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How Scientists and Artists are Discovering Musical Patterns in Protein Structures
Markus Buehler
Amino acid
synthesizer
Prepared for Leonardo Art/Science Evening Rendezvous of 10 September 2019 – San Francisco
by
Willard G Van De Bogart
Beautiful Humans Anirban Bandyopadhaya
https://www.beautifulhumans.info/anirban-bandyopadhyay/
Nanao BrainScientists:
Anirban Bandyopadhaya
Joel Sternheimer
Markus Buehler
Zhao Qin
Hans Geesink
Dirk Meijer
Anirban Bandyopadhaya - Microtubules 2014
Sound synthesis - Van De Bogart - McVeety
Additional research by Stuart Hameroff and Roger Penrose
Joel Sternheimer - Theoretical physicist - France
https://studiotomassarceno.org/about/tps://studiotomassaraceno.org/about/
G D V E K G K K I F I M K C S Q C H T V E K G G
the first 24 amino-acids of human cytochrome C.
https://www.researchgate.net/publication/281103244_EPIGENETIC_REGULATION_OF_PROTEIN_BIOSYNTHESIS_
BY_SCALE_RESONANCE_Invited_lecture
Cells healing themselves
with sound:
Plants
Animals
Humans
Wave dynamics
Scaling waves
Louis de Broglie
Endorphine
Signal protein
Spider web protein music by Markus Buehler and Zhao Qin - MIT
1, 2bjy 1.00 1.008378436 1.030715836 1.042870685 1.05679907 1.197504816...;
2, 1mfr 1.00 1.004021038 1.008026787 1.009678011 1.013072195 1.345060086...;
3, 1jre 1.00 1.008745375 1.031036908 1.062318442 1.087392594 1.199064306...;
4, 1ji4 1.00 1.003761123 1.017001498 1.062119683 1.0803596 1.256459652...;
5, 1qgh 1.00 1.031281534 1.038941382 1.067944837 1.091459499 1.213160872...;
6, 1l8h 1.00 1.003180136 1.024905972 1.091780571 1.110586185 1.250007645...;
7, 1jxv 1.00 1.017980002 1.06477999 1.094991285 1.119377427 1.1889582...;
8, 1gl6 1.00 1.009662722 1.082759991 1.091428921 1.142830933 1.166131548...;
9, 1hzd 1.00 1.025563404 1.03620463 1.108292817 1.129330642 1.226722319...;
10, 1a0c 1.00 1.013072195 1.078479039 1.105632511 1.186573097 1.201082469...;
11, 1fwu 1.00 1.056248662 1.06667584 1.104730453 1.150643672 1.214812097...;
The format of the data file (attached as Supporting Information) that contains the vibrational
spectrum of all proteins analyzed is
[PROTEIN ID], [PROTEIN ID IN PDB] [f_0/f_0] [f_1/f_0] [f_2/f_0] [f_3/f_0]...;
Analogy of protein structure to musical structures – Markus Buehler
http://web.mit.edu/mbuehler/www/papers/BioNanoScience_2011_3.pdf
Amino acid synthesizer
by Zhao Qin and Markus Buehler
MIT scientists have converted the molecular structures of proteins
into audible sound that resembles musical passages. Reversing the
process means they can introduce variations and convert the music
back into new proteins.
AI and the human
Protein Synthesizer
Zhao Qin – Markus Buehler
Protein synthesizer MAX plugin
Quantum wave mechanics
Protein
Folding
options
Van De Bogart - DeGeorge
Abelton 10 Live
Geesink and Meijer
Protein synthesizer Max plugin graphical representation for Abelton Live 10 DAW
Protein Synthesizer Control Panel
“Quantum aesthetics entails the
creation of both and art and a
literature based on the most
revolutionary findings within
quantum physics and the psychology
developed after it.”
Maria Caro and Andrés Monteagudo
The World of Quantum Culture
Artists:
John Dunn
Willard Van De Bogart
Gregorio Morales
Combining sound with quantum thought forms
Protein folding model by Hans Geesink and Dirk Meijer
The integration of the human brain and the quantum field
Visualizing wave dynamics in space effecting protein molecules
https://www.researchgate.net/publication/315706536_The_Folding_of_a_Life_Proteins_On_the_role_of_long-
and_short_range_electromagnetic_pilot_mechanisms
Hans Geesink and Dirk Meijer
The folding of life proteins
Life Music: https://www.jstor.org/stable/1576622?seq=1#page_scan_tab_contents
John Dunn
A collaboration with biologist Dr. Mary Anne Clark, produced
from the primary and secondary structure of protein
sequences, using software and synths.
In each piece, pitch is determined by amino acid identity and
instrumentation is chosen according to protein folding pattern,
with different instruments representing regions of alpha-helix,
beta-strands and turns. Lysozyme 254L
Protein Data Base
Lysozyme
Compositional techniques using electronic synthesizers
Man machine interface – AI verses the human - What happens to us when we listen to the sounds of proteins
Designing sonic wave shape topologies with the AniMoog synthesizer
Designing folding patterns using
the AniMoog wavetable synthesizer
Creating wave shapes on a Waldorf NAVE synthesizer to a protein synthesizer
Combining sonified elements in the universe with Synthscaper synthesizer
by Igor Vasliev
Quasar
Pulsar
Comet
TH
ORNG
SH
OW
CH
Creating neuroacoustic architecture
Combining amino acid sounds, phonemes and scales
Topological space
using 44 phonemes
from the English
language
20 Amino Acids Erv Wilson micro tonal scale
Hebdomekontany
Creating space music: combining Thought forms, Protein sounds, Sonified galactic, and Voice
Quantum Thought forms Synthesizers Cosmic/Space sounds Protein Sounds
Idea Instrument Direction Tone Voice
xenolinguistics
Individual sounds
Combined sounds
The xenosphere of our existence
We are at the threshold of discovering ourselves through sound

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How scientists and artists are discovering musical patterns in protein structures.

  • 1. How Scientists and Artists are Discovering Musical Patterns in Protein Structures Markus Buehler Amino acid synthesizer Prepared for Leonardo Art/Science Evening Rendezvous of 10 September 2019 – San Francisco by Willard G Van De Bogart
  • 2. Beautiful Humans Anirban Bandyopadhaya https://www.beautifulhumans.info/anirban-bandyopadhyay/ Nanao BrainScientists: Anirban Bandyopadhaya Joel Sternheimer Markus Buehler Zhao Qin Hans Geesink Dirk Meijer
  • 3. Anirban Bandyopadhaya - Microtubules 2014 Sound synthesis - Van De Bogart - McVeety Additional research by Stuart Hameroff and Roger Penrose
  • 4. Joel Sternheimer - Theoretical physicist - France https://studiotomassarceno.org/about/tps://studiotomassaraceno.org/about/ G D V E K G K K I F I M K C S Q C H T V E K G G the first 24 amino-acids of human cytochrome C. https://www.researchgate.net/publication/281103244_EPIGENETIC_REGULATION_OF_PROTEIN_BIOSYNTHESIS_ BY_SCALE_RESONANCE_Invited_lecture Cells healing themselves with sound: Plants Animals Humans Wave dynamics Scaling waves Louis de Broglie Endorphine Signal protein
  • 5. Spider web protein music by Markus Buehler and Zhao Qin - MIT 1, 2bjy 1.00 1.008378436 1.030715836 1.042870685 1.05679907 1.197504816...; 2, 1mfr 1.00 1.004021038 1.008026787 1.009678011 1.013072195 1.345060086...; 3, 1jre 1.00 1.008745375 1.031036908 1.062318442 1.087392594 1.199064306...; 4, 1ji4 1.00 1.003761123 1.017001498 1.062119683 1.0803596 1.256459652...; 5, 1qgh 1.00 1.031281534 1.038941382 1.067944837 1.091459499 1.213160872...; 6, 1l8h 1.00 1.003180136 1.024905972 1.091780571 1.110586185 1.250007645...; 7, 1jxv 1.00 1.017980002 1.06477999 1.094991285 1.119377427 1.1889582...; 8, 1gl6 1.00 1.009662722 1.082759991 1.091428921 1.142830933 1.166131548...; 9, 1hzd 1.00 1.025563404 1.03620463 1.108292817 1.129330642 1.226722319...; 10, 1a0c 1.00 1.013072195 1.078479039 1.105632511 1.186573097 1.201082469...; 11, 1fwu 1.00 1.056248662 1.06667584 1.104730453 1.150643672 1.214812097...; The format of the data file (attached as Supporting Information) that contains the vibrational spectrum of all proteins analyzed is [PROTEIN ID], [PROTEIN ID IN PDB] [f_0/f_0] [f_1/f_0] [f_2/f_0] [f_3/f_0]...;
  • 6. Analogy of protein structure to musical structures – Markus Buehler http://web.mit.edu/mbuehler/www/papers/BioNanoScience_2011_3.pdf
  • 7. Amino acid synthesizer by Zhao Qin and Markus Buehler MIT scientists have converted the molecular structures of proteins into audible sound that resembles musical passages. Reversing the process means they can introduce variations and convert the music back into new proteins. AI and the human
  • 8. Protein Synthesizer Zhao Qin – Markus Buehler Protein synthesizer MAX plugin Quantum wave mechanics Protein Folding options Van De Bogart - DeGeorge Abelton 10 Live Geesink and Meijer
  • 9. Protein synthesizer Max plugin graphical representation for Abelton Live 10 DAW
  • 11. “Quantum aesthetics entails the creation of both and art and a literature based on the most revolutionary findings within quantum physics and the psychology developed after it.” Maria Caro and Andrés Monteagudo The World of Quantum Culture Artists: John Dunn Willard Van De Bogart Gregorio Morales Combining sound with quantum thought forms
  • 12. Protein folding model by Hans Geesink and Dirk Meijer The integration of the human brain and the quantum field
  • 13. Visualizing wave dynamics in space effecting protein molecules https://www.researchgate.net/publication/315706536_The_Folding_of_a_Life_Proteins_On_the_role_of_long- and_short_range_electromagnetic_pilot_mechanisms Hans Geesink and Dirk Meijer The folding of life proteins
  • 14. Life Music: https://www.jstor.org/stable/1576622?seq=1#page_scan_tab_contents John Dunn A collaboration with biologist Dr. Mary Anne Clark, produced from the primary and secondary structure of protein sequences, using software and synths. In each piece, pitch is determined by amino acid identity and instrumentation is chosen according to protein folding pattern, with different instruments representing regions of alpha-helix, beta-strands and turns. Lysozyme 254L Protein Data Base Lysozyme
  • 15. Compositional techniques using electronic synthesizers Man machine interface – AI verses the human - What happens to us when we listen to the sounds of proteins
  • 16. Designing sonic wave shape topologies with the AniMoog synthesizer Designing folding patterns using the AniMoog wavetable synthesizer
  • 17. Creating wave shapes on a Waldorf NAVE synthesizer to a protein synthesizer
  • 18. Combining sonified elements in the universe with Synthscaper synthesizer by Igor Vasliev Quasar Pulsar Comet
  • 19. TH ORNG SH OW CH Creating neuroacoustic architecture Combining amino acid sounds, phonemes and scales Topological space using 44 phonemes from the English language 20 Amino Acids Erv Wilson micro tonal scale Hebdomekontany
  • 20. Creating space music: combining Thought forms, Protein sounds, Sonified galactic, and Voice Quantum Thought forms Synthesizers Cosmic/Space sounds Protein Sounds Idea Instrument Direction Tone Voice xenolinguistics Individual sounds Combined sounds
  • 21. The xenosphere of our existence We are at the threshold of discovering ourselves through sound