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Opportunities in Plant-based Food
Technologies
Liz Specht
Senior Scientist at The GFI
Opportunities in plant-based
food technologies
Liz Specht, Ph.D.
Senior Scientist
The Good Food Institute
October 3, 2018
gfi.org
Today’s roadmap
1) What is the problem we’re trying to solve? Why is this so urgent?
2) What market trends are driving interest in – and development of –
plant-based foods? And who’s involved?
3) What opportunities are there for technological solutions to pressing challenges
in plant-based meat and other plant-based products?
2
gfi.org
The Good Food Institute
3
SCIENCE AND TECHNOLOGY
Director of Science and Technology David Welch, Ph.D.
INNOVATION
Director of Innovation Brad Barbera
CORPORATE ENGAGEMENT
Director of Corporate Engagement Alison Rabschnuk
POLICY
Director of Policy Jessica Almy, Esq.
UNITED STATES
BRAZIL
INDIA
ISRAEL
EUROPE
CHINA
Fall 2018
Our programmatic departments
INTERNATIONAL ENGAGEMENT
Director of International Engagement
Nicole Rawling, Esq.
Managing Director (Israel) Yaron Bogin, Ph.D.
Managing Director (India) Varun Deshpande
Managing Director (Brazil) Gus Guadagnini
gfi.org
Global demand for meat is on the rise,
despite increasing consumer awareness of its
environmental burden
2005 vs. 2050 (in tons)
Source: Food and Agriculture organization of the United Nations, ESA Working Paper No. 12-03, p. 131
4
gfi.org
We cannot continue with business as usual
5
29% land 71% oceanEarth’s surface
71% habitable land
10%
glaciers
19% barren landLand surface
77%
livestock
23%
cropsAgricultural land
50% agriculture 37% forests
11%
shrubHabitable land
1% urban
1% freshwater
33%
Meat &
dairy
67%
Plant-based
food
Protein supply
Adapted from OurWorldInData.org and based on UN FAO statistics
gfi.org
Sustainable food systems require radically rethinking
meat – not incremental efficiency gains
6
Feed
(calories)
Movement;
thermal energy;
growing bone,
brain, feathers,
etc…
Food
(calories)
“We have pushed animals to their biological limits.”
(Nature, 2018)
gfi.org
Here’s another perspective: producing meat is the
most perverse food waste problem imaginable
7
0
20
40
60
80
100
120
Food waste by
consumers or in
supply chain
Food consumed
0
500
1000
1500
2000
2500
3000
3500
Food waste by
consumers or in
supply chain
Food consumed Food waste in
production
(chicken)
Food waste in
production (beef)
gfi.org
Let me pitch you on a new, improved protein
production platform!
8
gfi.org
Animal agriculture is, and will always be, inefficient.
Thermodynamics and basic biology assure it.
9
gfi.org
The majority of mammal biomass on earth is either
humans or our livestock
10XKCD; also see YM Bar-On et al., 2018
gfi.org 11
Animal agriculture is “one of the most significant contributors
to the most serious environmental problems, at every scale
from local to global.”
– Livestock’s Long Shadow, 2006, UN FAO
monocrops
gfi.org
Superbugs could cost the
world $100 trillion by 2050
THE TELEGRAPH
In their latest test, Consumer
Reports found bacterial
contamination on 97% of chicken.
Drug resistant infections kill
half a million people a year
THE GUARDIAN
Despite increasing
awareness that eating
animal meat is
harmful, consumption
continues to rise.
gfi.org
The solution: plant-based meat, clean meat, and
other alternative proteins
13
PLANT-BASED
MEAT
CLEAN MEAT
gfi.org
Today’s roadmap
1) What is the problem we’re trying to solve? Why is this so urgent?
2) What market trends are driving interest in – and development of –
plant-based foods? And who’s involved?
3) What opportunities are there for technological solutions to pressing challenges
in plant-based meat and other plant-based products?
14
gfi.org
“If we can grow the meat
without the animal, why
wouldn’t we?”
— Tom Hayes, Tyson Foods CEO, 2018
gfi.org
Big Meat companies are rebranding as
“protein companies”
gfi.org
“Our vision is to be the most trusted
name in premium protein,” Chairman
Jim Perdue said. "It doesn’t say
premium meat protein, just premium
protein. That’s where consumers are
going.”
gfi.org
Visionaries agree — plant-based is the future of food
“What I was experiencing [Beyond
Meat’s chicken] was more than a clever
meat substitute. It was a taste of the
future of food.” -Bill Gates
“I believe that in 30 years or so we will no longer
need to kill any animals and that all meat will either
be clean or plant-based, taste the same and also be
much healthier for everyone.”
– Richard Branson
gfi.org 19Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18.
-10%
0%
10%
20%
30%
40%
50%
60%
70%
Creamer Yogurt Cheese Ice
Cream
and
Novelty
Meat Milk Butter
$%ChgYA
Plant-based Animal-based
Plant-based products are exploding across all categories
gfi.org
27% 57% 61%
The plant-based meat market is booming
20
Year-over-year growth
gfi.org
Acquisitions
21
gfi.org
Millennials are driving this trend, and it will accelerate
• 30% eat meat alternatives every day
• 50% eat meat alternatives a few times per
week
• “These numbers, coupled with the size and
spending power of Millennials, indicates a
strong potential market for meat alternatives
in the future.”
- Billy Roberts, Sr. Food & Drink Analyst, Mintel
Source: Mintel’s The Protein Report – Meat Alternatives - 2017
gfi.org
What’s driving the shift to plant-based eating?
gfi.org
Consumers choose plant-based foods for many reasons
gfi.org
Consumers overwhelmingly view plant-based proteins
as healthy
•Millennial and Gen X
consumers believe plant-
proteins are healthier than
animal-based proteins
•Consumers know that plant-
based proteins are better for
the environment than animal-
based options
Souce: Mintel - Plant-based proteins report. January 2018.
gfi.org
But in the end… it’s always about taste!
“Plant-based
protein eaters swear
it’s about taste” -
Mintel
New research from the research firm Mintel revealed taste
as the top reason U.S. adults who eat plant-based proteins
do so (52%), outranking concerns over diet (10%), animal
protection (11%), the environment (13%) and even health
(39%).
The research was based on responses from 1,876 U.S.
internet users aged 18 or over that eat plant-based
proteins. The study also indicated that 46% of Americans
agree that plant-based proteins are better for you than
animal-based options. Whether a desire to avoid
processed foods (39%), manage weight (31%) or promote
muscle growth (16%), many plant-based protein
consumers are motivated by maintaining or improving
their health and well-being, according to the Mintel survey.
Souce: Mintel - Plant-based proteins report. January 2018.
gfi.org
Taste, Price, & Convenience
● Fastest growing brands are ones that focus on
flavor
● Plant-based foods starting to achieve price
parity with increased scale
● Plant-based foods are now available in more
retail and foodservice outlets and are
increasingly placed in the main sections of
menus and store shelves, not in specialty areas
Deloitte Food Value Equation Survey, 2015
gfi.org
Price parity
gfi.org
Taste
gfi.org
Convenience
gfi.org
Plant-based milk & meat have the most items on shelf
Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18.
gfi.org
Plant-based milk market share at 13% vs. meat 1% (U.S.)
Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18.
0%
2%
4%
6%
8%
10%
12%
14%
Milk Meat Cheese
MarketShare
2018 2017
gfi.org
Global Access
The global meat substitutes
market is projected to be worth
$5.96 billion by 2022
Source: Markets and Markets
gfi.org
Globally, what is top-of-mind for the meat industry?
Source: State of the Global Meat Industry 2017
gfi.org
Global launches: Europe and the U.S. dominate,
despite projected global meat demand rises elsewhere
gfi.org
Desired attributes vs. product claims don’t always align
gfi.org
Today’s roadmap
1) What is the problem we’re trying to solve? Why is this so urgent?
2) What market trends are driving interest in – and development of –
plant-based foods? And who’s involved?
3) What opportunities are there for technological solutions to pressing challenges
in plant-based meat and other plant-based products?
37
gfi.org
Protein alternatives fit into four categories from a
production/cost/infrastructure perspective
38
ANIMAL CELL
CULTURE
NON-ANIMAL
CELL CULTURE
RECOMBINANT
PROTEINS
PLANT-BASED
PROTEINS
gfi.org
Protein alternatives fit into four categories from a
production/cost/infrastructure perspective
39
ANIMAL CELL
CULTURE
NON-ANIMAL
CELL CULTURE
RECOMBINANT
PROTEINS
PLANT-BASED
PROTEINS
gfi.org
Non-animal cell culture can take many forms
Primary nutrient source is a key consideration for competitiveness.
40
Long-term, validated low cost at scale: mycoprotein
Moving rapidly towards scale: bacterial protein
Still small scale and high cost: algal protein
These represent incredibly diverse kingdoms of life with
unexplored biosynthetic pathways for natural sources of
high-value flavorings, stabilizers, pigments, vitamins, etc.
gfi.org
Basic infrastructure requirements for all single-cell
growth exhibits cross-platform similarities
41
gfi.org
Protein alternatives fit into four categories from a
production/cost/infrastructure perspective
42
ANIMAL CELL
CULTURE
NON-ANIMAL
CELL CULTURE
RECOMBINANT
PROTEINS
PLANT-BASED
PROTEINS
gfi.org 43
Lots of room for enzyme adaptation, prospecting, or engineering
to functionalize plant protein sources.
Recombinant protein production can be used for high-
value ingredients and enzymatic functionalization
gfi.org
Protein alternatives fit into four categories from a
production/cost/infrastructure perspective
44
ANIMAL CELL
CULTURE
NON-ANIMAL
CELL CULTURE
RECOMBINANT
PROTEINS
PLANT-BASED
PROTEINS
gfi.org
The cell culture medium is a nutrient broth
containing the vitamins, lipids, sugars, and
amino acids cells need to grow.
It also contains signaling molecules called
growth factors.
The core components of the nutrient feed and scaffold
for clean meat are derived from biomass
45
The scaffold can be
made of a number of
plant- or fungal-derived
polymers or gels.
gfi.org
Protein alternatives fit into four categories from a
production/cost/infrastructure perspective
46
ANIMAL CELL
CULTURE
NON-ANIMAL
CELL CULTURE
RECOMBINANT
PROTEINS
PLANT-BASED
PROTEINS
gfi.org
What is plant-based meat?
47
Plant-based meat products are structured plant- or
fungus-derived foods designed to replace animal-based
meat either as stand-alone products or within recipes.
gfi.org
PLANT-BASED
MEAT
TECHNOLOGY
CROP
ANALYSIS &
OPTIMIZATION
FUNCTIONAL
ANALYSIS
TRAIT
MAPPING
DIGITAL
PHENOTYPING
HIGH
THROUGHPUT
BREEDING
GENETIC
EDITING &
ENGINEERING
NOVEL
INGREDIENTS
AGRICULTURAL
TECHNOLOGY
CHEMICAL
FUNCTION-
ALIZATION
RAW MATERIAL
SOURCING &
OPTIMIZATION MECHANICAL
FRACTIONATION
CHEMICAL
FRACTIONATION
BIOLOGICAL
FUNCTION-
ALIZATION
MECHANICAL
FUNCTION-
ALIZATION
COMPOSITION
& PROCESS
OPTIMIZATION
COMPOSITIONAL
ANALYSIS
STRUCTURAL
ANALYSIS
SENSORY
EVALUATION
PROCESS
OPTIMIZATION
DISTRIBUTION
SUPERMARKET
SUPPLY
FOOD SERVICE
SUPPLY
MARKETING
POSITIONING
JUST-IN-TIME
DELIVERY
gfi.org
How to achieve tastes and textures that mimic meat?
49
gfi.org
Crop Analysis and Optimization
50
Thus far, plant-based meat
manufacturers have been dealing with
rather sub-par and limited materials.
CROP
ANALYSIS &
OPTIMIZATION
FUNCTIONAL
ANALYSIS
TRAIT
MAPPING
DIGITAL
PHENOTYPING
HIGH
THROUGHPUT
BREEDING
GENETIC
EDITING &
ENGINEERING
NOVEL
INGREDIENTS
AGRICULTURAL
TECHNOLOGY
gfi.org
NUTRITION
FUNCTIONALITY
PERFORMANCE
COST
PRECISION
BREEDING
GENE
EDITING
Optimizing Crops to Improve Raw Materials
51
gfi.org
Protein source in
top products
Wheat Soy Myco-
protein
Pea Other
Morningstar X X
Gardein X X
Lightlife X X
Boca X X
Quorn X
Tofurky X X X
Field Roast X
Dr. Praeger’s X X X
Beyond Meat X X X
gfi.org
Explore beyond traditional crops for high-value
ingredients and bulk protein sources
gfi.org
Raw Material Sourcing and Optimization
54
CHEMICAL
FUNCTION-
ALIZATION
RAW MATERIAL
SOURCING &
OPTIMIZATION MECHANICAL
FRACTIONATION
CHEMICAL
FRACTIONATION
BIOLOGICAL
FUNCTION-
ALIZATION
MECHANICAL
FUNCTION-
ALIZATION
Methods to isolate and functionalize
raw materials for plant-based meats
gfi.org
Optimizing Raw Materials to Improve Plant-based Meats
FUNCTIONALIZATIONFRACTIONATION
55
Chemical isolation of raw
materials
Biological and chemical
processes to functionalize
ingredients
Mechanical methods to
separate and isolate raw
materials
Mechanical methods to
enhance raw material function
gfi.org
Functionality is derived from biochemistry
56
Heck et al. 2013
gfi.org
Composition and Process Optimization
57
COMPOSITION
& PROCESS
OPTIMIZATION
COMPOSITIONAL
ANALYSIS
STRUCTURAL
ANALYSIS
SENSORY
EVALUATION
PROCESS
OPTIMIZATION
Establishing the correct mix of
ingredients and processes to create
the desired taste, texture, smell, and
structure
gfi.org
Ingredient Optimization Enhances the Final Product
OPTIMIZING FLAVOR AND
FUNCTIONALITY
IMPROVING TASTE AND
TEXTURE THROUGH FAT
ENCAPSULATION
ENHANCING NUTRITIONAL
PROFILES THROUGH
BIOFORTIFICATION
RECAPITULATING THE
CONSUMER EXPERIENCE
OF COOKING
Biochemistry is transforming plant-based meats
58
gfi.org
As consumers increasingly demand “clean labels”,
find natural alternatives to synthetic additives
59
gfi.org
CROP
OPTIMIZATION
RAW MATERIAL
OPTIMIZATION
COMPOSITION AND
PROCESS OPTIMIZATION
Data will be central
to the next phase of
plant-based meat
60
• GENOTYPE
• PHENOTYPE
• MACRONUTRIENTS
• MICRONUTRIENTS
• FUNCTIONALITY
• PROTEIN STRUCTURING
• CONSUMER PREFERENCE
• SOIL CONDITIONS
DATA COLLECTION AND ANALYSIS
gfi.org
Data will be central
to the next phase of
plant-based meat
61
KeyGene
gfi.org
Data will be central
to the next phase of
plant-based meat
62
gfi.org
How saturated is the meat alternatives field?
What is the opportunity for exploratory research
to translate into a revolutionary commercial reality?
63
gfi.org
gfi.org
$1.275 Billion Invested
in Plant-based and Clean Meat, Egg, and Dairy Companies
Source: Crunchbase; YTD as of 8/18
gfi.org
Strategic Investors and Partners
gfi.org 67
SOLAR
Spheres represent global R&D investment into
renewable energy in a single year (2011).
Total combined R&D into meat alternatives,
across all years: about $1 billion
WIND BIOMASS BIOFUELS HYDRO MARINE GEOTHERMAL
Data: Global Trends in Renewable Energy 2012
$147.4bn $83.8bn $10.6bn $6.8bn $5.8bn
$2.9bn $0.2bn
67
Development of alternative proteins is highly tractable
gfi.org
Recap: Opportunities abound
68
Market trends indicate that alternative proteins – and especially meat alternatives – will
experience tremendous growth.
Expertise in meat science, synthetic biology, genomics, biochemistry, mechanical
engineering, and data analytics will accelerate development of novel and improved
products.
Leverage biological systems: room for strain improvement from crops to lactobacillus to
filamentous fungi.
Strategics are counting on external innovation to fuel this transition, followed by
investment and/or acquisition.
gfi.org | #
Resources
70
www.gfi.org

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Impact.tech: Opportunities in Plant-based Food Technologies by Liz Specht

  • 1. Opportunities in Plant-based Food Technologies Liz Specht Senior Scientist at The GFI
  • 2. Opportunities in plant-based food technologies Liz Specht, Ph.D. Senior Scientist The Good Food Institute October 3, 2018
  • 3. gfi.org Today’s roadmap 1) What is the problem we’re trying to solve? Why is this so urgent? 2) What market trends are driving interest in – and development of – plant-based foods? And who’s involved? 3) What opportunities are there for technological solutions to pressing challenges in plant-based meat and other plant-based products? 2
  • 4. gfi.org The Good Food Institute 3 SCIENCE AND TECHNOLOGY Director of Science and Technology David Welch, Ph.D. INNOVATION Director of Innovation Brad Barbera CORPORATE ENGAGEMENT Director of Corporate Engagement Alison Rabschnuk POLICY Director of Policy Jessica Almy, Esq. UNITED STATES BRAZIL INDIA ISRAEL EUROPE CHINA Fall 2018 Our programmatic departments INTERNATIONAL ENGAGEMENT Director of International Engagement Nicole Rawling, Esq. Managing Director (Israel) Yaron Bogin, Ph.D. Managing Director (India) Varun Deshpande Managing Director (Brazil) Gus Guadagnini
  • 5. gfi.org Global demand for meat is on the rise, despite increasing consumer awareness of its environmental burden 2005 vs. 2050 (in tons) Source: Food and Agriculture organization of the United Nations, ESA Working Paper No. 12-03, p. 131 4
  • 6. gfi.org We cannot continue with business as usual 5 29% land 71% oceanEarth’s surface 71% habitable land 10% glaciers 19% barren landLand surface 77% livestock 23% cropsAgricultural land 50% agriculture 37% forests 11% shrubHabitable land 1% urban 1% freshwater 33% Meat & dairy 67% Plant-based food Protein supply Adapted from OurWorldInData.org and based on UN FAO statistics
  • 7. gfi.org Sustainable food systems require radically rethinking meat – not incremental efficiency gains 6 Feed (calories) Movement; thermal energy; growing bone, brain, feathers, etc… Food (calories) “We have pushed animals to their biological limits.” (Nature, 2018)
  • 8. gfi.org Here’s another perspective: producing meat is the most perverse food waste problem imaginable 7 0 20 40 60 80 100 120 Food waste by consumers or in supply chain Food consumed 0 500 1000 1500 2000 2500 3000 3500 Food waste by consumers or in supply chain Food consumed Food waste in production (chicken) Food waste in production (beef)
  • 9. gfi.org Let me pitch you on a new, improved protein production platform! 8
  • 10. gfi.org Animal agriculture is, and will always be, inefficient. Thermodynamics and basic biology assure it. 9
  • 11. gfi.org The majority of mammal biomass on earth is either humans or our livestock 10XKCD; also see YM Bar-On et al., 2018
  • 12. gfi.org 11 Animal agriculture is “one of the most significant contributors to the most serious environmental problems, at every scale from local to global.” – Livestock’s Long Shadow, 2006, UN FAO monocrops
  • 13. gfi.org Superbugs could cost the world $100 trillion by 2050 THE TELEGRAPH In their latest test, Consumer Reports found bacterial contamination on 97% of chicken. Drug resistant infections kill half a million people a year THE GUARDIAN Despite increasing awareness that eating animal meat is harmful, consumption continues to rise.
  • 14. gfi.org The solution: plant-based meat, clean meat, and other alternative proteins 13 PLANT-BASED MEAT CLEAN MEAT
  • 15. gfi.org Today’s roadmap 1) What is the problem we’re trying to solve? Why is this so urgent? 2) What market trends are driving interest in – and development of – plant-based foods? And who’s involved? 3) What opportunities are there for technological solutions to pressing challenges in plant-based meat and other plant-based products? 14
  • 16. gfi.org “If we can grow the meat without the animal, why wouldn’t we?” — Tom Hayes, Tyson Foods CEO, 2018
  • 17. gfi.org Big Meat companies are rebranding as “protein companies”
  • 18. gfi.org “Our vision is to be the most trusted name in premium protein,” Chairman Jim Perdue said. "It doesn’t say premium meat protein, just premium protein. That’s where consumers are going.”
  • 19. gfi.org Visionaries agree — plant-based is the future of food “What I was experiencing [Beyond Meat’s chicken] was more than a clever meat substitute. It was a taste of the future of food.” -Bill Gates “I believe that in 30 years or so we will no longer need to kill any animals and that all meat will either be clean or plant-based, taste the same and also be much healthier for everyone.” – Richard Branson
  • 20. gfi.org 19Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18. -10% 0% 10% 20% 30% 40% 50% 60% 70% Creamer Yogurt Cheese Ice Cream and Novelty Meat Milk Butter $%ChgYA Plant-based Animal-based Plant-based products are exploding across all categories
  • 21. gfi.org 27% 57% 61% The plant-based meat market is booming 20 Year-over-year growth
  • 23. gfi.org Millennials are driving this trend, and it will accelerate • 30% eat meat alternatives every day • 50% eat meat alternatives a few times per week • “These numbers, coupled with the size and spending power of Millennials, indicates a strong potential market for meat alternatives in the future.” - Billy Roberts, Sr. Food & Drink Analyst, Mintel Source: Mintel’s The Protein Report – Meat Alternatives - 2017
  • 24. gfi.org What’s driving the shift to plant-based eating?
  • 25. gfi.org Consumers choose plant-based foods for many reasons
  • 26. gfi.org Consumers overwhelmingly view plant-based proteins as healthy •Millennial and Gen X consumers believe plant- proteins are healthier than animal-based proteins •Consumers know that plant- based proteins are better for the environment than animal- based options Souce: Mintel - Plant-based proteins report. January 2018.
  • 27. gfi.org But in the end… it’s always about taste! “Plant-based protein eaters swear it’s about taste” - Mintel New research from the research firm Mintel revealed taste as the top reason U.S. adults who eat plant-based proteins do so (52%), outranking concerns over diet (10%), animal protection (11%), the environment (13%) and even health (39%). The research was based on responses from 1,876 U.S. internet users aged 18 or over that eat plant-based proteins. The study also indicated that 46% of Americans agree that plant-based proteins are better for you than animal-based options. Whether a desire to avoid processed foods (39%), manage weight (31%) or promote muscle growth (16%), many plant-based protein consumers are motivated by maintaining or improving their health and well-being, according to the Mintel survey. Souce: Mintel - Plant-based proteins report. January 2018.
  • 28. gfi.org Taste, Price, & Convenience ● Fastest growing brands are ones that focus on flavor ● Plant-based foods starting to achieve price parity with increased scale ● Plant-based foods are now available in more retail and foodservice outlets and are increasingly placed in the main sections of menus and store shelves, not in specialty areas Deloitte Food Value Equation Survey, 2015
  • 32. gfi.org Plant-based milk & meat have the most items on shelf Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18.
  • 33. gfi.org Plant-based milk market share at 13% vs. meat 1% (U.S.) Source: Nielsen custom defined data set, xAOC + WFM, 52 weeks ending 8/11/18. 0% 2% 4% 6% 8% 10% 12% 14% Milk Meat Cheese MarketShare 2018 2017
  • 34. gfi.org Global Access The global meat substitutes market is projected to be worth $5.96 billion by 2022 Source: Markets and Markets
  • 35. gfi.org Globally, what is top-of-mind for the meat industry? Source: State of the Global Meat Industry 2017
  • 36. gfi.org Global launches: Europe and the U.S. dominate, despite projected global meat demand rises elsewhere
  • 37. gfi.org Desired attributes vs. product claims don’t always align
  • 38. gfi.org Today’s roadmap 1) What is the problem we’re trying to solve? Why is this so urgent? 2) What market trends are driving interest in – and development of – plant-based foods? And who’s involved? 3) What opportunities are there for technological solutions to pressing challenges in plant-based meat and other plant-based products? 37
  • 39. gfi.org Protein alternatives fit into four categories from a production/cost/infrastructure perspective 38 ANIMAL CELL CULTURE NON-ANIMAL CELL CULTURE RECOMBINANT PROTEINS PLANT-BASED PROTEINS
  • 40. gfi.org Protein alternatives fit into four categories from a production/cost/infrastructure perspective 39 ANIMAL CELL CULTURE NON-ANIMAL CELL CULTURE RECOMBINANT PROTEINS PLANT-BASED PROTEINS
  • 41. gfi.org Non-animal cell culture can take many forms Primary nutrient source is a key consideration for competitiveness. 40 Long-term, validated low cost at scale: mycoprotein Moving rapidly towards scale: bacterial protein Still small scale and high cost: algal protein These represent incredibly diverse kingdoms of life with unexplored biosynthetic pathways for natural sources of high-value flavorings, stabilizers, pigments, vitamins, etc.
  • 42. gfi.org Basic infrastructure requirements for all single-cell growth exhibits cross-platform similarities 41
  • 43. gfi.org Protein alternatives fit into four categories from a production/cost/infrastructure perspective 42 ANIMAL CELL CULTURE NON-ANIMAL CELL CULTURE RECOMBINANT PROTEINS PLANT-BASED PROTEINS
  • 44. gfi.org 43 Lots of room for enzyme adaptation, prospecting, or engineering to functionalize plant protein sources. Recombinant protein production can be used for high- value ingredients and enzymatic functionalization
  • 45. gfi.org Protein alternatives fit into four categories from a production/cost/infrastructure perspective 44 ANIMAL CELL CULTURE NON-ANIMAL CELL CULTURE RECOMBINANT PROTEINS PLANT-BASED PROTEINS
  • 46. gfi.org The cell culture medium is a nutrient broth containing the vitamins, lipids, sugars, and amino acids cells need to grow. It also contains signaling molecules called growth factors. The core components of the nutrient feed and scaffold for clean meat are derived from biomass 45 The scaffold can be made of a number of plant- or fungal-derived polymers or gels.
  • 47. gfi.org Protein alternatives fit into four categories from a production/cost/infrastructure perspective 46 ANIMAL CELL CULTURE NON-ANIMAL CELL CULTURE RECOMBINANT PROTEINS PLANT-BASED PROTEINS
  • 48. gfi.org What is plant-based meat? 47 Plant-based meat products are structured plant- or fungus-derived foods designed to replace animal-based meat either as stand-alone products or within recipes.
  • 49. gfi.org PLANT-BASED MEAT TECHNOLOGY CROP ANALYSIS & OPTIMIZATION FUNCTIONAL ANALYSIS TRAIT MAPPING DIGITAL PHENOTYPING HIGH THROUGHPUT BREEDING GENETIC EDITING & ENGINEERING NOVEL INGREDIENTS AGRICULTURAL TECHNOLOGY CHEMICAL FUNCTION- ALIZATION RAW MATERIAL SOURCING & OPTIMIZATION MECHANICAL FRACTIONATION CHEMICAL FRACTIONATION BIOLOGICAL FUNCTION- ALIZATION MECHANICAL FUNCTION- ALIZATION COMPOSITION & PROCESS OPTIMIZATION COMPOSITIONAL ANALYSIS STRUCTURAL ANALYSIS SENSORY EVALUATION PROCESS OPTIMIZATION DISTRIBUTION SUPERMARKET SUPPLY FOOD SERVICE SUPPLY MARKETING POSITIONING JUST-IN-TIME DELIVERY
  • 50. gfi.org How to achieve tastes and textures that mimic meat? 49
  • 51. gfi.org Crop Analysis and Optimization 50 Thus far, plant-based meat manufacturers have been dealing with rather sub-par and limited materials. CROP ANALYSIS & OPTIMIZATION FUNCTIONAL ANALYSIS TRAIT MAPPING DIGITAL PHENOTYPING HIGH THROUGHPUT BREEDING GENETIC EDITING & ENGINEERING NOVEL INGREDIENTS AGRICULTURAL TECHNOLOGY
  • 53. gfi.org Protein source in top products Wheat Soy Myco- protein Pea Other Morningstar X X Gardein X X Lightlife X X Boca X X Quorn X Tofurky X X X Field Roast X Dr. Praeger’s X X X Beyond Meat X X X
  • 54. gfi.org Explore beyond traditional crops for high-value ingredients and bulk protein sources
  • 55. gfi.org Raw Material Sourcing and Optimization 54 CHEMICAL FUNCTION- ALIZATION RAW MATERIAL SOURCING & OPTIMIZATION MECHANICAL FRACTIONATION CHEMICAL FRACTIONATION BIOLOGICAL FUNCTION- ALIZATION MECHANICAL FUNCTION- ALIZATION Methods to isolate and functionalize raw materials for plant-based meats
  • 56. gfi.org Optimizing Raw Materials to Improve Plant-based Meats FUNCTIONALIZATIONFRACTIONATION 55 Chemical isolation of raw materials Biological and chemical processes to functionalize ingredients Mechanical methods to separate and isolate raw materials Mechanical methods to enhance raw material function
  • 57. gfi.org Functionality is derived from biochemistry 56 Heck et al. 2013
  • 58. gfi.org Composition and Process Optimization 57 COMPOSITION & PROCESS OPTIMIZATION COMPOSITIONAL ANALYSIS STRUCTURAL ANALYSIS SENSORY EVALUATION PROCESS OPTIMIZATION Establishing the correct mix of ingredients and processes to create the desired taste, texture, smell, and structure
  • 59. gfi.org Ingredient Optimization Enhances the Final Product OPTIMIZING FLAVOR AND FUNCTIONALITY IMPROVING TASTE AND TEXTURE THROUGH FAT ENCAPSULATION ENHANCING NUTRITIONAL PROFILES THROUGH BIOFORTIFICATION RECAPITULATING THE CONSUMER EXPERIENCE OF COOKING Biochemistry is transforming plant-based meats 58
  • 60. gfi.org As consumers increasingly demand “clean labels”, find natural alternatives to synthetic additives 59
  • 61. gfi.org CROP OPTIMIZATION RAW MATERIAL OPTIMIZATION COMPOSITION AND PROCESS OPTIMIZATION Data will be central to the next phase of plant-based meat 60 • GENOTYPE • PHENOTYPE • MACRONUTRIENTS • MICRONUTRIENTS • FUNCTIONALITY • PROTEIN STRUCTURING • CONSUMER PREFERENCE • SOIL CONDITIONS DATA COLLECTION AND ANALYSIS
  • 62. gfi.org Data will be central to the next phase of plant-based meat 61 KeyGene
  • 63. gfi.org Data will be central to the next phase of plant-based meat 62
  • 64. gfi.org How saturated is the meat alternatives field? What is the opportunity for exploratory research to translate into a revolutionary commercial reality? 63
  • 66. gfi.org $1.275 Billion Invested in Plant-based and Clean Meat, Egg, and Dairy Companies Source: Crunchbase; YTD as of 8/18
  • 68. gfi.org 67 SOLAR Spheres represent global R&D investment into renewable energy in a single year (2011). Total combined R&D into meat alternatives, across all years: about $1 billion WIND BIOMASS BIOFUELS HYDRO MARINE GEOTHERMAL Data: Global Trends in Renewable Energy 2012 $147.4bn $83.8bn $10.6bn $6.8bn $5.8bn $2.9bn $0.2bn 67 Development of alternative proteins is highly tractable
  • 69. gfi.org Recap: Opportunities abound 68 Market trends indicate that alternative proteins – and especially meat alternatives – will experience tremendous growth. Expertise in meat science, synthetic biology, genomics, biochemistry, mechanical engineering, and data analytics will accelerate development of novel and improved products. Leverage biological systems: room for strain improvement from crops to lactobacillus to filamentous fungi. Strategics are counting on external innovation to fuel this transition, followed by investment and/or acquisition.