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Haematinics
๏ƒ˜ Haematinic - a medicine that increases the hemoglobin content of the
blood
OR
๏ƒ˜ A hematinic is a nutrient required for the formation of blood cells in the
process of hematopoiesis
๏ƒ˜ The main hematinics are iron, B12, and folate
1
The healthy range for hemoglobin is:
For men, 13.2 to 16.6 grams per deciliter.
For women, 11.6 to 15 grams per deciliter.
Anaemiaโ€ฆ..
Anemia is a medical condition in which the red blood cell count or
hemoglobin is less than normal.
Anemia is caused by either a decrease in production of red blood cells or
hemoglobin, or an increase in loss (usually due to bleeding) or destruction
of red blood cells.
2
IRON
๏ƒผ Total Iron in human body is 2.5-5 gm.
๏ƒผ Iron tablets can help restore iron levels in your body. If possible,
you should take iron tablets on an empty stomach, which helps the
body absorb them better.
๏ƒผ Iron supplements may cause constipation or black stools.
Dietary Source:-
โ€ข Red meat, pork and poultry
โ€ข Seafood, Beans
โ€ขDark green leafy vegetables, Dried fruit, breads and
pastas
โ€ข Peas, egg yolk, Milk Apple
3
4
Distribution of Iron in Body
5
Haemoglobin : 66 %
Iron stored as Ferritin and Haemosiderin : 25 %
Myoglobin in Muscles : 3 %
Parenchymal iron : 6 %
Inorganic Haematinics
โ€ข Ferrous Sulphate
โ€ข Ferrous Gluconate
Chemical Properties of Ferrous Sulfate โ€“ FeSO4
1. Ferrous sulfate reacts with aluminium
under displacement reaction forming aluminium
sulfate and metallic iron. The chemical reaction is
given below.
2Al + 3FeSO4 โ†’ Al2(SO4)3 + 3Fe
2. Ferrous sulfate reacts with potassium
permanganate in the presence of sulphuric acid
forms ferric sulfate, manganese sulfate, potassium
sulfate, and water.
10FeSO4 + 2KMnO4 + 8H2SO4 โ†’ 5Fe2(SO4)3 +
2MnSO4 + 8H2O + K2SO4
Assay of calcium gluconate
Weigh 0.5 g and dissolve in 50 ml of
warm water; cool, add 5.0 ml of 0.05
M magnesium sulphate and 10 ml of
strong ammonia solution and titrate
with 0.05 M disodium edetate using
mordant black II mixture as an
indicator.
Carry out a blank titration.
Thanking you

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Haematinics Notes (1).pptx

  • 1. Haematinics ๏ƒ˜ Haematinic - a medicine that increases the hemoglobin content of the blood OR ๏ƒ˜ A hematinic is a nutrient required for the formation of blood cells in the process of hematopoiesis ๏ƒ˜ The main hematinics are iron, B12, and folate 1 The healthy range for hemoglobin is: For men, 13.2 to 16.6 grams per deciliter. For women, 11.6 to 15 grams per deciliter.
  • 2. Anaemiaโ€ฆ.. Anemia is a medical condition in which the red blood cell count or hemoglobin is less than normal. Anemia is caused by either a decrease in production of red blood cells or hemoglobin, or an increase in loss (usually due to bleeding) or destruction of red blood cells. 2
  • 3. IRON ๏ƒผ Total Iron in human body is 2.5-5 gm. ๏ƒผ Iron tablets can help restore iron levels in your body. If possible, you should take iron tablets on an empty stomach, which helps the body absorb them better. ๏ƒผ Iron supplements may cause constipation or black stools. Dietary Source:- โ€ข Red meat, pork and poultry โ€ข Seafood, Beans โ€ขDark green leafy vegetables, Dried fruit, breads and pastas โ€ข Peas, egg yolk, Milk Apple 3
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  • 5. Distribution of Iron in Body 5 Haemoglobin : 66 % Iron stored as Ferritin and Haemosiderin : 25 % Myoglobin in Muscles : 3 % Parenchymal iron : 6 % Inorganic Haematinics โ€ข Ferrous Sulphate โ€ข Ferrous Gluconate
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  • 8. Chemical Properties of Ferrous Sulfate โ€“ FeSO4 1. Ferrous sulfate reacts with aluminium under displacement reaction forming aluminium sulfate and metallic iron. The chemical reaction is given below. 2Al + 3FeSO4 โ†’ Al2(SO4)3 + 3Fe 2. Ferrous sulfate reacts with potassium permanganate in the presence of sulphuric acid forms ferric sulfate, manganese sulfate, potassium sulfate, and water. 10FeSO4 + 2KMnO4 + 8H2SO4 โ†’ 5Fe2(SO4)3 + 2MnSO4 + 8H2O + K2SO4
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  • 13. Assay of calcium gluconate Weigh 0.5 g and dissolve in 50 ml of warm water; cool, add 5.0 ml of 0.05 M magnesium sulphate and 10 ml of strong ammonia solution and titrate with 0.05 M disodium edetate using mordant black II mixture as an indicator. Carry out a blank titration.