Study of genome-wide SNPs, mitochondrial DNA and Y-chromosomal DNA variation can provide a valuable information about the population structure and peopling of human populations. To explain a genetic homogeneity of Koreans and population structure of Koreans and the East Asian populations, we analyzed 153 individuals from the Korea and 77 individuals from the East Asia at 46,559 common single-nucleotide polymorphic loci. The 137 CHB and 113 JPT individuals at 25,769 common SNPs from the International HapMap project were further analyzed to reveal the population structure of the East Asians. Principal Component analyses (PCA) and population differentiation ( ) are examined. In the PCA test, the Jeju individuals were slightly different from other Koreans but their values were not significant. This reflect the genetic homogeneity of Korea population. In general, all the individual samples studied here were clustered into subset of ethnic origin according to their geographical location except Mongolians. Whole genome sequencing of Koreans and other population genome by next generation sequencing technology will provide great opportunity to understand the population expansion and peopling of Korea better.
Human genetic diversity and origin of major human groupsMayank Sagar
Humans are 99.9% genetically identical and yet we are all so different. Even monozygotic twins have infrequent genetic differences due to mutations occurring during development and gene copy-number variation.
The power point presentation describes development of Ru(II) complexes for cancer treatment. The presentation is prepared based on three review articles published in Chemical Society Reviews on 2017 and 2018:
(1)Chem. Soc. Rev., 2017,46,5771
(2)Chem. Soc. Rev., 2017,46,7706
(3)Chem. Soc. Rev., 2018,47, 909-928.
Human genetic diversity and origin of major human groupsMayank Sagar
Humans are 99.9% genetically identical and yet we are all so different. Even monozygotic twins have infrequent genetic differences due to mutations occurring during development and gene copy-number variation.
The power point presentation describes development of Ru(II) complexes for cancer treatment. The presentation is prepared based on three review articles published in Chemical Society Reviews on 2017 and 2018:
(1)Chem. Soc. Rev., 2017,46,5771
(2)Chem. Soc. Rev., 2017,46,7706
(3)Chem. Soc. Rev., 2018,47, 909-928.
The climbing vine kudzu, a member of the leguminous
pea family (Fabaceae), was introduced into the USA
from its native Asia in the 1800s. It was initially lauded
for efficacy in erosion control along highways and as a
high-quality grazing crop for livestock. P. montana var.
lobata has since become a truculent invasive, spreading
via vegetative runners and seed dispersal. Seven
million acres of the American southeast are now
plagued by this vine.
Project Overview: Ecological & Evolutionary Genetics of Southwestern White Pi...Justin C. Bagley
Provides a brief overview of our project on the ecological and evolutionary genetics of southwestern white pine (SWWP), an alpine white pine distributed in the sky-islands of the North American desert southwest.
I am working with collaborators in Brazil, the U.S., and Mexico to complete genetic data analyses and manuscripts from two postdoctoral research fellowships. This slideshow presents a brief overview of the two main funded research projects that I am involved in.
Bioinformatics & biostatistics tools for monogenic and multifactorial disease...Pasteur_Tunis
Présentation de Mourad Sahbatou réalisée durant le cours du réseau international des instituts Pasteur de "Médecine Génomique: du diagnostic à la thérapie " (17-21 octobre 2016)
Deze slides introduceren linux. Waarom Linux? Linux is een volwaardig, veilig en stabiel alternatief voor Windows XP.
Voor hulp, contacteer me op http://www.jakonix.be. Veel succes!
The climbing vine kudzu, a member of the leguminous
pea family (Fabaceae), was introduced into the USA
from its native Asia in the 1800s. It was initially lauded
for efficacy in erosion control along highways and as a
high-quality grazing crop for livestock. P. montana var.
lobata has since become a truculent invasive, spreading
via vegetative runners and seed dispersal. Seven
million acres of the American southeast are now
plagued by this vine.
Project Overview: Ecological & Evolutionary Genetics of Southwestern White Pi...Justin C. Bagley
Provides a brief overview of our project on the ecological and evolutionary genetics of southwestern white pine (SWWP), an alpine white pine distributed in the sky-islands of the North American desert southwest.
I am working with collaborators in Brazil, the U.S., and Mexico to complete genetic data analyses and manuscripts from two postdoctoral research fellowships. This slideshow presents a brief overview of the two main funded research projects that I am involved in.
Bioinformatics & biostatistics tools for monogenic and multifactorial disease...Pasteur_Tunis
Présentation de Mourad Sahbatou réalisée durant le cours du réseau international des instituts Pasteur de "Médecine Génomique: du diagnostic à la thérapie " (17-21 octobre 2016)
Deze slides introduceren linux. Waarom Linux? Linux is een volwaardig, veilig en stabiel alternatief voor Windows XP.
Voor hulp, contacteer me op http://www.jakonix.be. Veel succes!
This presentation provides some technical details on the function of the Galaxy toolshed. It was prepared for a group (Biobix at UGent), during my previous job.
Part 6 of RNA-seq for DE analysis: Detecting biology from differential expres...Joachim Jacob
Sixth part of the training session 'RNA-seq for Differential expression analysis'. We explain how we extract biological meaningful results from differential expression analysis results, based on RNA-seq. Interested in following this session? Please contact http://www.jakonix.be/contact.html
Article critiques ( Min 1500 words) Styles of leadership. .docxdavezstarr61655
Article critiques :( Min 1500 words)
Styles of leadership.
Note :-( Rules for submission) The structure includes:
• Title – informs us it is a review
• Informative Abstract – informs us this is a meta-analysis (novel analysis in a novel context of previously published data)
• Introduction
• Body – Material & Methods, Results (including the use of tables and figures to display novel findings), Discussion
• Conclusion – a listing of novel findings of the meta-analysis
• References – organized alphabetically
1. Abstract On your abstract page, center the word “Abstract” at the top of the page without any additional formatting.
On the next line, write a concise summary of your critique. This should be a brief summary about the article and your critique. Examples of points to make in this paragraph include objectively analyzing the article and evaluating its contributions to learning. This paragraph should be between 150 to 250 words.
2. Main Body Type your title at the top of the page without any additional formatting. Following a double space, begin writing your critique. Journal critiques analyze a variety of topics. Examples of issues you may want to include in this section include whether you found any errors of fact or interpretation, the author was objective.
Choose one of the following subjects:
1-Bureaucratic Leadership
2-Charismatic Leadership
3-Servant Leadership
4-Transactional Leadership
References
Bacco, Alessandra Di, and Grace Gill. "The Secreted Glycoprotein CREG Inhibits Cell Growth Dependent on the Mannose-6-phosphate|[sol]|insulin-like Growth Factor II Receptor." Nature News. Nature Publishing Group, 21 Aug. 2003.
Bauer, Matthias, Anne C. Hamm, Melanie Bonaus, Andrea Jacob, Jens Jaekel, Hubert Schorle, Michael J. Pankratz, and Joerg D. Katzenberger. "Starvation Response in Mouse Liver Shows Strong Correlation with Life-span-prolonging Processes." Physiological Genomics. American Physiological Society, 13 Apr. 2004.
Briers, Demarcus. "Liver: Cell Types Found in Liver Simplified." DBrierscom. N.p., 20 Sept. 2012.
Bulla, Gary A. "Selective Loss of the Hepatic Phenotype Due to the Absence of a Transcriptional Activation Pathway." Somatic Cell and Molecular Genetics, 7 Mar. 1997.
Bulla, Gary. "Extinction of Alpha1-antitrypsin Expression in Cell Hybrids Is Independent of HNF1alpha and HNF4 and Involves Both Promoter and Internal DNA Sequences." Nucleic Acids Research 27 April. 1999. 1190-197.
Bulla, Gary A., Caitlin M. Aylmer, Adele L. Dust, Jeffrey L. Kurkewich, Leon K. Mire, and Arnold B. Estanda. "Genome-wide Analysis of Hepatic Gene Silencing in Hepatoma Cell Variants." Genomics 100.3 (2012): 176-83.
Bustin, Stephens. “Absolute Quantification of mRNA Using Real-Time Reverse Transcription Polymerase Chain Reaction Assays.” Journal of Molecular Endocrinology 25 (2000): 169–193.
Castell James and Gomez-Lechon John. “Liver Cell Culture Techniques.” Methods in Molecular Biology 481 (2009): 36-46.
.
Perspectives of identifying Korean genetic variationsHong ChangBum
Single Nucleotide Polymorphism (SNP) is the genetic variation most frequently occurred in human genome. SNP is considered as one of the well characterized genetic marker which is useful for the research on human disease genomics as well as the human population stratification. Currently a type of structural variation in the genome, so called Copy Number Variation (CNV), have received public attention in the hope to get additional genetic information that can not be answered by SNPs.
To gain insight into Korean specific genetic markers, we analyzed 54,794 SNPs from 159 individuals in 10 regional areas in Korea (CheonAn, NaJu, GimJe, UlSan, Jeju, YeonCheon, JeCheon, GoRyeong, GyeongJu, PyeongChang) and obtained from 1,629 individuals in Pan-Asia (70 population) data set. In addition, we analyzed considerable number of CNVs typed from 16 pairs of twins in Korea.
In our study we were able to identify several informative SNP markers that are valuable to distinguish Korean from other ethnic groups. In addition, the investigation of the distribution of identity by descent (IBD) distance within a large Korean family provided a way to examine relationship between individuals. Another interesting finding resulted from this study include the differences in CNV patterns between identical twins. Possible application of genotype data to figuring out individual phenotypes (such as pigmentation, eye color, hair color, height, blood type, etc.) would be an additional profit obtained from this study in the hope to montage or even identify individuals (such as criminal suspects) using genotype data in the near future.
In this presentation, I will discuss results generated from this study which may represent the most comprehensive characterization to date for the Korean genome.
4. ొ׆րࢂڍு ୪ு
0ᶣFSTᶣ0.05: not significantly differentiated; FSTᶤ0.25: significantly differentiated; FST=1:completelyisolated(WrightS,1978)
1
Chromosome;
2
SNPs fo rwhich p values less than 10
-3
are listed;
3
p values for the Cochran-Armitage trend test of genotype
frequencies; 4
notavailable
6. ొ׆րࢂڍு ୪ு
૦ኞᑺ
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7. ొ׆րࢂڍு ୪ு
Study of genome-wide SNPs, mitochondrial DNA and Y-chromosomal DNA variation can provide a valuable
information about the population structure and peopling of human populations. To explain a genetic
homogeneity of Koreans and population structure of Koreans and the East Asian populations, we analyzed
153 individuals from the Korea and 77 individuals from the East Asia at 46,559 common single-nucleotide
polymorphic loci. The 137 CHB and 113 JPT individuals at 25,769 common SNPs from the International
HapMap project were further analyzed to reveal the population structure of the East Asians. Principal
Component analyses (PCA) and population differentiation ( ) are examined. In the PCA test, the Jeju
individuals were slightly different from other Koreans but their values were not significant. This reflect
the genetic homogeneity of Korea population. In general, all the individual samples studied here were
clustered into subset of ethnic origin according to their geographical location except Mongolians. Whole
genome sequencing of Koreans and other population genome by next generation sequencing technology will
provide great opportunity to understand the population expansion and peopling of Korea better.
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