The document discusses hand hygiene and its importance in preventing healthcare-associated infections. It begins by introducing healthcare-associated infections as a major patient safety issue and how the hands of healthcare workers are a common mode of transmission. It then discusses the history of hand hygiene dating back to Ignaz Semmelweis who introduced the concept of handwashing. The document outlines the steps involved in the transmission of pathogens from one patient to another via healthcare workers' hands if hand hygiene is not properly performed. It describes the various methods and appropriate times for performing hand hygiene and stresses it as a cornerstone for preventing transmission of infections in healthcare settings.