This document discusses the management of hospital pharmacies. It outlines the responsibilities of hospital staff like pharmacists and supply managers. It describes how hospital pharmacy services are organized with sections for storage, dispensing, and production. It discusses the hospital drug and therapeutics committee which establishes medication policies. The committee membership includes representatives from medical, pharmacy, nursing and administration. The document also summarizes inpatient medication management systems, formulary management, and proper disposal of pharmaceutical waste.
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
Drug distribution is one of the basic service provided by the hospital pharmacy.
Drug distribution system falls in to 3 categories -
1)Ward – controlled system
2)Pharmacy controlled imprest based system
3)Pharmacy controlled patient issue system
Hospital Formulary - presentation gives the detail idea about Hospital formulary, its advantage, disadvantage, how to prepare Hospital formulary and much more. this will be useful for Pharm.D-IV YEAR students, which was in their Hospital pharmacy subject. regards APOLLOJAMES
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
Drug distribution is one of the basic service provided by the hospital pharmacy.
Drug distribution system falls in to 3 categories -
1)Ward – controlled system
2)Pharmacy controlled imprest based system
3)Pharmacy controlled patient issue system
Hospital Formulary - presentation gives the detail idea about Hospital formulary, its advantage, disadvantage, how to prepare Hospital formulary and much more. this will be useful for Pharm.D-IV YEAR students, which was in their Hospital pharmacy subject. regards APOLLOJAMES
The all the content in this profile is completed by the teachers, students as well as other health care peoples.
thank you, all the respected peoples, for giving the information to complete this presentation.
this information is free to use by anyone.
Clinical Pharmacy Introduction to Clinical Pharmacy, Concept of clinical pptxraviapr7
b) Clinical Pharmacy
Introduction to Clinical Pharmacy, Concept of clinical pharmacy
Functions and responsibilities of clinical pharmacist, Drug therapy monitoring
Medication chart review, clinical review., pharmacist intervention
Ward round participation, Medication history and Pharmaceutical care.
Dosing pattern and drug therapy based on Pharmacokinetic & disease pattern
Patient Safety is a health care discipline that emerged with the evolving complexity in health care systems and the resulting rise of patient harm in health care facilities.
It aims to prevent and reduce risks, errors and harm that occur to patients during provision of health care.
A cornerstone of the discipline is continuous improvement based on learning from errors and adverse events.
Let us see what Pharmacists, Doctors and Patients can do about it.
Introduction
Pharmacy & therapeutic committee (PTC)
Hospital formulary
Infection control committee
In these days of modern medicine, a large number of drugs are available for the treatment of a disease.
Considering the complexities surrounding their effective use, it is necessary for the hospital to establish a system to bring the best medicinal agents to the attention of the medical staff and help them in proper selection of therapeutic substances.
In order to ensure proper rationality in the use of drugs a “PHARMACY AND THERAPEUTIC COMMITTEE” need to be organized and constituted in a hospital.
It is an advisory group of medical staff and the administration of hospital on matters related to the therapeutic use of drugs.
FUNCTIONS
To advise the medical staff on usage of drugs.
To develop and compile formulary of drugs accepted for use in the hospital.
To plan/establish suitable educational programs.
To review adverse drug reactions.
To make recommendations concerning drugs to be stocked in hospital patient care areas.
To advise the pharmacy in the implementation of effective drug distribution and control procedures.
HOSPITAL FORMULARY
Hospital Formulary is defined as a list of drugs used in the hospital.
Formulary system is method whereby the medical staff of an institution, working through the PTC, evaluates, appraises, and selects from among the numerous available drug entities & drug products those that considered most useful in patient care.
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MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
2. Contents
Responsibilities of hospital staffs
Organization of hospital pharmacy services
Hospital drugs and therapeutic committee
Inpatient medication management
Small scale hospital pharmaceutical production
Pharmaceutical disposal
Controlling leakage and drug abuse
3. Responsibilities of hospital staffs
Hospital pharmacist- expert
on medicines who advises
on
prescribing,administering,
monitoring
Supply manager-ensures that
medicines are available
through
procurement,storage,distri
bution,inventory control,&
quality control,assurance.
4. Responsibilities of hospital staffs
• The responsibility for establishing policies & procedures realated to
medication selection , procu , distri & use often lies with DTC
• The medicine process is multidisciplinary,the committee should
include representatives from all functional areas involved;
• Medical staff
• Pharmacy
• Quality assurance coordinator
• Hosp administrator
• Nursing
Subcommittees are often formed for in-depth analysis of particular
issues
5. Purchasing and stock management
• In some hospitl a separate dept manages all
hosptl purchasing
• This dept called- medical stores or material
management
• In such cases chief pharmacist prepares an
annual budget request for pharmaceutical
purchases and places orders for medicines
through the medical stores
• Pharmacy dept manages pharmaceutical
purchasing
• Designated committee review & approve all
purchases
• DTC may manage
6. Medication
use
The medication-use
process can be divided into 4 components-
1. Prescribing
2. Preparation and dispensing
3. Medication administration
4. Monitoring the effects of medications on the
patient & ordering appro changes in therapy
• Govt agencies and licensing boards regulate
medications through laws and professional practice
standards
7. Organization of hospital pharmacy
In organizing hospital pharmacy services , both
the way in which the staff is organized and the
physical layouts of the building must be
considered-
Personnel
Can be divided into
3 major categories;
Management
Professional staff
Support staff
8. Physical organization
Extent of pharmacy’s physical facility - the size of the hospt &
service provided.
Large pharmacy dept -- sections within one physical space or in
separate locations throughout the hospt-
Administrative offices
Bulk storage
Narcotics or dangerous drug lockers
Manufacturing & repackaging
IV soln compounding
Inpatient and outpatient dispensing
Medicine info resource center
After –hours pharmacy
Emergency medical storage
9. Hospital Drug & therapeutics
committee(DTC)
• DTC is responsible foe developing policies &
procedures to promote rational medicine use
• Its functions include-
• Management of the approved medicine list &
hospital formulary
• Ongoing drug use review
• Adverse drug event reporting & implementation
of safe medication practices
10. DTC membership
An effective DTC requires that members
participate in meetings and assist with other
committee activities
Members –representative from:-
Medical staff ( from each dept)
Pharmacy (chief pharmacist often serves as
the secretary)
Nursing
Hospital administration
Quality assurance staff
8-15 members
Invite specialist to make
presentation
or provide advice on
particular issue
11.
12.
13. Hospital formulary management
• Cornerstone of medication management
• Should be the principal concern of the DTC
• Issues related to medication selection
14. Guidelines for the hospital setting
• Limit the formulary list to conserve resources-stocking all
medicines on the national formulary is usually not
necessary
• Eliminate generic duplication-only one brand or label of
each generic medicine should be routinely stocked
• Minimize the number of strengths stocked can be same
medication;multiples of lower strengths can be used for
frequently needed higher strengths
• Select medications for the formulary based on disease and
conditions treated at the facility
• Include second-line alternatives to medicines of choice as
needed,but minimize therapeutic duplication
• Ensure that the hospital formulary corresponds with any
national or regional standard treatment guidelines that
have been formally approved by the health system
15. • In addition to the basic formulary process,
many hospitals add two more features —
therapeutic substitution and use restrictions
for certain medication in the formulary
16.
17. Inpatient medication management
Medication distribution systems
Medication distribution has long been the
primary function of hospital pharmacy services
4 basic types of medication distribution systems
exist—
1. Bulk ward stock replenishment
2. Individual medication order system
3. Unit-dose system
4. Automated medication dispensing
18.
19. Patient medication profiles
Patient medication profile are necessary if hospital
pharmacists are to monitor inpatient medication
therapy
Each profile contains data on the patient’s current
& recent pharmaceutical therapy, allergies ,
diagnosis,height,weight,age,sex
Profile allows the pharmacist to review all
medications that a patient is taking before
dispensing the first dose and with each new
medication order
Problems with pharmaceutical therapy can be
detected and avoided or corrected
22. Small scale hospital pharmaceutical
production
• Include secondary production from existing raw
material imported packaging or repackaging
of finished goods into smaller dispensing packs &
course-of-therapy(COT) packages (tertiary
production)
• SSP divided into
sterile &
non-sterile production
or compounding
25. • Hospital- return products to the facility from
where they were obtained
• If this option is not available then,
• Proper disposal plan & regularly monitored
• Depending on property –pharmaceutical
waste incineration, land disposal,
inertization(product is mixed with cement)
26. Special care must taken—
Narcotics
Toxic drugs
Anticancer medicines
Before disposal technique is
instituted any govt laws &
regulations relevant to
health care waste
management and
environmental protection
should reviewed
27. Controlling leakage and drug abuse
• Systematic approaches for detecting,analyzing &
preventing pharmaceutical losses caused by
theft,bribery and fraud
• Applicable to hospitals and healthcare facilities
• The control of narcotics – concerns in hospital
because it may be the only type of institution
regularly stocking,dispensing,administering them
• Drug addiction among
physician,pharmacists,nurses is quite common
28. To avoid drug abuse and prevent leakage
• Be alert to changes in
performance,injuries,mood
swings in workers
• Ensure double-witness &
double-signature procedures
for wastage of narcotics
• Limit access to narcotic
storage areas
• Check patient charts & medication administration
records for patterns of consumption; be suspicious if
patients receive noticeably more narcotics during a
29. • Ask patients if they received medications
• Use locked boxes or wire cages to ensure security for
medication moved from the pharmacy to the wards
• Issue individual narcotics boxes to each
anesthesiologists daily,and make sure that the box is
returned to the pharmacy at the end of the day with a
written record of quantities used for each patient
• Count narcoti stocks daily and reconcile with
inventory records
• Sometims –for antibiotics
• Antiretroviral to treat HIV/AIDS