Reverse engineering the human body and biology can help save lives by deciphering protein interactions and developing causal networks to understand disease pathways. Machine learning can combine data from over 50 databases on drugs, proteins, clinical trials, and more to generate networks that model human physiology and predict drug responses, biomarkers, and adverse events. This system has already helped develop new treatments and biomarkers while aiding pharmaceutical companies, and its continued use promises more personalized medicine tailored to individual pathologies and biology in the future.

1. Reverse engineering the human biology….
Probably is going to save your life or the life of someone you care about

3. A source code of 3200 million letters (AGTC)

4. The sequence is cut and folded by ribosomes

5. Proteins stitch together or with molecules when they fit in shape
and electrical field

6. Different functions: structural, metabolic, transporting,
messenger, antibodies.

8. ?
Deciphering the real network of interactions
is a reverse engineering problem…machine
learning

9. Drug, compound information, protein sequence and structure, protein interactions,
Clinical trials, active site DDBBs, Patent Web Pages, pathologies and pathways, indications, drug adverse
events, publications, micro arrays, demographic databases…
More than 50 DDBB

10. RNA sequencing and microarrays cheaply measure the “state” of thousands of proteins at once

11. What’s the physiological path
from the stimulus to the
response?
Response
Stimulus
Response
We developed a system to combine all those evidences in populations of plausible
causal networks

12. INPUT OUTPUT
DRUG
INDICATION
?
YES/NO
MACHINE LEARNING

13. network is adjusted to populations with a certain disease
What protein to measure to detect if some one have or will
have that disease?
What to change in the network to make it work as a normal
population?
Is this drug going to work for what it is designed?
Which adverse events is going to produce my drug?

14. New treatments in Alzheimer, glaucoma, neuronal regeneration,…
New biomarkers for drug hepatotoxicity detection, response to
malaria vaccines, …
Helped a lot of pharma’s to understand their drugs

15. The future….
Your treatment will depend of your pathology and of your
biology
Personalized medicine