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2014 AHA/ACC Guideline for the Management of Patients With 
Non–ST-Elevation Acute Coronary Syndromes 
DR. JUAN CARLOS BECERRA MARTÍNEZ 
Fellow en Cardiología Intervencionista, UMAE HE CMNO 
ACC Fellow in-Training 
Miembro ESC, EAPCI, SCAI, SOLACI, SOCIME, CCJ 
JACC. September 23, 2014. Accepted Manuscript
JACC. September 23, 2014. Accepted Manuscript
Pathophysiology 
JACC. September 23, 2014. Accepted Manuscript
Presentation 
JACC. September 23, 2014. Accepted Manuscript
TIMI Risk Score 
JACC. September 23, 2014. Accepted Manuscript
GRACE Risk Model 
JACC. September 23, 2014. Accepted Manuscript
Early Risk Stratification 
JACC. September 23, 2014. Accepted Manuscript
Cardiac Biomarkers 
JACC. September 23, 2014. Accepted Manuscript
Medical Management 
JACC. September 23, 2014. Accepted Manuscript
Medical Management 
JACC. September 23, 2014. Accepted Manuscript
Medical Management 
JACC. September 23, 2014. Accepted Manuscript
Medical Management 
JACC. September 23, 2014. Accepted Manuscript
Aspirin 
JACC. September 23, 2014. Accepted Manuscript
P2Y12 Inhibitors 
JACC. September 23, 2014. Accepted Manuscript
GP IIb/IIIa inhibitors 
Abciximab: better downstream 
JACC. September 23, 2014. Accepted Manuscript
Parenteral anticoagulant 
JACC. September 23, 2014. Accepted Manuscript
JACC. September 23, 2014. Accepted Manuscript
JACC. September 23, 2014. Accepted Manuscript
Strategies 
JACC. September 23, 2014. Accepted Manuscript
Non-anginal pain management 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Special patient groups 
JACC. September 23, 2014. Accepted Manuscript
Puntos a discutir… 
1.- Ya no usar CKMB ni mioglobina en el abordaje diagnóstico 
2.- BNP es útil en estratificación 
3.- Mejor ticagrelor/prasugrel que clopidogrel 
4.- Prasugrel solo si se colocan stents 
5.- Mejor eptifibatide/tirofibán que abciximab para terapia “upstream” 
6.- Bivalirudina solo en estrategia invasiva 
7.- Pacientes con fondoparinux: hacer switch a otro anticoagulante en caso de 
cateterismo 
8.- La estrategia “conservadora inicial” ahora se llama “guiada por isquemia”
Puntos a discutir… 
9.- Cuatro estrategias de tratamiento: 
- Guiada por isquemia (antes conservadora) 
- Invasiva Inmediata (2 hrs) 
- Invasiva temprana (24 hrs) 
- Invasiva tardía (25-72 hrs) 
10.- Se añade la pirámide invertida de analgésicos 
11.- B-bloqueadores pueden desencadenar espasmo coronario en 
pacientes con uso reciente de cocaína / metaanfetaminas 
12.- Nuevas recomendaciones sobre Takotsubo
Gracias!

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