The document reports on a study that examined hormone levels in postmenopausal women with osteoarthritis compared to controls. The study found that women with osteoarthritis had significantly lower levels of estrogen compared to controls, suggesting that estrogen deficiency after menopause may contribute to the development of osteoarthritis. No significant differences were found in thyroid, progesterone, or calcitonin hormone levels between the two groups.
Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to determine whether the levels of thyroid and sex hormones are associated with osteoarthritis (OA) in postmenopausal women. Forty three patients suffering from OA and twenty control subjects were included in this study. Thyroid and sex hormones were measured in the serum by enzyme linked immunosorbent assay technique. In OA patients serum estrogen levels were low as compared to control subjects(p<0.001), but these patients did not show any significant change in thyroid hormones and progesterone hormone levels when compared with control subjects. The findings suggest that estrogen deficiency after menopause may contribute to develop OA in postmenopausal women.
Prof. Nicholas Harvey's presentation from Osteoporosis 2016: Calcium, with or without vitamin D supplementation, is not associated with ischaemic heart disease or cardiac death: the UK Biobank cohort.
Find out more at: https://nos.org.uk/conference
A study of serum Cadmium and lead in Iraqi postmenopausal women with osteopor...IOSR Journals
Postmenopausal status is an independent risk factor for osteoporosis. Several studies have reported that heavy metals, including lead, mercury, cadmium, and arsenic, have harmful effects on bone. The aim of this study was to evaluate the effect of heavy metals, including Cadmium and Lead on osteoporosis in postmenopausal Iraqi women. This prospective study included a total of 70 postmenopausal women divided as 40patients with osteoporosis compared to 30 apparently healthy women as controls during 2011. Serum levels of Cadmium and Lead were measured using atomic absorption while serum Calcium, Phosphorus and Alkaline phosphatase were measured by spectrophotometry.The results showed that there was no significant difference between patients and controls regarding age, Body Mass Index, Calcium, Phosphorous, and Alkaline phosphatase. Serum levels of Cadmium and Lead were higher in patients compared to controls, p < 0.001 and p< 0.01 respectively. It is concluded that increased serum levels of cadmium and lead maybe associated with higher risk of osteoporosis in postmenopausal women.
Metabolic abnormalities observed in osteoarthritis of knee: A single center e...Apollo Hospitals
Osteoarthritis (OA) has become a major public health problem not only because of increasing prevalence worldwide (about 21 million people affected in the United States) but also frequent association with cardiovascular diseases-the leading cause of death in the industrialized countries.
Osteoarthritis is the most common disease of women after menopause. There are many factors to develop the disease. Hormones play important role to in this context. The objective of the present study is to determine whether the levels of thyroid and sex hormones are associated with osteoarthritis (OA) in postmenopausal women. Forty three patients suffering from OA and twenty control subjects were included in this study. Thyroid and sex hormones were measured in the serum by enzyme linked immunosorbent assay technique. In OA patients serum estrogen levels were low as compared to control subjects(p<0.001), but these patients did not show any significant change in thyroid hormones and progesterone hormone levels when compared with control subjects. The findings suggest that estrogen deficiency after menopause may contribute to develop OA in postmenopausal women.
Prof. Nicholas Harvey's presentation from Osteoporosis 2016: Calcium, with or without vitamin D supplementation, is not associated with ischaemic heart disease or cardiac death: the UK Biobank cohort.
Find out more at: https://nos.org.uk/conference
A study of serum Cadmium and lead in Iraqi postmenopausal women with osteopor...IOSR Journals
Postmenopausal status is an independent risk factor for osteoporosis. Several studies have reported that heavy metals, including lead, mercury, cadmium, and arsenic, have harmful effects on bone. The aim of this study was to evaluate the effect of heavy metals, including Cadmium and Lead on osteoporosis in postmenopausal Iraqi women. This prospective study included a total of 70 postmenopausal women divided as 40patients with osteoporosis compared to 30 apparently healthy women as controls during 2011. Serum levels of Cadmium and Lead were measured using atomic absorption while serum Calcium, Phosphorus and Alkaline phosphatase were measured by spectrophotometry.The results showed that there was no significant difference between patients and controls regarding age, Body Mass Index, Calcium, Phosphorous, and Alkaline phosphatase. Serum levels of Cadmium and Lead were higher in patients compared to controls, p < 0.001 and p< 0.01 respectively. It is concluded that increased serum levels of cadmium and lead maybe associated with higher risk of osteoporosis in postmenopausal women.
Metabolic abnormalities observed in osteoarthritis of knee: A single center e...Apollo Hospitals
Osteoarthritis (OA) has become a major public health problem not only because of increasing prevalence worldwide (about 21 million people affected in the United States) but also frequent association with cardiovascular diseases-the leading cause of death in the industrialized countries.
Dr Jennifer Walsh's presentation from Osteoporosis 2016: Management of osteoporosis in the young adult.
Find out more at: https://nos.org.uk/conference
Dr Steve Cummings presentation from Osteoporosis 2016: Patients receiving bisphosphonates should not take holidays from treatment.
Find out more at: https://nos.org.uk/conference
Dr Jennifer Walsh's presentation from Osteoporosis 2016: Management of osteoporosis in the young adult.
Find out more at: https://nos.org.uk/conference
Dr Steve Cummings presentation from Osteoporosis 2016: Patients receiving bisphosphonates should not take holidays from treatment.
Find out more at: https://nos.org.uk/conference
Hypoglycaemia and improved testicular parameters in Sesamum radiatum treated ...lukeman Joseph Ade shittu
The development of a new dietary adjunct with a novel natural antioxidant impact on diabetes mellitus with prevention of its long term deleterious effect on the male fertility in general has been increasingly expressed in recent time. Hence, we aim to evaluate the effects of aqueous extract of Sesame radiatum leaves on adult male Sprague Dawley rats’ testis using unbiased stereological, biochemical and hormonal studies. Thirty adult male rats were divided into three groups of 10 rats each. The treated groups; 1 and 2 received 28.0 and 14 mg/kg bwt of aqueous extract of sesame leaves via oral garvage, respectively, while the control group received equal volume of 0.9% (w/v) normal saline per day for 6 weeks. Serum follicle-stimulating hormone (FSH), testosterone and blood glucose were assayed. In addition five microns of uniformly random transverse sections of processed testicular tissues were equally analyzed using an un-biased stereological study. The result showed that the mean percentage volume fractions (Vf) of epithelial cells and lumen of the testis were 76% (P<0.05)><0.05),>0.05) higher than the control in a dose related manner. Serum testosterone and FSH were significantly higher and lower, respectively, in the high dose sesame when compared to control. Sesame leaves intake improved glucose profile and testicular parameters in a dose related manner via possible improved insulin activity on the cells with a stimulatory impact on sperm production. This also confirmed its folkloric claims.
The Gut Microbiome, Aging and Longevity An Overviewijtsrd
The gut microbiome is a contributory factor in ageing related health loss and in several non communicable diseases in all age groups. Some age linked and disease linked compositional and functional changes overlap, while others are distinct. The gut microbiota undergoes extensive changes across the lifespan, and age related processes may influence the gut microbiota and its related metabolic alterations. The aim of this systematic review was to summarize the current literature on aging associated alterations in diversity, composition, and functional features of the gut microbiota. Longevity is one of the most complex phenotypes, and its genetic basis remains unclear. This study aimed to explore the genetic correlation and potential causal association between gut microbiota and longevity. Human longevity has a strong familial and genetic component. Dynamic characteristics of the gut microbiome during aging associated with longevity, neural, and immune function remained unknown. Here, we aim to reveal the synergistic changes in gut microbiome associated with decline in neural and immune system with aging and further obtain insights into the establishment of microbiome homeostasis that can benefit human longevity. In this paper we will discuss The Gut Microbiome, Aging and Longevity an Overview. Dr. G. Renuka | K. Vaishnavi | L. Vijayalaxmi | P. Srihitha | R. Himabindu "The Gut Microbiome, Aging and Longevity- An Overview" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-7 | Issue-6 , December 2023, URL: https://www.ijtsrd.com/papers/ijtsrd61302.pdf Paper Url: https://www.ijtsrd.com/biological-science/microbiology/61302/the-gut-microbiome-aging-and-longevity-an-overview/dr-g-renuka
THE FIRST SYSTEM OF REFERENCE FOR THE MEDICAL PRACTICE OF HOMEOPATHY IN FRANCEhome
PB7 445 THE FIRST SYSTEM OF REFERENCE FOR THE MEDICAL PRACTICE
OF HOMEOPATHY IN FRANCE
J. BILLOT* (AP-HP Hôpital Corenton-Celton, Issy-les -Moulineaux, France)
Introduction At least 30% of the French population has recourse to homeopathy, with a large
proportion of elderly persons. Some 25000 practitioners prescribe homeopathic treatments.
Object: Development of a system of reference for the medical practice of homeopathy in
order to meet with the legal obligations of evaluation and training of homeopaths. Method :
1- Creation by the Société Française d’Homéopathie of a working group of expert specialists
representative of the medical practice of homeopathy to determine: - a basic methodology:
self-evaluation according to the method of practice groups; - the subject: « the homeopathic
medical file»; - the aims and requirements of quality; - the standards of evaluation; - the
number and content of items or inquiries 2- Verification of the text’s form by a reader’s
group; 3- Verification of acceptability and feasibility by a group test; 4- New meeting of the
working group to register the modifications shown necessary by the feasibility study; 5-
Presentation of the text to the methodologists approved by the Haute Autorité de la Santé
(Health Department); 6- Finalization of the project and transmission to the Haute Autorité de
la Santé for validation. Results: Elaboration of a system of analysis with reference to the
«homeopathic medical file», according to the method of practice groups. This system of
reference includes a questionnaire concerning the symptoms noted in the patient’s file: in
order to be of homeopathic value, the symptoms must be precisely characterized and
organized according to their relative importance. Conclusion This system of reference was
validated by the Haute Autorité de la Santé in February 2007. Several practice groups have
already used this system of reference to validate the legal obligations of their profesional
practice. The complete text of this system of reference can be downloaded on web-site:
WWW. homeopathie- francaise. fr
CLINICAL EVALUATION OF THE EFFECT OF OMEGA-3 FATTY ACIDS ON OSTEOPOROTIC FEMA...Mohamed A. Galal
Mohamed A. Galal ; Mushira A. Dahaba, ; Basma M. Zaki
and Hanaa M. Elshenawy. CLINICAL EVALUATION OF THE EFFECT OF OMEGA-3 FATTY ACIDS ON OSTEOPOROTIC FEMALES HAVING CHRONIC PERIODONTITIS. Cairo Dental Journal (30)Number (1), 1:10January, 2014.
Current treatments for postmenopausal osteoporosis
suffer from side effects. Safe and natural milk
proteins, ribonuclease, and lactoferrin promote formation
of new capillaries and bone formation.
Bone health of postpartum women: Unexpected high prevalence of a health probl...Premier Publishers
The aim was to see the effect of pregnancy on Bone Mineral Density (BMD) and bone turnover markers (BTMs) in the immediate postpartum period and 12 months thereafter. Eighty women delivered at KAUH (May 2009-Oct 2010) had BMD, bone profile, 25-OH vitamin D and (BTMs). Inclusion criteria: Singleton pregnancy without medical or pregnancy complications. Exclusion criteria: multiple pregnancies, history of diabetes thyroid or bone disease, and use of any medication that affect calcium metabolism. Biochemical tests were repeated for 27 women after one year. Statistical analysis was done using SPSS 16. Eighty women had BMD before discharge. Sixty four women (80%) had low BMD; sixteen of these (25%) had osteoporosis. Although bone profiles were normal, Vitamin D levels were moderately or severely deficient in 35.37% of women. After adjustment for BMI and age there was no correlation between BMD and other variables. Multiple linear regressions showed that BMI was the predictor for BMD (P=0.0014). There was no significant difference between postpartum bone BTMs and bone profiles, and those after twelve months.
Osteoporosis/ osteopenia is a significant health problem in this group of women. Further studies are needed to look into predisposing factors.
we need to update our knowledge regarding management of endometriosis.
Which is better: medications or surgery? let's see what can this talk tell us about
2. Sadia et al., World J Pharm Sci 2014; 2(1): 49-51
50
osteoarthritis, such as pain, stiffness, soreness,
aching, discomfort, swelling & tenderness.
Radiographs were taken for assessment of
severity of osteoarthritis. Patients taking any
hormone replacement therapy (HRT), non
steroidal anti inflammatory drugs (NSAID),
having metabolic disease, rheumatoid arthritis
(RA), joint, systemic lupus erythromatosis
(SLE) were excluded from the study.
Control Postmenopausal women were selected
having no sign of osteoarthritis clinically. BMI
(Body mass index) was calculated of all
patients and control subjects. Blood
samples from osteoarthritis female patients
and control subjects were collected. About
10ml blood was collected in centrifuge tubes.
Serum was separated by centrifugation and
was kept at -70ºC till the further analysis of
biochemical parameters. Estradiol,
progesterone, calcitonin were analyzed by
ELISA.
RESULTS AND DISCUSSION
A total of 43 female postmenopausal
osteoarthritis patients and 20 control subjects
participated in the study.
Table 1 shows the age and BMI of controls
and osteoarthritic subjects, but no significant
differences were found between BMI of
patients and control subjects.
Table 2 shows the status of thyroid, calcitonin,
estrogen and progesterone hormones in
patients and control groups. Estrogen hormone
was statistically decreased (p<0.001) in
patients as compared with control subjects.
Osteoarthritis is a chronic painful, disabling
condition affecting synovial joints. It is a
common age related disorder, which is present
in more then 10% of the persons older than 65
years of age, it results in substantial disability
and economic cost in elderly person[8]
.Osteoarthritis is a disease of cartilage, early
cartilage abnormalities in patients with this
disease are followed by changes in
periarticular trabecular bone & thickning of
the subchondral plate [9,10]. The women
experience more severe arthritis in the knee.
Genetics, anatomy and prior knee injury are
risk factors for developing osteoarthritis[11].
There are several risk factors of osteoarthritis
obesity may be an important risk factor. Body
weight & body mass index was associated
with an increased risk of osteoarthritis at all
joints [12].In healthy peoples, cartilage defects
increase with increasing age and body mass
index.
The high incidence of osteoarthritis in women
just after menopause has suggested that
estrogen deficiency play a role in causing
disease. The studies have shown that women
taking estrogen have a decreased prevalence &
incidence of radiographic osteoarthritis[13]. In
the present study there was a significant
decrease in the level of estrogen in post
menopausal women patients as compared to
post menopausal control women. Thyroid
hormones are essential for the development,
growth & metabolism of tissue, including
bone. It is known that the action of thyroid
hormones on bone tissue can be direct [14,15].
Osteoarthritis is a disease in which there is no
balance between synthesis and degradation of
collagen & evidences tell us that thyroid
hormones fail to inhibit collagen synthesis .
Present study do not show any change in the
level of thyroid hormone in the osteoarthritis
patients as compared to control subjects
(Table-2) ,chaisson et al found no change in
thyroid hormone levels. Evidences tell us that
thyroid hormones fail to inhibit collagen
synthesis [16].
CONCLUSIONS
Osteoarthritis is a disease of old age and
mainly affected by several factors. Our
findings suggest that hormones, like estrogen
deficiency after menopause may develop the
disease of OA in postmenopausal women.
3. Sadia et al., World J Pharm Sci 2014; 2(1): 49-51
51
Table 2 : Hormones in control and osteoarthritis subjects
Group T3 T4 Calcitonin Estrogen Progesterone
ng/dl ug/dl pg/ml pg/ml ng/ml
129.27+1.44 6.15+0.28 21.17+0.12 51.02 3.65
Control +5.38 +0.71
(20) (20)
*
130.09 5.97 20.87 27.55 2.89
Patients +1.91 +0.23 +0.11 +3.46 +0.45
(43) (43) (43) (43) (43)
Values are the mean ± S.E.M. * p < 0.001 as compared to control subjects
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