Ignite Seattle - It\'s Only a Little Prick

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This document provides tips for organizing a blood donation party or drive. It encourages the reader to distract themselves during donation by bending their knees or thinking of other things. Organizing a party with others makes the experience better and the reader is encouraged to reach out on social media to recruit donors for their party or drive.

Type A Humor Source: Frank and Ernest by Thaves

It’s your move @jshuey Puget Sound Blood Center Organize a Party A Party of One is OK It’s Even Better if it’s a Blood Drive! bit.ly/psbc-don

Millennials are the Future of Partnership. Many of them are already in the working world and more are entering the workforce every day. - 10,000 Millennials are reaching the age of 21 every day - By 2025, 3 out of every 4 workers globally will be Millennials - Today there are 55 million Millennials in the workplace Helping them become understand the opportunities with partnering is the responsibility of today's generation. Microsoft needs to play a role as a platform provider. Current partners, which are often comprised of Baby Boomers and Gen X'ers have a role to play too. Baby Boomers play a big role here: - 10,000 Baby Boomers are reaching retirement age every day. - They aren't (necessarily) retiring ... they have Big Plans. - The bring The FEM Factor In this presentation you'll see some of the factors that are impacting the partner community and what collectively we can do about it ... together. Note: Millennials and Gen Z's are starting business every day. This is a good thing. The challenge is ... How do we get them to consider doing this in the Microsoft partner ecosystem.

Seven Tips for Collaborative Success

Jeff Shuey

Microsoft is enabling Collaborative Disruption ... there are (at least) 7 applications that everyone should have on their devices ... and they are all FREE. Every SharePoint and Office 365 deployment has immense capabilities right at their fingertips and most of it is FREE. In this session I will discuss 7 Tips that will improve anyone's ability to get more done, do more with data, and share it with the team. I'll discuss some tools that many people have never heard of or didn't realize were available across all devices - Android, iOS and Windows. I'll discuss Office Lens, SWAY, OneNote, Yammer, Outlook, Power BI and Delve and two bonus points.

6 things every LinkedIn profile needs

Jeff Shuey

If you are serious about your business you need to be on LinkedIn. This session will cover 6 of the most critical elements every LinkedIn Profile needs. Whether you are an executive, manager or new employee, LinkedIn has something to offer. Every attendee will receive crisp, concise and actionable advice for managing and making the most of their LinkedIn profile. This was delivered live at the Microsoft Worldwide Partner Conference in Orlando on July 13, 2015

5 Questions you should ask before starting a corporate blog

Jeff Shuey

Before touching a keyboard, there are 5 important questions you should ask yourself and your company before beginning a blogging effort. If your company already has a corporate blog this session might expose a few new ideas to spice things up. In this fast-paced session a few time-tested and proven ideas will be explored and shared for getting started and staying on-track. Originally presented at #WPC15 in Orlando on 7-14-2015

SharePoint - A Few Good Deployments

Jeff Shuey

SharePoint can do a lot of things. As an out-of-the-box (OOTB) product there are a lot of solutions that can be developed. But, there is an entire partner ecosystem that has grown up around and with SharePoint. These partners can make your SharePoint deployments more efficient, easier to use and often times more cost effective. This session will highlight a few real-world deployments and will talk about some of the challenges related to OOTB functionality and how partners have filled gaps to add extended capabilities for things like scanning paper documents, adding workflow processes, declaring records and storing content for long term archiving. Customers in every market segment often end up needing one or more of these to provide a complete solution. This is a business oriented session and will not dive into the details of how to configure SharePoint or how to integrate partner solutions. Attendees are encouraged to bring their ideas and business challenges. With time permitting we will talk about possibilities for building out your own Real-World SharePoint deployment.

The Future of SharePoint (FOSP) is going to be all about data and access to data. Data is being created everywhere today – from traditional corporate processes to social media and mobile computing efforts. Capturing, Managing and Governing this data will be critical to every business. SharePoint is at the early stages of reaching its full potential and to being THE PLACE where data is surfaced from disparate repositories.

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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...

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i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource. This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and Associate Division Director for Ambulatory Operations The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma. STATEMENT OF NEED Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL. Target Audience Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL). Learning Objectives 1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL 2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults 3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection

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The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.

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RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0). CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.

Physiology of Special Chemical Sensation of Taste

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Title: Sense of Taste Presenter: Dr. Faiza, Assistant Professor of Physiology Qualifications: MBBS (Best Graduate, AIMC Lahore) FCPS Physiology ICMT, CHPE, DHPE (STMU) MPH (GC University, Faisalabad) MBA (Virtual University of Pakistan) Learning Objectives: Describe the structure and function of taste buds. Describe the relationship between the taste threshold and taste index of common substances. Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation. Recognize different abnormalities of taste perception and their causes. Key Topics: Significance of Taste Sensation: Differentiation between pleasant and harmful food Influence on behavior Selection of food based on metabolic needs Receptors of Taste: Taste buds on the tongue Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper) Primary and Secondary Taste Sensations: Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami Chemical basis and signal transduction mechanisms for each taste Taste Threshold and Index: Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine) Taste index relationship: Inversely proportional to taste threshold Taste Blindness: Inability to taste certain substances, particularly thiourea compounds Example: Phenylthiocarbamide Structure and Function of Taste Buds: Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers Location of Taste Buds: Found in papillae of the tongue (Fungiform, Circumvallate, Foliate) Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus Mechanism of Taste Stimulation: Interaction of taste substances with receptors on microvilli Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes Taste Sensitivity and Adaptation: Decrease in sensitivity with age Rapid adaptation of taste sensation Role of Saliva in Taste: Dissolution of tastants to reach receptors Washing away the stimulus Taste Preferences and Aversions: Mechanisms behind taste preference and aversion Influence of receptors and neural pathways Impact of Sensory Nerve Damage: Degeneration of taste buds if the sensory nerve fiber is cut Abnormalities of Taste Detection: Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia) Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels Neurotransmitters and Taste Threshold: Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity Supertasters: 25% of the population with heightened sensitivity to taste, especially bitterness Increased number of fungiform papillae

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As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions. Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says. This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots. To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare. Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself. Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places. Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages. Stay informed, stay safe, and get your flu shot today!

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