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In humans, the sickle-cell trait is caused by a single detective allele, but sickle-cell disease only
occurs in individuals that are homozygous for the sickle-cell allele. Two people carry the trait but
do not have sickle-cell disease. What is the probability that they will have two children with
sickle-cell disease? 1/16 1/2 3/8 1/4
Solution
Answer is 1/2.
Parents are carriers. Ss x Ss. The children will be of genotypes SS, Ss, sS, ss.

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