Hyperviscosity syndromes refer to clinical sequelae caused by increased blood viscosity. Increased blood viscosity can be caused by elevated levels of immunoglobulins, blood cells, or reduced red blood cell deformability. This leads to vascular stasis, tissue hypoperfusion, and signs like bleeding, visual changes, and neurological symptoms. Diagnosis involves measuring elevated serum viscosity in patients showing characteristic symptoms, especially those with underlying blood disorders. Treatment focuses on plasma exchange to reduce viscosity along with treating the underlying condition. Prognosis depends on the underlying disorder, its severity, and response to treatment.