S, O’Connor CK. Duplex Ultrasound screening for deep vein thrombosis in spinal cord injured patients at rehabilitation admission.
Arch Phys Med Rehabil 1999;80(9): 1044-6.
11. Less and incosistent data on the actual risk during the sub-acute
phase *
The 3rd to the 12th month in 8-12% **
At three months, at six months, and at one year: 34%, 1.1%, and
0.4%, respectively***
Three and six months after the trauma: ranged from 0.5% to
6.0% and from 2.0% to 8.0%, respectively****
SCI: Incidence in sub-acute and chronic
phase
*Jones Tet al. Venous thromboembolism after spinal cord injury: incidence, time course, and associated risk factors in 16,240 adults and children. Arch
Phys Med Rehabil 2005; 86: 2240-7.
*Giorgi et al. The short- and long-term risk of venous thromboembolism in patients with acute spinal cord injury: a prospective cohort study. Thromb
Haemost 2013; 109: 34-8.
**Furlan et al. Role of screening tests for deep venous thrombosis in asymptomatic adults with acute spinal cord injury: an evidence-based analysis.
Spine 2007;32(17):1908-16.
**Boudaoud et al. Endothelial fibrinolytic reactivity and the risk of deep venous thrombosis after spinal cord injury. Spinal Cord 1997; 35(3):151-7.
**Mackiewicz-Milewska et al. Deep venous thrombosis in patients with chronic spinal cord injury
***Green et al. Spinal Cord Injury Assessment for Thromboembolism (SPI- RATE Study). Am J Phys Med Rehabil 2003; 82: 950-956.
****Alabed et al. Thromboembolism in the sub-acute phase of spinal cord injury: A systematic review of the literature. Asian Spine J 2016; 10: 972-981.
12. The lack of large-scale population prevalence studies
The majority of cases are asymptomatic or subclinical and go
unnoticed or difficult to diagnose
Can be confused with many other entities
True incidence??
Donald A et al. Traumatic Brain Injury Is Associated With the Development of Deep Vein Thrombosis Independent of Pharmacological
Prophylaxis. J Trauma. 2009;66:1436-1440.
Phelan HA. Venous thromboembolism after traumatic brain injury. Semin Thromb Hemost 2013;39:541-8.
Nyquist P, et al. Prophylaxis of venous thrombosis in neurocritical care patients: an evidence- based guideline: a statement for healthcare
professionals from the neurocritical care society. Neurocrit Care 2016;24:47-60.
Denson K, et al. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J Surg 2007;193:380-4.
Bahloul M, et al. Pulmonary embolism following severe traumatic brain injury: incidence, risk factors and impact outcome. Intensive Care
Med 2017;43:1433-5.
Praeger AJ, et al. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study.
Crit Care Resusc 2012;14:10-3
13. Most of the studies are heterogeneous in populations, design
and outcome reporting
Studies have limitations inherent to the methodology and
diagnostic tools employed
True incidence??
Donald A et al. Traumatic Brain Injury Is Associated With the Development of Deep Vein Thrombosis Independent of Pharmacological
Prophylaxis. J Trauma. 2009;66:1436-1440.
Phelan HA. Venous thromboembolism after traumatic brain injury. Semin Thromb Hemost 2013;39:541-8.
Nyquist P, et al. Prophylaxis of venous thrombosis in neurocritical care patients: an evidence- based guideline: a statement for healthcare
professionals from the neurocritical care society. Neurocrit Care 2016;24:47-60.
Denson K, et al. Incidence of venous thromboembolism in patients with traumatic brain injury. Am J Surg 2007;193:380-4.
Bahloul M, et al. Pulmonary embolism following severe traumatic brain injury: incidence, risk factors and impact outcome. Intensive Care
Med 2017;43:1433-5.
Praeger AJ, et al. Deep vein thrombosis and pulmonary embolus in patients with traumatic brain injury: a prospective observational study.
Crit Care Resusc 2012;14:10-3