immunotherapy

1. Basic immunotherapy
What every oncologists have to know
BY
Ereny S. Ploes
Ass.lec , clinical oncology department
Assiut University

2. * content
1. Basic immunology.
2. Response of immune system against cancer.
3. Immunogenic vs non- immunogenic tumours.
4. Tumour infiltrate lymphocytes (TLS).
5. Physiological functions of immune system bakes.
6. Immuno-escape phenomena.
7. Mechanism of action of immunotherapy
biologics.

4. 1- Basic immunology

10. Immune response against cancer

14. Deep look inside

18. Immunogenic Vs Non Immunogenic

25. Possible causes of low tumour
immunogenicity

27. Tumor Infiltrating Lymphocytes(TLS)

29. Immune Escape Mechanism

39. Immune inhibition, why it is needed
Physiological function of immune
checkpoints

43. Maturation and
differentiation

57. Mechanism of CTLA4 inhibitors

64. Take Home Message
• Understanding the normal physiology is the first step to
target the pathological one.
• When dealing with cancer cell we should have to realize
that we deal with the most powerful , complex and
INTELLIGENT biological system and we should to respect
our enemy.
• Especially in the era of target therapy and biologic
immunotherapy , we should adopt deeply the concept of
personalized medicine and give up size fit all approach