Hepatitis is an inflammation of the liver that is most commonly caused by viral infections such as hepatitis A, B, or C. The major signs and symptoms of acute hepatitis include fatigue, flu-like symptoms, dark urine, pale stool, abdominal pain, loss of appetite, unexplained weight loss, and jaundice. Hepatitis can affect multiple organs systems beyond just the liver, including the digestive system, circulatory system, central nervous system, skin, and immune system.