This document discusses initiatives to improve patient safety in Greater Manchester. It outlines (A) the Sign up to Safety pledges that organizations can commit to, (B) the Patient Safety Collaborative topics being addressed, and (C) the Q Initiative to train 5,000 patient safety fellows by 2020. The overarching goals are to reduce avoidable harm, continually learn from patients and staff, be transparent about progress and mistakes, collaborate across services, and support staff in improving safety and celebrating successes. Patient safety remains the central focus of these efforts to create a culture of partnership and learning.