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IMMUNOTHERAPY
FOR BREAST CANCER
Introduction
• Immunotherapy is used to:
 Stop or slow cancer cell growth
 Stop cancer cells from spreading to other parts of the body
 Be better at killing cancer cells
• Activates or suppresses the immune system
• Monoclonal antibodies are the most traditional form of
immunotherapy
• Types of immunotherapy
Monoclonal Antibody
• Immune checkpoint inhibitors to treat breast cancer are:
 Tecentriq (chemical name: Atezolizumab)- triple-negative breast cancer
 Chemotherapy medicine –Abraxane
• Immunotherapy medicines to treat breast cancer are:
 Herceptin (chemical name: trastuzumab)
 Perjeta (chemical name: pertuzumab)
 Kadcyla (chemical name: T - DM1)
Mechanism
• HER2-positive breast cancer by targeting the HER2 receptors on breast
cancer cells
• In addition to blocking HER2 receptors, these medicines can also help fight
breast cancer
• The immune system to destroy cancer cells
• It is called “immune targeted therapies”
• Monoclonal antibodies can also interferes with the following:-
• cell signalling
• blocks cell growth
• communication of tumor cells

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Immunotherapy for Breast Cancer: Types and Mechanisms

  • 2. Introduction • Immunotherapy is used to:  Stop or slow cancer cell growth  Stop cancer cells from spreading to other parts of the body  Be better at killing cancer cells • Activates or suppresses the immune system • Monoclonal antibodies are the most traditional form of immunotherapy • Types of immunotherapy
  • 3. Monoclonal Antibody • Immune checkpoint inhibitors to treat breast cancer are:  Tecentriq (chemical name: Atezolizumab)- triple-negative breast cancer  Chemotherapy medicine –Abraxane • Immunotherapy medicines to treat breast cancer are:  Herceptin (chemical name: trastuzumab)  Perjeta (chemical name: pertuzumab)  Kadcyla (chemical name: T - DM1)
  • 4. Mechanism • HER2-positive breast cancer by targeting the HER2 receptors on breast cancer cells • In addition to blocking HER2 receptors, these medicines can also help fight breast cancer • The immune system to destroy cancer cells • It is called “immune targeted therapies” • Monoclonal antibodies can also interferes with the following:- • cell signalling • blocks cell growth • communication of tumor cells