Tim Draws, Jody Liu, and Nava Tintarev explore using joint topic models to help users discover perspectives in opinionated text corpora related to debates. They conducted an experiment comparing regular topic models and joint topic models on a dataset of 600 documents annotated with stances and perspectives on abortion. Their Transformed Aspect Model (TAM) performed the best at identifying the correct perspectives, extracting more keywords that explicitly expressed perspectives. However, they found no evidence that users were more likely to identify perspectives that aligned with their own stance over opposing stances. The study provides implications for applications involving journalism, policy-making, and generating explanations.
What is e-research?
Enhancing research practice
e-Research Methods, Strategies, and Issues
Tips For Finding Useful Information
Some Search Tools for doing e-research
Research Design
Quantitative Research
Qualitative Research
Ethics & The e-Researcher
How The Net Complicates Ethics?
Privacy, Confidentiality, Autonomy, And The Respect For Persons
Tips For Ethical e-Research
Collaboration Tools
Why Consensus?
Net-based dissemination of E-research results
Dissemination through peer-reviewed articles
Advantages of a peer-reviewed article
Dissemination through email lists or Usenet groups
Dissemination through a virtual conference
The Evolution of e-Research: Machines, Methods and MusicDavid De Roure
David De Roure's Inaugural Lecture on 28th October at Oxford e-Research Centre, University of Oxford, UK
10 years ago we saw a few early adopters of e-Science technology; now we see acceleration of research through broader adoption and sharing of tools, techniques and artefacts, both for 'big science' and the 'long tail scientist'.
Will this incremental trend continue or are we seeing glimpses of a phase change ahead, where researchers harness these emerging digital capabilities to address research questions in ways that simply were not possible before?
This talk will describe three generations of e-Research, using the myExperiment social website as a lens to glimpse future research practice, and focusing on a web-scale computational musicology project as an illustration of 3rd generation thinking.
Also available from http://wiki.myexperiment.org/index.php/Presentations
"Reproducibility from the Informatics Perspective"Micah Altman
Dr. Altman will provide expert comment on the need for informatics modeling as part of the National Academies workshop: Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results
This workshop focuses on the topic of addressing statistical challenges in assessing and fostering the reproducibility of scientific results by examining three issues from a statistical perspective: the extent of reproducibility, the causes of reproducibility failures, and potential remedies.
Presented in the workshop session "What Bioinformaticians Need to Know about Digital Publishing Beyond the PDF" at ISMB 2013 in Berlin. https://www.iscb.org/cms_addon/conferences/ismbeccb2013/workshops.php
Towards Automatic Analysis of Online Discussions among Hong Kong StudentsCITE
HU, Xiao (University of Hong Kong)
http://citers2013.cite.hku.hk/en/paper_619.htm
---------------------------
Author(s) bear(s) the responsibility in case of any infringement of the Intellectual Property Rights of third parties.
---------------------------
CITE was notified by the author(s) that if the presentation slides contain any personal particulars, records and personal data (as defined in the Personal Data (Privacy) Ordinance) such as names, email addresses, photos of students, etc, the author(s) have/has obtained the corresponding person's consent.
Library Connect Webinar - Calculating sharing metrics: Possible approaches Library_Connect
This presentation from Lorraine Estelle, Director, Project Counter, was part of the Dec. 3, 2015 Library Connect Webinar, How researchers share articles: impact on library resources and services.
View the webinar recording: http://libraryconnect.elsevier.com/library-connect-webinars?commid=167539
Find out more about the Beyond Downloads project: http://libraryconnect.elsevier.com/beyond-downloads
Library Connect Webinar - The secret life of articles: From download metrics ...Library_Connect
This presentation from Suzie Allard, Associate Dean for Research, University of Tennessee, Knoxville, was part of the Dec. 3, 2015 Library Connect Webinar, How researchers share articles: impact on library resources and services.
View the webinar recording: http://libraryconnect.elsevier.com/library-connect-webinars?commid=167539
Find out more about the Beyond Downloads project: http://libraryconnect.elsevier.com/beyond-downloads
What is e-research?
Enhancing research practice
e-Research Methods, Strategies, and Issues
Tips For Finding Useful Information
Some Search Tools for doing e-research
Research Design
Quantitative Research
Qualitative Research
Ethics & The e-Researcher
How The Net Complicates Ethics?
Privacy, Confidentiality, Autonomy, And The Respect For Persons
Tips For Ethical e-Research
Collaboration Tools
Why Consensus?
Net-based dissemination of E-research results
Dissemination through peer-reviewed articles
Advantages of a peer-reviewed article
Dissemination through email lists or Usenet groups
Dissemination through a virtual conference
The Evolution of e-Research: Machines, Methods and MusicDavid De Roure
David De Roure's Inaugural Lecture on 28th October at Oxford e-Research Centre, University of Oxford, UK
10 years ago we saw a few early adopters of e-Science technology; now we see acceleration of research through broader adoption and sharing of tools, techniques and artefacts, both for 'big science' and the 'long tail scientist'.
Will this incremental trend continue or are we seeing glimpses of a phase change ahead, where researchers harness these emerging digital capabilities to address research questions in ways that simply were not possible before?
This talk will describe three generations of e-Research, using the myExperiment social website as a lens to glimpse future research practice, and focusing on a web-scale computational musicology project as an illustration of 3rd generation thinking.
Also available from http://wiki.myexperiment.org/index.php/Presentations
"Reproducibility from the Informatics Perspective"Micah Altman
Dr. Altman will provide expert comment on the need for informatics modeling as part of the National Academies workshop: Statistical Challenges in Assessing and Fostering the Reproducibility of Scientific Results
This workshop focuses on the topic of addressing statistical challenges in assessing and fostering the reproducibility of scientific results by examining three issues from a statistical perspective: the extent of reproducibility, the causes of reproducibility failures, and potential remedies.
Presented in the workshop session "What Bioinformaticians Need to Know about Digital Publishing Beyond the PDF" at ISMB 2013 in Berlin. https://www.iscb.org/cms_addon/conferences/ismbeccb2013/workshops.php
Towards Automatic Analysis of Online Discussions among Hong Kong StudentsCITE
HU, Xiao (University of Hong Kong)
http://citers2013.cite.hku.hk/en/paper_619.htm
---------------------------
Author(s) bear(s) the responsibility in case of any infringement of the Intellectual Property Rights of third parties.
---------------------------
CITE was notified by the author(s) that if the presentation slides contain any personal particulars, records and personal data (as defined in the Personal Data (Privacy) Ordinance) such as names, email addresses, photos of students, etc, the author(s) have/has obtained the corresponding person's consent.
Library Connect Webinar - Calculating sharing metrics: Possible approaches Library_Connect
This presentation from Lorraine Estelle, Director, Project Counter, was part of the Dec. 3, 2015 Library Connect Webinar, How researchers share articles: impact on library resources and services.
View the webinar recording: http://libraryconnect.elsevier.com/library-connect-webinars?commid=167539
Find out more about the Beyond Downloads project: http://libraryconnect.elsevier.com/beyond-downloads
Library Connect Webinar - The secret life of articles: From download metrics ...Library_Connect
This presentation from Suzie Allard, Associate Dean for Research, University of Tennessee, Knoxville, was part of the Dec. 3, 2015 Library Connect Webinar, How researchers share articles: impact on library resources and services.
View the webinar recording: http://libraryconnect.elsevier.com/library-connect-webinars?commid=167539
Find out more about the Beyond Downloads project: http://libraryconnect.elsevier.com/beyond-downloads
Would you like to be my friend: Patron responsiveness to academic library Fac...parfitt123
A Masters student presentation - presented by Suzanne Parfitt (Master of Information Studies student at Charles Sturt University, Australia) at the MMIT 2015 Conference, Sheffield University, UK in September 2015
This material caters the descriptions and different techniques of Internet-based researches. This material also caters helpful web sites and search engines.
SocialCite makes its debut at the HighWire Press meetingKent Anderson
A new service designed to allow readers and researchers to comment on the appropriateness, quality, and type of citations made in the literature made its debut at the HighWire Press Publishers Meeting yesterday.
Recomendations for infrastructure and incentives for open science, presented to the Research Data Alliance 6th Plenary. Presenter: William Gunn, Director of Scholarly Communications for Mendeley.
Identifying and preventing plagiarism: issues for HE tutors in FE CollegesJISC RSC Southeast
Accompaying presentation from Dr Fiona Duggan of the JISC Plagiarism Advisory Service, at the RSC SE / JISC PAS workshop - Identifying and preventing plagiarism: issues for HE tutors in FE Colleges. July 04th Northbrook College
Slides describing Force11 Work and background of several of the speakers, used for talks to University of Lethbridge, Carnegie Mellon and to Elsevier internally
Personal online reputation: the development of an approach to investigate how...Frances Ryan
Paper presented at International Data and Information Conference, 13 January 2016
Personal online reputation: the development of an approach to investigate how personal reputation is evaluated and managed in online environments
By Frances VC Ryan, Peter Cruickshank, Hazel Hall, and Alistair Lawson (Edinburgh Napier University)
Explainable AI is not yet Understandable AIepsilon_tud
Keynote of Dr. Nava Tintarev at RCIS'2020. Decision-making at individual, business, and societal levels is influenced by online content. Filtering and ranking algorithms such as those used in recommender systems are used to support these decisions. However, it is often not clear to a user whether the advice given is suitable to be followed, e.g., whether it is correct, whether the right information was taken into account, or if the user’s best interests were taken into consideration. In other words, there is a large mismatch between the representation of the advice by the system versus the representation assumed by its users. This talk addresses why we (might) want to develop advice-giving systems that can explain themselves, and how we can assess whether we are successful in this endeavor. This talk will also describe some of the state-of-the-art in explanations in a number of domains (music, tweets, and news articles) that help link the mental models of systems and people. However, it is not enough to generate rich and complex explanations; more is required in order to understand and be understood. This entails among other factors decisions around which information to select to show to people, and how to present that information, often depending on the target users and contextual factors
Would you like to be my friend: Patron responsiveness to academic library Fac...parfitt123
A Masters student presentation - presented by Suzanne Parfitt (Master of Information Studies student at Charles Sturt University, Australia) at the MMIT 2015 Conference, Sheffield University, UK in September 2015
This material caters the descriptions and different techniques of Internet-based researches. This material also caters helpful web sites and search engines.
SocialCite makes its debut at the HighWire Press meetingKent Anderson
A new service designed to allow readers and researchers to comment on the appropriateness, quality, and type of citations made in the literature made its debut at the HighWire Press Publishers Meeting yesterday.
Recomendations for infrastructure and incentives for open science, presented to the Research Data Alliance 6th Plenary. Presenter: William Gunn, Director of Scholarly Communications for Mendeley.
Identifying and preventing plagiarism: issues for HE tutors in FE CollegesJISC RSC Southeast
Accompaying presentation from Dr Fiona Duggan of the JISC Plagiarism Advisory Service, at the RSC SE / JISC PAS workshop - Identifying and preventing plagiarism: issues for HE tutors in FE Colleges. July 04th Northbrook College
Slides describing Force11 Work and background of several of the speakers, used for talks to University of Lethbridge, Carnegie Mellon and to Elsevier internally
Personal online reputation: the development of an approach to investigate how...Frances Ryan
Paper presented at International Data and Information Conference, 13 January 2016
Personal online reputation: the development of an approach to investigate how personal reputation is evaluated and managed in online environments
By Frances VC Ryan, Peter Cruickshank, Hazel Hall, and Alistair Lawson (Edinburgh Napier University)
Explainable AI is not yet Understandable AIepsilon_tud
Keynote of Dr. Nava Tintarev at RCIS'2020. Decision-making at individual, business, and societal levels is influenced by online content. Filtering and ranking algorithms such as those used in recommender systems are used to support these decisions. However, it is often not clear to a user whether the advice given is suitable to be followed, e.g., whether it is correct, whether the right information was taken into account, or if the user’s best interests were taken into consideration. In other words, there is a large mismatch between the representation of the advice by the system versus the representation assumed by its users. This talk addresses why we (might) want to develop advice-giving systems that can explain themselves, and how we can assess whether we are successful in this endeavor. This talk will also describe some of the state-of-the-art in explanations in a number of domains (music, tweets, and news articles) that help link the mental models of systems and people. However, it is not enough to generate rich and complex explanations; more is required in order to understand and be understood. This entails among other factors decisions around which information to select to show to people, and how to present that information, often depending on the target users and contextual factors
Modeling health related topics in an online forum designed for the deaf & har...Hang Dong
The main objective of this presentation is to elicit some discussions about whether a computational or a semi-computational method is suitable for understanding health related topics.
The slides were presented at the 1st XJTLU Research Symposium on Healthy Ageing & Society, Xi'an Jiaotong-Liverpool University, Suzhou, on 14 Dec, 2015. For uploading online, the slides were last revised on 9th Jan 2016. All websites referenced in the slides were retrieved on 5th Jan 2016.
Professor Dagobert Soergel's talk (2009 CISTA Award Recipient): Task-centric ...kristenlabonte
"The task-centric revolution. Weaving information into workflows." Systems should be centered around tasks, not applications. This talk will present ideas and techniques towards the design of task-centric systems.
Trust and Accountability: experiences from the FAIRDOM Commons Initiative.Carole Goble
Presented at Digital Life 2018, Bergen, March 2018. In the Trust and Accountability session.
In recent years we have seen a change in expectations for the management and availability of all the outcomes of research (models, data, SOPs, software etc) and for greater transparency and reproduciblity in the method of research. The “FAIR” (Findable, Accessible, Interoperable, Reusable) Guiding Principles for stewardship [1] have proved to be an effective rallying-cry for community groups and for policy makers.
The FAIRDOM Initiative (FAIR Data Models Operations, http://www.fair-dom.org) supports Systems Biology research projects with their research data, methods and model management, with an emphasis on standards and sensitivity to asset sharing and credit anxiety. Our aim is a FAIR Research Commons that blends together the doing of research with the communication of research. The Platform has been installed by over 30 labs/projects and our public, centrally hosted FAIRDOMHub [2] supports the outcomes of 90+ projects. We are proud to support projects in Norway’s Digital Life programme.
2018 is our 10th anniversary. Over the past decade we learned a lot about trust between researchers, between researchers and platform developers and curators and between both these groups and funders. We have experienced the Tragedy of the Commons but also seen shifts in attitudes.
In this talk we will use our experiences in FAIRDOM to explore the political, economic, social and technical, social practicalities of Trust.
[1] Wilkinson et al (2016) The FAIR Guiding Principles for scientific data management and stewardship Scientific Data 3, doi:10.1038/sdata.2016.18
[2] Wolstencroft, et al (2016) FAIRDOMHub: a repository and collaboration environment for sharing systems biology research Nucleic Acids Research, 45(D1): D404-D407. DOI: 10.1093/nar/gkw1032
A Summary of Computational Social Science - Lecture 8 in Introduction to Comp...Lauri Eloranta
Final lecture of the course CSS01: Introduction to Computational Social Science at the University of Helsinki, Spring 2015.(http://blogs.helsinki.fi/computationalsocialscience/).
Lecturer: Lauri Eloranta
Questions & Comments: https://twitter.com/laurieloranta
Discussion 1 Affinity Group Checkpoint #4This week, you will onVinaOconner450
Discussion 1: Affinity Group Checkpoint #4
This week, you will once again have the help and support of your peers by engaging in a discussion of your coursework with your Affinity Group. Just as you would like to receive meaningful comments on your work, allow others the same privilege and try to provide meaningful feedback.
To prepare for this Discussion:
Review this week’s Learning Resources, especially:
Wiseman, L. (2017). Multipliers: How the best leaders make everyone smarter (Rev. ed.). New York, NY: HarperCollins.
· Chapter 9, “Becoming a Multiplier”
Assignment:
Respond to two of your colleagues’ postings that contain a perspective other than yours.
· Share an insight about what you learned from having read your colleagues’ postings and discuss how and why your colleague’s posting resonated with you professionally and personally. (Note: This may be a great opportunity to help you think about passions you share with your colleagues who could become part of your Walden network.)
· Offer an example from your experience or observation that validates what your colleague discussed.
· Offer specific suggestions that will help your colleague build upon his or her perceptions as a leader.
· Offer further assessment from having read your colleague’s post that could impact a leader’s effectiveness.
· Share how something your colleague discussed changed the way you consider your own leadership qualities.
· 4–5 paragraphs in length
· No Plagiarism
· Cite References
1st Colleague - Natasha Mills
Research Paper Track – Research Methods
Top of Form
My research study seeks to investigate the types of support leaders can provide Gen Z in the workplace to help them grow in their careers, as well as for the realization of organizational goals. Therefore, the participants of the study will comprise of Gen Z employees and organizational leaders, mostly managers. The participants will be selected using a convenience sample that will include Gen Z in my workplace, whose help I will use to recruit their friends who are also Gen Z in various workplaces. According to Dudovskiy (2022), convenience sampling is a non-probabilistic method that involves getting participants from wherever is convenient, and wherever one can find them. At the same time, convenience sampling has no inclusion criteria and is used for issues about perceptions. Therefore, convenience sampling will be an appropriate sampling method for this study because it involves investigating the perceptions of particular groups about an issue affecting them.
The confidentiality and anonymity of participants is a critical issue to pay attention to when gathering data. Adhering to these tenets informs the ethical side of research. Anonymity is mostly associated with qualitative studies and involves collecting data without identifying or personal information of the participants (Coffelt, 2017). Whereas anonymity is important in any research study, it will be more critical for my researc ...
Bridging the missing middle for al_tversionfinal_14_08_2014debbieholley1
Presentation to ALT-C 2014
Taking innovation from concept through to scalable delivery is complex, contested and under-theorised process. This report aims to capture the current major themes underpinning scaling, and apply these to the context of the Learning Layers project. An external review of our early ‘Design Research framework for scaling’ has highlighted that the approach is too linear and may rely too heavily on the diffusion of innovation paradigm originally proposed by Everett Rogers in the 1960s, which is less appropriate for scaling innovations in our project. Rather, we start out from design-based research principles where co-design with the users is producing both theories and practical educational interventions as outcomes of the process. This is a robust and appropriate approach suitable for addressing complex problems in educational practice for which no clear guidelines or solutions are available. We suggest that it is therefore also appropriate for multi-faceted and complex research projects such as Learning Layers.
NISO Two Day Virtual Conference:
Using the Web as an E-Content Distribution Platform:
Challenges and Opportunities
Oct 21-22, 2014
Maryann Martone, Ph.D., Professor of Neuroscience, University of California, San Diego
This presentation was provided by Kristi Holmes of Northwestern University during the NISO hot topic virtual conference "Effective Data Management," which was held on September 29, 2021.
Seminar for LERN, Legal Education Research Network, UK, @ IALS, 28 Jan 2015, on the use of new media tools and the need for digital research literacies in legal education research.
Similar to Helping Users Discover Perspectives: Enhancing Opinion Mining with Joint Topic Models (20)
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
3. 3
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Discovering perspectives
Unstructured set of
textual opinions
?
Perspective 1
Supporting
Perspective 2
Perspective 3
Perspective 4
Perspective 5
Perspective 6
Perspective 7
Perspective 8
Perspective 9
Perspective 10
Opposing
Structured set of
perspectives
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Topic models
• Topic model = unsupervised model to discover
hidden structures (i.e., topics) in corpora of text
– Example: Latent Dirichlet Allocation (LDA) [1]
– Topics are probability distributions over words
– If applied to a corpus of documents related to a debate,
topics could be interpreted as perspectives
• Joint topic model = adding additional components
(e.g., sentiment analysis) to a classical topic
model (e.g., LDA)
5. 5
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Our paper
RQ1. Can joint topic models support users in discovering
perspectives in a corpus of opinionated documents?
RQ2. Do users interpret the output of joint topic models
in line with their personal pre-existing stance?
Contributions:
1. Perspective-annotated data set
2. User study
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Data
Document Stance Perspective
You cannot be a
Christian and support
abortion…
Against Abortion is the killing of a human
being, which defies the word of
God.
No one in the world has
any right to judge over
what someone else
does with their body, …
For Reproductive choice empowers
women by giving them control over
their own bodies.
Why put a child through
the pain of an unloving
mother…
For A baby should not come into the
world unwanted.
… … …
Final data set: 600 documents; 6 perspectives
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Experimental setup
1
2
3
4
5
• Ran each model on the final
data set (i.e., for 6 topics)
• Between-subjects study: each
participant sees output of one
of the models
• Participants need to identify
the correct 6 perspectives from
the model output
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Procedure
Step 1 Step 2 Step 3
Participants state:
• Age
• Gender
• Personal stance
towards abortion
• Familiarity with the
abortion debate
Participants state:
• Perceived usefulness
• Perceived awareness
increase
• Confidence in task
performance
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Results: descriptive
• 158 participants (recruited from Prolific)
– After excluding 12 participants due to failing both honeypot topics
– 150 required according to power analysis
• 50.6% female, 49.4% male
• 33.3 years old on average (range 18 to 64)
• Most (57.8%) at least somewhat familiar with the topic
• Sample skewed towards the supporting viewpoint
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Results: hypothesis tests
H1: Users find more correct perspectives when being exposed
to the output of a joint topic model compared to the output of a
regular topic model or baseline.
– We find a difference between models (p < 0.001, η2 = 0.126)
– TAM is the only one that performs significantly better than the baseline
3
4
5
TF−IDF LDA JST VODUM TAM LAM
Model
MeannCor
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Results: hypothesis tests
H2: Users are more likely to identify sets of keywords as
perspectives that are in line with their personal stance compared
to perspectives that they do not agree with.
– No evidence for for such a relationship (ρ = 0.122, p = 0.163)
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Discussion and future work
• Why did TAM perform better?
– It extracted more keywords that appeared explicitly in the perspective expression
Abortion is the killing of a human
being, which defies the word of God.
Reproductive choice empowers
women by giving them control over
their own bodies.
A baby should not come into the
world unwanted.
• Future work: different domains, novel topic models
13. 14
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Take home
• Joint topic models such as TAM can perform
perspective discovery
• No evidence for tendency of users to interpret
output in line with their personal stance
• Implications for several areas: journalism,
policy-making, generating explanations
(All supplementary materials are openly available at
https://osf.io/uns63/.)
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References
[1] D. Blei, A. Ng, and M. Jordan, “Latent dirichlet allocation,” Journal of Machine Learning Research, vol. 3, pp. 993–
1022, 05 2003.
[2] M. Paul and R. Girju, “A two-dimensional topic-aspect model for discovering multi-faceted topics.” in AAAI, vol. 1, 01
2010. [Online]. Available: http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.
226.3550&rep=rep1&type=pdf
[3] C. Lin and Y. He, “Joint sentiment/topic model for sentiment analysis,” in Proceedings of the 18th ACM Conference on
Information and Knowledge Management, ser. CIKM ’09. New York, NY, USA: Association for Computing
Machinery, 2009, p. 375–384. [Online]. Available: https://doi.org/10.1145/1645953.1646003
[4] T. Thonet, G. Cabanac, M. Boughanem, and K. Pinel-Sauvagnat, “Vodum: A topic model unifying viewpoint, topic and
opinion discovery,” in ECIR, vol. 9626. Toulouse, France: Springer, 03 2016, pp. 533– 545.
[5] D. Vilares and Y. He, “Detecting perspectives in political debates,” in EMNLP. Association for Computational
Linguistics, 01 2017, pp. 1573–1582.
Editor's Notes
Introduce myself
Second year PhD
Imagine you are a journalist writing an article about the abortion debate
Abortion is a commonly debated topic with many people on both sides; and many perspectives
Explain stance-perspective difference
Naturally these debates are carried out online in news, social media, and fora
For you as a journalist it would be great to have an automatic way to distil these perspectives
Formalize
What existing techniques could be used here?
Sentiment analysis and stance detection no good because supervised
Perspectives are unstructured and different for every topic unsupervised
In sum, two research questions
To answer them, we
Created a data set (openly available)
Conducted a user study showing that some joint topic models can perform perspective discovery
Needed data set of opinionated documents with perspective annotation
Documents: around 3000 debate forum posts on abortion
Human annotator noted stance and perspective
Perspectives taken from ProCon list of 31
Then balanced data set of 600 documents
First describe joint topic models, then baselines
Ran all these models on the final corpus and then conducted user study with their output
Between-subjects design, randomly assigned each participant to one model
Topic model output on the left (6 topics + two honeypots)
Select one of 16 different perspectives for each topic
Step 3 we measured experience with the task
Interesting that they were skewed; as we performed Prolific pre-screening
Describe again why and what we did in this hypothesis test; we used ANOVA
post hoc tests: TAM is the only one that is better than the TF-IDF baseline model
Confirmation bias (ambiguous model output)
spearman correlation – no evidence
Normalized distribution over perspectives (x-axis)
P1-p6 in the corpus, rest not
Plot shows how often each perspective was selected
Some perspectives were well represented in all models, like P5 (or people are familiar with them)
TAM was good with perspectives that other models struggled with, such as P1 and P6
More exploratory results in the paper
Other topics more sentiment-related words
Future work: different domains, novel topic models
Supplementary material is available on our repository
Generating explanations to help people overcome biases