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Future of Life Sciences

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At some point in the next few decades, the capability of technology could outpace that of life. However, life and technology are not disparate streams but are already starting to converge as high-impact research findings show in synthetic biology, DNA nanotechnology, nanomedicine, neuroimaging, whole brain simulation and longevity.

Published in: Technology, Health & Medicine

Future of Life Sciences

  1. 1. Future of Life Sciences: The great convergence of life and technology Melanie Swan Research Associate MS Futures Group m@melanieswan.com www.melanieswan.com CONTACT 2009 April 3, 2009 Slides: http://slideshare.net/LaBlogga/slideshows
  2. 2. 2 CONTACT 2009 April 3, 2009 Agenda 1. Introduction: convergence of life and technology 2. Status of relevant high-impact research 3. Future implications
  3. 3. 3 CONTACT 2009 April 3, 2009 Source: http://www.kurzweilai.net/pps/Unither Full human brain neural simulation est: 2018 Average human: an estimated 20,000 trillion IPS and 1,000 TB memory2 IBM Roadrunner: 1 petaflop/s (>1,000 trillion IPS) and 80 TB memory1 1 http://www.top500.org/lists/2008/11, http://www.top500.org/system/8968 2 http://paula.univ.gda.pl/~dokgrk/bre01.html
  4. 4. 4 CONTACT 2009 April 3, 2009 Engineering life into technology 2029 Machine Human Human′ ? Capability Year Intelligence convergence: Life and Technology
  5. 5. 5 CONTACT 2009 April 3, 2009 Agenda 1. Introduction: convergence of life and technology 2. Status of relevant high-impact research  Evolving concept of life sciences  Genomic era  Synthetic biology  Nanomedicine  Intelligence research  Longevity 1. Future implications
  6. 6. 6 CONTACT 2009 April 3, 2009 Evolving concept of life sciences Model and simulate Enumerate and experiment Build BioSpice.org SimTK.org PartsRegistry.org
  7. 7. 7 CONTACT 2009 April 3, 2009 Cure Improvement Normalization Prevention Enhancement Self- expression Conditions Symptoms Genome Biomarkers Behavior Environment Health outcomes Measure Research Treat Intervene Experiment Track Measure Actions Self Professionals Peers Evolving definition of health Source: http://www.mdpi.com/1660-4601/6/2/492 A new model of health and health care
  8. 8. 8 CONTACT 2009 April 3, 2009 Evolving computing models Current model extensibility Linear, von Neumann Linear, von Neumann ParallelParallel Cloud, grid, distributed Cloud, grid, distributed Biological models Novel models Traditional model QuantumQuantum Optical computing Optical computing Cell broadband engine Cell broadband engine Liquid computer Liquid computer New materials New materials 3D chip stacking 3D chip stacking Molecular electronics Molecular electronics Solar transistors Solar transistors DNA nanotech DNA nanotech DNA computing DNA computing BiosensorsBiosensors Cellular colonies Cellular colonies Bacterial intelligence Bacterial intelligence Bioparadigm discovery Bioparadigm discovery
  9. 9. 9 CONTACT 2009 April 3, 2009 Genomic era Carlson curves: 12 mo speedups  Sequencing  (reading)  Synthesizing  (writing) Source: http://www.synthesis.cc/graphics/carlson_cost_per_base_nov_08.jpg
  10. 10. 10 CONTACT 2009 April 3, 2009 Direct-to-consumer genomics: 23andme 580,000 SNPs scanned and mapped to 78 conditions Source: http://www.23andme.com; open source genomes http://www.snpedia.com/index.php/Genomes
  11. 11. 11 CONTACT 2009 April 3, 2009 23andme colorectal cancer marker Source: http://www.23andme.com
  12. 12. 12 CONTACT 2009 April 3, 2009 Next-gen sequencing: Pacific Biosciences Sources: http://www.pacificbiosciences.com/video_lg.html, http://www.sciencemag.org/cgi/content/abstract/323/5910/133, Science 2 January 2009: Vol. 323. no. 5910, pp. 133 – 138, DOI: 10.1126/science.1162986 Phospholinked nucleotides DNA polymerase wrapped around DNA chain Phospholinked nucleotide binds, fluoresces and detaches as nucleotide base is read 1 2 3a 3b
  13. 13. 13 CONTACT 2009 April 3, 2009 Next-gen biotech: synthetic biology  Engineering biological systems  Parts Registry  BioBricks Foundation  iGEM competition  Key work: Drew Endy, Jay Keasling, Craig Venter, Christina Smolke, Tom Knight Sources: http://openwetware.org, http://bbf.openwetware.org, http://www.igem.org, http://partsregistry.org
  14. 14. 14 CONTACT 2009 April 3, 2009 Registry of Standard Biological Parts Source: http://partsregistry.org  Modular building block components
  15. 15. 15 CONTACT 2009 April 3, 2009 Parts Registry: select measurement system Source: http://partsregistry.org
  16. 16. 16 CONTACT 2009 April 3, 2009 Parts Registry: obtain and print sequence DNA Synthesizer Source: http://partsregistry.org
  17. 17. 17 CONTACT 2009 April 3, 2009 Nanomedicine  Nanoparticles  DNA nanotechnology  DNA walker  Programmable matter  Quantum dots  Nanomachines Respirocytes Microbivore Artery cleaner Nanoparticles Sources: Nanoparticles: http://www.unithertechnologyconference.com DNA Nanotechnology: http://www.pnas.org/content/101/3/717.full.pdf Nanorobots: http://www.foresight.org/Nanomedicine/gallery/index.html#ExhibitCat VasculocyteClottocytes DNA walkerStructural DNA: Holliday junction Quantum dot dyes
  18. 18. 18 CONTACT 2009 April 3, 2009 Radiosurgery and on-demand physicians Teleradiology da Vinci Robotic SurgeryOR-Live.com On-demand consultation: American Well Accuray radiosurgery delivery path Accuray cyberknife radiosurgery
  19. 19. 19 CONTACT 2009 April 3, 2009 Simulation, modeling and virtual health Entelos virtual patient biosimulation Testis tour: OSU Medicine Sources: http://biospice.org, http://www.youtube.com/watch?v=O1YuRSyzBAE, secondlife://PalomarWest%20Hospital/36/125/34/, secondlife://NHS%20London/248/11/26 Second Health Operating Theatre BioSPICE open source simulation software Virtual hospital: Palomar West
  20. 20. 20 CONTACT 2009 April 3, 2009 Intelligence research by approach  Computer simulation  Cortical column simulation  Whole brain emulation  Neuroimaging & connectomics  KESM tissue volumes  Integration  Brain-computer interfaces (BCIs)  Body area networks (BANs)  IEEE standard 802.15.6  Robotics and AI Blue Brain rat cortical column Mouse brain block and cortex slice Sources: http://seedmagazine.com/content/article/out_of_the_blue, http://www.mcb.harvard.edu/lichtman/ATLUM/ATLUM_web.htm, http://research.cs.tamu.edu/bnl/kesm.html Vesicle
  21. 21. 21 CONTACT 2009 April 3, 2009 Longevity: extending lifespan and healthspan  Aging as a multidisciplinary pathology  Aubrey de Grey: Strategies for Engineered Negligible Senescence (SENS)  Nucleic and mitochondrial mutations  Intracellular and extracellular junk  Cell loss and senescence  Extracellular crosslinks  Solutions and escape velocity  Biomedical remediation  Mutation anti-suppressors  Cell strengthening  RealAge.com estimation tests 0 10 20 30 40 50 60 70 80 90 1850 1900 1950 2000 2050 U.S. Life Expectancy, 1850 – 2050e 83 77 69 50 39 Source: http://www.infoplease.com/ipa/A0005140.html Source: http://earthtrends.wri.org/text/population-health/variable-379.html Sources: http://www.mfoundation.org/index.php?pagename=mj_sens_sens, http://pimm.wordpress.com/2007/09/03/sens3-program-john-schloendorn-medical-bioremediation, http://www.mfoundation.org/files/sens/manu16.pdf, http://www.lmrf.org/LysoSENS.html LysoSENS: stained lysosomes
  22. 22. 22 CONTACT 2009 April 3, 2009 Agenda 1. Introduction: convergence of life and technology 2. Status of relevant high-impact research 3. Future implications
  23. 23. 23 CONTACT 2009 April 3, 2009 Engineering life into technology 2029 Machine Human Human′ ? Capability Year Convergence: Life and Technology  Evolving concept of life sciences  Genomic era  Synthetic biology  Nanomedicine  Intelligence  Longevity Foundations of Convergence
  24. 24. 24 CONTACT 2009 April 3, 2009 What can be expected in the short-term? Image: Natasha Vita-More, Primo Posthuman  Onboard computation and communication  Whole human genome scan  Era of personalized medicine  Next-gen biotech, the new cleantech  Focus on key cures: obesity, cancer  Peer-to-peer health  Health social networks  Long tail of medicine  Culture of biohacking
  25. 25. 25 CONTACT 2009 April 3, 2009 Ultimate possibilities for life and technology  All matter (including life) designed to spec  Purpose-driven form factor, elective embodiment  Issues  Multiple persistent copies  Transhumanism, posthumanism  Utility functions and emotion  Intelligence  Ultimate possibilities for life and technology once joined?  Aesthetics?  Analytics?
  26. 26. 26 CONTACT 2009 April 3, 2009 Resources  Conferences, podcasts and video  http://www.unithertechnologyconference.com  http://www.usc.edu/medicine/bcc  http://www.cs.duke.edu/~reif/FNANO  http://www.onemedplace.com  http://www.or-live.com  Journals, news, blogs, advocacy groups, etc.  http://www.nature.com/nbt/index.html  http://www.nbtc.cornell.edu  http://www.eyeonDNA.com  http://phylogenomics.blogspot.com  http://www.personalizedmedicinecoalition.org  Ethics and biotechnology industry watch groups  http://www.bioethics.net (American Journal of Bioethics)  http://www.etcgroup.org
  27. 27. Thank you Melanie Swan Research Associate MS Futures Group m@melanieswan.com www.melanieswan.com Slides: http://slideshare.net/LaBlogga/slideshows Creative Commons 3.0 license

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