Spermiogenesis or Spermateleosis or metamorphosis of spermatid
Implants in Ophthalmology
1. PRESENTER : DAISY VISHWAKARMA
POST – GRADUATE STUDENT
DEPTT. OF OPHTHALMOLOGY
AMCH
2. TABLE OF CONTENTS
1. INTRODUCTION
2. EYELID IMPLANTS
3. CORNEAL IMPLANTS
4. IMPLANTS FOR GLAUCOMA SURGERY
5. INTRAOCULAR LENSES
6. CAPSULAR TENSION RINGS
7. DRUG DELIVERY FOR POSTERIOR SEGMENT
8. RETINAL IMPLANTS
9. ORBITAL IMPLANTS
10. IMPLANTS FOR ANOPHTHALMIC SOCKET &
ORBITAL WALL
11. IMPLANTS FOR LACRIMAL SYSTEM
12. RECENT ADVANCES
3. IMPLANT
An implant is an object or material
that is inserted or grafted in the body
for certain specific purposes.
IDEAL IMPLANT :
Environmentally stable
Easy to insert & manipulate
Bio-compatible
Non-toxic & Non-carcinogenic
Should not arouse fibrous tissue formation
Reasonably priced.
5. • Used to restore closure of the lid in
severe cases of symptomatic
lagophthalmos.
• TYPES :
• Gold
• Platinum
• Bismuth
• Weight adjustable
magnet
• The implants are inert & composed
of 99.99% pure gold or platinum.
EYELID IMPLANTS
6. • Weight ranges from 0.6- 1.8 gm.
• COMPLICATIONS :
Migration of the implant
Inflammation
Bulging
Astigmatism
Pseudoptosis
Allergic reaction
Extrusion.
9. KERATOPROSTHESIS
Artificial cornea used in patients not managed
with conventional keratoplasty.
INDICATIONS:
Steven Johnson syndrome with
keratinization
Ocular cicatrical pemphigoid
Severe chemical injury
B/L stem cell loss or deficiency
Severely vascularised recipient eyes
Multiple previous failed corneal grafts
11. NON-BIO INTEGRATED
PMMA cylinder is placed in cornea through a central
opening
COMPLICATIONS:
Prob with integration with cornea
Leaks around cylinder
Retroprosthetic membrane (RPM)
Raised IOP
Infectious endophthalmitis
Sterile vitritis
RD & Vit Hem (rare)
13. First implanted in soft subcutaneous tissues of the
patient’s malar region to develop a soft tissue
cover, then used to integrate them with ocular
surface of eye.
BIO- INTEGRATED
16. INTRA-CORNEAL RING SEGMENTS
ICR are semicircular PMMA devices
implanted into the corneal stroma causing an
alteration in its curvature & leading to a
change in its refractive power.
PRINCIPLE: When vol is added to corneal
periphery or removed from centre, it leads to
flattening of the central cornea reducing
corneal power.
INDICATIONS :
Myopia
Keratoconus & other ectatic
corneal disorders
18. INTACS :
• 2 PMMA pieces
• Hexagonal in cross-
section
• Arc of 150°
• Diam: ext. – 8.1 mm
int. – 6.7 mm
• Thickness : 0.25 – 0.4 mm
• Recently , a new INTACS
segment ( INTACS SK )
design with inner diam. of
6mm & oval cross – section in
shape was produced.
19. ADVANTAGES
Reversible procedure
Centre of cornea
spared
No ablation of
corneal tissue
No induced
weakness of cornea
COMPLICATIONS
Improper centration
Too shallow or deep
insertion
Corneal perforation
Infectious keratitis
Segment
displacement
Segment exposure
Corneal melt
Corneal scarring
Deposits around
21. IMPLANTS FOR GLAUCOMA SURGERY
GLAUCOMA DRAINAGE
IMPLANTS
Drainage implants were developed
to enhance trabeculectomy
surgery.
Artificial devices that work by
creating an alternate pathway
for aqueous outflow by
channeling aqueous from
anterior chamber through a tube
24. INDICATIONS:
Neovascular glaucoma
PK with glaucoma
RD Sx with glaucoma
ICE syndrome
Traumatic glaucoma
Uveitic glaucoma
OAG with failed
trabeculectomy
Epithelial down growth
Refractory infantile
glaucoma
CL wearers who need
glaucoma filtration Sx
Ahmed GDD
Baerveldt GDD
25. CONTRA-INDICATIONS:
Eyes with severe scleral or
sclera-limbal thinning
Extensive fibrosis of conjunctiva
Ciliary block glaucoma
RELATIVE
CONTRA-INDICATIONS:
Vitreous in AC
Intra-ocular silicone oil-implant
if required is placed infero-
temporal quadrant
27. THE EX-PRESS GLAUCOMA
SHUNT:
Recently introduced
Both as primary procedure
or when conventional
therapy fails
Made of stainless steel
3 mm long tube
External diam : 400µ
Inner diam : 50µ
Used under a scleral flap.
28. MIGS
Indications- patients with glaucoma less
severe than that requiring traditional
incisional surgery
should preserve the conjunctiva from
surgical dissection.
Types-
Bypass TM resistance with stents into SC
- iStent, Hydrus
Via drainage into the suprachoroidal space
- Cypass, iStent Supra
By excision of TM itself
- Trabectome
Endo-cyclodiode - directly observed ablation of
ciliary processes under endoscopic control .
29. iStent® Trabecular Micro-Bypass
Hydrus Microstent
Tri-modal mechanism:
Tail end provides a direct inlet from AC into Schlemm’s
canal
Body of the stent maintains the patency of the canal
30. CYPASS Micro-stent
Withdrawn in August 2018
Detection of a dramatic rise in endothelial cell loss (ECL)
among patients who received the CyPass microstent
during cataract Sx. Trabectome
Micro-electrocautery
handpiece designed to
ablate TM & SC inner wall
tissue.
Descemet’s injury
Ciliary body injury
Reflux bleeding, hyphema
32. A procedure that
surgically opens Schlemm’s
canal, exposes Descemet’s
memb & bypasses the
highest resistance to
outflow – juxtacanalicular
TM.
To prevent the
inevitable late stage fibrosis
various materials have
been used.
IMPLANTS FOR NON- PENETRATING
DEEP SCLERECTOMY:
Aquaflow (collagen)
34. Advantages
Avoids sudden
hypotony
Complication
Perforation of
trabeculo-
Descemet’s memb
Scleral perforation &
choroidal prolapse
Disadvantages
Difficult technique
Less effective IOP
control compared to
trabeculectomy
35. INTRA-OCULAR LENS
Intra-ocular lens (IOL ) is an artificial lens that
is implanted inside the eye during cataract or
refractive surgery, to correct the eye’s optical
power.
36. IDEAL IOL
Non-reactive
Non-carcinogenic
Non-biodegradable
Transparent
High optical resolution
UV filtering
Accommodating for near &
distance
Should pass through smallest
incisions
Withstand stress of implantation
37. CLASSIFICATION
Capsular support intact
PCIOL
No capsular support
ACIOL
Iris supported
Scleral fixated
Phakic IOL
Post chamber sulcu
fixated
Angle supported
Iris supported
Method of fixation
39. Advantages
No capsular support
required
Technically less
traumatic
Easy to implant
Complications
Uveitis glaucoma
hyphaema
Corneal
decompensation, PBK
CME
Pupillary block
Fibrosis of angle
Iris atrophy & fibrosis
ACIOL
40. IRIS SUPPORTED
Fixed on iris with sutures,
loops or claws
Singh & Worst
Iris Claw lens
Retropupillary iris claw lens
ARTISAN
41. IRIS SUPPORTED
Advantages
No capsular support
required
Cosmetically more
acceptible
Difficult to diff from
PCIOL
No ant segment/
angle complication
Unrestricted
dilatation of iris
Excellent centration
Complications
Insufficient iris
enclavation
Iris chaffing
Pupillary distortion
Chronic inflammation
CME
Distortion on pupillary
dilatation
Endothelial
decompensation
42. SFIOL
This procedure involves
securing the IOL to the
sclera using surgically
created tunnels or sutures.
43. SFIOL
Disadvantages
Difficult technique
Longer time of
surgery
Complications
Suture erosion
Corneal endoth
damage
CME
Endophthalmitis
Hyphaema/ Vit hem
Lens tilt/decentration
RD
Suprachoroidal hem
44.
45. CLASSIFICATION
IOL optic material
Non-foldable
PMMA
Foldable
silicone
acrylic
temperature
dependent polymers
Rollable
Hydrogel (HEMA)
IOL bio-compatibility
Uveal
Capsular
FB reaction is a marker of
IOL biocompatibility.
Hydrophobic acrylic IOL-
max late FBGC reaction
Silicone IOL- min late FBGC
reaction
Hydrophilic acrylic IOL- max
PCO
46. Optic edge
Round edge- Min glare
Max PCO
Square edge
Opti-edge- rounded
anterior
sloping side
sharp vertical posterior
Enhanced edge-
elevated ridge at O-H
junction
Textured edge- rough
edge with frosted app
CLASSIFICATION
47. CLASSIFICATION
Modified J loop IOL
Modified C loop IOL
Angling the loops
IOL with coloured
haptics
IOL with positioning
holes
48. One piece IOL
Three piece IOL
Disc/ plate lens
CLASSIFICATION
49. ASPHERIC IOL
Designed to correct +ve spherical aberration of
cornea
Modified ant prolate surface
Aspheric post surface – AcrySof
Aspheric ant & post surface – aberration free
DISADVANTAGES – IOL decentration cancels
benefits
Degrades near & intermediate BCVA
Asymmetric aberrations cannot be compensated
Surgery can induce SA
50. MULTIFOCAL IOLS
TYPES – Refractive Mf IOL
diff refractive powers in
diff circular zones
Array lens, ReZOOM (5
zones)
Diffractive Mf IOL
diffraction of light
from multiple ring steps on the
post surface of lens which
provides near vision by
constructive interference (30
52. Advantages
Better performance at
near vision activities,
social activities, etc.
Spectacle use is lower
Increased depth of
focus
Disadvantages
Halos, flare, flash, glare,
streak
Decrease in contrast
sensitivity
Astigmatism causes
reduced visual function
Smaller pupil size –
worse near VA
Decentration – worse
distance & intermediate
VA
58. CAPSULAR TENSION RINGS
Endocapsular device was first introduced by
HARA et al and NAGAMOTO et al of Japan in
1991 (Equator ring).
Used for expanding, centering and stabilizing the
capsular bag.
Helps prevent capsular phimosis & resists
capsular shrinkage.
59. TYPES :
• STANDARD CTR
• MODIFIED CTR OR CIONNI’S RING
• HENDERSON CTR
• CAPSULAR TENSION SEGMENT OR
AHMED CTS
STANDARD CTR :
TYPES:
MORCHER (REFORM) Ring
OPHTEC (STABILEYES) Ring
60. MODIFIED CTR OR CIONNI’S RING :
Developed by DR. ROBERT CIONNI in
1998
HENDERSON CAPSULAR TENSION
RINGS :
61. CAPSULAR TENSION SEGMENT OR AHMED
CTS
Designed by IKE AHMED IN 2002.
FUNCTIONS OF CTR :
• Expansion of capsular equator
• Buttress areas of weak zonules
• Recruit & redistribute tension
from
existing zonules.
• Re- center a mildly subluxated
capsular bag.
• Place tension on the posterior
capsule to decrease incidence of
PCO.
62. CONTRA-INDICATIONS :
• Complete CCC not attained
• PCR or anterior radial tear
• Extensive generalized zonular
weakness
• M- CTR in pts of scleral disorder.
COMPLICATIONS :
• Pupillary capture
• Secondary glaucoma
• Retinal detachment
• Inadvertent tear of anterior capsule
• Decentration or displacement of IOL
63. DRUG DELIVERY IMPLANTS
Sustained Release drug delivery implants have
been developed for treatment of ocular
diseases.
TYPES : INTRA-OCULAR & EXTRA-OCULAR
ADVANTAGES :
Achieve prolonged therapeutic concentration
Limits side-effects of systemic therapy
Limits frequent dosing
Better patient compliance
Cost effective
64. INTRA- VITREAL IMPLANTS:
RETISERT :
• Disc- shaped non-
biodegradable implant
(3x2x5) mm3
• Contains matrix of
fluocinolone acetonide (0.59
mg) coated with silicone &
poly vinyl alcohol attached
to a 5.5 mm silicone suture
tab.
65. VITRASERT :
• Ganciclovir sustained release
implant for treatment of CMV
retinitis.
• Tablet of 4.5mg ganciclovir
released over a period of 5-8 m
ILUVIEN :
• Previously, known as Medidur
• Non-erodable implant in phase
3
clinical trials for extended
delivery of fluocinolone
acetonide in diabetic
66. OZURDEX :
• Bio-degradable, slow release
implant containing
Dexamethasone 0.7 mg released
over a period of 6 m
• FDA approved for treatment of
macular edema associated with
retinal vein occlusion.
POSURDEX :
• Polymer pellet that releases
drug
as it degrades
• Completely dissolves in 37
70. RETINAL IMPLANTS
A retinal implant is a biomedical implant
technology meant to partially restore useful
vision to people who have DOV due to
degenerative conditions eg. RP or macular
degenerations.
TYPES :
Epiretinal – on retina
Subretinal – behind retina
Suprachoroidal – above vascular choroid
71. Epiretinal Implants:
Epiretinal prostheses are
placed on the anterior
surface of the retina, where
they stimulate ganglion
cells.
ARGUS device
Learning Retinal Implant
EPI-RET device
72. ARGUS II DEVICE
(A) Wearable external unit with the camera attached to glasses and the TX coil on
the corner.
(B) Implant RX coil encirculating the eyeball being powered from an external TX coil
using the NRIC scheme in the epiretinal implant (The RX coil is placed on the
side of the eyeball, whereas the electrode array is inserted into the eyeball
through an incision centrally on the retina, adjacent to the optic nerve).
(C)Actual retinal implant device
73. Advantages
Bypass large portion
of retina & rely on
ganglion cells
function
Provide visual
perception in retinal
diseases beyond
photoreceptor layer
Disadvantages
Requires external
apparatus
External camera
requires a subject to
make head
movements to change
their gaze
Stimulate nearby
axons – distorted
stimulation pattern
(corrected by
electronic processing)
74. Subretinal Implants:
Subretinal devices are placed
beneath the retinal pigment
epithelium in the photoreceptor
layer
Optobionics
Retina Implant Alpha IMS
Boston Subretinal Implant
project
79. ORBITAL IMPLANTS
For patients who underwent
enucleation or evisceration
operation and want a more
natural appearance and
movement that mimic that of
their normal eye.
PURPOSE:
Replace the volume lost by
the enucleated eye
Impart motility to prosthesis
Maintain cosmetic symmetry
80. AN IDEAL IMPLANT :
Mimics normal globe closely
Replaces sufficient volume
Minimal rate of exposure, extrusion,
infection, inflammation
Non-antigenic, inert
Socket motility transmitted to prosthesis
Completely buried
Light wt., anchored to orbital tissue
Integrate into EOM & orbital tissues
without adhesions
Affordable & easily available
82. NON- INTEGRATED IMPLANTS
Advantages: Inexpensive
Exposure is rare
Least complication rates
Can attach muscles if
wrapped with
sclera
Disadvantage: poor motility if not
wrapped
Examples: PMMA , Silicone
83. NON- INTEGRATED IMPLANTS
Attachment of EOM in tunnels on
anterior surface for better motility
Allens, Iowa, Universal, etc.
Advantages:
Good motility
Inexpensive
PMMA
Disadvantages :
Ant. Surface is irregular
Discomfort & high extrusion/ erosion
rates
86. IMPLANTS FOR ANOPHTHALMIC SOCKET
These are meant to enhance the growth of the
involved orbit to allow retention of a suitable
prosthesis & to maximize facial symmetry.
87. EXPANDABLE IMPLANTS:
Expand in vivo
Stimulate orbital growth
In congenital clinical anophthalmos/
microphthalmos
Fill deficits in enophthalmic sockets
Eg. Silicon balloon expanders, Hydrogel socket,
orbita expanders
SETE devices (Self Expanding Tissue Expanders)
Absorb body fluids to 8 times of original volume
89. IMPLANTS FOR ORBITAL FLOOR FRACTURE
The most common orbital walls to be
affected by trauma are the floor & the medial
wall.
CLINICAL INDICATIONS FOR REPAIR :
• Diplopia
• Extraocular muscle entrapment
• A large # (greater than 50% of wall )
• Enophthalmos greater than 2mm
90. IMPLANTS USED ARE :
• Alloplastic implant : Porous polyethylene
(Medpor) silastic, teflon, silicone, PMMA,
hydroxyapatite
• Autologous materials : Dermis fat graft
Fascia lata grafts & sclera
• Dissolvable alloplastic material : Gelfilm,
Lactosorb
• Allogenic material : Banked bone or lyophilized
cartilage
93. IMPLANTS FOR LACRIMAL SYSTEM
PUNCTAL PLUGS :
Used in patients with
chronic dry eye not adequately
controlled with medications.
Other uses :
To enhance efficiency of
ocular therapeutics
(glaucoma therapy)
To prevent drainage of
drugs into nasolacrimal
system in susceptible
patients.
94. TYPES OF PLUGS :
• Absorbable: Made of collagen or
polymers. Occlusion duration ranges from
7- 180 days.
• Non- absorbable: Made of silicone.
Two types available :
punctal & intra-canalicular
• Cylindrical smart plug : Made of
thermo-sensitive,
hydrophobic acrylic
polymer that changes
from rigid solid to soft
95.
96. INTUBATION IN LACRIMAL
SURGERY
Essential in some congenital
& acquired cases especially as a
sequel to trauma.
It is useful to treat epiphora in
selected group of patients esp. in
children & as an alternative to DCR.
97. INTUBATION IN DCR
INDICATIONS :
Cong dacryocystitis
-failed multiple probings
-child >1y
Partial NLD obstruction
Failed DCR
Post traumatic dacryocystitis
Canalicular obstruction
Conjunctival DCR with Jones tube
Canalicular laceration
Crawford
lacrimal
intubation set
AIM OF STENT : Used to maintain proper
alignment of an anastomoses & to prevent
scarring.
98. CONJUNCTIVO-DCR WITH JONES TUBE
INTUBATION:
Cases of canalicular obstruction
Made of
Pyrex glass
Polyethylene
Silicon
99. Canalicular Lacerations: Repair
with the Mini-Monoka®
monocanalicular Intubation
INTUBATION IN CANALICULAR LACERATION
Goal: reanastomose
mucosa of canaliculi so that
anatomical & physiological
functions are restored.
100. TYPES :
• Mono-canalicular stents
Eg. Mini-Monoka, Ritleng stent
• Bi-canalicular stents
MATERIALS :
• Organic : thick hair, catgut,
metal probes, metal rod with 4’o
braided silk etc
• Synthetic: nylon, pyrex-glass,
poly-ethylene, silicone, etc.
101. RECENT ADVANCES IN IMPLANTS
PresVIEW SCLERAL IMPLANT for presbyopia
4 plastic segments
Act like spacers, pulling sclera away from lens,
tightening the zonules & allowing them to aid
accommodation
102. Kamra inlay for presbyopia
3.8 mm disc with 1.6 mm opening in centre
Placed directly in front of pupil
105. CONCLUSION
The globe is home to the most common implant,
the IOL after cataract surgery. The lid and lacrimal
implants harbor devices that improve
physiological function.
Orbital fractures are repaired with light metals.
The anophthalmic sockets, depending on its age,
have been filled with many implants.
All implants may have complications which
include ocular or orbital infections, migration or
extrusion.
Implants in ophthalmology are of wide range & in
every sphere, much advancement is going on,
both in terms of material as well as in technique.