This document provides information on proper hand hygiene practices. It discusses who should practice hand hygiene, what hand hygiene entails, where it should be performed, why it is important, when the four key moments for hand hygiene are, and how to correctly perform hand hygiene using alcohol-based hand rub or soap and water. The four moments for hand hygiene are before contact with a patient or their environment, before clean/aseptic procedures, after body fluid exposure risk, and after contact with a patient or their environment. Proper hand hygiene, including thorough washing or rubbing, is key to preventing the spread of germs.